How to use Berodual for inhalations: instructions and feedback from people

Berodual is a medicinal product that is used when there is a bronchospastic syndrome for relief of shortness of breath and acute choking.

It is used for the treatment of obstructive bronchitis in a chronic form. Medication has long been the leader in the number of sales among other bronchodilators, it is used for the treatment of patients of any age category, and its popularity is due to convenience application.

On this page you will find all information about Berodual: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Berodual for inhalations. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Broncholytic drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Berodual? The average price in pharmacies is at the level of300 rubles.

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Form of issue and composition

Composition:

• 1 ml of inhalation solution contains active ingredients: 261 μg of ipratropium bromide monohydrate, based on anhydrous ipratropium bromide (250 μg) and 500 μg fenoterol hydrobromide.
• Auxiliary components: benzalkonium chloride, disodium edetate dihydrate, sodium chloride, hydrochloric acid 1Н, purified water.

Transparent colorless or almost colorless liquid, free from suspended particles. The smell is almost imperceptible.

Pharmacological effect

Berodual's pharmacological action is aimed at combating suffocating cough due to relaxation of muscles of smooth muscles and removal of bronchospasm. The drug has an expectorant effect, dilates the bronchi, dilutes and removes mucus and sputum, accumulating in the lungs and the respiratory tract.

The therapeutic effect of the drug is provided by two active components: ipratropium bromide and fenoterol. Fenoterol has a blocking effect on inflammatory mediators, eliminates the tension of smooth muscles bronchus and prevents the development of spasms that can occur under the influence of histamine, cold air or allergens.

Indications for use

At what cough are inhalations given Berodual? When coughing caused by infectious and non-infectious respiratory diseases, accompanied by obstruction (narrowing) of the respiratory tract, with reversible bronchospasm. Indication for use in accordance with the instruction is the presence of bronchospastic reactions that arise under the influence of internal mediators (methacholine, histamine), as well as external allergens.

In the instructions for the use of Berodual's solution, the following diseases are noted, in which the preparation is shown:

• obstructive bronchitis;
• pneumonia;
• bronchial asthma;
• COPD.

Contraindications

It is forbidden to use the drug in such situations:

• prenatal period of fetus intrauterine production;
• hypertrophic obstructive cardiomyopathy;
• the first trimester of pregnancy;
• hereditary or acquired intolerance of the constituent components of the pharmaceutical preparation;
• disturbance of the rhythm of cardiac activity by the type of tachyarrhythmia;
• hypersensitivity to the active ingredients or excipients that make up the drug.

The appointment of a pharmaceutical product against the background of the following pathological conditions necessarily requires compliance with measures increased caution (for example, the passage of a conservative course in a specialized pulmonological hospital):

• diabetes;
• hyperthyroidism;
• angle-closure glaucoma;
• heart failure;
• arterial hypertension;
• cardiac ischemia;
• cystic fibrosis;
• myocardial infarction in the anamnesis for the last three months;
• obstruction of the neck of the bladder (a special organogenic character);
• pheochromocytoma or other hormone-dependent neoplasms;
• benign prostatic hyperplasia;
• marked defeat of the cerebral and peripheral bloodstream.

Application in pregnancy and lactation

Berodualal solution for inhalation is not prescribed in the first and third trimesters of pregnancy.

During breastfeeding and the second trimester of pregnancy, the drug should be administered with extreme caution.

Instructions for use

The instructions for use indicate that when using Berodual for inhalations, the following dosages are recommended:

1. In adults (including the elderly) and adolescents over 12 years of age with acute attacks of bronchospasm in Depending on the severity of the attack, doses may vary from 1 ml (1 ml = 20 drops) to 2.5 ml (2.5 ml = 50 drops). In particularly severe cases, the drug can be used in doses as high as 4 ml (4 ml = 80 drops).
2. In children aged 6-12 years with acute attacks of bronchial asthma, depending on the severity of the attack, the doses can vary from 0.5 ml (0.5 ml = 10 drops) to 2 ml (2 ml = 40 drops).
3. In children under 6 years of age (body weight? 2 kg) due to the fact that information on the use of the drug in this age group is limited, the use of the following dose is recommended (only under condition of medical observation): 0.1 ml (2 drops) per kg of body weight, but not more than 0.5 ml (10 drops).

Treatment at home is possible only after consulting a doctor in cases where a fast-acting β-adrenoceptor agonist at a low dose is not effective enough. Also, the inhalation solution can be recommended to patients in the case where the aerosol for inhalation can not be used or if it is necessary to use in higher doses.

The dose should be selected individually, depending on the severity of the attack. Treatment usually begins with the lowest recommended dose and is discontinued after a sufficient reduction in symptoms is achieved.

Rules for the use of the drug:

1. The solution for inhalation should be used only for inhalations (with a suitable nebulizer) and not to be used orally.
2. The recommended dose should be diluted with 0.9% solution of sodium chloride to a final volume of 3-4 ml, and used (completely) with a nebulizer.
3. The diluted solution should be used immediately after preparation.
4. Do not dilute with distilled water.
5. Dilution of the solution should be carried out every time before use; the remnants of the diluted solution should be destroyed.

Mortar for inhalation Berodual can be used with various commercial models of nebulizers. The dose reaching the lungs and the system dose depend on the type of nebulizer used and may be higher than appropriate doses using Berodual's HFA and CFC metered aerosol (which depends on the type inhaler). In those cases where there is wall oxygen, the solution is best used at a flow rate of 6-8 l / min.

Side effects

Berodual is usually well tolerated. In some situations, it is possible to develop undesirable side effects from different systems.

The most common side effects reported in clinical trials were cough, dry mouth, headache pain, tremor, pharyngitis, nausea, dizziness, dysphonia, tachycardia, palpitations, vomiting, increased systolic blood pressure and nervousness.

From the nervous system:

• change in taste and dry mouth;
• nervousness;
• headache;
• dizziness;
• tremor.

On the part of the respiratory system:

• cough;
• irritation of the mucosa of the respiratory tract;
• development of paradoxical bronchospasm (rarely).

On the part of the digestive system:

• digestive disorders (nausea, vomiting);
• violation of intestinal motility (mainly in patients with cystic fibrosis).

From the cardiovascular system:

• increased heart rate;
• tachycardia;
• increased systolic and decreased diastolic pressure;
• arrhythmia.

Allergic reactions:

• rash;
• hives;
• angioedema.

From other systems:

• Myalgia (muscle pain) and muscle cramps;
• disturbance of visual accommodation;
• hypokalemia;
• increased sweating;
• weakness;
• retention of urination.

If the solution gets into the eye, the pupil dilates, the intraocular pressure rises, which is accompanied by pain or discomfort in the eyeball, fuzzy vision of objects, the appearance of colored spots in front of the eyes and redness conjunctiva.

Overdose

The most likely symptoms of an overdose are as follows:

• increasing the difference between systolic and diastolic blood pressure;
• angina pectoris and symptoms accompanying it (for example, a feeling of heaviness behind the sternum);
• hyperemia of the skin of the face and accompanying sensation of fever;
• subjective sensation of heartbeat and tachycardia confirmed by hardware methods;
• increase or decrease in blood pressure (depending on individual predisposition);
• strengthening of the bronchial obstructive pathological process;
• metabolic acidosis.

Also, an overdose can be caused by excessive intake into the bodyipratropium bromide, but in this case it is weakly expressed and has a transient (passing) character. This is due to the breadth of therapeutic use of this component in pharmacy. In this case, it can be observeddry mouthordisabilityorgans of sight.

special instructions

A solution for inhalation with caution should be taken with diabetes, arterial hypertension, angle-closure glaucoma, heart disease and vessels (IHD, heart failure, aortic stenosis, heart disease, marked lesions of peripheral and cerebral arteries), recently transferred infarction (during the last three months), prostatic hyperplasia, pheochromocytoma, hyperthyroidism, cystic fibrosis and obstruction of the cervical the bubble.

Regular use of increasing doses of Berodual and other preparations containing β 2 -adrenomimetics to stop obstruction leads to uncontrolled deterioration of the course of the disease. An increase in the dose with increased bronchial obstruction above the recommended is unacceptable, not justified and dangerous. To prevent the deterioration of the course of the disease and to prevent a life-threatening condition of the patient, the physician should time to revise the patient's treatment plan with substitution for adequate anti-inflammatory therapy with inhalation corticosteroids.

Drug Interactions

Since the active ingredient of Berodual is a combination of m-cholinoblocker and β2-adrenomimetics, when combined with other substances / preparations, the following interactions:

• β-adrenoblockers: a significant reduction in the bronchodilator effect of Berodual is possible.
• Glucocorticosteroids (GCS) and / or cromoglycic acid: increase the effectiveness of treatment.
• Tricyclic antidepressants and monoamine oxidase (MAO) inhibitors: are able to enhance the action of β-adrenergic agents.
• Anticholinergics for systemic use, other β-adrenomimetics, xanthine derivatives (including theophylline): may increase the side effects and bronchodilating effect of Berodual.
• Inhaled halogenated anesthetics (eg, halothane, trichlorethylene or enflurane): may increase the effect of β-adrenergic agents on the cardiovascular system;
• Xanthine derivatives, corticosteroids and diuretics: may increase hypokalemia associated with the use of β-adrenomimetics (it is especially important to take into account such interaction in the treatment of severe forms of obstructive diseases respiratory tract).
• Digoxin: probably increased risk of arrhythmias due to hypokalemia associated with the use of β-adrenomimetics, in addition, the negative effect hypokalemia on the heart rhythm can increase hypoxia (if necessary, this combination of drugs should regularly check the potassium level in the serum blood) /

Reviews

We picked up some of the people's comments about Berodual:

1. Galina. Spasm removes well (a child 2 years) morning inhalation, we were prescribed 12 cap. But when we breathe in the evening of 20.00, then in 2-3 hours the child begins a terrible attack of coughing up to vomiting.
2. Rita. We are helped... we do inhalations through a nebulizer (we have a compressor bivel, white with a blue lid), I dilute with fiz solution by 8 drops for a single inhalation, if the solution remains after the procedure, it is necessary to pour out, it is not stored for a long time, it can not be reused. Allergies did not observe him in the child.
3. Snezana. Berodualom in the nebulizer rescues our son from seasonal allergies. This is the best remedy for strong drugs and it is not worth taking it without prescribing a doctor, since the method of application is better for a doctor will tell you (there are nuances like taking, inhaling or exhaling), and in general you can at first do something easier, for example suprastin. So I advise you to take it through a doctor.
4. Larissa. I use Berodual to relieve the attacks. At me a bronchial asthma and this preparation in my case is simply irreplaceable. Always carry a spray can with me. If I feel that the attack is on the way, I inhale two doses. Within 2 seconds the spasm disappears and I can again lead an ordinary life. I know that you can still do inhalation with Berodual, but this is not my case. If the attack caught on the street, inhalation can not be done exactly. Of course, I'm not only saving my balloon with aerosol, but every year I go through a course of treatment and see a specialist.

Analogues

The pharmaceutical industry produces a number of Berodual analogs that have a similar therapeutic effect. We list the most popular tools:

• Duolin
• Berotex
• Ventolin
• Salbutamol

Before using analogues, consult your doctor.

Storage conditions and shelf life

The drug is stored out of reach of children, protected from the sun, at room temperature (below 30 ° C). Shelf life is 5 years. Do not apply the solution after the end of the storage period indicated on the package.

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