Tavanik

Tavanic is a patented synthetic antimicrobial agent that represents a group of fluoroquinolones.

Pharmacologically active substance in the composition of tavamine, its driving therapeutic force is the left-handed isomer of ofloxacin-levofloxacin, It has a broad spectrum of action and is active against the majority of known virulent strains of microorganisms.

The most effective Tavanik in the treatment of acute sinusitis, acute and chronic bronchitis, pneumonia, as well as complicated infectious diseases of the urinary system, skin and soft tissues.

Clinical and pharmacological group

Antibacterial drug of the group of fluoroquinolones.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much is Tavanik 500 mg in pharmacies? The average price is at the level of500 rubles.

Composition and form of release

Avanik is produced in the following forms:

tablets covered with a film membrane: biconvex, oblong, pale yellowish-pink, on both sides there is a separation groove (Tavanik 250 mg - 3, 5, 7 or 10 pieces in blisters, in a cardboard bundle one blister; Tavanik 500 mg - for 5, 7 or 10 pieces in blisters, in a cardboard bundle one blister);
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solution for infusions: greenish-yellow, transparent (100 ml in glass colorless bottles, in a cardboard bundle one bottle).

Composition of 1 tablet:

active ingredient: levofloxacin (in the form of levofloxacin hemihydrate) 250 mg or 500 mg;
auxiliary components: crospovidone, sodium stearyl fumarate, hypromellose, microcrystalline cellulose;
film shell: macrogol 8000, talc, hypromellose, iron oxide yellow dye, titanium dioxide, red iron oxide dye.

Composition of 1 ml of solution:

active ingredient: levofloxacin (in the form of levofloxacin hemihydrate) - 5 mg;
auxiliary components: hydrochloric acid, sodium chloride, sodium hydroxide, water for injection.

pharmachologic effect

The antibiotic Levofloxacin influences the processes of supercoiling the DNA of cells of harmful bacteria. The synthesis of protein, DNA and RNA is inhibited, which leads to the inevitable death of pathogenic microorganisms.

It should be noted that levofloxacin is much stronger than ofloxacin. The agent shows bactericidal activity in relation to aerobic, anaerobic, gram-positive and-negative microorganisms. In particular, cocci, streptococci, various intracellular pathogens, hemophilic rod, enterobacteria and Pseudomonas aeruginosa. The antibiotic is practically useless with the control of strains of Staphylococcus aureus, salmonella, shigella, enterococcus, gonococcus, pseudomonas, some strains of pneumococci.

In the body, the patient quickly (within 2 hours) penetrates almost all organs affected by bacteria. It is excreted as a rule by the kidneys for 6-8 hours. In people with kidney disease, the pharmacokinetic parameters may vary.

Indications for use

Tablets and solution for infusion Tavanic administration have the same indications for use, since the antibiotic is active against the same microorganisms.

Tavanik is indicated for use in the treatment of the following infections that are caused by bacteria that are sensitive to it:

Acute sinusitis;
Pneumonia;
Infections of the abdominal cavity organs;
Stage of exacerbation of chronic bronchitis;
Chronic prostatitis of bacterial nature;
Infectious diseases of the skin and soft tissues (for example, muscles, ligaments, etc.);
Sepsis (blood poisoning) associated with any of the above infections;
Uncomplicated and complicated infectious diseases of the urinary tract (cystitis, urethritis, pyelonephritis, etc.);
As part of complex therapy of resistant forms of tuberculosis.

Contraindications

The drug Tavanik has absolute and relative contraindications to the use. In the presence of absolute contraindications, an antibiotic can not be taken under any circumstances. And in the presence of relative contraindications Tavanik can be used, but with care and under careful medical supervision of the human condition.

Absolute contraindications to the use of Tavanic is the presence of the following conditions:

period of pregnancy;
breast-feeding;
epilepsy;
tendonitis caused by the use of any system quinolones (eg, ciprofloxacin, ofloxacin, etc.) in the past;
age younger than 18 years;
allergy, hypersensitivity or intolerance to Tavanic components.

Relative contraindications for the use of Tavanic are the following conditions:

myocardial infarction;
bradycardia (loss of heart rhythm);
intake of hypoglycemic drugs (eg, Glibenclamide or Insulin) for the treatment of diabetes;
the presence of severe adverse reactions in response to the use of any other drugs from the group of fluoroquinolones (eg, Ciprofloxacin or Ofloxacin, etc.);
increased convulsive readiness (for example, people who have suffered a stroke in the past, or who are taking Fenbufen and Theophylline in the present);
deficiency of the enzyme glucose-6-phosphate dehydrogenase;
kidney failure;
low concentration of magnesium or potassium;
chronic heart failure;
presence of pseudo-paralytic myasthenia gravis.

Intended use for pregnancy and lactation

Tavanik is contraindicated for use in the treatment of women during pregnancy and breastfeeding. In the course of laboratory studies it was found that the active active substance of the drug can lead to the formation of congenital developmental anomalies.

If it is necessary to treat a lactating mother, the question of stopping lactation should be solved, since the active substance of the Tavanic preparation is excreted in breast milk.

Dosage and route of administration

As indicated in the instructions for use Tavanik ingested by 250 or 500 mg 1 or 2 times / day. Tablets should be swallowed without chewing and drinking with a sufficient amount of liquid (0.5 to 1 cup). If necessary, the tablets can be broken on the separating groove.

The drug can be taken before meals or at any time between meals. eating does not affect the absorption of the drug. Tavanik should be taken at least 2 hours before or 2 hours after taking antacid preparations containing magnesium and / or aluminum, zinc, iron salts or sucralfate.

Dosing regimen is determined by the nature and severity of the infection, as well as the suspected pathogen susceptibility. Duration of treatment varies depending on the course of the disease.

Patients with normal renal function (CK> 50 mL / min)the following dosing regimen and duration of treatment are recommended:

Pyelonephritis: 2 tab. 250 mg 1 time / day or 1 tab. 500 mg 1 time / day (respectively 500 mg of levofloxacin) - 7-10 days.
Chronic bacterial prostatitis: 2 tab. 250 mg or 1 tab. 500 mg once a day (correspondingly 500 mg of levofloxacin) - 28 days.
Infections of the skin and soft tissues: 2 tab. 250 mg or 1 tab. 500 mg 1-2 times / day (respectively 500-1000 mg of levofloxacin) - 7-14 days.
Acute sinusitis: 2 tab. 250 mg or 1 tab. 500 mg 1 time / day (respectively 500 mg of levofloxacin) - 10-14 days.
Exacerbation of chronic bronchitis: 2 tab. 250 mg or 1 tab. 500 mg 1 time / day (respectively 500 mg of levofloxacin) - 7-10 days.
Community-acquired pneumonia: 2 tab. 250 mg or 1 tab. 500 mg 1-2 times / day (respectively 500-1000 mg of levofloxacin) - 7-14 days.
Uncomplicated urinary tract infections: 1 tab. 250 mg 1 time / day (respectively 250 mg of levofloxacin) - 3 days.
Complicated urinary tract infections: 2 tab. 250 mg 1 time / day (respectively 250 mg of levofloxacin) or 1 tab. 500 mg 1 time / day (respectively, 500 mg of levofloxacin) - 7-14 days.
Prevention and treatment of anthrax during airborne infection: 2 tab. 250 mg or 1 tab. 500 mg (respectively 500 mg levofloxacin) 1 time / day - up to 8 weeks.
As a part of complex therapy of drug-resistant forms of tuberculosis: 1 tab. 500 mg 1-2 times / day (respectively 500-1000 mg of levofloxacin) - up to 3 months.

Given that the bioavailability of levofloxacin in the use of the drug Tavanik in tablets is 99-100%, in the case of patient transfer with iv administration of the drug for taking tablets should continue treatment at the same dose that was used for IV infusion.

If the kidney function is impaired (SC 50 ml / min and below)the dosage regimen of tablets and Tavanik solution is adjusted individually, taking into account the magnitude of the CK and the clinical indications of the patient:

KK 50-20 ml / min: the first dose - 250 mg, then - 125 mg once a day; the first dose is 500 mg, then 250 mg once or twice a day;
KK 19-10 ml / min: the first dose - 250 mg, then - 125 mg once every 2 days; the first dose is 500 mg, then 125 mg once or twice a day;
CK less than 10 ml / min [including continuous outpatient peritoneal dialysis (CAPD) and hemodialysis]: first dose 250 mg, then 125 mg once every 2 days; the first dose is 500 mg, then 125 mg once a day.

After hemodialysisor CAPD, no additional drug intake is required.

When a violation of liver functionand elderly patients, correction of the Tavanic dosage regimen is not required.

If the drug is missed, it is necessary to take the tablet as soon as possible and continue taking Tavanic according to the recommended dosing regimen.

Side effect

The use of the drug Tavanik can cause the following side effects:

The digestive system: often - attacks of nausea, vomiting; infrequently - flatulence, indigestion, constipation, abdominal pain.
Respiratory system: infrequently - dyspnea; frequency unknown - allergic pneumonitis, bronchospasm.
Musculoskeletal system: rarely - muscle weakness, tendon damage, including tendonitis.
The immune system: rarely - angioedema; infrequently - hives.
Mental disorders: often - insomnia; rarely - depression, sleep disturbances, agitation (agitation), nightmarish dreams, mental disorders (paranoia, hallucinations).
Bile ducts and liver: often - increased activity of AST, ALT, GGT, APF; infrequently, an increase in the level of bilirubin in the blood.
Labyrinthine disorders and the organ of hearing: rarely - ringing in the ears.
Subcutaneous tissues and skin: infrequently - hyperhidrosis, urticaria, rashes, itching.
Central nervous system: often - dizziness, headache; infrequently - dysgeusia (perversion of taste), tremor, drowsiness.
Cardiovascular system: rarely - decreased blood pressure, palpitations, sinus tachycardia.
Hemopoiesis system: rarely - thrombocytopenia, neutropenia; infrequently - eosinophilia, leukopenia.
Body of vision: rarely - visual impairment, uveitis, transient loss of vision - frequency unknown.
Parasitic and infectious diseases: infrequently - development of resistance of pathogenic microorganisms, fungal infections.
Metabolism: rarely - hypoglycemia, especially in patients with diabetes mellitus (possible signs of hypoglycemia: nervousness, trembling, sweating, "wolfish" appetite); infrequently - anorexia; frequency unknown - hypoglycemic coma, hyperglycemia.
Urinary tract: rarely - severe renal failure (eg, as a result of the development of interstitial nephritis); infrequently - increased serum creatinine levels.
Common reactions: rarely - pyrexia (fever); infrequently, asthenia.

In addition to the infusion solution: the reaction at the injection site (congestion, soreness of the skin).

Overdose

In the case of using Tavanik drug uncontrolled and in large doses, the patient develops signs of an overdose, characterized by augmentation the above-described side effects, the development of acute renal and hepatic insufficiency, malfunction of the heart and central nervous system.

When developing signs of an overdose, the patient should immediately be taken to the hospital, where the stomach is washed, enterosorbents enter and if necessary carry out symptomatic treatment.

special instructions

As well as during treatment with other antibiotics, when applying Tavanik (especially long-term) it is possible to strengthen multiplication of insensitive to levofloxacin microorganisms, which leads to superinfection. In order to avoid such situations, periodic re-evaluation of the patient's condition should be made periodically during the period of therapy, so that appropriate measures can be taken in time for the development of superinfection.

When hospital infections caused by Pseudomonas aeruginosa (Pseudomonas aeruginosa), it may be necessary to perform combination therapy.

Tavanik can affect psychomotor and cognitive functions (cause drowsiness, dizziness and visual impairment, reduce reaction speed and ability to concentration of attention), which should be taken into account by drivers of vehicles and patients engaged in potentially hazardous industries.

Interaction with other drugs

Preparation Tavanik with caution appoint with the following medicines: theophylline, fenbufen, non-steroidal anti-inflammatory drugs, indirect anticoagulants (required regular monitoring of the coagulation system), cimetidine and probenecid (especially in patients with renal insufficiency), cyclosporine, glucocorticosteroids (increases risk of rupture of tendons), QT prolonging interval (macrolides, tricyclic antidepressants, neuroleptics, antiarrhythmic drugs of class IA and III).

Reviews

We offer you to read reviews of people who used the drug Tavanik:

Tatyana. Pills Tavanik was assigned to me by a urologist.. After the first pill... Eerie pains in the stomach... The kidneys were aching and in general it was very bad... I do not know... Maybe it would be easier if taken with probiotics... But I could not... Very many side effects.. And they all work ...
Anna. My husband was diagnosed with pneumonia. The foci were very large. Breathing is intermittent and painful. The therapist prescribed "Tavanik" as a strong antibiotic. The course was 10 days, but after 4 days the centers began to decrease! After graduation from pneumonia, only a dry cough remained. It is very convenient that the drug is not tied to the reception of food. Disadvantages - dry mouth.
Galina. I was helped very much, bronchitis, strong wheezing, coughing and hammering for a month and a half, could not sleep. Although I'm allergic to almost all antibiotics, this drug immediately took off a cough, it became a full chest, I could feel it all under my ribs, my sputum stopped. This antifungal drug, you may have a wrong diagnosis once did not help. The dream on the contrary was normalized, before reception on 2-3 times woke up a sputum coughs. I hypotonic, the pressure is always low, I sit on coffee usually, I did not notice a strong drop, I could have slept for an hour or two more, but this was due to a decrease in the cough, though I slept.

Analogues

Structural analogs for the active substance:

Glevo;
Ivacin;
Lebel;
Levot P;
Levotech;
Levoflox;
Levofloxabol;
Levofloxacin;
Leobeg;
Leflobact;
Lefokcin;
Matlevo;
OD Levoks;
Oftakwix;
Remedy;
Signictsef;
Tavanik;
Tanflomed;
Flexine;
Floracid;
Hayleflex;
Ecology;
Eleflox.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Storage of Tavanic should be carried out in a place protected from moisture, light and temperature above 25 degrees Celsius. Shelf life Tavanik tablets of both dosages - 5 years, vials with a solution - 3 years. A solution that is exposed to room lighting for 3 days becomes unsuitable.