Effervescent tablets ATSTS: instruction on the use of cough

ATSTS - a medicinal product with expectorant and mucolytic action, which contributes to liquefaction and escape of viscous sputum.

This is one of the most well-known medicines used in the treatment of respiratory diseases, accompanied by the formation of a difficult-to-separate secret

On this page you will find all information about ATSTS: full instructions for use for this medication, medium prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used the ATS tablets. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Mucolytic drug.

Conditions of leave from pharmacies

Available without a prescription.

Price list

How much are the effervescent tablets of ACC? The average price in pharmacies is at the level of200-300 rubles.

Form of issue and composition

The drug is produced in different dosage forms:

ATSTS 100 mg (effervescent tablets);
ATSTS 200 mg (effervescent tablets);
ATSTS 600 mg (effervescent tablets);

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ATSTS granules for the preparation of syrup;
Powder for solution preparation;
ATSTS syrup.

They are produced with different concentrations of active ingredient - contain 100, 200 and 600 mg of active substance acetylcysteine + auxiliary components. Tablets ATSTS 100 mg are intended for children, and the drug with the highest concentration of acetylcysteine (600 mg) is called ATSTS Long and is prescribed for adults and adolescents over 14 years.

Pharmacological effect

The mucolytic effect of the drug is provided by the active substance acetylcysteine, which is a derivative of cysteine (amino acid). The molecule of acetylcysteine has sulfhydryl groups in its structure, which contributes to the disruption of the disulfide bonds of mucopolysaccharides in the sputum that provide the viscosity of the secretion. As a result, sputum is softened and easier to separate from the walls of the bronchi.

The drug has a direct effect on the density and rheological properties of sputum, while retaining proper activity even with purulent impurities in the bronchial secretion. In the preventive use of acetylcysteine, patients with cystic fibrosis and chronic bronchitis report a decrease in the number and a decrease in the severity of exacerbations.

Another effect of acetylcysteine is an antioxidant pneumoprotective effect, which is realized by binding and neutralizing chemical radicals with sulfhydryl groups. The drug accelerates the synthesis of glutathione, a factor of intracellular defense against a number of cytotoxic substances and oxidative toxins of internal and external origin, which allows the use of ATSs in case of an overdose of paracetamol.

Indications for use

ATSTS for children and adults is recommended for diseases associated with accumulation in the upper respiratory tract and bronchial tree of thick viscous sputum:

laryngitis (inflammation of the mucous membrane of the larynx);
tracheitis (inflammation of the mucosa of the trachea);
bronchitis (acute, chronic, obstructive);
bronchoectatic disease (chronic suppuration in irreversibly deformed bronchi);
bronchial asthma;
bronchiolitis (inflammation of bronchioles);
average exudative otitis (damage to the mucous membranes of the middle ear cavities);
sinusitis (inflammation of one or more paranasal sinuses);
cystic fibrosis (severe violations of the respiratory and gastrointestinal tract).

Contraindications

Contraindications to the use of ATSTS are:

pulmonary hemorrhage;
pregnancy;
peptic ulcer of the stomach and duodenum in the phase of exacerbation;
hemoptysis;
lactation period (breastfeeding);
children's age till 14 years (medicinal forms of the preparation with the content of acetylcysteine 600 mg);
children's age till 6 years (the preparation in the form of granules for preparation of a solution for intake of 200 mg);
hypersensitivity to acetylcysteine and other components of the drug.

FROMcautionshould be used in patients with varicose veins of the esophagus, with an increased risk of pulmonary hemorrhage and hemoptysis, with bronchial asthma, adrenal diseases, hepatic and / or renal insufficiency.

ATSTS LONG should not be administered to children under the age of 14 years. In this category of patients it is recommended to use dosage forms of the drug for oral administration with a lower content of acetylcysteine.

Application in pregnancy and lactation

The embryotoxic effect in acetylcysteine is absent, but during pregnancy, as well as breastfeeding, it is prescribed only if there is evidence under the supervision of a doctor.

Instructions for use

The instructions for use indicate that the effervescent tablets of ACS are taken orally after meals. They should be dissolved in 1 glass of water and immediately drunk, in exceptional cases, you can leave the finished solution for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug.

With short-term catarrhal diseases, the duration of admission is 5-7 days. In chronic bronchitis and cystic fibrosis, the drug should be used longer for the prevention of infections.

Instructions for ACC 200:

Children aged 6 to 14 years are recommended to take 1 tablet. (ATSTS 200) 2 times / day, which corresponds to 400 mg of acetylcysteine per day.
For children aged 2 to 6 years, the drug is recommended to take 1/2 tablet. (ATSTS 200) 2-3 times / day, which corresponds to 200-300 mg of acetylcysteine per day.
Adults and adolescents older than 14 years are recommended to prescribe a drug of 200 mg (ATSTS 200) 2-3 times / day, which corresponds to 400-600 mg of acetylcysteine per day, or 600 mg (ATSTS Long) 1 time / day.
In cystic fibrosis, children older than 6 years of age should take 1 tablet. (ATSTS 200) 3 times / day, which corresponds to 600 mg of acetylcysteine per day. Children aged 2 to 6 years - 1/2 tab. (ATSTS 200) 4 times / day, which corresponds to 400 mg of acetylcysteine per day.

Side effects

Effervescent tablets ATSTS as a whole are transferred well, when they are taken orally as a solution, a number of side effects can develop, which include:

On the part of the digestive system - nausea, sometimes vomiting, heartburn, upset of a stool in the form of diarrhea (diarrhea).
Allergic reactions - develop rarely, the severity may be different. Appear in the form of a rash on the skin, itching, hives (rash and swelling of the skin, outwardly reminiscent of a nettle burn). In extremely rare cases, there may be a reaction from the bronchi in the form of their spasm resembling an attack of bronchial asthma. With very severe course of an allergic reaction, anaphylactic shock develops with the development of multiple organ failure on the background of a progressive decrease in systemic arterial pressure.
From the cardiovascular system - tachycardia (increased heartbeats), arterial hypotension (lowering the level of systemic blood pressure).
From the central nervous system - headache, tinnitus,

In case of symptoms of adverse reactions, the drug should be discontinued and seek medical help.

Overdose

Various disorders of the digestive system (stool disorders, nausea, vomiting, heartburn, stomach pain).

When these phenomena occur, a pharmacological treatment of symptoms is performed.

special instructions

Mucolytic effects of ATSs are enhanced by additional fluid intake.
Patients with obstructive bronchitis and bronchial asthma require regular monitoring of bronchial patency in the period of treatment with ATSTS.
The drug is incompatible with proteolytic enzymes and antibiotics (with cephalosporins, tetracycline, penicillins, erythromycin and amphotericin B).
You should not combine the drug with antitussive drugs, since suppressing the cough reflex caused by the latter can lead to dangerous stagnation of mucus.
With caution should be used remedy for violations of the liver and kidneys, diseases of the adrenal glands, varicose veins expansion of the esophagus, as well as peptic ulcer of the stomach and duodenum in the phase of exacerbation.

Drug Interactions

Tetracycline and its derivatives (except doxycycline) can not be used together with ATSTS in pediatrics.

During in vitro experimental studies, no cases of inactivation of other types of antibacterial drugs were detected. Nevertheless, it is recommended to observe the interval between admission of ATSTS and antibiotics in 2 hours (not less). In vitro, the incompatibility of acetylcysteine with semisynthetic penicillins, antibiotics of aminoglycoside and cephalosporin series has been proved. Such studies were not conducted with erythromycin, amoxicillin and cefuroxime.

Simultaneous reception of antitussive agents can lead to stagnation of the secretion of the airways.

Use with nitroglycerin can enhance the vasodilator action of the latter.

Reviews

We picked up some feedback from people about the preparation of ATSTS:

Anastasia. At the beginning of the treatment of a wet, non-coughing girlfriend, I was advised to try ATSTS powder. When I went to the pharmacy, I was embarrassed at first because of the price of the medicine. It cost somewhere around 130 rubles, which against the background of analogs is very strange and inexpensive. Decided yet to try and was not mistaken, the cold passed for 3 days, and breathing normalized.
George. A negative, protracted cough, from which no pills are saved, gathering of herbs and sprays is a very unpleasant thing. It was like this: I coughed so much that my pectoral muscles ached. There was a feeling that, the sputum was densely settled in the lungs, and nothing could be withdrawn from there. My girlfriend helped me, and when she saw my torment, I took out the package of ATSTS from the bag. I ordered one tablet three times a day. Already on the second day after the beginning of the reception, I felt relief: the walls no longer shuddered from the attacks of a rending cough. The sputum began to recede, and a pleasant sensation of normal breathing appeared in the lungs.
Anton. I have long suffered from coughing. To say that he was dry, I can not, but the sputum still did not come out. I decided to go to the hospital and the doctor advised me to try ACTS long in effervescent tablets. I drank the course, as it was said to the instructions to the medicine - 5 days. The cough did not go away at all, but it became much easier to breathe, and the sputum was already coming out of the bronchi.
Irina. There was obstructive bronchitis. I was treated for 18 days. The pressure dropped, dyspnoea started, cough became dry, intestinal bleeding started during defecation. Doctors are not competent, prescribe antibiotics and acetas, the instructions say that they are not compatible. Peeled ceftriaxone. As always - the rescue of drowning people is the work of the drowning themselves. Inhalations help perfectly. Do not be ill! Be healthy!

Analogues

Among the structural analogues of ACC, the following drugs can be distinguished:

The mukonist;
Acestin;
Acetylcysteine;
Mukobene;
Fluimucil.

If, for some reason, the drugs with acetylcysteine are not the patient's, the doctor will choose other medications with the same therapeutic effect. It can be such means, as: