Trittico

Trittico - an antidepressant, which is widely used in psychiatric practice for the treatment of such disorders of the psyche, As depressive states, recurrent depressive episodes, accompanied by anxiety or without it.

The drug effectively affects the somatic (headache, palpitation, frequent urination, muscle pain, hyperventilation, sweating) and mental (irritability, affective tension, insomnia, fear) anxiety symptoms. Also helps to improve mood, stabilize emotional state, reduce pathological attraction to alcohol in patients with chronic alcoholism patients during the withdrawal syndrome and during remission.

Trittico does not affect the neutral capture of dopamine and norepinephrine, by body weight, does not lead to addiction.

Clinical and pharmacological group

Antidepressant, a derivative of thiazolopyridine.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Trittico cost in pharmacies? The average price is at the level of690 rubles.

Composition and form of release

instagram viewer

Triticot is available in the form of white colored tablets, the main active ingredient of which is trazodone hydrochloride. As auxiliary substances in tablets of Trittico are applied: carnauba wax, sucrose, povidone, magnesium stearate.

Tablets are available in 75 and 150 mg.

pharmachologic effect

The preparation Trittico is synthesized on the basis of trazodone, which is a derivative of triazolpiridine. Effective in the treatment of depressive conditions, as well as pathologies associated with anxiety, problems with falling asleep. It is characterized by a quick action - already during the first week the antidepressant Trittico begins to show action in eliminating the symptoms of depression.

Trazodone, as an active substance, acts as a serotonin reuptake inhibitor and a receptor antagonist, activating which are usually associated with the development of anxiety, insomnia, changes in sexual function and psychomotor agitation. Unlike other psychotropic drugs, this antidepressant is approved for use in glaucoma and diseases urinary system, does not cause extrapyramidal effects and does not potentiate adrenergic transmission.

Does not have effects on heart function, typical of antidepressants of tricyclic nature. It is excreted half during the half-day, mainly with urine in the form of inactive metabolic products. Metabolised in the liver.

Indications for use

This drug is intended for the treatment of the following conditions:

psychogenic depression (neurotic and reactive depression);
benzodiazepine dependence;
alcoholic depression;
anxiety-depressive states that are endogenous in nature (involutional depression);
anxiety-depressive conditions caused by organic diseases of the central nervous system (Alzheimer's disease, dementia, atherosclerosis of the brain vessels, etc.);
Depressive states with prolonged pain syndrome;
disorders of potency and libido (disorders of erectile dysfunction in depression).

Contraindications

According to instructions, Trittico can not be used in such cases:

in the presence of high sensitivity to the components included in the preparation;
lactation and pregnancy.
age less than 6 years.

With caution appoint to persons with AV blockade, ventricular arrhythmia, myocardial infarction, arterial hypertension, hepatic or renal insufficiency, as well as persons under 18 years of age, due to the risk of developing suicidal behavior (aggressiveness, suicidal plans, anger).

Intended use for pregnancy and lactation

No evidence of harm to the fetus has been found, but if the future mother took Trittico before the birth, control of the condition of the newborn is required. Take only under medical supervision and with caution.

Trazodone can penetrate in small amounts into breast milk, therefore it is recommended to interrupt breastfeeding while it is being used.

Dosage and route of administration

As indicated in the instructions for use, the Trittico tablets are taken orally, swallowing whole, with enough water, 0.5 hours before or 2-4 hours after meals.

Recommended dosing Trittico:

depression with and without anxiety: the initial dose is 100 mg once before bedtime. After three days of therapy, the dose can be increased to 150 mg. Further, until the optimal clinical effect is reached, the dose should be increased by 50 mg every 3-4 days. If the daily dose exceeds 150 mg, then it should be divided into 2 receptions: after dinner, a smaller dose is taken, before bedtime - the main one. The maximum daily dose: for outpatients - 450 mg, for patients in the hospital - 600 mg;
treatment of impotence: monotherapy - more than 200 mg per day, as part of combination therapy - 50 mg per day;
treatment of libido disorders: 50 mg per day;
benzodiazepine dependence: according to the scheme, which involves a simultaneous reduction of the dose of benzodiazepine by 1/4 or 1/2 tablets and an increase of 50 mg of trazodone, are taken within 21 days. Then continue to gradually reduce the dose of benzodiazepines, each time increasing the dose of trazodone. After the complete abolition of benzodiazepine, a daily dose of trazodone is lowered by 50 mg with an interval of 21 days.

The initial dose of Trittico for attenuated and elderly patients should not exceed 100 mg per day. It is selected individually and prescribed once before bedtime or divided into two doses. The dose should be increased under the supervision of the doctor, taking into account the effectiveness and tolerability of the drug. For this category of patients it is not recommended to exceed the maximum daily dose of 300 mg.

For children aged 6 to 18 years, the dose is determined taking into account the weight of the child at a rate of 1.5-2 mg per 1 kg of body weight per day and divide it into several receptions. To achieve the desired therapeutic effect, the initial dose of Trittico can be gradually increased, observing the interval of 3-4 days. The maximum daily dose for children should not exceed 6 mg per 1 kg of body weight.

Side effects

During the reception of the Trittico tablets, patients may develop some side effects:

on the part of the organs of the digestive system - dry mouth, thirst, pain in the stomach, nausea, intestinal atony, a feeling of heaviness in the abdomen, bloating and flatulence, stool retention, constipation, in severe cases, intestinal obstruction;
from the side of the skin and the musculoskeletal system - itching, erythematous rash, excessive sweating, joint pain, muscle pain;
from the genitourinary system - priapism, urination disorder;
from the blood indicators - thrombocytopenia, agranulocytosis, eosinophilia, leukopenia, iron-deficiency anemia;
from the nervous system - dizziness and headaches, confusion, phobia, hallucinations, paresthesia, the violation of taste sensations, tremor of the extremities, seizure attacks by the type of epileptic fit;
from the side of the cardiovascular system - heart palpitations, ventricular type extrasystole, decrease in blood pressure indicators, syncope, development of acute vascular insufficiency;
increased fatigue, drowsiness, apathy, fever, flu-like symptoms.

If one or more side effects occur, the drug should be discontinued and consult a doctor.

Overdose

In case of an overdose, the following symptoms are noted:

tachycardia;
hypotension;
hyponatremia;
drowsiness;
dizziness;
vomiting;
nausea;
respiratory insufficiency;
convulsivity.

In cases of severe overdose, a coma develops. Symptomatic complex from the heart may include bradycardia and tachycardia. Symptoms may appear within 24 hours after an overdose and later. Simultaneous use with other antidepressants is dangerous development of serotonin syndrome.

There is no specific antidote for the drug. Adults with an overdose of more than 1 g trazodone or children with an overdose of more than 0.15 g should take activated charcoal within an hour after the detection of overdose symptoms. In other cases, it is advisable to wash the stomach.

It is necessary to monitor the patient's condition within twelve hours after an overdose. It is recommended to control blood pressure, pulse, oxygen saturation. Patients with heart diseases need to monitor cardiac activity.

With short-term cramps, treatment is not indicated. Frequent and prolonged seizures are eliminated by intravenous injection of diazepam or lorazepam. If these measures did not help to eliminate convulsivity, put a dropper of Phenytoin.

With arterial hypotension and a sedative effect, supportive and symptomatic therapy is used.

special instructions

Before you start using the drug, read the special instructions:

Contraindicated use of alcohol during the period of taking the medicine.
If the patient has a prolonged and inadequate erection against the background of taking the tablets, you should consult a doctor.
The lack of anti-cholinergic action in Trittico allows its use in the case of hypertrophy of the prostate gland, angle-closure glaucoma, cognitive impairment, elderly patients.
When appointing Trittico to patients with impaired cardiac conduction, AV blockade or after a recent heart attack myocardium should take into account the adrenolytic activity of trazodone and the risk of bradycardia and lowering blood pressure.
During the period of treatment it is recommended to periodically carry out the analysis of peripheral blood, including when there is pain in the throat when swallowing or fever. This will allow timely diagnosis of agranulocytosis and establish cases of development of severe leukopenia.

During the period of depression, the risk of suicidal thoughts or behavior increases, including when taking antidepressants, especially at the age of 24 years. Therefore, before the onset of severe remission, patients need careful monitoring. When unusual changes in behavior occur, consult a doctor immediately.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

A case of piruet-type arrhythmia is described with the simultaneous use of trazodone with amiodarone.
A case of a moderately pronounced decrease in the anticoagulant effect of warfarin with simultaneous application to trazodone is described.
With simultaneous use with lithium salts, tremors, reversible symptoms of neurotoxic action are possible.
When pseudoephedrine is taken against the background of trazodone therapy, a case of anxiety, panic, darkening of consciousness, depersonalization is described.
With simultaneous use with ethanol, the depressing effect on the central nervous system increases.
With simultaneous use, it is possible to increase the concentration of digoxin in the blood plasma and the development of symptoms of intoxication.
At simultaneous application with carbamazepine the case of increase of concentration of carbamazepine in a blood plasma is described.
With simultaneous use with thioridazine, an increase in the concentration of trazodone in the blood plasma is possible; with tryptophan - a case of development of anorexia, psychosis, hypomania; with phenytoin - a case of increased side effects of phenytoin; with fluoxetine - there may be an increase in side effects; with chlorpromazine, trifluoperazine - it is possible to develop arterial hypotension.

Reviews

We offer you to read reviews of people who used the drug Trittico:

Victoria. I take 50 mg for THREE YEARS, for sleeping. It helps very well. Only in the morning you need to immediately drink coffee, and no sleepiness the whole day. For me it was a rescue from insomnia. All of health!
Angelina. Trittico was prescribed to me by a neurologist with insomnia and a depressed mood. Previously, taking benzodiazepine tablets, got used to them, the doctor said that he at the same time will allow and get out of benzodiazepine. It helped me, it was good to sleep, but not without side effects - my head ached, I felt sick from time to time, then passed.
Alexander. An excellent product. He began to feel better - there was a calm sleep, there was a muscle pain in the legs, legs became light, even the gait changed. I wake up like a child, even deep breathing after receiving improved preoporatov taken from me from asthma, sputum expectoration improved and I myself controlled this process. Of side adverse effects - a small ringing in the ears, but this is a trifle compared to positive results.

Analogues

Antidepressants based on trazodone hydrochloride, except Trittico, are not available. According to the mechanism of action and relation to one pharmacological group, the following drugs are considered to be analogues of this drug: