Antidepressant Valdoksan: user's manual and reviews

Valdoxane belongs to a group of drugs that have antidepressant properties.

The drug contains agomelatine. This drug is prescribed in case of diagnosis in a patient of a major depressive disorder. The drug does not affect the work of think tanks, which are responsible for memory and concentration. In the case of insomnia contributes to the normalization of sleep, increases its duration.

On this page you will find all information about Valdoxan: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Valdoksan. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antidepressant.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Waldoxan? The average price in pharmacies is at the level of1 000 rubles.

Form of issue and composition

Tablets are oblong, covered with a film coating of yellow-orange color, on one of the sides is the logo of the manufacturer.

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Tablets contain 25 mg of active substance - agomelatine in a single dose;
Excipients: lactose monohydrate, magnesium stearate, corn starch, povidone, silicon colloidal dioxide, sodium carboxymethyl starch and stearic acid;
The film membrane consists of glycerol, hypromellose, iron oxide of yellow oxide, macrogol and other components.

Pharmacological effect

On the human body, Valdoxane has the following curative effects:

stimulates melatonin receptors;
reduces body temperature;
normalizes sleep;
increases the production of dopamine and norepinephrine, thereby improving mood;
improves mood and psycho-emotional state.

Affects the brain, in particular the prefrontal zone, stimulating certain receptors, which increase the release of norepinephrine and dopamine. The substances in the composition are absorbed completely and quickly. The equilibrium concentration is achieved one to two hours after taking the tablets. Metabolism of the active component occurs in the liver.

Indications for use

The main indication for prescribing the drug is the presence of confirmed depression. The drug can also be used to treat neuropathic pain of central and peripheral origin in composition of complex therapy, used as a therapeutic and prophylactic for migraine.

Contraindications

The drug can not be administered in the following cases:

With lactose intolerance (lactase deficiency, galactosemia, glucose malabsorption syndrome or galactose).
At the age of 18 years.
With severe hepatic insufficiency.
When hypersensitivity to agomelatine and excipients of the drug.
Women during the lactation period.

The drug should be taken with caution to the following groups of patients:

Persons with suicidal tendencies.
Patients with manic or hypomanic attacks.
Elderly patients aged 65 years and over;
Pregnant women;
Patients suffering from moderate or severe renal failure against a background of major depressive episodes.
Persons who abuse alcohol or take drugs that contribute to the development of functional disorders of the liver.

Application in pregnancy and lactation

Data on the use of agomelatine in pregnancy are absent or limited (less than 300 pregnancy outcomes).

Studies in animals have not revealed direct or indirect adverse effects on the course of pregnancy, embryo and fetus development, labor activity and postnatal development. As a precaution, it is recommended to avoid the appointment of the drug Valdoxan in pregnancy.

It is not known whether agomelatine penetrates breast milk in women during lactation. ATexperimentalresearchon animals it was shown that agomelatine and its metabolites penetrate into breast milk. If treatment with agomelatine is necessary, breastfeeding should be discontinued.

Instructions for use

The instructions for use indicate that Valdoxane is intended for oral use. Tablets, covered with a film shell, should be swallowed whole, not crushing. Take regardless of food intake, but it is recommended to do this in the evening. If you miss the next dose, take the pill as soon as possible, but if it's time to take the next dose, you should not double the dose (do not take the missed pill). For simplicity of reception control, a calendar is placed on the blister.

The duration of therapy and the dose of the drug Valdoxan is determined by the doctor.

The average recommended daily dose is 25 mg of agomelatine (1 tablet of the drug Valdoxan). If the therapeutic effect is inadequate 2 weeks after the start of treatment, the dose of agomelatine can be increased to 50 mg per day (2 tablets of the drug Waldoxan in the evening).

During the period of therapy with the drug Valdoxan, it is recommended to monitor the liver function (as a rule, the samples are taken before the beginning of therapy, and also 3, 6, 12 and 24 weeks after the beginning of the admission). Also, liver function monitoring is necessary with increasing doses of agomelatine. For complete cessation of symptoms and prevention of recurrence, clinical depression should be treated for at least 6 months. At the end of therapy with agomelatine, a gradual dose reduction is not required.

Side effects

In most cases, many patients in the first 14 days from the start of the course of therapy observed development side effects on the drug, which are the norm and, as a rule, do not require discontinuation of treatment.

Side effects were as follows:

Increased sweating, tinnitus;
Pain in the lumbar region and general malaise;
In rare cases, hypersensitivity in patients observed the development of urticaria, skin itching, edema Quincke;
Changing the picture of blood - an increase in liver transaminases, in rare cases, icterus of the skin;
On the part of the organs of the digestive tract - nausea, constipation, sometimes pain in the epigastric region;
From the nervous system - dizziness, drowsiness or insomnia, headaches, in rare cases, paresthesia.

At first, the anxiety, anxiety, increased irritability, nightmares can disturb the patient's medication.

Overdose

Reviews of Valdoksan contain little data on cases of drug overdose.

Overdose of Valdoxanum is manifested: pain in epigastrium, drowsiness, weakness, anxiety, agitation, stress, cyanosis, dizziness, malaise.

Treatment with an overdose of Valdoxanum is symptomatic, with monitoring the patient's condition in the hospital.

special instructions

You should stop taking medication if you have any mania symptoms.
Special care should be taken when administering Valdoxan to obese patients, diabetes mellitus, in significant quantities, alcohol or drugs that are capable of provoking a disorder of the hepatic function.
Admission Valdoxan requires control of liver function. If symptoms of its violation are manifested - dark urine, discolored feces, yellowness of the skin and eye proteins, pain in the right hypochondrium, unexplained fatigue - the drug is subject to cancellation.
In case of prescribing simultaneously with propranolol, grepafloxacin, enoxacin (inhibitors of isoenzyme CYP1A2), care should be taken in connection with the possible increase in the concentration of agomelatine.
Due to the increased risk of self-harm and suicide attempts, patients taking Waldoxan, especially at the beginning of treatment, should be under careful medical control to stabilize the mental state.

Given such side effects of Valdoxan, like dizziness and drowsiness, it is not recommended during the treatment to drive vehicles and complex mechanisms.

Drug Interactions

With other drugs, Valdoxane interacts as follows:

Inhibitors of the isoenzyme CYP1A2 (Ciprofloxacin, Fluvoxamine) - increases the concentration of agomelatine.
Rifampicin decreases the bioavailability of the active ingredient.

Reviews

We picked up some feedback from people about the drug Valdoksan who tell how they feel after it:

Michael. Hello! I am 32 years old. After the road accident and the survived ISPUGA alarm began, even panic, sleep disorder, then depression with hysterics, tears and snot... I thought I would stay forever in this condition, since nothing helped.... Started the treatment first with my own afobazol, novopasita, tenoten, sonopaks... .not helped! turned to the neurologist - he prescribed fluoxetine, cytoflavin... .not helped! They sent me to a sanatorium-and-spa treatment in Belokurikha, where a good psychotherapist conducted hypnosis, appointed Valdoxan (1 t per night) and Adaptol (1 t three times a day) - a month later I returned to work! Valdoxan should be drunk for a long time, I drank 10 months, then I gave it up immediately, there was no getting used to it. The dream has fully recovered, the depression has passed. Adaptol I drank courses for a month, well calms. Be healthy! By the way, you can buy all this without a prescription. Of the side effects, I note that on the first days of taking Valdoksana felt the heat in the body, but then passed, nothing more incidental did not feel, the dream was restored gradually somewhere 2 weeks, depression noticeably improvement has come or has taken place in a month-one and a half. But if you do not want retsedivov drink need a long time - up to a year.
Olga. I was prescribed this drug by a psychotherapist when I was fighting panic attacks. In addition to taking complex other tranquilizers. But definitely I can say that it helps to sleep and sleep well. I had no side effects on him. Just went to bed and immediately turned off. And with my diagnosis to fall asleep was a problem. In the morning woke up easily, a normal condition - not foggy.
Marina. Effect in a month not earlier. Sleep only normalizes at first. I drink the drug for 1.5 months, the mood has improved, sleep has normalized, anxiety and constant depressing thoughts have left. I can not say what's normal, but it's better. From pobachek, fatigue and a bit of vision affected.
Oleg. With depression, this drug was drunk. I want to note that I began to sleep better in two weeks. Among the adverse reactions was the sensation of heat in the body. I did not observe other phenomena. Noticeable effect occurs not earlier than a month of therapy. Noticeable improvements in sleep and mood, anxiety and obsessive thoughts have left. To sleep it would be desirable already in half an hour after the use of tablets. I began to feel a little better, although I will not say that it is perfect. After intake, there is fatigue.

Despite the responses of people, the choice of an antidepressant should be approached with special responsibility and take only the funds prescribed by a specialist in a certain dosage.

Analogues

The main analogue is agomelatin. There are also other analogues of Valdoxan, for example - Adaptol and Paxil.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Shelf life of the drug is 3 years from the date of manufacture. It is recommended to keep the tablets away from children at a temperature of no higher than 25 degrees.