Dona: instruction on the use of powder, tablets, injections

Prick of the Don for joints: instructions for use

Dona is a medicinal preparation that stimulates the regeneration of cartilaginous tissue.

Has anabolic, anti-catabolic, anti-inflammatory, analgesic and chondroprotective effect.

It stimulates the processes of synthesis of mediators and nutrients necessary for the restoration of damaged tissues (including calcium), facilitates their deposition in the region of the joints.

This leads to inhibition of inflammatory and degenerative processes and relieves pain symptoms.

On this page you will find all information about the Don: complete instructions for use on this medication medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied pricks of the Don. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Chondroprotector.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much do dona prizes in pharmacies cost? The average price for 1 package (6 ampoules) starts from 1450 rubles to 1800, the price for a powder also varies from 1350 to 1650 rubles. It is expensive enough at first glance, but the effect is also promised.

Form of issue and composition

Produce the drug in the following variations:

1. Powder for solution for oral administration (per, g in bags, in a pack of cardboard 20 or 30 packets);
2. The tablets covered with a film cover: oblong form, white color; On the cross-section, two layers are visible: the outer layer white and inner - white with a brownish hue (in polyethylene bottles of 60 or 180 pcs., in a pack of cardboard 1 bottle);
3. Solution for intramuscular administration: colorless or light yellow, transparent (2 ml each in ampoules of transparent light-protective glass, in a pack of cardboard 6 ampoules in a PVC tablet complete with 6 ampoules of solvent in PVC tablet).

Active substance: glucosamine (in the form of sulfate):

• 1 tablet 750 mg;
• 1 packet with powder - 1500 mg;
• 1 ml of the solution - 200 mg.

The solvent applied to the solution (colorless transparent liquid) consists of water for injection and diethanolamine.

Pharmacological effect

Stimulator of cartilage tissue regeneration, has anti-catabolic, anabolic, chondroprotective, analgesic, anti-inflammatory action.

The active substance of Dona - glucosamine sulfate, is an amino saccharide with a low molecular weight, a natural component of the articular cartilage.

Glucosamine activates the synthesis of syngeneal proteoglycans by cells of the cartilaginous tissue (hyaluronic acid and glucosaminoglycans), inhibits enzymes, which cause the destruction of cartilage tissue (phospholipase A2, collagenase, etc.), inhibits the formation of superoxide radicals, reduces the activity of enzymes lysosomes.

Due to the action of glucosamine, the drug initiates sulfur fixation processes in the formation of chondroitinsulfuric acid and has a positive effect on the processes of normal deposition calcium in the bone tissue, and also prevents the formation of glycosaminoglycans that cause non-steroidal PVA to disrupt, and protects the chondrocytes from damage corticosteroids. In the formation of glycosaminoglycans and in the course of normal metabolic processes, sulfo groups participate, and sulfoethers, located in side chains in the composition of proteoglycans, participate in maintaining the elasticity of the cartilaginous tissue, promoting retention in it water.

Dona, replenishing the endogenous deficiency of glucosamine, increases the permeability of the joint capsule and promotes the restoration of normal enzymatic processes in cells of articular cartilage and synovial membrane

Indications for use

What helps? The main indications for prescribing the drug are the following:

1. Primary and secondary osteoarthritis;
2. Shoulder-humeral periarteritis;
3. Chondromalation of patella;
4. Osteoarthritis of the intervertebral space;
5. Treatment of osteortrosis of different localization (hip, spondylarthrosis, osteochondrosis, knee arthrosis, wrist and others).

Contraindications

Drug preparation in the form of injections can not be administered in the following situations:

1. Complex functional changes in the kidneys and liver;
2. Epileptiform cramps;
3. Children up to 12 years;
4. Acute congestive heart failure and changes in cardiac conduction;
5. Pregnancy and lactation;
6. High sensitivity to lidocaine and glucosamine.

Care must be taken when using this medication if the patient has an allergic reaction to mollusks, shrimps.

Application in pregnancy and lactation

Due to the lack of sufficient data on the efficacy and safety of the use of the drug in pregnant and lactating women, taking the medication in this period is contraindicated.

The medication should be discontinued in women who have fertility problems and undergo a special examination.

Instructions for use

The instructions for use indicate that the Don solution for intramuscular injection is used as follows: the ampoule of the preparation in one syringe is mixed with the ampoule of the solvent. Enter deep intramuscularly three times a week for 1-1.5 months.

To increase the effectiveness of treatment, it is advisable to combine the parenteral administration of Don with oral administration of the drug.

Pills:

• Take at the same time with a meal of 1 or 2 pieces three times a day.

Powder:

• Take in before meals in 30 minutes, first dissolving 1 packet in a glass of water once a day for 1-3 months. The second course is 2 months later.

Side effects

As a rule, Dona is well tolerated.

In some cases during the therapy can develop flatulence, gastralgia, diarrhea, nausea, constipation, drowsiness, headache, allergic reactions (in the form of erythema, urticaria and itching).

When Dona is used in the form of a solution for injection, because of the lidocaine included in its composition, nausea, vomiting, drowsiness, diplopia, dizziness, headache, numbness of the oral mucosa and tongue, tremor, disorientation, euphoria, cardiac dysfunction conductivity.

Overdose

Cases of overdose are unknown. However, if an overdose occurs, treatment should be symptomatic, aimed at restoring the water-electrolyte balance.

special instructions

When using Dona in patients with severe renal and hepatic insufficiency, as well as impaired glucose tolerance, medical supervision is necessary.

With caution should take the drug for diabetes and bronchial asthma.

Drug Interactions

The drug enhances the effect of adrenoblockers, glucocorticosteroids, MAO inhibitors, hypnotics and sedatives, coumarin anticoagulants.

Reduces - Chloramphenicol, semi-synthetic penicillins.

Reviews

We picked up some people's comments about the drug Don:

1. Tamara. To me of 60 years, last years five I am excruciated with an arthrosis, pains in knees. The doctor prescribed injections of Don, a course twice a year. The pains have decreased, now I can at least rise to the 4th floor without help
2. Anna. Delivered 11 injections while and drank 20 powders, there are still 7 injections. I want to be treated for two or three months, I have coke-arthrosis 2st. While the result could not say anything, there is probably very little time left.
3. Irina. Very good drug, came to him by trial and error. Prior to that, I took other chondroprotectors, but did not notice a special effect. C bottom is different, I really forget about the fact that I have painful joints. I have been taking courses for 4 years as needed (approximately 2 times a year).
4. Natalia. I finish the third pack of injections and drink the second pack of powder, the only shift is the pain with TB, the knees of the knees are terribly ill, possible from them, perhaps in itself another disease. But I want to drink powder for another three months, because the terrible severity in the joints and stiffness. At me koksartroz 2st.

Analogues

Analogues of the drug Don in injections for pharmacological properties are: Yunium, Elbona, Chondroxide Maximum, Pharmaskin THC, Sustilac, Glucosamine Sodium Sulfate Chloride, Glucosamine Sulfate 750, Glucosamine Hydrochloride, Glucosamine, Aminoarthrin.

Before using analogues, consult your doctor.

Storage conditions and shelf life

According to the instruction, Don should be stored at a temperature of no more than 25 ° C in a place inaccessible to children. Shelf life of the solution for the / m introduction of 2 years, tablets and powder - 3 years.

A source: http://simptomy-lechenie.net/dona-ukoly/

Instructions for use on the drug Don with prices, reviews and analogues

Another useful property of glucosamine - this substance reduces the negative effect of non-steroidal anti-inflammatory drugs, which are almost always prescribed to patients diagnosed with coxarthrosis.

The fact is that NSAIDs reduce the synthesis of natural glucosaminoglycans, and their shortage causes drug destruction of the bone structure. The preparation of Don neutralizes this side effect of non-steroidal anti-inflammatory drugs.

In addition to glucosamine sulfate, the preparation contains additional substances:

• Tablets: macrogol 6000, microcrystalline cellulose, povidone K25, magnesium stearate, croscarmellose sodium, talc.
• Powder: citric acid, sodium chloride, sorbitol, aspartame, carbowax 4000.
• The substance for injections: sodium chloride, lidocaine hydrochloride, water for injection.

Briefly enumerate the main characteristics of the drug:

• The trade name of the drug is Dona.
• Non-trading name: glucosamine.
• Latin name: Glucosamine.
• Pharmacological group: correctors of bone and cartilage tissue metabolism.
• Indication: all stages of arthrosis.
• Contraindications: it is forbidden to apply medicine to pregnant and lactating women; children under 12 years; people who observe the sodium diet; patients with intolerance to seafood; suffering from cardiac and renal insufficiency; with allergy to composition Dons. The powder contains aspartame, which is inadmissible for administration in phenylketonuria.
• Overdose: there were no cases of death after use of increased doses of Dona.
• Method of use: depends on the form of release of the Don (instructions for the use of capsules, solution and powder are different).
• Pharmacological compatibility: according to the instructions, the drug is well compatible with non-steroidal anti-inflammatory drugs and glucocorticosteroids.
• Pharmacological incompatibility: enhances the absorption of tetracyclines, reduces the effectiveness of semisynthetic penicillins and chloramphenicol.
• Shelf life: tablets and powder - 3 years from the date of manufacture; solution for injection - 2 years.
• Conditions of leave in pharmacies: the drug Don is released without a doctor's prescription.
• Producer: "Madaus GmbH Germany (representative of the manufacturer in Russia - Moscow representative office of the firm "Rottafarm").

You will be interested in:Exercises for hip joints with arthrosis

How long is the course

Do not trust the reviews, in which people say that they already take Don a couple of weeks, but there is no effect and, therefore, the drug is bad. Such reviews are written by people who know nothing about how this medicine works.

The drug acts on the root cause, and therefore the results become visible only after passing the full course.

Reduction of clinical symptoms of arthrosis on the background of taking Dona will be noticeable at least 2-3 weeks after the start of taking the medication, but the maximum effect can be felt only after 1-2 months.

The positive result remains for 50 days after the end of the course of treatment.

Method of use

There are three forms of medication:

• white capsules, packaged in plastic jars of 60 tablets, are intended for oral administration;
• powder, packaged in bags of weight, g (in one packet of 20 or 30 bags); are intended for oral ingestion;
• solution in ampoules (4 mg each) for intramuscular administration.

Instructions for use for different variants of the Don are different. In the first case, the capsule is already a ready-made preparation, which is simply washed down with water. Take Don capsules one by one three times a day. The course is 5-12 weeks.

Powder must first be dissolved in a glass of liquid (1 packet = 1 dose) and drink for half an hour before meals. In this form, take the drug only once a day. The course of powder intake is the same as that of capsules.

Injections are given with severe symptoms. With advanced forms of arthrosis, the doctor can prescribe both tablets (or powder), and a prick at the same time - to enhance the effect.

This course significantly accelerates the effect of drug substances, as a result, pain is quickly removed, inflammation removed and joints restored much faster.

Injections of Don should be done 3 times a week. Judging by the reviews, the injections are quite noticeable, therefore, as an auxiliary substance, to reduce pain, the composition includes an anesthetic lidocaine.

Before use, the solution of Dona should be mixed in a syringe with the solvent included with the drug.

Don instructions are recommended for 28-32 days, although this time can be adjusted by the doctor.

The drug exists in the form of injections

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According to patient reviews and clinical tests, the drug is well tolerated by most people. Adverse reactions are rare and, as a rule, have a weakly expressed character. Most often it can be a small digestive tract disorder or slight weakness.

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In one case of a hundred, an allergic reaction is easy.

However, if the allergy begins to manifest itself, you must stop taking Don and ask the doctor to choose an analog (most popular analogs are such agents as Artradol, Alflutop, Artra Chondroitin, Teraflex, Sodium chondroitin sulfate).

Cost

The price of the drug depends on its form and packaging:

Form and packing of the preparation	Approximate retail price, rub.
Powder, 20 pcs.	From 1160
Powder, 30 pcs.	From 1200
Capsules, 60 pcs.	From 1360
Injection	From 1050

The price of the drug is quite high, if you compare it with analogues:

• Artradol in ampoules for the / m introduction (10 pcs.) - from 730 rubles.
• Arthra in tablets (60 pcs.) - from 1050 rubles.
• Sodium chondroitin sulfate in ampoules (10 pcs.) - from 668 rubles.

But Dona is a remedy with a good reputation, tested for years and proved effective compared to other chondroprotectors.

The doctors' comments about Don are reduced to the fact that this is a very effective drug for getting rid of arthrosis, including coxarthrosis: it eliminates pain, relieves inflammation, promotes regeneration of cartilaginous and bone tissue, normalizes the work the joint.

A source: http://ProKoksartroz.ru/preparaty/dona-instrukciya-po-primeneniyu-cena-otzyvy-i-analogi

Dona - instructions for use, indications, doses, analogues

Don - a drug that regulates metabolic processes in the cartilaginous tissue.

Form of issue and composition

Dona is produced in the following dosage forms:

• Film-coated tablets: white, oblong; on the cross-section two layers: the outer - white, internal - white with a brownish hue of color (in polyethylene bottles of 60 or 180 pcs., 1 bottle per carton pack);
• Powder for solution for oral administration (in packets of 1500 mg, 20 or 30 bags in a cardboard bundle);
• Solution for intramuscular injection (in dark glass ampoules of 2 ml, 6 ampoules in a cardboard bundle complete with a solvent).

The composition of 1 tablet includes:

• Active substance: glucosamine 750 mg (in the form of sulfate);
• Auxiliary components: macrogol 6000, microcrystalline cellulose, povidone K25, magnesium stearate, croscarmellose sodium, talc.

Composition of the film shell: copolymer (:) methyl methacrylate and methacrylic acid (Eudragit L 1,), ground titanium dioxide, talc, triacetin, copolymer () methyl methacrylate, ethyl acrylate and trimethylammonioethyl methacrylate chloride (Eudragit RL 30 D), macrogol 6000.

The composition of 1 packet of powder for the preparation of solution for oral administration includes:

• Active substance: glucosamine - 1500 mg (in the form of sulfate);
• Auxiliary components: citric acid, sodium chloride, sorbitol, aspartame, carbowax 4000.

The composition of 1 ml solution for intramuscular injection includes:

• Active substance: glucosamine - 200 mg (in the form of sulfate);
• Auxiliary components: sodium chloride, lidocaine hydrochloride, water for injection.

Solvent: diethanolamine, water for injection.

Indications for use

• Osteoarthritis (primary and secondary);
• Spondylarthrosis;
• Osteochondrosis.

Contraindications

• Age under 12 years;
• Pregnancy and lactation;
• Hypersensitivity to the components of the drug.

Don should be used with caution in patients with allergies to seafood (shellfish, shrimp).

In addition, the drug is contraindicated in the following diseases:

• Tablets: severe chronic renal failure;
• Solution for intravenous injection: acute heart failure, cardiac conduction disorders, severe functional disorders of the kidneys and liver, epileptiform convulsions in the anamnesis.

Don in the form of a solution for injection should be used with caution in patients with arterial hypotension and chronic heart failure.

Dosing and Administration

The scheme and duration of treatment is determined by the doctor.

Don in the form of tablets are taken orally, with a glass of water, preferably with food.

Usually prescribed 2 times a day for 1 tablet (750 mg) or once a day for 1 packet (1500 mg).

Symptomatic effect occurs after 14-21 days from the start of therapy. The minimum duration of the treatment course is 4-6 weeks.

If necessary, with an interval of 2 months, the course can be repeated.

Before use, the drug solution should be mixed in a single syringe with a solvent. The resulting volume (3 ml) is administered intramuscularly (multiplicity -3 times a week).

The duration of therapy is 4-6 weeks. Injection can be combined with taking Dona inside.

Side effects

As a rule, Dona is well tolerated.

In some cases during the therapy can develop flatulence, gastralgia, diarrhea, nausea, constipation, drowsiness, headache, allergic reactions (in the form of erythema, urticaria and itching).

When Dona is used in the form of a solution for injection, because of the lidocaine included in its composition, nausea, vomiting, drowsiness, diplopia, dizziness, headache, numbness of the oral mucosa and tongue, tremor, disorientation, euphoria, cardiac dysfunction conductivity.

special instructions

The composition of the tablets includes sodium, which should be taken into account by patients observing a controlled sodium diet.

When using Dona in patients with severe renal and hepatic insufficiency, as well as impaired glucose tolerance, medical supervision is necessary.

With caution should take the drug for diabetes and bronchial asthma.

Drug Interactions

Don can be used simultaneously with non-steroidal anti-inflammatory drugs, glucocorticosteroids and paracetamol.

The drug reduces the absorption of chloramphenicol and semisynthetic penicillins, increases - tetracyclines, and also enhances the effect of the action of coumarin anticoagulants.

Caution should be exercised when administering Dona injections concurrently with digitoxin, beta-blockers, amnodaron, aymalin, verapamil, novocaineamide, quinidine, thiopental or sodium hexenal, monoamine oxidase inhibitors, cimetidine, polymyxin-B, sedatives or hypnotics means.

Analogues

Dona analogues are: Artiflex, Arthron Flex, Arthromax, Glucosamine, Glucosamine sulfate, Gerron, Remisid, Sustagard Arthro, Sustilac, Sinagra, Structum, Elbona, Fleksamine, Fleczerin, Hogroxide.

Terms and conditions of storage

Keep out of the reach of children at temperatures up to 25 ° C.

Shelf life:

• Tablets and powder for solution for oral administration - 3 years;
• Solution for intramuscular injection - 2 years.

Conditions of leave from pharmacies

It is released by prescription.

A source: http://www.neboleem.net/dona

Instruction for the use of Don medicine

:

• Effect of the drug
• Indications
• Forms of production and methods of application
• Contraindications
• Reviews and Price

Diseases of the joints, unfortunately, are very common today. It is noteworthy that young people sometimes suffer from them.

But medicine does not stand still, and many drugs have been developed to eliminate some problems. One of these drugs is Dona.

Instructions for use of this tool, as well as indications and contraindications are presented below.

Effect of the drug and its effectiveness

How does the drug work for the joints of the Don? The spectrum of action is quite extensive. So, the components of the drug have an anti-inflammatory effect, which is extremely important in certain diseases of the musculoskeletal system.

In addition, the reception is filled with a deficiency of glucosamine, and also stimulates the production of synovial fluid, which is an important component of the cartilaginous tissue.

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But thanks to some substances, other components of the cartilage also begin to be actively developed. Even the activity of enzymes that destroy the fiber of joints is practically suppressed.

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Also, when receiving the correct deposition of calcium in the bones, and the joints are regenerated. And, importantly, the pain syndrome, accompanying most of the joint diseases, is stopped.

As for safety, it has been clinically proven. And this confirms the rationality of the use of the drug for the purpose of prevention.

In addition, recently, scientists have found that such components of the "Dona" as chondroitin and glucosamine are part of the drugs used as a prophylaxis for colorectal cancer.

And during the research it was confirmed that in fact patients, a long period of time who took remedies on the basis of such substances, suffered much less from intestinal oncology diseases.

Indications for use

If you study the instruction on the use of injections, powder or capsules of "Don then you can identify the following indications for use:

• treatment and prevention of osteoarthrosis of various locations (eg, knee, wrist or hip);
• osteochondrosis;
• arthrosis (primary deforming);
• humeral and scapular periarthritis;
• chondromalacia of the patella;
• Other diseases of the musculoskeletal system associated with problems in the functioning and pathologies of the joints.

Forms of production and methods of application

The instructions for glucosamine "Don" indicate that there are several forms of release of the drug: powder and capsules for ingestion, as well as injection. Depending on the specific form, the application methods will differ. Let us dwell in detail on each individual case.

Let's start with the powder. The contents of the package must be dissolved in water (200 ml). The received structure should be taken only once a day, preferably 20 minutes before eating. The course can last 1-3 months. Repeat it if necessary, you can after 6-8 weeks.

Now about the solution for injections.

To prepare it, you need to open a container with a solvent (labeled "B") and a container with the active substance (on it will be the letter "A") and mix the contents of these two ampoules in one syringe. As a result, 3 ml of solution will be released. The injection is injected intramuscularly. Injections should be done only 3 times a week for 6-8 weeks.

It should be noted that in some cases, oral administration along with injections may be prescribed. This application allows you to increase the activity of components and accelerate the onset of the effect of the application.

Contraindications and side effects

The drug for the joints of the "Don" in most cases does not cause any side effects. In rare cases, there may be some digestive disorders, such as diarrhea, nausea, vomiting, or constipation.

Even more rare are such manifestations as headache and minor vision impairment, double vision, dizziness, tremors and heart rhythm disturbances. All this is due to the content of lidocaine in the injection solution.

Also possible allergic reactions (in the form of urticaria).

Now for more details about contraindications. There are practically none, but in some cases the remedy can not be used.

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For example, in solution for injections, as already noted, lidocaine is available, so injections are contraindicated in people with heart failure and intolerance to the substance.

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And as part of the powder can detect aspartame, which should not be used by persons suffering from phenylketonuria.

It is worth noting that the clinical trials of the drug on pregnant and lactating women, as well as children under 12 years of age, were not carried out, therefore there are no data on the use of Dona by this group of people. So it's not worth the risk.

Reviews about the drug and its price

What is the average price of the drug "Don" in Moscow and other cities? The drug in ampoules (only in a package of 6 of them) in pharmacies can be bought for about 1200-1300 rubles, this is the minimum cost of such a drug. Approximately the same amount and capsules (in the package and only 20). A powder has a price equal to 1000 rubles. In this case, there are 20 sachets in the package.

Now a little about the responses of people. Many people say that the condition of the joints has improved significantly.

Cartilage became more robust, the pain receded after the first 2-3 injections (usually the injections are done during periods of exacerbation). In addition, the effect persisted for a long time.

With prolonged course treatment, problems were virtually eliminated completely. In rare cases, patients complained of allergies and digestive disorders.

In conclusion, we can only add that, despite the safety and efficacy of the drug Don, Such a drug should be started only after a complete examination and only on the recommendation of the treating person doctor.

A source: https://vashaspina.ru/instrukciya-po-primeneniyu-lekarstva-dona/

Don for joints: application, reviews, analogues, price

Almost all diseases of the joints are accompanied by a pain syndrome that occurs against the background of acute or chronic inflammatory processes. Treatment, regardless of the cause, is always lengthy and requires an integrated approach.

One of the drugs used for combined therapy of joint pathologies is a remedy on the basis of glucosamine - a natural component of the cartilaginous tissue of the joint - an Italian medicine Dona.

Information on the effect of the drug Don on the joints, the way of application, feedback and price can be found in the sections below.

Joints are mobile joints that connect bones to each other and allow a person to perform various movements.

The joint cavity is hermetically sealed with an articular capsule (bag), the outer layer of which consists of a strong fibrous connective tissue.

From the inside, the articular bag is covered with the synovial membrane, which forms a synovial fluid that nourishes the joint, moisturizing the moving elements of the joint, protecting them from damage.

The most common diseases of joints are various types of arthrosis. Reducing the volume of synovial fluid, destruction of cartilaginous tissue is accompanied by joint inflammation and severe pain syndrome.

Dosage forms and manufacturer

The drug Don is manufactured by the Italian pharmaceutical company Rottapharm.

The manufacturer regularly conducts clinical studies that confirm the effectiveness of the drug and identify possible contraindications and side effects.

This explains the relatively high cost of the drug, which can reach up to 1500 rubles per package.

Dona is available in three dosage forms. For complex treatment of joint pathologies, oral forms of the drug are usually prescribed:

1. tablets of Don, covered with a soluble film membrane;
2. Don powder, which must be diluted with water to produce a solution.

In acute conditions accompanied by severe pain syndrome, the agent can be used in the form of a solution for intramuscular injection.

Active ingredient and auxiliary ingredients

The active substance in all dosage forms of the drug Don is glucosamine in the form of sulfate.

It is a monosaccharide, which is produced in the human body by cartilaginous structures and is one of the components of synovial fluid and chondroitin - the molecular component of hyaline cartilage containing protein collagen.

One tablet contains 750 mg of glucosamine. In bags with powder it is twice as much

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The powder and tablets contain auxiliary components, which in some cases can be hazardous to health.

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For example, the powder contains an industrial sweetener, aspartame, which is contraindicated in cases of protein metabolism disorders.

In the manufacture of medicine also used:

• citric acid (preservative);
• Sorbitol - a sugar substitute, which has choleretic and laxative effect;
• povidone - an insoluble substance with high sorption properties;
• titanium dioxide;
• microcrystalline cellulose.

The main function of the drug is to fill the deficiency of glucosamine, which results from the influence of internal factors. It can be systemic diseases, metabolic and metabolic disorders, imbalance in the diet.

With a course application, Don stimulates the formation of synovial fluid, and also enhances the synthesis of certain substances, affecting the health of the joint tissue: hyaluronic and chondroitinsulfuric acids, proteoglycans (complex protein structures).

Don has the following therapeutic effect:

• reduces the intensity of painful sensations in the spine and joints;
• normalizes the permeability of the joint bag;
• helps to establish metabolic processes and enzymatic activity in cells of the synovial membrane and cartilaginous fibers;
• ensures the prevention of degenerative changes;
• eliminates inflammation.

The drug also helps to adjust the mineral balance of articular elements due to the fixation of sulfur and calcium. This allows to restore the volume of motor activity of the joint and reduce the severity of the pain syndrome.

Indications for use

Don can be used as a part of combined treatment regimens or as a mono drug for the therapy and prevention of joint diseases. These include:

• defeat of tendons with signs of a reactive form of inflammation at the place of attachment to bone tissue, having a degenerative nature (periatritis);
• dystrophic disorders in the cartilaginous tissue of the joints of the spine (osteochondrosis, spondylarthrosis);
• joint diseases, developing against a background of degenerative and dystrophic processes in cartilaginous fibers (osteoarthritis);
• deforming arthrosis.

The use of the drug for preventive purposes is indicated in the presence of joint pathologies in the history and joint pain. Prophylactic and therapeutic treatment with Don is permissible only according to the doctor's prescription.

Dosage and route of administration

The daily dose of the drug should be determined by the doctor, taking into account the age of the patient, the underlying disease and the degree of deformation of the joints.

Usually the therapeutic dose is -3 g, but in some cases the dosage can be increased to, g glucosamine per day (this is 6 tablets).

Take Don's pills at the same time as eating 1-2 times 3 times a day.

In the case of mild forms of articular diseases, the Don can be administered in the form of a powder containing, r active ingredient. The contents of one packet must be dissolved in 150 ml of water, stirred and drunk half an hour before meals. Take the drug in the form of an oral solution you need 1 time per day.

The duration of therapy depends on the dynamics of treatment and can range from 1 to 3 months.

If the patient is shown intramuscular injection of medication, the treatment usually takes 30-45 days. The drug is injected deep into the muscle 3 times a week. Dosage - 1 ampoule solution, mixed with the ampoule solvent.

Don tablets have no contraindications except for hypersensitivity or intolerance to the components of the drug.

The drug in the form of a powder can not be taken by patients with phenylketonuria because of the presence of an industrial sweetener.

Intramuscular injection of Dona is contraindicated in the following diseases:

• convulsive seizures;
• any form of heart failure;
• epilepsy;
• impaired conduction of heart valves;
• severe violations in the liver system and kidneys.

Injectable form of the drug Don is not assigned to pregnant and lactating women, as well as children under 12 years.

Side effects

In most cases, the treatment of Dona is well tolerated, but in some categories of patients, according to their reviews, there were side effects. These include:

1. skin rash;
2. dyspeptic disorders (flatulence, heartburn);
3. stool disorder;
4. headache;
5. numbness of the tongue;
6. disruption of the taste buds;
7. tremor of extremities;
8. drowsiness.

In clinically severe cases, disorientation in space may occur, so people who are treated with Don's drug are advised not to drive the car and work at altitude.

Overdose

Cases of exceeding the recommended dose have not been fixed to date. If you accidentally take a large amount of the drug is recommended to wash the stomach with warm water with adding salt (4 teaspoons to 500 ml of water) and take any sorbent preparation and then consult a doctor.

How much is

The cost of one package of the drug is from 1100 to 2600 rubles. The price of a medicine depends on the dosage form, the number of tablets in the package (for the Don tablets) and the sales region.

On average, the price of one package of the drug of Don in Russia is:

1. solution in ampoules (for 6 pieces) - 1400 rubles;
2. medicine in powder (20 sachets) - 1280 rubles;
3. Tablets No 60 - 1360 rubles.

Dona's Analogues

If necessary, the drug can be replaced with drugs with a similar composition and pharmacological properties.

The full structural analogues of the Don are:

1. Teraflex,
2. Elbona,
3. Chondroxide.

Drugs with a similar therapeutic effect:

All listed medicines have different indications and restrictions for use, therefore it is strictly not recommended to take them without consulting a specialist.

Patient Reviews

Almost 87% of reviews about the drug Don are positive. Patients noted the rapid healing effect and good tolerability of the drug.

Only 13% of patients noted minor digestive disorders and headaches on the background of Dona's treatment.

In other cases, complaints about poor health at the time of taking the drug were not received.

Dona is one of the most effective drugs for eliminating inflammatory processes in the joint tissues, which is well tolerated.

The only drawback of the tool can be considered its cost, but it is justified by a persistent medical result, which can be achieved in almost 70% of patients.

A source: http://pomogispine.com/lechenie/lekarstva/preparat-dona-dlya-sustavov.html

Dona powder: description, instruction, reviews

The drug Don, containing glucosamine sulfate, has a positive effect on the cartilage, preventing progression of such a disease as osteoarthritis and while doing much less inflammatory process in the joint.

Dona enjoys confidence in the whole world. All the last years of successful fight against osteoarthritis are the key to this trust. The effectiveness of the drug is confirmed by numerous statistical studies and positive reviews of patients.

Thanks to this compatibility, the drug is able not only to prevent destructive processes in the affected cartilage and strengthen its structure, but also effectively combat pain syndrome and other unpleasant symptoms ailment.

Chondrocyte cartilage components use glucosamine as an initial building material for synthesis of other bioactive compounds, on the presence of which in the cartilaginous tissue depends its elasticity and strength.

Pharmacological effect

After the course of treatment with the drug, the cartilaginous tissue of the joints and the necessary amount of joint fluid is restored. Intra-articular metabolism is normalized.

It is proved that therapy with the drug Don delays the development of osteoarthritis, due to which:

• there is no need for surgical intervention;
• improves the quality of life, reduces the suffering of patients;
• prevent disability of the population for osteoarthrosis;
• reduce the financial costs of treatment.

Due to its anti-inflammatory and chondro-stimulating effects, the Don can inhibit the development of intra-articular degenerative processes, reduce pain, return joints to normal functioning.

A positive result of treatment with the drug comes within a two-week period from the time of admission.Patients are getting better.

Positive feedback about the drug, both patients and doctors confirm this.

Patients notice a marked improvement in the mobility of the joint, decreases discomfort, and less pain.

The drug was widely used in rheumatologists, traumatologists, neurologists, as well as in sports medicine.

Advantages of using drugs of the chondroprotector group:

• reduction of symptoms of diseases;
• the possibility of application in combination with analgesics and non-steroidal anti-inflammatory agents;
• long-term effect of the course of therapy;
• absence of serious contraindications;

In the initial phase of the disease use drugs in the form of powders, ointments, tablets. As the disease develops, injections may be required.

Indications for use

The use of the drug is indicated in diseases associated with degenerative and dystrophic lesions of the joints. Especially effective in osteoarthritis.

It is irreplaceable in cases of knee and hip joints.

Dona is also used in the treatment of patellar chondromalitis, spinal osteochondrosis, spondyloarthrosis, and humeropathy periarthritis.

Contraindications

Don powder is contraindicated in case of intolerance detection of the active component of glucosamine, in the presence of a metabolic disease phenylketonuria (since aspartame is included in the sachet).

Solution for injection is contraindicated if hypersensitivity to lidocaine or glucosamine is noticed. In addition, the drug is contraindicated in pathologies of cardiac conduction, heart failure, epilepsy and if earlier the patient had seizures.

Age less than 12 years, pregnancy and lactation are also included in the number of contraindications.

Form of issue

The composition of the drug Don is glucosamine sulfate, subjected to thorough purification from external macromolecular compounds.

Forms of issue:

• powder for oral administration with a dose of glucosamine 1.500 grams per sachet;
• solution for injections with a dose of glucosamine 0.400 grams per ampoule;
• tablets with a dose of glucosamine 0.750 grams per tablet.

Dosing and Administration

Powder of the Don. 1 sachet poured into a glass of water. Take 1 time per day before meals for 20 minutes. The duration of the course is 6 to 12 weeks. Break 2 months.

Solution for injection Don. Intramuscular injections are done 3 times a week for 3 milliliters. Powder and injections of Don can be combined. The dosages do not change.

Don Tablets. 1 tablet 2 times a day for food, washed down with water.

More information on dosage tells the instruction for the use of the drug.

Overdose

Cases of drug overdose in clinical practice are not described.

Side effects

Although, as they say, the tolerability of the drug is very good, side effects are still possible. In some cases, when administered orally, there may be phenomena of flatulence, itchy skin, diarrhea, urticaria.

After the injection of the drug, the patient may begin dizziness and loss of orientation, nausea and vomiting, lethargy, numbness in the oral cavity, euphoria.

Sometimes the pain increased at the beginning of the course of treatment with the drug Don. In the future, the condition improved. Instruction on the use of the drug gives more detailed information on side effects.

Interaction

Taking the drug inside increases the absorption of tetracyclines and reduces absorption in drugs such as chloramphenicol and semisynthetic penicillins.

The drug is fully compatible with glucocorticoid drugs and NSAIDs.

The preparation of Don in injections should be administered with caution along with quinidine, verapamil, digitoxin, hexenal, cimetidine, hypnotics. The instruction details the interaction with other drugs.

What diseases heals

Degenerative and dystrophic joint diseases occur due to severe disturbances in metabolic processes in the joint and bone tissues.

Their development occurs usually in the elderly, when the ability to resist and resist the load on the joints becomes insufficient in comparison with the loads.

Slowly, but steadily, cells of the cartilaginous tissue stop coping with the role of the shock absorber. They begin various metabolic disturbances, the number of dying cells exceeds the number of cells that come to replace them.

The process of degeneration of cartilage and bone tissue begins.

There are also secondary osteoarthritis, developing not only in the mature, but also at a young age as a result of the injuries and inflammations in the joint. The course of the disease is rather slow and rarely leads to severe dysfunction of the joints.

An exception is osteoarthritis, affecting the hip joint. This joint has certain structural features and this causes a rapid progression of the disease with a significant disruption of the functionality of the joint.

They treat osteoarthritis with the prescription of drugs that make blood circulation better, analgesics, and conduct physiotherapy sessions.

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But best of all, osteoarthritis is treated with drugs that actively affect the metabolic processes in the tissues of the joints. These drugs belong to the group of chondroprotectors. As testimonies testify, one of the leaders among these means is don.

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In addition to osteoarthrosis, Don is better than other medications also for osteochondrosis (like articular damage to the spine), softening of the patella, which occurs if this area is subjected to permanent injuries. Dona is appointed for rehabilitation after trauma and surgical intervention, and also as an integral part in the combined treatment of autoimmune and inflammatory diseases.

For preventive purposes, Don can be prescribed to athletes with increased physical exertion and elderly people. Reviews about the drug at all the best. Information on contraindications can be given by the instruction.

Analogues

The Italian pharmaceutical company Rottafarm produces the drug Don. She produces a powder for ingestion, an ampoule with a solution for injection.

Preparations containing glucosamine as an active substance are produced by other companies.

They bear the names: glucosamine, a hundred-partrose, junium, aminoarthrin.

A source: http://bolit-sustav.ru/vybiraem/poroshok-dona/