Finasteride

Finasteride refers to antiandrogenic drugs, reduces the activity of the enzyme that converts testosterone to dihydrotestosterone (has a greater activity).

The greater the level of dihydrotestosterone in the blood, the greater the hypertrophy (increase in size) of the prostate. Testosterone is responsible for the formation of typical male characters. Finasteride lowers the testosterone content.

One of the positive side effects of its effect is the ability to prevent hair loss, which allows using the drug to combat premature male pattern baldness.

Clinical and pharmacological group

Has antiandrogenic effect.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Finasteride cost in pharmacies? The average price is at the level of270 rubles.

Composition and form of release

The finasteride tablets are white in color and round in shape. The main active substance of the drug is Finasteride, its content in one tablet is 5 mg. It also includes auxiliary components, which include:

instagram viewer

Sodium dodecyl sulfate.
Lactose monohydrate.
Magnesium stearate.
Microcrystalline cellulose.
Hydrophosphate calcium dihydrate.
Giprolose.

Tablets are packaged in a contour acheikova packing in an amount of 10 pieces. The cardboard pack contains one contour mesh package, as well as instructions for the use of the preparation.

Pharmacological effect

Finasteride is a synthetic hormone that affects the enzyme 5-alpha-reductase contained in the prostate gland. With its help, testosterone, which is secreted by the testicles, turns into a more active form - dihydrotestosterone.

Often benign prostatic hyperplasia, in which Finasteride is shown, is due to the excessive conversion of the male androgen into its active metabolite. Reducing the amount of the latter in plasma and prostate tissue, the drug contributes to the normalization of the size of this organ. The medicine begins to work within half an hour after ingestion. The maximum concentration of its active component in the blood is observed after 2 hours after taking the tablet.

80% of the active substance reaches the prostate tissue. Assimilation of the drug is not dependent on food intake. In the blood, finasteride is almost completely bound to proteins, by means of which it is transported to the site of direct action. The drug has the property of slowly accumulating in the body. Long-term therapy leads to the fact that the substance is found in semen, cerebrospinal fluid. This is not a pathology.

The remedy is released through the intestines and kidneys in a modified form. The half-life is between 6 and 8 hours. In older people, finasteride is slower, but this does not affect the administration of the dose of the drug. Does not affect the excretion of chronic renal failure. With it, most of the active substance is excreted through the intestine. Influence on the amount of the drug taken can only need hemodialysis in the patient.

Indications for use

Finasteride is used to treat patients with benign prostatic hyperplasia (adenoma).

Under the influence of the drug:

there is a significant reduction in the size of the affected gland;
the rate of urine outflow is maximized;
the probability of the development of the mechanism of acute urinary retention is significantly reduced, for the elimination of which there is a need to apply catheterization or in performing prostatectomy (removal of the entire prostate gland or part thereof) and transurethral resection (minimally invasive surgical intervention aimed at the rapid elimination of problems with urination) of the prostate.

Contraindications

obstruction of the urinary tract;
prostate cancer;
age to 18 years;
increased sensitivity to any component of the drug.

With caution should be used in patients with impaired liver function.

Dosage and route of administration

As indicated in the instructions for use, Finasteride tablets are intended for oral administration. They are taken once a day, regardless of food, do not chew and drink with enough water.

The average therapeutic dosage is 5 mg. The course of therapy is long.

Adverse Reactions

decreased libido and potency;
decrease in ejaculatory volume;
increased mammary glands;
hypersensitivity reactions (rash, swelling of the lips).

All adverse reactions are rare, usually of a mild and transient nature, and the frequency of disorders in the genital area is reduced during treatment.

Overdose

Patients took a single dose of the drug to 400 mg and a regular dose of up to 80 mg per day for three months without the occurrence of undesirable effects.

There are no developed recommendations for the therapy of an overdose of Finasteride.

special instructions

With caution appoint finasteride with hepatic insufficiency.

With a large volume of residual urine and / or a sharply reduced urine flow, one must keep in mind the development of obstructive uropathy.

Before the beginning of treatment with finasteride and periodically during the treatment should be carried out rectal examination, as well as research by other methods for the presence of prostate cancer.

Compatibility with other drugs

There was no clinically significant interaction of finasteride with propranolol, digoxin, glyburide, warfarin, theophylline and antipyrin.

Apparently, finasteride does not have a significant effect on the enzymatic system of cytochrome P450 and, accordingly, not affects the pharmacokinetic parameters of drugs metabolized by microsomal liver enzymes.

With simultaneous application of finasteride with ACE inhibitors, alpha-adrenoblockers, beta-blockers, calcium channel blockers, nitrates, diuretics, blockers histamine H2 receptors, inhibitors of HMG-CoA reductase, NSAIDs, quinolones and benzodiazepines, there was no clinically significant drug interaction.

Reviews

We offer to read reviews of men who used Finasteride:

Maksim. Hyperplasia of the prostate was diagnosed after the appearance of problems with urination. I took Finasteride for four months, on a pill a day. The doctor has assured that under normal immunity the treatment of such a duration is safe. Side effects did not observe, for the period of treatment stopped taking diuretics, because of incompatibility.
Gennady. The drug really helps. After a course of taking medication (6 months), the prostate volume decreased by 15%. PSA decreased by 25%. Potency is reduced, but after stopping the drug, it is restored.
Alexander. The adenoma with the violation of the functions of the urethra I treated with the use of this remedy. The course is long, but since I have good immunity, there were no side effects, with potency everything was normal. I received the first results after 6 weeks, took a pill every day. Drank full course (18 weeks).

Analogues

Structural analogs for the active substance:

Alfinal;
Grain;
Penester;
Proscar;
Prosteride;
Urofin;
Finast;
Finasteride OBL;
Finasteride Teva;
Finpros.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Shelf life of Finasteride tablets is 3 years from the date of their manufacture. The drug should be stored in its original factory packaging, dark, dry, inaccessible to children at an air temperature of no more than + 25 ° C.