Ksefokam nyxes: instructions for use

Xefokam is a non-steroidal anti-inflammatory agent (NSAID) analgesic and anti-inflammatory, belonging to the class of oxycomas.

Used to relieve the pain syndrome and symptomatic therapy of rheumatic diseases.

The anti-inflammatory effect of the drug is due to the ability of lornoxicam to inhibit the synthesis of prostaglandins, which are one of the regulators of biochemical processes in the body, as well as suppress the release of free radicals that are involved in provoking inflammatory processes.

Clinical and pharmacological group

NSAIDs.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How many hundredth nicks Xsefokam? The average price in pharmacies is at the level of750 rubles.

Form of issue and composition

Xephocam is available in the form of lyophysiata for the preparation of a solution for further injection. The medicine is packed in glass dark bottles complete with a solvent in plastic pallets for 1, 5 and 10 bottles in a cardboard box with the attached instruction.

• One vial with lyophilizate Ksefokam includes 8 mg lornoxicam.
• Auxiliary components: edetate disodium, trometamol, mannitol.

Pharmacological effect

The drug has analgesic and anti-inflammatory effect. The anti-inflammatory effect of lornoxicam is due to inhibition of the activity of cyclooxygenase isoenzymes, which inhibits the synthesis of prostaglandins. Ksefokam suppresses the release of activated free radicals by leukocytes.

Xefokam's analgesic effect is not associated with drug effects. The drug does not affect the opioid receptors of the central nervous system, does not depress respiration, does not cause addiction and drug dependence.

The active substance is rapidly absorbed from the gastrointestinal tract and completely metabolized in the liver. The drug is excreted in the form of metabolites mostly with bile, in part with kidneys.

Indications for use

Indications for the use of xefocam in neurological practice are short-term courses of therapy of pain syndrome of various genesis, mainly with vertebrogenic pathology.

The main use of the drug is rheumatological practice.

Contraindications

There are a lot of contraindications to prescribing the drug, which must be taken into account when treating the pain syndrome. Thus, xephocam is contraindicated in the following conditions:

• hemorrhagic stroke;
• dehydration, hypovolemia (decrease in blood volume);
• bronchial asthma;
• disorders of blood clotting;
• ulcerative colitis, ulcers of the stomach or duodenum in the stage of exacerbation;
• kidney disease of severe form;
• significant violations of liver function;
• hearing loss;
• heart failure;
• deficiency of glucose-6-phosphate dehydrogenase.

The use of Xsefokam is contraindicated in patients who have not reached the age of 18, pregnant women and patients breastfeeding.

Use in pregnancy and lactation

Xefokam is contraindicated for use in pregnancy and lactation (breastfeeding).

The use of the drug may adversely affect female fertility and is not recommended for women planning pregnancy.

Dosage and route of administration

The instructions for use indicate: Xefokam lyophilisate is used parenterally. The drug should be applied at the lowest effective dose with the minimum possible short course.

With postoperative pain, the drug is given in / m or / in, with an acute attack of lumbago / ishalgia - in / m. In / m injections make a long needle.

1. The initial dose may be 8 mg or 16 mg. With an insufficient analgesic effect of the drug at a dose of 8 mg, you can also add the same dose.
2. Maintenance therapy: 8 mg 2 times / day.
3. The maximum daily dose is 16 mg.

The injection solution is prepared immediately before use by dissolving the contents of one vial (8 mg Xefokam powder) with water for injection (2 ml). After the solution is prepared, the needle is replaced. The solution thus prepared is administered iv or I / m. The duration of IV administration of the solution should be at least 15 seconds, v / m - not less than 5 seconds.

Than to breed Xefokam?

It is best to dilute Xefokam's lyophilizate with special water for injections, which is sold in pharmacies in ampoules or vials. Such water is not only distilled, but also de-ionized, that is, all impurities are completely removed from it. Thus, dilution of Xefokam powder with water for injection guarantees maximum efficacy of the drug and minimal risk of side effects.

If for any reason it is impossible to dilute Xefokam with water for injection, then it can be done by physiological solution (sterile), novocaine or lidocaine. In this case, 2 ml of solvent should also be added to one bottle of Xephocam powder, and then change the needle on the syringe before the injection.

Side effects

To the undesirable effects of Xefokam reviews and instructions include:

1. Urinary system: dysuria, decreased glomerular filtration, peripheral edema; nocturia (for solution);
2. Organs of the senses: impaired vision, tinnitus;
3. The system of hematopoiesis: leukopenia, thrombocytopenia, anemia, agranulocytosis;
4. Blood coagulation system: increased bleeding time, hemorrhagic rash;
5. Respiratory system: rhinitis, pharyngitis, cough, dyspnea, bronchospasm;
6. Allergic reactions: angioedema, urticaria;
7. Local reactions: soreness in the injection site, hyperemia.
8. Dermatological reactions: skin rash, ecchymosis, pruritus, alopecia, edematous syndrome, Lyell syndrome, Stevens-Johnson syndrome;
9. Nervous system: dizziness, headache, sleep disturbances, agitation, drowsiness, tremor, taste disorder, paresthesia, depression; aseptic meningitis (for tablets);
10. Cardiovascular system: tachycardia, heart palpitations, heart failure, increased blood pressure; hematomas and tides (for solution);
11. Digestive system: diarrhea, abdominal pain, vomiting, dyspepsia, nausea, glossitis, stomatitis, dry mouth, flatulence, constipation, heartburn, eructation, anorexia, esophagitis, gastritis, dysphagia, erosive-ulcerative lesions of the mucous membrane of the stomach and intestines (incl. with perforation and bleeding), bloody vomiting, melena, increased level of hepatic transaminases, impaired liver function;
12. Other: changes in body weight, increased sweating, myalgia, arthralgia.

Overdose

In case of an overdose, side effects are intensified. Specialists produce symptomatic therapy.

When symptoms of overdose are detected, it is necessary to take activated charcoal. This drug reduces the likelihood of developing symptoms of an overdose only if you take it right away.

special instructions

Before you start using the drug, read the special instructions:

1. It is forbidden to apply the drug at the same time as other anti-inflammatory non-steroid drugs.
2. In the elderly, as well as those suffering from arterial hypertension or obesity, it is necessary to monitor blood pressure.
3. With long-term use of the drug, hematologic parameters, as well as renal and liver parameters, should be regularly monitored.
4. If there are signs of liver damage (jaundice of the skin, itching, vomiting, nausea, darkening of the urine, abdominal pain, increase the content of hepatic transaminases), you should immediately stop using the medication and consult a doctor.
5. Xefokam is able to change the properties of platelets, but it does not replace the prophylactic effect of Aspirin in cardiovascular disorders.
6. Patients with impaired renal function, provoked by severe blood loss or dehydration, the drug as a inhibitor of biosynthesis prostaglandins, can be prescribed only after the relief of hypovolemia and the resulting risk of reducing renal perfusion.
7. It is especially important to observe the function of the kidneys in elderly patients, as well as in people taking diuretics or drugs potentially damaging kidney tissues.
8. The described drug can cause an increase in urea and creatinine in the blood, as well as sodium retention, water, arterial hypertension, peripheral edema and some other initial symptoms of nephropathy. Long-term therapy of such patients Xefokam can cause glomerulonephritis, nephrotic syndrome and even acute kidney failure.
9. Like any other oxicam, the described drug inhibits platelet aggregation, which causes an increase in the duration of bleeding. When using the drug, you need to closely monitor the condition of patients who need a normal physiological functioning of the coagulation system (including those who are planned to perform a surgical operation) having coagulation disorders or taking medications that suppress coagulation in order to detect signs of bleeding in time.
   The likelihood of ulcerogenic action of the drug can be reduced by simultaneous administration of proton pump inhibitors and artificial prostaglandin analogues. When bleeding occurs from the digestive organs, the medication should be stopped immediately and emergency measures taken. It is especially necessary to observe patients with pathology of the gastrointestinal tract, who first take the drug.

Persons receiving the drug are strongly advised to refrain from driving and drinking alcohol.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. In combination with other NSAIDs or GCS, the risk of bleeding from the gastrointestinal tract increases.
2. With simultaneous admission with Methotrexate, there is an increase in the concentration of methotrexate in the serum.
3. Cyclosporine increases the nephrotoxicity of cyclosporine.
4. In combination with beta-blockers and ACE inhibitors, their hypotensive effect may decrease.
5. Tacrolimus increases the risk of nephrotoxic effect due to the inhibition of prostacyclin synthesis in the kidneys.
6. In combination with diuretics, the diuretic effect and hypotensive effect are reduced.
7. Quinolone antibiotics can increase the risk of convulsive syndrome.
8. Ethanol, corticotropin, potassium preparations may increase the risk of GIT side effects.
9. In combination with cefoperazonom, cefotetan, valproic acid increased risk of bleeding.
10. In combination with anticoagulants or inhibitors of platelet aggregation, an increase in bleeding time is possible. Therefore, MHO monitoring is required.

Reviews

We picked up some reviews of people taking the drug Xefokam:

1. Larissa. Xefokam started taking menstrual cramps. I know that a very strong drug, I know that a lot of pobochek, I feel it, but I can not find a replacement for it, analogies are not it. From the very beginning I suffer insanely painful menstrual, happened to loss of consciousness. Once again, my mom called an ambulance, the doctor was in shock, but made a shot of Xefokama. Since then, every month I take this drug. With Xephocamus I can live a normal life, without loss of life every month of one day.
2. Irina. It is difficult to name my acquaintance with Xefokam. Injections of this drug were prescribed to me by a neurologist with severe pain in the right shoulder and arm, and the diagnosis issued after the examination - acute brachialgia. I did not like the fact that this pain medication is in the form of a powder and requires an additional purchase of a solvent. After receiving two injections, I noted that the pain had subsided a little, it could sleep at night. But I was happy early, because the next day I was awoken by terrible pains in the abdomen, nausea and heartburn. And I began to treat then exacerbated gastritis. Considering also its high price, it is better to choose a medicine more effective and safe.
3. Alya. The doctor prescribed me xefokam for back pain. I took a course of ten injections. After three shots, it even seemed to me that the pain had gone. But then I started a terrible vomiting and dizziness. The doctor urgently canceled me xefokam, because it was he who caused me such a reaction. In general, the acquaintance with this drug was not very successful.

Analogues

Very often patients seek financial resources to save financial resources, the substance of which is the same as the prescribed medication. Among Xefokam's analogues, the following drugs are most popular:

• Piroxicam;
• Meloks;
• Meloksikam;
• Movalis;
• Oxycamox;
• The Texman.

Before using analogues, consult your doctor.

Movalis or Xefokam?

Movalis has a more pronounced anti-inflammatory effect, and Xefokam - an analgesic. In addition, Movalis has a less pronounced negative effect on the gastric mucosa.

Therefore, Movalis is better to prefer for relief of pain and inflammation, if a person has had a stomach ulcer in the past or in the present he suffers from gastritis. Also, Mawalis is preferable for course therapy for various inflammatory joint diseases (rheumatism, arthritis, osteochondrosis, etc.) that occur with moderate or mild pain. A Xefokam is recommended for taking in a severe pain syndrome of any origin or for a course application in the absence of diseases of the digestive system.

Storage conditions and shelf life

The drug Xefokam should be stored in a room in which the temperature is not lower than 15 degrees and not more than 25 degrees Celsius. Ready to use Ksefokam solution should be used throughout the day, after 24 hours it is considered unfit.

Shelf life - 5 years.

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