Antiviral "Zanamivir": reviews, instructions for use, description, analogies
In the period of epidemics and colds, which are more often in the cold season, people use all sorts of ways to increase immunity. Some people use ancient and proven recipes for folk medicine. Others resort to medicinal compounds. The opinions of doctors about such prevention are very divergent.
This article will tell you about what the "Zanamivir" medication has. You will learn about the trade names of this medication and can get acquainted with the reviews about them.
Drugs containing zanamivir
In modern pharmacy chains you can purchase a medicine with the trade name "Relenza". It is released recently only by the doctor's prescription. However, unscrupulous sellers can give it back without a corresponding piece of paper.
Many consumers are interested in whether there are other available drugs containing zanamivir? It is possible to answer with full confidence this question negatively. Manufacturers of medicines have not yet created an absolute substitute for this drug.
general characteristics
What are the medicines Zanamivir reviews, you can find out more. To begin with, it is worth giving a description of this drug. As you already know, the trade name of the drug is Relenza. The composition is in the form of a powder. It is used exclusively by inhalation. Internal use is unacceptable and contraindicated.
The composition of the drug includes 20 doses. Each of them contains 5 milligrams of zanamivir. Lactose can also be mentioned among the additional substances. In the kit for the drug "Zanamivir" the instruction is attached necessarily. Also in the package there is an apparatus for inhalation administration of the drug. The method of using it is described in detail in the annotation.
Cost of medicinal product
What is the price of the drug with the active substance zanamivir price? It all depends on where you will buy the medicine. In pharmacy chains, which release the product according to the appropriate prescription, the drug costs about 1300 rubles for one pack. In the event that you do not have a doctor's appointment, pharmacists can, from their own advantage, inflate the price to , 00 rubles and release you the product. Repeatedly such situations were registered.
Also, some consumers say that the price of Zanamivir is about 3-5 thousand rubles. In this case, the medication is ordered through the Internet. This manipulation does not require a prescription, but it is completely illegal. Please note that the medicinal compounds must be purchased exclusively at the relevant points, licensed and authorized to sell them. Treatment with poor-quality medicines purchased at underground stations can lead to disastrous consequences.
How to replace the drug?
The active substance of zanamivir analogs is different. As you already know, the drug does not have an absolute substitute, which would have an identical composition. However, there are means with another active substance working in the same way. The closest drug to the described is Tamiflu. Zanamivir and oseltamivir relate to inhibitors of neurominidase. They block the release of harmful particles from cells that are already infected with the virus. Note that the active substances zanamivir and oseltamivir are unique. They have no analogues with the same composition. The drug "Tamiflu" is available in tablets for internal use and can not be used by inhalation.
Has an active substance zanamivir analogues and another plan. Such drugs include Interferon, Isoprinosine, Rimantadine, Anaferon, Derinat, Isoprinosin, and many others. They all have a lower cost. At the same time they are available for sale without appropriate prescriptions from the doctor. The listed medicines can be in the form of tablets, injections, drops for nasal application and inhalations.
Indications for prescription
As you already know, the drug with the active substance zanamivir (Relenza) is sold exclusively on prescription. In this case, you should appoint a doctor to the therapist. The doctor writes out a form on which the amount of the drug and the duration of the course of use are indicated. Also, your data (name and surname) are mandatory. On this document you can freely purchase the specified facility.
The drug Zanamivir (Relenza) is used as an antiviral and immunomodulating agent. It is used for treatment and for preventive purposes. In the annotation it is indicated that the powder for inhalations is prescribed for the influenza A and B virus. In this case, doctors sometimes recommend medicines in other situations. The medicine can be used for viral bronchitis, pneumonia and other diseases.
Restrictions in use
About the drug "Zanamivir" instruction says that it should not be used with increased sensitivity to the components of the drug. The composition is not prescribed for diabetes and lactase deficiency. On this, the funds end.
However, doctors have a slightly different view on this matter. They supplement the described data with others. About the drug "Zanamivir", experts say that the drug should not be used by children under the age of 5 years. All because the baby can not take the drug correctly. Also in this means, it is not possible to divide the present dose into several parts.
additional information
Can I use Tamiflu and Zanamivir in pregnancy and lactation? As you already know, medications are contraindicated for young children. So can they harm the baby through the body of his mother? We will deal with this issue.
The annotation states that you should not use the described medication in the first trimester of pregnancy. In the second and third part of the term, use is only permissible according to the doctor's prescription, taking into account all risks. Physicians are of a different opinion. About the medicine "Zanamivir" (trade name - "Relenza"), experts report the following. Administration of the drug in large doses, as well as the use of the analog "Tamiflu", can have a teratogenic effect on the developing fetus. It is especially dangerous to use drugs in a large dose.
Negative reactions: side effects
The active substance zanamivir (the trade name of the drug - Relenza) is usually well tolerated by consumers. However, the annotation reports that the drug can cause side reactions.
The instructions describe the following cases:
- Allergic reaction, manifested by a rash, itching and hives.
- Cough that leads to bronchospasm.
- Swelling of the face, larynx, difficulty breathing.
If you encounter such a situation, it is recommended that you contact a specialist as soon as possible. Further use of this medication is unacceptable and dangerous.
Method of use of medicament
From the flu, "Zanamivir" is inhaled. Medication has no other way of use. Many patients are interested in whether there are pills with the name "Zanamivir"? This form of release of the drug is not yet available.
Before you begin to use, you must carefully read the instructions. Also, strictly follow all the recommendations that the doctor gave you. If there were none, then follow the annotations.
Take the container for inhalations and carefully consider it. Remove the cover and insert one rotadisk. After that, latch the container and start inhalation. Depending on the purpose of the drug, its dose may vary greatly.
Treatment of influenza
Antiviral "Zanamivir" is prescribed for adults and children over five years of age. In children, the use of the drug should be controlled by adults. The dosage of the drug is two inhalations twice a day. It is desirable to apply at the same time at the same interval.
One rotadisk is enough for you on the day of treatment. The duration of the course is 5 days. With the help of mathematical calculations, you can find out that the medicine package is sufficient for the whole course.
Preventive actions
Zanamivir is recommended for prevention. However, recently it has been used less and less. The reason for this was the sale of medicines on prescription. Specialists try to prescribe other, more accessible and safe means for the prevention of viral diseases.
As a preventive measure for influenza and viral infections, medication is used in adults and children after 10 years. Previously, use it in the absence of disease is not recommended. The instruction for use advises to observe the following algorithm. In a day, two inhalations of 5 milligrams of the active substance are administered once. In order not to get sick after contact with an infected person, it is necessary to continue this therapy up to 10 days. One pack of medication is just designed for this period.
Persons with respiratory diseases
The drug "Zanamivir" in rare cases leads to such a side effect as bronchospasm. However, this reaction is not ruled out. Especially it affects people who have a history of respiratory diseases. Most often it is asthmatics.
If you do not have the opportunity to refuse the described remedy, then you must have bronchodilator preparations for the entire period of treatment. Do not think that if one time reaction has not occurred, then it will not be after. With the development of bronchospasm it is necessary to immediately stop the manipulation. As soon as possible, take the appropriate medicine that relieves bronchial spasm and dilates their lumen. This will help you to restore normal breathing. During the procedure, breathe as you do in normal life. Do not perform very deep and sharp breaths.
Zanamivir: patient feedback
What are the opinions about the described medicine from those who used it for treatment or prevention? Many people used this tool during epidemics. Until recently, it could be purchased without a doctor's appointment. Patients say that the drug "Zanamivir" is very effective. The medicine quickly has a positive effect on the body. It increases immunity and strengthens resistance. Immediately it is worth saying that the timely use of the drug after contact with the infected does not allow the person to fall sick.
Also, many patients used an agent to treat the disease. The drug is prescribed for such severe and dangerous diseases as pork or avian flu. It is these diseases that often lead to complications and death. Consumers report that after the initiation of therapy, it became much easier for them. Improvement of the condition was observed already on the second or third day. The general course of treatment was five days. In rare cases, the doctor recommended increasing the duration of the medication.
Patients testify that the drug "Zanamivir" is convenient to use. You can always take with you a device for inhalation and rotadiski. If you can not go to a sick leave and have to go to work, then this will be an invaluable plus.
Opinions of specialists
Often patients are interested in a doctor about the drug Zanamivir, where to buy it? The specialist should always explain to his patient that this medication is dispensed solely on prescription. Do not look for workarounds and buy the drug in non-specialized points. Doctors say that often there were cases of detection of the above-mentioned adverse reactions from therapy. At the same time, the consumer used the clandestine method of purchasing a drug. Nobody knows what is actually in such a preparation.
Therapists say that the drug should not be used for preventive purposes. At present, there are many alternative means that are recognized as safer and more accessible. You can easily buy them in a pharmacy and conduct a preventive course of admission. The drug "Zanamivir" is prescribed only if the disease is already diagnosed.
Some experts report that the drug "Zanamivir" has no proven effectiveness. Physicians argue that the action of the drug is based on the effect of a placebo. However, the price of the medication and its instruction report the opposite. Of course, reviews are very important for specialists and consumers of the drug. However, do not rely solely on them. Doctors are advised to study information about the drug before using it. But it is necessary to get acquainted with the instruction for use and take into account the opinion of doctors.
Is there an addiction?
About the medicine "Zanamivir" experts say that it never becomes addictive. Many consumers have a wrong opinion. They believe that viruses can develop resistance to this substance. After all, this is the case with uncontrolled or incorrect use of antibiotics.
In fact, this is not so. This drug acts on its own immunity, strengthening it. The drug blocks the release of neurominidase. That is why it is called an inhibitor. The agent after entering the respiratory tract recognizes the affected cells and prohibits their work. Also, the powder for inhalation containing zanamivir does not allow the virus to penetrate further. The maximum effect of the medication occurs when the therapy is performed in the first two days after the first symptoms of infection are manifested. Usually it is a headache, a sharp increase in body temperature. In this case, the flu is usually characterized by numbers from 39 degrees and above. Often the patient is unable to eliminate the fever with the usual antipyretic agents.
Interaction
Often the drug "Zanamivir" is prescribed concomitantly with other drugs. The most common combination of non-steroidal anti-inflammatory drugs with this medication. This interaction is entirely permissible. Negative reactions to treatment do not occur. Together, the drugs have a positive effect on the patient's body, relieving inflammation, lowering the temperature and blocking the multiplication of the virus.
It happens that sorbents are prescribed with this medication. They are used to remove toxins that are secreted by multiplying viruses. With this combination of drugs, you must always take a break. Doctors usually recommend taking one remedy and only after 2-3 hours resorting to the use of another. Otherwise, the antiviral drug may not work in full measure.
The purpose of the drug can be carried out simultaneously with antibiotic therapy. In this case, most antimicrobial compounds are normally combined with the indicated drug. But it is worth remembering that when using medicines at the same time, you should always consult your doctor. If you have to take any medication, you have been prescribed a medicine Zanamivir, tell your doctor about it. If necessary, the doctor will help you to choose the most suitable reception scheme.
The drug should not be used with other antiviral and immunomodulating agents, if such a recommendation was not given by a doctor. Such therapy can lead to an overdose of an active substance. Any wrong combination of drugs is fraught with consequences.
Summarize…
You have heard about the drug Zanamivir. The drug has the trade name "Relenza". It is impossible to replace it with medicines with the same substance. Acquiring a medicine without a prescription from a doctor is difficult and unsafe. Remember that restrictions in the use of medicines are not just created. In this way, the state tries to protect the person from the wrong treatment, which can do him harm.
In most cases, this medication is well received. He has almost no contraindications. According to the instructions, the medicine effectively fights against viruses of different types. However, not all specialists are convinced of the effectiveness of the medication. To this day, there are active disputes and research on this subject. To get the right, effective and qualified appointment, you need to contact the doctor. If necessary, the doctor will assign you a series of studies, and then recommend one or the other remedy. Remember that the flu is an insidious disease. It often leads to complications that can result in death. It is not necessary to hesitate and use known medications on your own. Strong to you health!
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"Zanamivir": analogue of the preparation, instruction for use
For the treatment of influenza, drug manufacturers have been developing unique drugs in recent years. Some drugs are taken orally in the form of tablets, others are administered by rectal use. On the shelves of pharmacy kiosks you can see a wide variety of compounds. One of the new drugs, which is still subject to massive disputes, is Zanamivir. Reviews, instructions, analogues of this medicine will be presented to your attention in the article.
What it is?
Before you find out what Zanamivir drug (zanamivir) has analogues, it is worth making its description. The drug has a pronounced antiviral effect. It is made in the form of a powder. The flowable agent is to be diluted and injected into the human body by inhalation.
The medication is dispensed solely on the prescription of a doctor. It can be purchased in almost every pharmacy chain. The drug costs within 1500 rubles. Its trade name is Relenza. For this amount, you can get 20 doses, each containing 5 mg of active ingredient.
Zanamivir: analogues of the preparation
The active substance described is an inhibitor of neuronididase. It blocks negative connections that are released after the virus has touched the cell of the human body. Also, the medicine prevents further spread of the disease.
Has a "Zanamivir" analog, which is known to everyone. This is Tamiflu. Its active substance is oseltamivir. This component works exactly the same as its predecessor. The main task of oseltamivir is to eliminate the neurominidase released after the contact of the virus and cells of the human body. The drug is available in the form of tablets for oral administration.
Other substitutes
The drug "Zanamivir" has no analogue. To date, no drugs with the same active substance have been created. However, there is a mass of antiviral drugs that come into the fight against the virus through another action.
Zanamivir's simpler and safer substitutes include Isoprinosine, Arbidol, Ergoferon, Ingaron, Derinat, Irs-19, and many others. These formulations have a different mode of administration. If we talk about the means that can be taken by inhalation, then the analogues of Zanamivir include the following drugs: Derinat, Interferon, Ingaron. You can buy them at a more affordable price than the original drug. Also for the purchase you do not need a prescription from the doctor.
Indications and limitations
The drug "Zanamivir", analogs of this medication and substitutes are prescribed for the treatment of viral diseases. More often these formulations are used for influenza of various kinds. Less often, medications are prescribed for herpes, hepatitis virus origin, chicken pox and other diseases. Before using the product, always pay attention to its contraindications.
Do not use Zanamivir medication with hypersensitivity to it. It is also forbidden to carry out treatment during pregnancy and breastfeeding. Do not give medicine to children under the age of 5 years.
Zanamivir: instructions for use
As you already know, the described medication is administered exclusively by inhalation. For treatment, two servings of medication are prescribed twice a day. When it comes to the need for prevention, the composition is taken once a day, the duration of therapy usually does not exceed 7 days. Prophylactic correction can last 10 days.
Substitutes of the described drug have different uses. One must be taken once, the other formulations should be drunk every hour. The duration of therapy can also vary significantly. A more detailed algorithm for taking medication should be studied in the annotation. Also, always ask questions of interest to the doctor.
Reviews about the drug "Zanamivir"
Most consumers who took the medicine were happy with it. The drug is well tolerated. Only in some exceptional situations can there be an allergy or bronchospasm.
Consumers say that the earlier the treatment with the indicated agent is started, the more noticeable effect is observed. Optimal use of medication for the first symptoms of the disease. Patients report that the instructions for use have been described rather scantily with Zanamivir. That is why when prescribing a medicine it is worthwhile to learn in detail about its application to a doctor.
Some pharmacy kiosks sell Zanamivir at an inflated price. However, they do not require a prescription. Such a purchase of a medicine is unacceptable. Remember that you should not buy goods from questionable sellers and clandestine producers. Before use, consult a doctor. Strong to you health!
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Oseltamivir: instructions for use, analogues, description of the preparation
What is the prescription for Oseltamivir? Instructions for use, analogs, indications and contraindications for this medication will be described below. Also, we will tell you about the form in which you can buy this medication, what properties it possesses, whether it has side effects, etc.
Form, composition, description of the medicinal product
In the sale of this drug comes in the form of white and yellow capsules. Oseltamivir is a pro-drug. When ingested, it undergoes hydrolysis and is converted to the active substance - oseltamivir carboxylate.
In addition to capsules, this medication is also available as a light powder for the preparation of an oral suspension.
Features of the drug
How does Oseltamivir work? The instruction for use states that the therapeutic effect of this drug is based on inhibiting the activity of enzymes that are located on the surface of the virion of the influenza virus.
After the receipt of the drug in the human body, its main component is transformed into an active metabolite. Thus, oseltamivir carboxylate selectively inhibits neurominidase. As a result of this influence, the process of multiplication of viral cells ceases.
According to specialists, this medication should be taken within 35 hours after the appearance of the first signs of influenza. Only so the duration of the disease can be reduced by 30%, and the probability of complications and the severity of the symptoms - by 40%.
Pharmacokinetics of the drug
Is the drug "Oseltamivir" absorbed? The instructions for use indicate that about 90% of oseltamivir phosphate is absorbed in the gastrointestinal tract. The active substance is converted to oseltamivir carboxylate, and then enters the systemic circulation.
About 3% of the active ingredient binds to plasma proteins. Its bioavailability is approximately 76-85%, and the half-life is 120 minutes.
From the human body, oseltamivir carboxylate is excreted by the kidneys (about 80%) and the intestines (20%). The half-life of this drug is 6-10 hours.
Indications for use
What is the prescription for Oseltamivir (Pharm. group - antiviral agents)? According to the attached instructions, this medication is used to treat influenza A and B. It is also often used to prevent these viral diseases.
Contraindications for use
Does Oseltamivir have contraindications (the description of the drug was presented above)? According to the instruction, this medication is forbidden to take at:
- hypersensitivity to the active component;
- renal failure (safety and efficacy of the drug in this category of patients have not been determined);
- in childhood to 1 year (there is uncertainty regarding the formation of BBB in children);
- pregnancy and breastfeeding (it is not known whether the drug is excreted into the breast milk of women, and whether it affects the fetus).
It should also be noted that this medication is not recommended for children under 13 years of age, since specialists The safety and effectiveness of Oseltamivir for the prevention and treatment of influenza have not been determined.
Oseltamivir preparation: instructions for use
Vidal (the reference book of medicines) contains in itself the complete information on how and in what dosages it is necessary to take the given preparation. However, it should be noted that only the attending physician should prescribe this medication. After all, only an experienced specialist will be able to select the right treatment regimen that will quickly and effectively eliminate all unpleasant symptoms of a viral disease.
So in what dosage is Oseltamivir prescribed? Instructions for use indicate that this drug should be used no later than 2 days after the first signs of influenza.
Children over 13 years and adults are prescribed medication in an amount of 75 mg twice a day for 5 days. It should immediately be noted that an increase in the dosage of the drug (eg, up to 150 mg per day) does not lead to an increase in the therapeutic effect.
If the drug should be prescribed to children aged 1-12 years, the dosage is selected depending on the weight of the child.
To prevent influenza, adults and children over 13 years of age are prescribed 75 mg 1 once a day for 6 weeks (for example, during an epidemic).
In patients with Cl creatinine less than 30 ml per minute, dosage adjustment is required (75 mg once daily for 5 days).
Side effects after taking medication
What adverse reactions occur after taking Oseltamivir? Instruction for use says that the most often manifested undesirable reactions are nausea and vomiting. In most cases, such effects are mild or moderately expressed and, as a rule, occur in the first days of treatment.
It should also be noted that in some patients on the background of taking the drug in question, bronchitis, vertigo, insomnia, unstable stenocardia, pseudomembranous colitis, anemia, pneumonia, fracture of the humerus, peritonsillar abscess and fever.
Very rarely, people taking Oseltamivir receive abdominal pain, hearing disorder, epistaxis and conjunctivitis. In most cases, such reactions occur once and independently disappear, despite the continuation of therapy. Such phenomena do not require the withdrawal of the medication.
After the appointment of an antiviral drug in children and adolescents, undesirable effects also appear. These include phenomena such as rash, toxic epidermal necrolysis, swelling of the tongue or face, arrhythmia, confusion, convulsions and worsening of the course of diabetes.
Drug Interactions
The information obtained during pharmacokinetic and pharmacological studies, says that the development of clinically significant drug interactions in this drug is unlikely.
In the instructions attached to the drug, it is said that the simultaneous use of this drug with probenecid results in a 2-fold increase in the AUC of the active metabolite. But dose adjustment is not required.
Cases of overdose
What signs are observed in patients when taking elevated doses of Oseltamivir? The testimonials and instructions say that until now no such cases have occurred. However, single doses of an antiviral drug may cause vomiting or nausea.
To eliminate such symptoms, symptomatic therapy is performed.
Special recommendations for taking the medicine
What should the patient know before taking Oseltamivir? Instructions for use (in children and adults there may be different side effects) indicates that this drug is not applicable for annual vaccination. It does not prevent the development of complications that may occur in viral disease, as well as in bacterial infection.
Analogs of the medicinal product
"Oseltamivir" is a medicinal product that is intended for the treatment and prevention of influenza. It is an antiviral agent that refers to inhibitors of neuraminidase. This medication is widely known as Tamiflu. There are no structural analogues to it. The closest, but slightly inferior in effectiveness, are the following substitute drugs: Relenc, Arbidol, Flustol, Kagocel and others.
Reviews and evaluations of the effectiveness of the drug
According to the test results that were obtained in the United States and Mexico, new viruses are sensitive to neuraminidase inhibitors ("Zanamivir" and "Oseltamivir"), but they are resistant to another group - adamantanes ("Rimantadine", "Amantadine").
It should also be noted that the experts have never established the effectiveness of this drug in the treatment of influenza in people with chronic cardiac and respiratory diseases.
According to doctors' reviews, this drug reduces the duration of symptoms for 1 day, but this is only if the treatment was started in the first few hours after contact with the patient.
To date, there is no reliable information about whether this drug affects the frequency of complications of viral or infectious diseases.
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