At what pressure is prescribed Anaprilin: instructions for use

Anaprilin is a beta-blocker of a non-selective type, effectively blocking adrenergic receptors.

It can reduce the frequency and strength of heartbeats, can lower the value of cardiac output and contractility of the myocardium. Also, due to its effect, it can reduce the need for myocardium in oxygen and reduce blood pressure.

Because of the action of anaprilin, the heart rhythm is normalized with sinus tachycardia, as well as tachyarrhythmic the form of atrial fibrillation passes into bradyarrhythmic, and irregularities in the palpitations gradually disappear

On this page you will find all information about Anaprilin: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Anaprilin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Non-selective beta-blocker.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Anaprilin cost? The average price in pharmacies is at the level of20 rubles.

Form of issue and composition

Anaprilin is available in several dosage forms.

• Tablets 10, 20 and 40 mg.
• Injections are presented in the form of 0.25% solution of 1 ml in the ampoule.
• Eye drops Anaprilin in concentration 1%. They are used as a means of normalizing intraocular pressure.

The content of the pill of the main component (propranolol) is 10 to 40 mg. As auxiliary elements, usually calcium stearate, talc, milk sugar, potato starch.

Pharmacological effect

Anaprilin is a non-selective beta-blocker acting on beta-1 and beta-2 receptors. The drug has antiarrhythmic, antihypertensive, anti-anginal action. According to the instructions to Anaprilin, the drug slows the heart rate, reduces the automaticity of the sinus node, myocardial contractility, inhibits AV conduction, reduces the need for myocardium in oxygen.

In addition, the drug reduces the excitability of cardiomyocytes, produces a membrane-stabilizing effect and reduces the occurrence of ectopic foci. Anaprilin has an antihypertensive effect, which becomes stable by the end of the second week of treatment with the drug. It also improves the tone of the bronchi.

What is Anaprilin used for?

The use of Anaprilin is effective in the treatment of arterial hypertension, angina pectoris and unstable angina, sinus and supraventricular tachycardia, tachysystolic form of atrial fibrillation, essential tremor, ventricular and supraventricular extrasystoles, alcohol abstinence (especially with agitation and trembling), anxiety, pheochrocytome (as an auxiliary treatment), diffuse-toxic goiter, thyrotoxic crisis.

With ischemic heart disease, taking the drug reduces the number of attacks of angina, increases resistance to physical exertion. Especially effective with concomitant arterial hypertension, arrhythmia. It is also expedient to use a medicament for the prevention of migraine.

Contraindications

Anaprilin categorically can not be taken at:

• severe heart failure;
• variant angina pectoris;
• bronchial asthma and propensity to bronchospasm;
• cardiogenic shocks;
• low pressure;
• sinoatrial and AV-blockades of the second-third degree;
• the heart rate is not less than 50 beats per minute;
• syndrome of weakness of sinus nodes;
• after a myocardial infarction for several days;
• impaired blood circulation in the peripheral artery;
• hypersensitivity.

Take medication with caution to patients with:

• psoriasis (skin disease);
• spastic colitis;
• muscle weakness;
• patients older than 50 years;
• diabetes mellitus and a tendency to hypoglycemia;
• chronic diseases of the bronchi and lungs;
• impaired hepatic and renal function;
• pregnant women and during lactation.

Application in pregnancy and lactation

The use of propranolol in pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus. If it is necessary to use during this period, careful monitoring of the fetal condition is necessary, for 48-72 h before the birth of propranolol should be discarded.

It should be borne in mind that a possible negative impact on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia.

Propranolol excreted in breast milk. If it is necessary to use during lactation, it is necessary to establish a medical supervision of the child or to stop breastfeeding.

Instructions for use Anaprilin

In the instructions for use, it is indicated that for adults with oral administration the initial dose of Anaprilin is 20 mg, a single dose of 40-80 mg, the frequency of admission is 2-3 times / day.

In / in slowly, slowly - the initial dose of 1 mg; then after 2 minutes, the same dose is administered again. If there is no effect, repeated injections are possible.

• Maximum doses:when ingested - 320 mg / day; with repeated administration of intravenous injection of a total dose of 10 mg (under the control of blood pressure and ECG).

Children aged 35 days to 150 days on the day of treatment initiation are intended for oral administration in a special dosage form. For preterm infants, the appropriate age should be determined by subtracting the number of weeks of premature pregnancy from the actual age of the child. The initial dose is 1 mg / kg / day in 2 divided doses (morning and evening at 0.5 mg / kg). The recommended therapeutic dose is 3 mg / kg / day in 2 divided doses (morning and evening 1.5 mg / kg). The interval between the two methods should be at least 9 hours.

Dose titration scheme: 1 mg / kg / day for 1 week; 2 mg / kg / day for the 2 nd week; from the 3rd week - 3 mg / kg / day. When the titration of the dose is completed, the amount of the drug administered is adjusted depending on the weight of the child. Clinical monitoring of the child's condition and dose adjustment should be done at least once a month. On the first day of treatment and on the days of the increase in the dose, the child must be in a medical facility under the supervision of the attending physician within 2 hours after the administration of the drug. It is necessary to measure heart rate and assess the general condition of the child at least every 60 minutes during the first 2 hours after the administration of the drug.

Duration of treatment is 6 months. Stopping the drug does not require a gradual dose reduction. In the case of relapse after the completion of therapy, treatment can be repeated if there is a satisfactory response.

Side effects

The drug is well tolerated. But in some cases, the use of Anaprilin can cause unwanted side effects, among which:

• sensory organs: a decrease in the secretion of tear fluid (dry eyes), keratoconjunctivitis, visual acuity;
• skin: psoriasis-like skin reactions, exacerbation of psoriasis, alopecia, increased sweating, skin hyperemia, exanthema;
• digestive system: nausea, vomiting, diarrhea / constipation, dry mouth, dysfunction of the liver, change in taste, the appearance of pain in the epigastric region;
• respiratory system: nasal congestion, rhinitis, bronchospasm, dyspnea, laryngospasm;
• metabolism: hypoglycemia (in patients with type 2 diabetes mellitus);
• reproductive system: decreased potency, decreased libido;
• endocrine system: decreased thyroid function;
• allergic reactions: itching, rash on the skin;
• influence on the fetus: intrauterine growth retardation, bradycardia, hypoglycemia;
• laboratory indicators: increased bilirubin, agranulocytosis;
• cardiovascular system: atrioventricular blockade, palpitations, arrhythmias, orthostatic hypotension, spasm of peripheral arteries, sinus bradycardia, heart failure, impaired conduction of the myocardium, lowering blood pressure (BP), chest pain, cold extremities;
• nervous system: in rare cases - insomnia / drowsiness, asthenic syndrome, agitation, paresthesia, weakness, short-term memory loss or confusion, tremor, headache, depression, fatigue, dizziness, hallucinations, decreased ability to rapid motor and mental reactions;
• Other: pain in the back and joints, in the chest, muscle weakness, thrombocytopenia, leukopenia.

Overdose

• Reduced blood flow in the limbs;
• Changing the heart rate;
• Bronchial spasm;
• Persistent lowering of blood pressure;
• Heart failure;
• Development of a shock state;
• Development of seizures.

If these symptoms occur, it is necessary to urgently cancel Anaprilin, perform gastric lavage followed by the use of activated carbon in the calculation of 1 tablet for every 10 kg of body weight and seek professional help.

special instructions

1. When ingestion Anadrilin is rapidly absorbed and excreted from the body. The half-life of the drug is 3-5 hours, and with prolonged use - for 12 hours (90% of the drug is excreted by the kidneys as metabolites, unchanged remains about 1%).
2. The use of Anaprilin simultaneously with hypoglycemic agents is prescribed only under the strict supervision of a physician (to avoid the development of hypoglycemia).
3. Patients with diabetes mellitus administration of the drug is carried out under the control of glucose in the blood.
4. Abrupt withdrawal can worsen exercise tolerance and increase the risk of ischemia myocardium, so stop taking the drug should be gradually and under the supervision of a doctor.

The intake of the drug may affect the ability to concentrate and the speed of motor reactions, so during treatment should take precautions when working with potentially dangerous mechanisms, as well as when driving vehicles.

Drug Interactions

The drug may intensify or weaken its action and the effect of other drugs if it is combined with other drugs.

Here are some examples of this interaction:

• The drug may enhance the effects of bupivacaine and lidocaine.
• If you use a drug with lithium carbonate, bradycardia can develop.
• When used with morphine, the depressing effect on the entire central nervous system, which usually causes morphine, can increase.
• If you use a medicine with sodium amidotrizoate, then severe arterial hypotension can develop.
• There are a number of changes that occur with a single application of the drug with verapamil, in particular, dyspnea, bradycardia, arterial hypotension and so on are possible.
• When used with haloperidol there is a small chance of developing severe arterial hypotension.
• If you use a drug with amiodarone, you may have bradycardia, asystole, ventricular fibrillation, and hypotension.
• When used with diltiazem, the drug increases its concentration in the blood, which leads to a depressing effect on the heart of the patient.
• When used with phenyldione and warfarin, the drug may increase their concentration.
• When the drug is used with clonidine, the antihypertensive effect is enhanced.
• The effect of hypoglycemic agents is increased, which increases the risk of hypoglycemia.
• When used with digitalis preparations, a pronounced bradycardia can develop.
• If you use the drug together with funds for inhalation anesthesia, you can increase the risk of oppression of myocardial function and / or progression of arterial hypotension.
• If you use a medicine with ketanserin, the hypotensive effect of the additive type may develop.
• If you use a drug with imipramine, the concentration of the latter in the blood plasma increases.
• When anaprilin is used with propafenone, the concentration of active anaprilin in the blood increases markedly.
• If you use a drug with antihypertensive drugs, the risk of bradycardia, or hypotension of the arterial type, increases.

And this is not all available options for the interaction of this drug with various substances and components. In order not to have negative effects, be sure to consult your doctor whether it is possible in principle to use anaprilin with what you are already taking at the moment.

Reviews

The drug has proved itself in cardiologists and therapists, taking tablets is possible without a stationary observation, suitable for constant reception, helps patients maintain health and increase life expectancy.

Systematic administration ensures a steady decrease in blood pressure. Doctors note frequent side effects - dyspepsia (nausea, vomiting, stool disorder), nervous disorders (insomnia, headache, anxiety).

Patients complain about the need for frequent medication.

Pros: low price, high availability, proven effectiveness, helps with maintenance therapy.

Analogues

How to replace Anaprilin? The active substance - propranolol hydrochloride - is contained in a number of drugs as an active substance. With certainty it can be said that the following drugs are analogous and similar not only in composition, but also in their effects, contraindications and side effects:

• Obsidan;
• Anaprinol;
• Phenazep;
• BetaCap TR;
• Stobetin;
• Propranolol;
• Noloten;
• Propranolobene;
• Propamine.

If you need to replace Anaprilin, then the following drugs should be considered, which are also a beta-blocker, but they are based on another active substance. In addition, these drugs are more modern and safe:

• Atenolol;
• Metoprolol;
• Nebivolol;
• Bisoprolol;
• Betaxolol.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The drug should be stored in a dry dark place inaccessible to children. The temperature should be between 8 degrees Celsius and 25 degrees Celsius.

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