Reduxin (10, 15 mg): for weight loss: side effects and reviews of women

Reduxin is a combined remedy, the action of the drug is due to the elements in it.

Sibutramine is a prodrug that acts with metabolites that inhibit the incorporation of monoamines. Increased content in the synapses of transmitters increases the activity of adrenergic and serotonin receptors, this contributes to a feeling of satiety and suppression of hunger, as well as the activation of thermo products.

In parallel with the decrease in the weight of a person, there is an increase in the concentration of HDL in the blood serum. Also, the total cholesterol, the amount of triglycerides, uric acid decrease.

Clinical and pharmacological group

The drug for the treatment of obesity central action.

Terms of sale from pharmacies

It is possible to buy under the prescription of the doctor.

Price

How much does Reduxin cost in pharmacies? The average price is at the level of2 000 rubles.

Composition and form of release

The drug Reduxin is available in the form of a capsule for oral administration. They have a blue or blue color (depending on the dosage), inside it is a powder of white or yellowish color.

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The composition of the agent includes active components: sibutramine hydrochloride monohydrate, as well as microcrystalline cellulose.
As an additional substance in the drug contains calcium stearate.
The capsule shell consists of gelatin, azorubin dye, titanium dioxide dye, a blue dye patented.

Capsules Reduxin are packaged in a contour acheive box of 10 pieces. Cardboard pack contains 3 or 6 contour squares, as well as instructions for the use of the drug.

Reduxin and Reduxin Light - what's the difference?

It should immediately take into account the differences in the composition of these funds. The instruction indicates that Reduxin Light is an additive that contains conjugated linoleic acid, vitamin E and additional substances. Active components of the drug contribute to the normalization of metabolism, activate the processing of fat. However, Reduxin Light is most expedient to use with an active lifestyle and constant physical exertion.

The price, in comparison with LS Reduxin, is slightly lower. The drug Reduxin has a different mechanism of action. Therefore, in each case, the doctor individually determines what is more effective and what is better to assign to the patient. Discussing Reduxin and Reduxin Light, the reviews leave the patients diverse, from positive to less enthusiastic.

pharmachologic effect

Tablets from obesity Reduxin have an effect directly on the nervous system of a person, so the remedy is released solely for the doctor's prescription. Their action is aimed at suppressing hunger, reducing appetite. Due to this, slimming reduces the number of snacks and the total amount of consumed food decreases. Due to the effect of thermogenesis, the energy consumption and calorie consumption are increased faster. In addition, the metabolism is accelerated, the level of glucose, cholesterol and lipids in the blood is normalized.

Described mechanism of action of diet pills Reduxin allows a person to lose weight effectively, while reducing weight occurs at a safe rate (about 1 kg per week). Nevertheless, taking medication from obesity can cause negative consequences in the form of side effects, so treatment should be under close supervision of the doctor.

Indications for use

The instruction indicates that Reduxin is used to reduce a person's weight. Like other drugs for weight loss, Reduxin is recommended for people suffering from normal obesity, while their body weight is 31 kg / m2. or more.

Also shown to people with diagnosed obesity is a BMI of 28 kg / m2. and there are other risk factors that are associated with excessive weight.

Contraindications

Before you start taking the medication, you should always take into account contraindications and side effects. Reduxin is contraindicated in the following cases:

Thyrotoxicosis;
Functional disorders of the liver / kidneys in severe course;
Pheochromocytoma;
Prostate adenoma;
Closed-angle glaucoma;
Confirmed drug / alcohol / drug dependence;
The period of pregnancy and breastfeeding;
The age is under 18 years old and over 65;
Serious disorders of the digestive system (bulimia nervosa / anorexia);
Organic causes of obesity (eg, hypothyroidism);
Gilles de la Tourette syndrome;
Mental illness;
Combined use with monoamine oxidase inhibitors (eg, with phentermine, fenfluramine, dexfenfluramine, ethylamphetamine, ephedrine) or their use for 14 days before the administration of Reduxine;
Combined use with other drugs acting on the central nervous system (eg, with antidepressants, antipsychotics);
Combined use with medicines shown in the treatment of sleep disorders containing tryptophan, as well as with other drugs of central action for weight loss;
Decompensated chronic heart failure, tachycardia, ischemic heart disease, congenital heart defects, arrhythmias, occlusive diseases of peripheral arteries, cerebrovascular diseases (transient disorders of cerebral circulation, stroke);
Uncontrolled arterial hypertension (at arterial pressure above 145/90 mm Hg);
Hypersensitivity to the constituents of the drug components.

Relative (Reduxin prescribe with caution in the presence of such diseases / conditions as):

Chololithiasis;
Diseases of the coronary arteries (including anamnestic data);
Neurological disorders, including convulsions and mental retardation (including anamnestic data);
Functional disorders of the liver / kidneys (mild or moderate severity);
Arterial hypertension (controlled and availability of anamnestic data);
Arrhythmias (anamnestic data);
Insufficiency of blood circulation in chronic course;
Motor and verbal tics (anamnestic data).

Intended use for pregnancy and lactation

Pregnancy and feeding are contraindications for taking the remedy.

How to take Reduxin?

As indicated in the instructions for use Reduxin is prescribed by mouth 1 time / day. Capsules should be taken in the morning without chewing and drinking with a sufficient amount of liquid (a glass of water). The drug can be taken as an empty stomach or combined with a meal. The dose is set individually, depending on the tolerability and clinical effectiveness.

The recommended initial dose is 10 mg / day, with poor tolerability, a dose of 5 mg / day is possible.

If within 4 weeks from the beginning of treatment there is no reduction in body weight less than 2 kg, the dose increases to 15 mg / day. Treatment with Reduxin should not last more than 3 months in patients who do not respond well enough to therapy, i.e. who during the 3 months of treatment can not achieve a reduction in body weight by 5% of the baseline. Treatment should not be continued if, in further therapy, after the body weight reduction is achieved, the patient again adds 3 kg or more in the body mass. Duration of treatment should not exceed 1 year, since there is no data on efficacy and safety for a longer period of sibutramine intake.

Treatment with Reduxin should be carried out in conjunction with diet and exercise under the supervision of a doctor who has practical experience in the treatment of obesity.

Side effect

Most often, side effects occur at the beginning of treatment (in the first 4 weeks). Their severity and frequency diminish over time. Side effects are generally light and reversible.

When using Reduxin 15 mg capsules, the following side effects may occur:

Cardiovascular system: tachycardia, strong palpitation, vasodilatation, high blood pressure;
Dermatological formations: purple Shenlein Genocha, skin itching, high sweating;
Digestive system: deterioration of appetite, constipation, manifestation of hemorrhoids, vomiting;
The reaction of the body, in general: rarely - dysmenorrhea, the appearance of edema, rhinitis, influenza-like inflammation, nephritis, the desire to drink, minor bleeding, thrombocytopenia;
Nervous system: thirst, sleep disturbance, dizziness, paresthesia, headache, lethargy, anxiety; rarely - nervos, depression, excitability, pain of the spine, convulsions.

On completion of drug use, adverse effects are noted in rare cases. Probably appearance of high appetite, pain in the head.

Overdose

There is no reliable data on the overdose of Reduxin capsules to date. Exceeding the recommended therapeutic dose may be accompanied by the development or increased side effects. In this case, you need to see a doctor who will prescribe the appropriate symptomatic therapy.

special instructions

Reduxin should be used only in those cases when all non-drug measures for weight loss are ineffective - if the reduction in body weight within 3 months was less than 5 kg.

Treatment with the drug should be carried out as part of a comprehensive therapy to reduce body weight under the supervision of a doctor who has practical experience in treating obesity.

Complex therapy of obesity includes both changing diet and lifestyle, and increasing physical activity. An important component of therapy is the creation of prerequisites for a persistent change in eating behavior and lifestyle, which are necessary to maintain the achieved weight loss and after the abolition of drug therapy. Patients need to change their lifestyle and habits within the drug therapy in such a way that after the completion of the treatment it is ensured that the achieved weight loss is maintained. Patients should clearly realize that failure to comply with these requirements will lead to a second increase in body weight and repeated calls to the treating physician.

In patients taking Reduxin, it is necessary to measure blood pressure and heart rate. In the first 3 months of treatment, these parameters should be monitored every 2 weeks, and then monthly. If the increase in heart rate at rest ≥10 bpm or systolic / diastolic pressure ≥ 10 mm Hg is detected at two consecutive visits, the treatment should be discontinued. In patients with hypertension who have BP above 145/90 mm Hg on the background of antihypertensive therapy, this control should be carried out particularly carefully and, if necessary, at shorter intervals. In patients in whom blood pressure twice exceeded the level of 145/90 mm Hg on repeated measurement. treatment with the drug should be canceled.

In patients with sleep apnea syndrome in a dream, it is necessary to carefully monitor blood pressure.

Special attention should be paid to the simultaneous administration of drugs that increase the QT interval. These drugs include blockers of histamine H1 receptors (astemizole, terfenadine); antiarrhythmic drugs that increase the QT interval (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol); GI motility stimulant (cisapride), pimozide, sertindole and tricyclic antidepressants. This also applies to conditions that can lead to an increase in the QT interval, such as hypokalemia and hypomagnesemia (see Fig. (see also the section "Drug Interactions").

The interval between the intake of MAO inhibitors (including furazolidone, procarbazine, selegiline) and the drug should be at least 2 weeks.

Although no relationship has been established between the use of the drug and the development of primary pulmonary hypertension has not been established, however, given the generally known risk of this group, with regular Medical control should pay special attention to symptoms such as progressive dyspnea (breathing disorder), chest pain and swelling on the legs.

When skipping a dose of the drug should not take the next dose of a double dose of the drug, it is recommended to continue taking the drug on a prescribed schedule.

The duration of the drug should not exceed 1 year.

With the joint administration of sibutramine and other serotonin reuptake inhibitors, there is an increased risk of bleeding. In patients who are prone to bleeding, as well as taking drugs that affect hemostasis or platelet function, sibutramine should be used with caution.

Although clinical data on addiction to sibutramine are not available, it should be ascertained whether there have been cases in the patient's history drug dependence, and pay attention to possible signs of abuse of medicines.

Interaction with other drugs

Special attention should be paid to the simultaneous administration of drugs that can increase the QT interval, such as some antiarrhythmic drugs (amiodarone, flecainide, quinidine, propafenone, mexiletine, sotalol), histamine H1 receptor blockers (terfenadine, astemizole) and gastrointestinal motility stimulants (tricyclic antidepressants, pimozide, cisapride, sertindole). In addition, caution should be observed patients who take Reduxin in the period when they have conditions, which are risk factors for increasing the QT interval (eg hypomagnesemia or hypokalemia).

Between the methods Reduxin and monoamine oxidase inhibitors should be observed at least 2-week interval.

Inhibitors of microsomal oxidation, including inhibitors of the 3A4 cytochrome P450 isoenzyme (including cyclosporine, erythromycin, ketoconazole) increase the concentration of sibutramine metabolites in the blood plasma, increase heart rate and clinically insignificantly increase the QT interval.

Macrolide antibiotics, phenobarbital, phenytoin, rifampicin, dexamethasone and carbamazepine can accelerate the metabolism of sibutramine.

The simultaneous use of several drugs that increase serotonin levels in the blood can lead to serious consequences of such drug interactions.

There are rare cases of the development of serotonin syndrome with the combined use of sibutramine with antitussive drugs (eg, dextromethorphan), potent analgesics (pethidine, pentazocine, fentanyl), selective serotonin reuptake inhibitors (antidepressants), some drugs for the treatment of migraine (sumatriptan, dihydroergotamine).

Sibutramine has no effect on oral contraceptives.

Reviews

We offer you to get acquainted with the opinions of people who used the drug Reduxin for weight loss:

Olga. I used to try to lose weight even on activated carbon, but, as my nutritionist told me: in my case, it is necessary not to drink coal, but to unload)) Therefore I decided to try this remedy. At first the results were not great. Then more and more, and then quite cool. I started eating correctly, I began to engage in sports more actively and are still doing it.
Lily. He helped me. With his help, I lost 12 kg. for 3 months. There are pluses and minuses. Pros: I had an appetite, so I ate very little, if only the stomach did not rumble; changed the sense of smell, so the delicious sausage or fried chicken seemed to me something vile and smelly. Disadvantages: the heart was pounding for the first time, the sleep disappeared-2-3 hours of sleep was enough for me, my nerves became nervous, I irritated everything, but a month later. Nervous and cores better of course not to take it. Here has passed or has taken place 3 months the weight while costs or stands on a place.
Marina. First of all, to cope with my pounds, I went to the gym and, as it was not ashamed, went to it every day. At first I caught various unpleasant glances from individual individuals saying, "what did the fat woman forget in the hall !?" but there were also those who simply helped. After two months of classes in the gymnasium, she began taking a reinforced light formula with an increased formula. Then the weight began to leave even faster. I will not say that right now I have an ideal figure, but my weight is 18 kg. less than ten months ago, and that's something. I go further.

Some reviews mention the program of Elena Malysheva, within the framework of which the group "We Lose Weight with Reduxin" was organized. The host claims that her participants got rid of extra 15-20 kg, and many were positive about the drug.

Doctor's comments

The opinion of dietitians and other doctors regarding the advisability of taking diet pills was divided. At the same time, most doctors hold the view that taking a medication should be a forced measure: The use of the drug is possible only if other methods have not helped to get rid of excessive body weight. Losing weight with Reduxin can cause serious damage to human health, causing problems with the heart, blood vessels, digestive system, etc.

The doctors' comments about Reduxin are controversial, but all specialists agree that the treatment with this remedy should be carried out under the supervision of a doctor. In addition, a person who has decided to lose weight with the help of this medicine should have good health (any pathology is a contraindication for the use of Reduxin). Before you start taking pills, it is recommended to have a checkup with a cardiologist.