Furazolidone

Furazolidone is an antimicrobial drug of the nitrofuran series with an impressive therapeutic "experience": it was first synthesized in 1953 by Soviet scientists S. A. Giller and R. YU. Kalnberg.

The mechanism of action of the drug is the blocking of the enzyme systems of the bacteria, a violation of the synthesis of its natural components, a slowing down of the process of reproduction. In high doses has a bactericidal effect. Has a curative effect in most infectious diseases (with the exception of anaerobic infection).

The drug is used to treat intestinal infections, diseases of the genitourinary system and is used for massive skin lesions to prevent the development of the infectious process.

Clinical and pharmacological group

Antibacterial drug, a derivative of nitrofuran.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Furazolidone in pharmacies cost? The average price is at the level of120 rubles.

Composition and form of release

Furazolidone is available in the form of yellow tablets, flat-cylindrical with a facet on one side for 10 pieces in a contour pack (2-3), in a cardboard box. Also, the tablets can be packed in cans of polymer material of 50 pieces. The preparation is accompanied by a detailed instruction with a description of the characteristics.

instagram viewer

Each tablet contains 50 mg of active active ingredient - Furazolidone, as well as a number of auxiliary substances.

Pharmacological effect

Furazolidone is a synthetic derivative of 5-nitrofurforol. The drug is effective in the treatment of inflammatory diseases caused by gram-negative aerobic bacteria. Gram-positive aerobic bacteria are less sensitive to it, as are fungi and protozoa. Insensitive to furazolidone are anaerobic pathogens.

Pharmacological action of this drug depends on the dosage. At low doses Furazolidon has bacteriostatic effect, and with increasing doses bactericidal. Antimicrobial action is based on the fact that the nitro groups that make up the drug are reduced to amino groups under the influence of enzymes of microorganisms and become toxic to them. The resulting amino groups are capable of violating the integrity of the bacterial cell walls and blocking many processes in them. The result of such an impact is the loss of the ability to reproduce by microorganisms.

Furazolidone has a small immunostimulating effect. This drug is able to increase the phagocytic activity of leukocytes and the titre of a compliment.

After taking Furazolidon inside, it is quickly and almost completely absorbed in the intestine. The therapeutic concentrations of the drug in the blood are preserved for 5-6 hours after the drug is consumed. The concentration of Furazolidone in CSF is almost equal to the concentration in the blood. Also, the concentration of the drug in the intestine is high. It is excreted mainly by the kidneys in the unchanged state or in the form of metabolites.

Indications for use

This drug is used to treat inflammatory and infectious diseases of the genitourinary system, gastrointestinal tract and skin.

According to the instructions Furazolidone is used to treat the following diseases:

Diarrhea caused by infectious causes, in particular food poisoning;
Trichomonas infection;
Typhus and paratyphoid;
Bacillary dysentery;
Lambliasis;
Enterocolitis;
Cystitis, urethritis;
Infected burns and wounds of skin.

Contraindications

Contraindications to the drug furazolidone:

congenital dehydrogenase deficiency of glucose-6 phosphate (possibly oppression of hematopoiesis);
the child's age is less than 1 month;
individual hypersensitivity;
critical stage of renal failure.

Relative contraindications (the benefit of the application should justify the possible harm, the drug is prescribed by the doctor in case of emergency):

transport management, machine work, etc. (furazolidone is able to cause disturbances in coordination of movements);
the age of the child (it is undesirable to use it for children up to a year);
pregnancy and lactation (it may be necessary to stop breastfeeding);
liver disease;
insufficiency of excretory function of the kidneys;
neurological diseases (nitrofurans may have neurotoxic effects);
age up to 3 years (in the dosage form of furazolidone tablets).

Intended use for pregnancy and lactation

The drug belongs to category C. This means that the study of the drug on animals has an adverse effect on the fetus, but there is no information on the effect on the fetus.

According to the instructions, the drug is contraindicated in pregnancy. Can be appointed only for vital necessity, taking into account the expected and risk to the fetus.

Dosage and route of administration

As indicated in the instructions for use, Furazolidon tablets are taken orally after meals. It is recommended to swallow the tablet immediately, without sniffing, squeezed with enough water. The dose of the drug and the duration of the course of treatment is determined by the doctor individually for each individual patient.

In dysentery, food poisoning, traveler's diarrhea and paratyphoid, adults are prescribed 2-3 tablets of the drug 4 times a day, the maximum daily dose of the drug should not exceed 800 mg. The duration of the course of treatment with the drug is 5-10 days.

For the treatment of giardiasis, adults are prescribed 2 tablets of the drug 4 times a day. Children under 12 years of age are treated individually, depending on the body weight - 10 mg / kg. The received dose of the drug is divided into equal parts for 3-4 doses.

Adverse Reactions

The drug Furazolidon has a low toxicity, has good tolerability, but can still cause some adverse reactions of the body, among which:

decreased appetite;
nausea, the urge to vomit;
allergic reactions of skin;
pain in the epigastric region.

The appearance of such symptoms often become an excuse for the withdrawal of the drug and the appointment of analogues. The closest analogs to the mechanism of action are drugs such as Nifuroxazide, Enterol, Enteroburil. In their composition, such drugs contain another active component, so they can be prescribed only by a doctor.

Overdose

During drug overdose, patients may experience toxic liver damage and development toxic acute hepatitis, polyneuritis may develop on the hematotoxic effect of the drug. There is no antidote to the drug.

If there was a case with an overdose, it is necessary to wash the stomach and take enterosorbent and salt laxatives. If there is a need, then they support the water-electrolyte balance, sometimes it is necessary to prescribe antihistamines and vitamins included in group B.

If an overdose has occurred in a patient with impaired renal function, hemodialysis should be performed.

special instructions

Before you start using the drug, read the special instructions:

Increases the sensitivity to the action of ethanol.
Aminoglycosides and tetracycline increase antimicrobial properties.
Medicines, alkalinizing urine, reduce the effect, and acidifying - increase.
For the prevention of neuritis with prolonged use it is necessary to combine with vitamins of group B.
Precautions should be followed during treatment, as with monoamine oxidase inhibitors, namely: Exclusion from the diet of products containing tyramine: cheese, cream, beans, pickled herring, strong coffee.

Compatibility with other drugs

Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, and therefore, their simultaneous administration is not recommended. Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephrine, tyramine can cause a sharp increase in blood pressure.

Reviews

We suggest you read the reviews of people who used Furazolidone:

Elena. I was sick, it was fever and diarrhea without end. even after 2 sips of water which I drank already sitting in the toilet, the dehydration of the body began. I'll get up and immediately faint. drank after eating furazolidone 2 tablets - and everything instantly stopped, and diarrhea and the temperature was asleep. like this.
Marina. The old, proven for years, a wonderful antibacterial agent. We use the whole family, if necessary, in case of acute disorders of the gastrointestinal tract. Two tablets in one session, basically, help with the first time and the adult and the child. By the way, children can be given from an infant. Furazolidone is simply indispensable in the period of "dirty hands and toys in the mouth." But we must carefully calculate the dose for small children, in order to avoid an overdose. Never caused side effects and allergies. A good drug at a very affordable price.
Tamara. The drug is really inexpensive, but it can not be called a panacea for diseases caused by various pathogenic microbes. Yes, remembering my childhood, I can say that with dysentery he was doing great then, and now, when there is sometimes an intestinal disorder, I take it, it helps. But here with rotovirusnoy infection, which was my child, furazolidone, written to him by a pediatrician, could not cope. Moreover, given its toxicity, I would not advise giving it to children.

Analogues

Structural analogues of the active substance of the drug Furazolidone does not.

Similar effects have nirofuran derivatives Nifuroxazid and Entprofuril, antibiotics Rifaximin, Imipenem, Azithromycin, Amikacin, Fluoroquinolone, Ciprofloxacin.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Furazolidone should be stored at room temperature in a dry place inaccessible to children. Its shelf life is three years. After the expiration date the drug can not be used for treatment.