Skinoren

Skinoren (a pharmacologically active substance - azelaic acid) - a remedy for the treatment of acne and hyperpigmentation.

Acne vulgaris or acne vulgaris develop in 80-90% of adolescents during puberty. As it grows, the severity of this dermatological disease fades, but in some cases (for example, with endocrine disorders), acne persists after 30-40 years.

Against the background of the use of the drug there is a significant decrease in the density of the colonies of propionibacteria acne, as well as a significant decrease concentration of free fatty acids in lipids on the surface of the skin (due to this, the fat content of the skin decreases).

Clinical and pharmacological group

The drug with antiproliferative and antibacterial action for the treatment of acne, hyperpigmentation and rosacea.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does Skinoren cost in pharmacies? The average price in 2018 is at the level of 750 rubles per gel, and , 00 rubles per cream.

Composition and form of release

The preparation Skinoren is available in the form of a gel and cream for external use.

1. Skinoren gel composition: micronized azelaic acid in the concentration of 150 mg / g, polysorbate 80, polyacrylic acid, propylene glycol, lecithin, sodium hydroxide, triglycerides, benzoic acid, disodium edetate, purified water.
2. In the composition of Skinoren, released in the form of an ointment, azelaic acid enters at a concentration of 200 mg / g. As auxiliary components are used: benzoic acid, macrogol glyceryl stearate, a mixture of cetostearyl alcohol, glyceryl stearate, glycerides of fatty acids of coconut oil and cetyl palmitate, cetostearyl ethylcaprolate, glycerol 85%, propylene glycol, purified water.

The cream is a matte, homogeneous white mass. The form of release - tubes 30 grams.

The gel has the appearance of a white or slightly yellowish opaque substance. The sale comes in tubes of 5, 15, 30 and 50 grams.

Which is better, cream or gel Skinoren?

Having studied the instructions for both products, it can be found that the cream and gel have insignificant differences in composition: thus, the concentration of the active substance in the gel is 15%, and in the cream - 20. This is due to the fact that the gel has a polymer base that excludes fat and alcohol content and due to which Azelaic acid is faster and easier to penetrate into the skin, providing faster relief from acne. Thus, the gel does not need an additional 5% of the active substance.

Approximately 70% of the gel consists of water, the concentration of fats in it - 3%. As for the cream, in it water is 50% of the volume, and fats - 15%.

Ointment (both cream and gel) should be applied to the skin twice a day. In this case, the gel is the optimal form for people with a fat-prone skin, but the cream is recommended for use in dry, normal or sensitive skin.

Complexly influencing the negative factors that provoke the appearance of acne and rosacea, the gel / cream does not overdry the skin and is not addictive.

pharmachologic effect

Therapeutic effect Skinorena provided by the properties of its main component - azelaic acid. The substance is a carboxylic acid derivative, considered the most sparing for the skin. Gently promotes the cleansing of the sebaceous glands, which eliminates the cause of acne and acne, counteracts the emergence of the gums.

After application to the skin, the acid restores the broken keratinization of the follicle, reduces the concentration of fatty acids in the cells, reduces the fat content in the skin. In addition, the drug component suppresses the activity of acne pathogens: staphylococci and anaerobic fixed bacteria propionibacterium acne.

Acid removes inflammatory processes, reducing the formation of neutrophils and free radicals. Also, the substance inhibits the growth and activity of abnormal melanocytes, which provoke malignant neoplasms. After applying to the surface of the dermis, the acid practically does not penetrate into the circulatory system. Some of the assimilated substance is excreted from the body with urine in an unchanged form, the rest is in the form of dicarboxylic acids formed during oxidation.

Azelaic acid is well tolerated by the body, but most importantly - it is not addictive, so the drug is well suited for long-term treatment. Skinoren cream can be used in monotherapy or in combination with other medicines, since it practically does not enter into the reaction. In addition, the active substance has a keratolytic effect: it activates exfoliation of damaged epidermal cells. As a result, the process of renewal and recovery of skin cells is accelerated. Simultaneously, the drug discolored post-acne.

Indications for use

Gel Skinoren is designed to treat papulopustular forms of acne on the face of mild and / or moderate severity, as well as to treat papulopustular rosacea.

Indications for the use of the cream are acne (common acne) and melasma.

Contraindications

The minimum number of contraindications allows the maximum use of this drug for any problems with skin of any type.

• age up to 12 years;
• increased sensitivity to Skinaren components.

Intended use for pregnancy and lactation

During pregnancy and during the period of feeding, use the gel with caution, after consulting a doctor. Studies have shown the absence of teratogenic properties of azelaic acid. The amount of active ingredient in the mother's milk was found to be minimal.

Its effect on the child's body is not associated with danger, since the toxicity of the drug is low.

Dosage and route of administration

As indicated in the instructions for use, the dosage regimen and the duration of therapy with Skinoren are set individually. It is prescribed for adults and children over 12 years.

Before use, the skin should be cleaned with water or a mild cleansing cosmetic, then dried.

The cream or gel is applied to the affected areas of the skin evenly with a thin layer 2 times / day (morning and evening) and lightly rubbed. The drug should be used in sufficient quantities, but not excessively (approximately 2.5 cm is sufficient for the entire surface of the face). The drug should be used regularly throughout the course of treatment, the duration of which depends on the clinical picture of the disease and the severity of the symptoms. With acne vulgaris (acne vulgaris), the improvement is usually observed after 4 weeks. To obtain the best results, the drug should be continued for several months. Additional protection of the skin from UV radiation during the treatment of acne is not required.

With melasma, the drug is used as a cream. The minimum duration of therapy is 3 months, for best results, Skinoren cream should be used regularly. During the entire period of melasma therapy, sunscreens (UVB and UVA) must be used to prevent The exacerbation of the disease caused by exposure to the sun and / or the re-pigmentation of the clarified areas.

Side effect

With a tendency to allergic manifestations or excessive sensitivity of the skin, the following negative manifestations on the treated surface may occur:

• skin peeling;
• the occurrence of itching and burning;
• symptoms of hives;
• redness;
• hypersensitivity of the skin;
• swelling of the epidermal tissues;
• exacerbation of cutaneous eczema.

Seldom there can be an exacerbation of such already available disease, as a bronchial asthma.

Overdose

With local use, an overdose was not found. Medicine such cases are not known. But experts recommend not to abuse the drug, not exceeding the dosage.

If the drug accidentally got inside, then it is worth taking any enterosorbent, before it caused vomiting.

special instructions

Additional skin protection from UV radiation during treatment with Skinoren is not required.

Avoid contact with the eyes and wound surfaces; In case of accidental contact, flush immediately with water.

In cases of skin irritation, the amount of a single application of the gel or cream should be reduced or the frequency application of the drug up to 1 time / day; if necessary, a short-term drug cancellation (for several days).

Epidermal and mixed epidermal-dermal types of melasma are well suited to therapy with Skinoren cream. Skinoren cream is not effective for dermal melasma. For differential diagnosis it is recommended to use a Wood lamp.

Interaction with other drugs

The interaction of Skinoren with other medications has not been revealed to date.

Reviews

We offer you to get acquainted with the opinions of people who used Skinoren:

1. Olya. I like skinnoren. First, it absorbs and does not leave any traces (in contrast to the azelik, by the way), and secondly, the acne cleans up quickly. Literally for two weeks my face cleared, despite the fact that I only used the metrogil for the first few days. Then he was no longer needed. The only thing that needs to be treated completely 3 months, but on myself I know, that patience does not suffice. It seems that the skin has cleared - and enough.
2. Michael. In the transition years, I suffered from severe acne. Simple cleansing and diet did not help, so I had to turn to a specialist. The beautician advised Skinoren, who at that time seemed very expensive to me. I had to buy an analog at a better price. He did not help me, only aggravated the condition, so I regretted that I did not obey.
3. Sergei. A good remedy against acne. I use about 4 months. When used, there is no allergy (burning). The agent is white, well rubbed into the skin. I used analogs before, but switched to skinnoren, I do not regret it.

Analogues

Structural analogs for the active substance:

• Azelaic acid;
• Azelik.

Related drugs:

• Basiron AS gel and cream;
• Dalacine gel;
• Differin cream;
• Zinerite solution;
• Clenzite-C gel;
• Clindes Cream;
• Resorcinol solution;
• Retasol solution;
• Retinoic ointment;
• Cynovite gel;
• Eclaran 5 and Eclaran 10 gel;
• Effegel gel.
• Quasis

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

The cream can be stored at a temperature of no higher than 30 degrees, avoid heating and direct sunlight on the tube. Shelf life of the drug in this form of release is 3 years from the date of production date indicated on the package.

The gel should be stored at a temperature not exceeding 20 degrees in a place inaccessible to children. Shelf life of the drug from the date of manufacture is 2 years, at the end of this period the gel needs to be discarded.

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