Griseofulvin tablets

Griseofulvin - a drug aimed at combating fungal formations.

It is most effective when exposed to dermatomycetes, such as mokrosporumy, trichophytonic associations, edipermophyton. Its peculiarity is complete inefficiency in the fight against candidiasis. Griseofulvin is recognized as the main drug used in the diagnosis of dermatomycosis.

On this page you will find all information about Griseofulvin: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Griseofulvin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antifungal antibiotic.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Griseofulvin cost? The average price in pharmacies is at the level of300 rubles.

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Form of issue and composition

Griseofulvin tablets have a white or light cream color, a round shape, a bitter taste. The main active ingredient is griseofulvin, its concentration in one tablet is 125 mg. It also includes auxiliary components, which include:

• Povidone.
• Polyethylene glycol.
• Magnesium stearate.
• Corn starch.
• Lactose monohydrate.

Griseofulvin tablets are packaged in a planar cell pack of 10 pieces. The cardboard pack contains 2 contour cell packs (20 tablets) and instructions for the use of the drug.

Pharmacological effect

Griseofulvin slows down the growth and growth of fungal microorganisms, and when the drug is used in concentrations of its fungicidal action against pathogenic fungi-dermatophytes. The drug accumulates in the cells of the hair, nails and skin, thereby preventing the spread of fungus in new cells that form during the treatment.

Cream and ointment Griseofulvin include in its composition salicylic acid, due to which they have the ability to penetrate into the deepest layers of the affected tissues. The drug in the form of cream and ointment, in addition to the antifungal effect, has keratolytic and antiseptic effects, and also somewhat reduces itching, providing an analgesic effect.

Indications for use

According to the instructions, Griseofulvin is used for mycosis of hair, skin and nails, including the following conditions:

1. Favus;
2. Trichophytia;
3. Microsporia of smooth skin;
4. Inguinal epidermophytia;
5. Epidermophytia of the feet;
6. Microsporia of the scalp;
7. Epidermophytia of smooth skin;
8. Dermatomycosis of mustache and beard;
9. Onychomycosis.

Contraindications

According to the instructions for use Griseofulvin is not used for the following diagnosis:

• Lupus erythematosus;
• Reduced leukocyte count;
• Organic pathologies of the kidneys and liver;
• Liver failure;
• Certain diseases of the circulatory system;
• Porphyria;
• Cancerous growths.

In addition to these pathologies, the drug is prohibited during pregnancy and lactation, with increased sensitivity to the components of the drug, infants.

Application in pregnancy and lactation

Griseofulvin is contraindicated in pregnancy and lactation.

Instructions for use

The instructions for use indicate that the tablets should be taken with food with vegetable oil (1 teaspoon).

1. With onychomycosis, trichophytosis and paw paws, the daily dose of the drug for adults with body weight up to 50 kg is 625 mg (5 tablets), then for every 10 kg of body weight the dose of the drug is increased by 125 mg (1 tab.). The maximum daily dose is 1 g (8 tablets).
2. In microsporia, the daily dose for adults is up to 1000 mg (8 tablets), children are prescribed at the rate of 21-22 mg / kg body weight / day. The drug should be taken daily until the first negative mycological analysis, and then in the same dose take 2 weeks every other day and 2 weeks 2 times a week.
3. With onychomycosis for children and adolescents, the drug is prescribed at the rate of 16 mg / kg body weight.
4. With trichophytosis and favus, the drug is prescribed to children at a rate of 18 mg / kg body weight / day. The course of treatment is conducted as in microsporia.
5. With onychomycosis, the drug is prescribed during the first month every day, the second month - every other day, then 2 times a week until the nail is completely replaced with a healthy one. The total duration of treatment should be at least 8 months.

Side effects

Misuse of the medication can lead to the development of undesirable effects in the form of dyspeptic phenomena. Some patients complain of headache and dizziness.

Complications are manifested as:

1. Disorientation.
2. Hives.
3. Nausea.
4. Vomiting.

In rare cases, the development of urticaria is diagnosed. With prolonged use of the drug, the level of leukocytes in the blood decreases, which leads to leukopenia. In rare cases, the development of leukocytosis is diagnosed.

If unwanted effects occur, the patient should stop treatment for several days. If a person is diagnosed with urticaria, he is recommended taking antihistamines. To eliminate nausea inside, - a solution of novocain in the amount of one tablespoon is taken.

Overdose

Cases of overdose of Griseofulvin tablets are unknown to date. There may be development of headache, nausea, vomiting, confusion. In such cases, it is necessary to wash the stomach, intestines and symptomatic therapy.

special instructions

• The active substance has a negative effect on the reproductive function, regardless of sex, so it is necessary to take contraceptives that do not contain hormones during its administration.
• In the process of using Griseofulvin it is recommended to perform a blood test every morphological for 2 weeks every week.
• The activity of griseofulvin is significantly reduced if its intake is combined with barbiturates.

When developing allergic reactions, it is necessary to prescribe antiallergic therapy, in case of intensification of allergic processes, it is necessary to cancel the drug for 3-4 days. After removing the manifestations of allergies, taking the drug should be resumed with 1/2 tablets per day, and gradually increasing (within 3-4 days), to bring to a therapeutic dose.

Drug Interactions

Simultaneously, the administration of the drug with indirect anticoagulants leads to a decrease in the activity of the latter. This is also true with regard to oral contraceptive use with Griseofulvin therapy.

Barbiturates weaken the antimycotic action of the drug.

Reviews

We picked up some feedback from people about the Griseofulvin product:

1. Dasha. Cured of ringworm. The only side effect in the first week was a headache, but then everything went away.
2. Sofia. I had mycosis of the skin. For treatment, I was prescribed Griseofulvin. Took 2 weeks and still processed the leg with ointment. Now I am absolutely healthy.

Reviews of doctors and patients who received Griseofulvin, in most cases indicate a high effectiveness of the drug. In their opinion, after several days of treatment, improvements are noticeable.

Analogues

Griseofulvin analogs on the mechanism of action: Atifin, Binafin, Brahamyl, Lamisil, Terbizil, Terbinafine, Terbinox, Terbifin, Thermicon, Tigal-Sanovel, Fungoterbine, Cidokan, Exeter, Exificin, Tebikur.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Griseofulvin is recommended to store in a dark and dry place out of reach of children, at a temperature not exceeding 20 ° C.

Shelf life of the tablets is 3 years 6 months.

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