Vitamin b12: instructions for use in ampoules

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  • 1Vitamin B12 in ampoules. Cyanocobalamin (vitamin B12): instructions for use:
    • 1.1The role of vitamin B12 in the body
    • 1.2The use of vitamin B12
    • 1.3How to make injections of vitamin B12
    • 1.4The use of vitamin for various diseases
    • 1.5Overdose of vitamin B12
    • 1.6Vitamin B12 in hair care
    • 1.7What foods contain vitamin B12?
    • 1.8Reviews on the effects of cyanocobalamin on the body
  • 2Vitamin B12 in ampoules with complete instructions for use
    • 2.1Effects on the body
    • 2.2Symptoms of deficiency and indications for use
    • 2.3Exposure to hair
    • 2.4Application of ampoules
    • 2.5How to make injections
  • 3Instructions for the use of vitamin B12: indications for taking medications, contraindications and some nuances
    • 3.1Indications for use of vitamin B12
    • 3.2Types of drugs with vitamin B12
    • 3.3How to prick vitamin B12 in ampoules?
    • 3.4Instructions for the use of certain tablets
    • 3.5Doses and rates of vitamin B12 consumption
    • 3.6Contraindications to use of B12 and possible side effects
    • 3.7about the various causes of vitamin B12 deficiency and what can it lead to?
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    • 3.8How to make injections correctly, including yourself
  • 4Vitamin B12 in ampoules: instructions for use, for which it is needed, contraindications and side effects
    • 4.1Forms of Vitamin
    • 4.2Indications for use
    • 4.3Contraindications and side effects
    • 4.4Instructions for use and dosage
    • 4.5Separate instructions for use
    • 4.6Preparations in ampoules
  • 5Cyanocobalamin (Vitamin B12), SOLUTION FOR INJECTIONS (AMPULS)
    • 5.1Contraindications

Vitamin B12 in ampoules. Cyanocobalamin (vitamin B12): instructions for use:

The benefits of B vitamins have already been said a lot. Its representatives are of paramount importance.

For example, to a woman had a dazzling appearance, you need to regularly replenish your body. They are available, they can be purchased at any pharmacy.

Vitamins are packaged in ampoules and can be either water-based or oil-based.

The role of vitamin B12 in the body

Cyanocobalamin (vitamin B12) was discovered in 1948. Isolated it from the crude liver. For a long time, scientists could not understand why patients who took a raw liver in small amounts managed to overcome malignant anemia.

Since then, vitamin B12 and its effect on the body have been thoroughly studied, it remains only to understand that this is an expensive gift of nature, which should be used wisely.

Vitamin B12 helps to avoid the effects of stress, it is he with the help of vitamins B5, B9 and C promotes the blocking of stress hormones, helps restore nerve cells and participate in the construction of new ones, that is, it is an active participant in the processes of amino acid biosynthesis and DNA synthesis and RNA. The substance improves the process of blood clotting, reduces the amount of cholesterol in it.

Vitamin B12 can both be obtained with food, and supplement its composition with the help of tablets and injections. Cyanocobalamin is found in animal products, which is why vegetarians tend to suffer from a lack of it in the body. It is not synthesized in plants.

The use of vitamin B12

Use vitamin B12 in ampoules is much more convenient. It is a slightly pink liquid.

Indications for injection of cyanocobalamin may include neuralgia of the trigeminal nerve, hepatitis, neurodermatitis, anemia, Down's syndrome, as well as migraine, diabetic neuritis, radiation sickness, multiple sclerosis, cerebral palsy paralysis. This vitamin has an effect on reproductive function - both female and male. Has a beneficial effect on the human immune system. If the body of HIV-infected people lack of vitamin B12, the disease progresses much faster.

It is impossible to prescribe injections of B12 in the presence of erythrocytosis, hypersensitivity to the drug, caution is also necessary in malignant and benign tumors and angina pectoris.

How to make injections of vitamin B12

As already mentioned above, vitamin B 12 belongs to the group of vitamins. It is widely used by traditional medicine as one of the components used to treat various diseases or to prevent them.

Therefore, if cyanocobalamin is appointed physician, then this discussion is not subject, but if someone independently decided to pierce vitamin B12 in ampoules, instructions for use in this case is subject to detailed study.


First of all, it is necessary to know that cyanocobalamin can be used intravenously, subcutaneously, intramuscularly.


And the instructions detail that it can not be used together with drugs that increase blood coagulation, it is also not possible one syringe to mix vitamins B1, B6 and B12, in addition, if the patient has an allergic reaction to vitamin B1, then B12 can significantly enhance. You can not combine cyanocobalamin with riboflavin and ascorbic acid, but colchicine, antiepileptic drugs and salicylates can reduce the degree of its absorption by the body. And there are many nuances that only a doctor can know, so to fully answer the question of how to prick vitamin B12, it can only he.

The use of vitamin for various diseases

Vitamin B12 in ampoules, the price, which is quite acceptable - from 17 to 25 rubles, depending on the manufacturer, has a significant effect in the treatment of various diseases. As practice shows, many people pierce cyanocobalamin at the appearance of such signs of insufficiency of this vitamin:

- headache and dizziness;

Fatigue and weakness;

- Irritability, neuritis and nervousness;

- the appearance of sores in the tongue and in the mouth;

Pallor of the skin;

- numbness;

- decreased appetite, back pain and sleep disturbance.

This drug is prescribed by doctors with well-defined diseases and for their prevention. At what diseases is B12 prescribed, how to stab it correctly?

The course for prevention can be from 7 to 15 days, with injections ranging from 200 μg to 500 μg per day.

Diseases associated with the central and peripheral nervous system:

- the first 3 days daily for 200 mcg;

- the next 4 days daily at 300 mcg.

If there are no complications within seven days, the course of treatment ends. In case of complications, the dose increases:

- 5 days daily for 400 mcg;

- the next 3 days daily for 500 mcg.

Another disease is quite serious, arising from the lack of B12 in the body - anemia.

A characteristic feature of this indisposition is that it develops almost asymptomatically and slowly, but, as a rule, affects the nervous system.

In the course of treatment, along with other drugs, cyanocobalamin is administered at a dose of 200 to 300 μg, if complications arise, it increases to 500 μg and is administered 1 or 2 times a day.

If the patient's condition worsens, the dose can reach up to 1000 micrograms. After 10 days, it can be reduced, but another 3 months the daily rate will be 300 μg of vitamin. And after the end of treatment for six months make one injection in two weeks.

Overdose of vitamin B12

Before piercing vitamin B12 in ampoules, it is superfluous to get acquainted with the consequences in case of an overdose: if the body has an increased sensitivity in this substance, then a large dose can cause an allergic reaction that manifests itself in the form of urticaria (rash on the body and mucous membranes), as well as pain in the heart, tachycardia, increased nervousness.

It should be remembered that the overabundance of cyanocobalamin is very difficult to remove from the body.

Vitamin B12 in hair care

Cyanocobalamin - an excellent assistant in hair care. At home, the vitamin can be added to the shampoo, thus making it vitamins. Add it also to hair masks.

For example, an excellent mask against hair loss - mix one teaspoon of honey and lemon juice and add to the mixture one ampoule of vitamin B6 and B12. Blend the mixture on clean hair, hold for 10 minutes, then rinse.

Repeat procedure five times a week.

But, as you know, external application by results is always inferior to the internal one.

How to be, if vitamin B12 can not be used in the form of injections because of the individual characteristics of the body, and while you want to have beautiful hair? In such cases, it is best to include in your diet enough food containing cyanocobalamin.

What foods contain vitamin B12?

The most vitamin B12 in the liver is beef or calf, but it also contains a large amount of chicken and pork liver. It is also found in marine products, such as crabs and oysters, in fish, egg yolks, meat, hard cheese, in dairy and sour-milk products.

Now a lot of vitamin supplements are offered, for example, oat flakes, muesli in the form of breakfast cereals.

In fact, it is hardly possible to find there a specified amount of vitamins, because long-term storage contributes to its reduction, and the preservatives contained in such products are harmful.

There is another nuance: vitamin B 12 is resistant to heat, which means that it does not break down when cooking. But at the same time, direct sunlight is damaging to it.

Reviews on the effects of cyanocobalamin on the body

As many testimonials testify, vitamin B 12 in ampoules with proper reception allows to solve a lot of problems. With his help, they even achieved weight reduction, but in general, he fights well with the deposition of fats in the liver.

Perhaps, this vitamin refers to the category of those about which nothing bad can not be said, except when the most consumers were an overdose was admitted, or when the drug was started without consulting a doctor, and the body reacted with an allergic reaction. To avoid unpleasant moments and taking a vitamin has benefited, it is better to consult a doctor after all. Perhaps he will even prescribe some definite tests, and after that, based on their results, he will establish the norm and the admission scheme for you.

A source:

Vitamin B12 in ampoules with complete instructions for use

Hello, readers of the blog! Vitamin B12 in ampoules is bought to cure both a number of independent diseases, and those caused by a lack of this substance. Deficiency of B12 can lead to anemia, neurological disorders and even death of nerve cells.

Treatment of a defect most often occurs with the help of internal injections.

This is by no means the most pleasant procedure, however, in this way it is possible to restore the body health in the shortest possible time.

Let's look at what exactly affects vitamin B12, and what ampoules with it is better to buy.

Effects on the body

B12 is not one single substance, it is a group of elements, but they are similar in many respects, so this group is often called simply cyanocobalamin.

Representatives of B12 affect:

  • correct synthesis of erythrocytes;
  • protection of blood cells;
  • the state of the myelin sheath, without which impulse transmission is impossible;
  • degeneration of fats in the heart, kidneys, etc.

Cyanocobalamin is at the beginning of the process of providing regeneration of tissues and organs, activating cell division. Due to this function it has a beneficial effect on anemia and some other pathologies.

Symptoms of deficiency and indications for use

If a person's body suffers from a lack of vitamin for a sufficient amount of time, then the following symptoms appear:

  • fast fatiguability,
  • irritability,
  • depression,
  • problems with the gastrointestinal tract,
  • inflammation of the tongue, its dryness and bright red color,
  • inflammation of the skin and mucous membranes,
  • hair loss,
  • dizziness,
  • illnesses of sight,
  • zero gastric acidity,
  • spinal cord diseases, personality degradation.
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Why still use vitamin B12 in ampoules? In addition to the symptoms of deficiency, it is used in the following diseases:

  • anemia,
  • hepatitis,
  • liver disease,
  • alcoholism,
  • Down's disease,
  • radiculitis,
  • skin diseases,
  • pathology of the central nervous system.

The need for additional B12 intake is almost always present in vegetarians and people who adhere to a too strict diet.

Getting enough of the substance from plant foods is extremely difficult.

To prevent such problems, go through the course "Healthy Nutrition" and again review your diet.

Exposure to hair

Vitamin B12 in ampoules for hair is a guarantee of their beauty, length and health. First of all, it is necessary that the human diet is saturated with this substance. To do this, use: • fish, • meat, • seafood, • dairy products, • eggs, • beef, pork liver,

• dry, low-fat milk.

Some amount of cyanocobalamin can be found in plant foods. For example, in spinach, sea kale or soy.

Look necessarily this video about vitamin B12 for hair.

Ampoules with liquid cyanocobalamin, the price of which usually does not exceed 30 rubles, can be administered intramuscularly by a ten-day course. Applied and tablets, such as Neurobionum and Neurovitan - the duration of the course will also be ten days, you need to take one or two tablets a day.

From tablets or a liquid in ampoules it is really possible to prepare a mask for hair. To do this, you can choose any recipe suitable for the type of hair, and add there liquid vitamin B12 or crushed tablets with it.

Application of ampoules

The price of vitamin B12 in ampoules varies depending on the form of release, quantity and manufacturer.

• Vitamin B12

The injection solution is sold in its pure form in most pharmacies. The cost of this drug varies from 20 to 150 rubles.

Instructions for the use of vitamin B12 in ampoules include a wide range of dosages that differ depending on the disease.


The drug is used intravenously or intramuscularly at 100-200 mcg per day with a break per day with Addison-Birmer disease.


In macrocytic anemia, the dosage is 500 μg every day for a week, then a weekly break between doses is added. Vitamin deficiency is treated with 1 mg of substance every day for two weeks.

• Barthel Drags Vitamin B12

Barthel Drags Vitamin B12 is an effective preparation with a high concentration of active ingredient. Self-treatment with any drug Barthel Drags is strictly prohibited.

All dosages and a plan of use should be prescribed by a qualified doctor, while the patient should constantly monitor the blood picture, its coagulability.

• Cyanocobalamin-Darnitsa

The drug is administered intravenously, subcutaneously or intramuscularly. With mielosis and lateral sclerosis, intraluminal use is possible. All dosages are prescribed by a doctor.

When anemia is introduced, 200 mg per day, 500 μg, if the disease affected the nervous system. With myelosis, the dose is 100 μg twice a month.

The number and frequency of admission is increased if there are neurological symptoms.

The cost of Cyanocobalamin-Darnitsa is about 30 r.

• Vitagamma

Unlike previous versions, Vitagamma has in its composition not only cyanocobalamin, but also other representatives of group B.

It is used for neuralgic diseases, osteochondrosis and convulsions.

The dosage of vitamin B12 in ampoules is 1 ampoule per day for 10 days, then Vitagamma is used three times in 2-3 weeks. The price of the drug is from 120 rubles.

• Compliments B


In the ampoule there is a majority of representatives of B vitamins and a number of additional substances.


Complicams are used for neuritis, neuropathic diseases, nocturnal cramps, plexopathy and spine diseases. Use during pregnancy is not recommended.

Ampoules are injected deep intramuscularly into 2 ml. The cost, depending on the amount, can be as much as 150, and 300 rubles or more.

• Beplex

The composition of this medicine contains vitamins from B1 to B12. More information about vitamin B1 can be found here. Also in the composition there is vitamin PP.

Due to this spectrum of components, Beplex, in addition to neurological diseases and anemia, is prescribed for the treatment of liver, GIT, skin, mucous and metabolic conditions.

It is used during pregnancy and breastfeeding. Dosage - 2-4 ml per day.

• Komlipen

Ampoules have in their composition, in addition to cyanocobalamin, thiamine and pyridoxine. In one package can be from 5 to 30 ampoules.

Kombilipen is indicated for inflammation of the facial nerve, neuralgia, polyneuropathy and diseases of the spine.

Injections are made during the week for 2 ml, then the frequency of intake is reduced to two to three times a week. The price of such ampoules is from 110 rubles.

How to make injections

The contents of the ampoules are injected into the skin, muscles or veins. Regardless of the point of entry, it is important to wash hands thoroughly before starting the process.

With the help of cotton wool and alcohol, the ampoule is disinfected, then it is opened with a special nail file, which is most often present in the package with the drug.

After the required dosage has been calculated and the expiration date of the medicine has been checked, the liquid is drawn up with a syringe.


It is necessary to knock on the syringe with a fingernail and make sure that the medicine does not contain air bubbles.


If they are available, they must be moved upwards and removed from the syringe by pressing the piston.

• Intramuscular injections

Exercise an injection in the gluteus muscle alone is unlikely to work for a person, unless he is a medic. In the event that no one can help with the procedure, it makes sense to practice in advance in front of the mirror and choose the most comfortable position.

If you mentally divide the gluteus muscle into four squares, the injection should come to the upper outer one.
Do not forget about disinfection of the injection site. The skin of an adult person needs to be stretched, and the skin of the child, on the contrary, is made a fold.

Introduce the drug slowly! Otherwise there is a risk of cones. At the end of the injection, the injection site is massaged, and the wound is disinfected.

• Intravenous injections

Despite the apparent simplicity, this type of injection is considered the most difficult.

It is best to provide such injections to a medical specialist, however, there are situations when it is necessary to conduct independent injections.

As in the situation with intramuscular injection, it is important not to forget about the disinfection of the hands, place and means of injection.


Most often the injection is made in the vein of the ulnar fossa, since there they have the largest size. To make the correct injection without seeing a vein is almost impossible.


In addition to the medication itself and peace of mind, a rubber tourniquet is needed for intravenous injections, which is superimposed on the middle part of the shoulder, but there is no need to clean clothes. Then it is necessary several times to unclench and clench the fist, to work the skin and, again clenching the fist, to introduce the syringe by one third.

There is a way to check if the needle has hit the vein. It is far from being the most pleasant, but it will avoid unnecessary lamentable consequences.

Slightly pull out the plunger - if you see blood in the syringe, then everything is done right.

Then it remains only to remove the tourniquet, to unclench the hand and slowly introduce the liquid.

Hold the injected area with the cotton wool while removing the needle. Bend your arm, keeping the cotton wool in place, and do not unbend it for a short amount of time.

Give preference to three-part syringes, if you do not want to cause yourself unnecessary pain. Change the injection site every two injections.

And now I recommend to watch this video about vitamins for hair in ampoules.

Also you should be interested to know:

Vitamin B12 in which foods it contains the most;

Mask for hair with vitamin 6 and 12;

Compatibility of vitamins and minerals among themselves.

A source:

Instructions for the use of vitamin B12: indications for taking medications, contraindications and some nuances

Further you will learn:

  • Important practical points from the instruction on the use of vitamin B12 in the form of injections, as well as in the form of tablets;
  • Indications for use of vitamin B12, as well as contraindications and side effects that may be encountered;
  • Names of popular cyanocobalamin preparations in ampoules and tablets and their dosage.

Generally speaking, in the body of a healthy normally eating human vitamin B12 (cyanocobalamin) comes in sufficient quantities with conventional foods.

And this useful substance comes exclusively with animal food, but in plant products, cyanocobalamin is practically not and people on a strict vegan diet often experience a serious defect in it (hypovitaminosis of varying degrees expression).

However, not only a vegetarian diet can cause a deficiency of vitamin B12 in the body - there are many other situations when there are indications for additional medication cyanocobalamin.

The following instructions for the use of vitamin B12 not only explain how to apply this or that drug, but also tell you which form of release to prefer - they are different.

In any case, if you are going to use vitamin B12 preparations, you need to take a very careful look at the important nuances of this process, so as not to be mistaken, for example, with dosages and to prevent serious mistakes during injections.

We will discuss this further.

Indications for use of vitamin B12 may differ slightly for different forms of release of drugs.

It is also important to remember that vitamin B12 for oral administration (ie, inside - for example, in the form of tablets and capsules) has less bioavailability than in the form of a solution for injection:

  • when cyanocobalamin enters the stomach, no more than 70% of the vitamin is absorbed from its content in the preparation (usually about 40%);
  • and at intravenous introduction it is acquired up to 97-98% of a useful substance.

Accordingly, for each group of drugs with vitamin B12, the instructions for use and the doses used are somewhat different.

Indications for use of vitamin B12

The most common reason to start taking vitamin B12 is hypovitaminosis of cyanocobalamin in people who are on a strict diet and do not eat animal food in normal quantities.In most cases, you can see distinct symptoms of a lack of this substance in the body, which appear even before the onset of serious disorders:

  • tingling in the tips of the fingers on the hands and feet;
  • tinnitus;
  • depression;
  • chronic fatigue;
  • visual impairment;
  • headache.

However, unfortunately, in practice, the situation is that doctors often turn to the help of doctors only when the lack of vitamin B12 in the body grows into diseases. It can be:

  • anemia;
  • hepatitis;
  • gastroduodenitis;
  • chronic pancreatitis;
  • memory loss.

In the presence of these disorders, the doctor usually prescribes primarily a blood test. If the matter really is in the lack of cyanocobalamin, the patient is prescribed injections of vitamin B12 as part of complex therapy.

Additional indications in the instructions for the use of vitamin B12 indications for its reception are:

  • radiation sickness;
  • weakening immunity and immunodeficiencies;
  • multiple sclerosis;
  • radiculitis;
  • polio;
  • encephalitis;
  • infectious diseases in newborns.

As a blood-forming factor, vitamin B12 is often prescribed precisely for anemia of any etiology - in pregnant women, with agrarian and pernicious anemia, as well as with serious blood loss. Sometimes prick vitamin B12 may be necessary and in violation of the menstrual cycle.

Indications for the use of vitamin B12 may be different, but the choice of a specific remedy should ideally be the attending physician - in order to avoid overdose and the development of side effects.

Types of drugs with vitamin B12

Vitamin B12 is produced in several pharmacological forms. It can be:

  • solutions for intramuscular, intravenous and intraluminic administration;
  • tableted preparations;
  • multivitamin complexes in the form of dragees, powders for breeding, as well as syrups.
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Solutions for injection have the greatest degree of assimilation and are as safe as possible because they do not contain any auxiliary substances that can cause an allergic reaction of the body.

They are used for therapy in serious diseases, for the administration of large doses of vitamin and in those cases when the patient It can not use drugs on its own in other forms (for example, for newborns or patients in a state coma).

Tableted vitamin B12 (or capsules) is taken by patients, due to their nutritional deficiencies, inadequate cyanocobalamin.

Another target audience of tablets with vitamin B12 - athletes, because of the great physical exertion and active work of the heart in need of increased amounts of this substance.


As part of multivitamin complexes, vitamin B12 acts as a preventive agent: their it is advisable to use as a complex vitamin support of the body and prevention hypovitaminosis.


Of course, the greatest difficulties people have when they have to chop the ampoules of vitamin B12 on their own - in this case deviations from the instruction can be most dangerous. Let's look at some points of this process in more detail.

How to prick vitamin B12 in ampoules?

In general, injections of vitamin B12 can be of the following types:

  1. Intravenous;
  2. Intramuscular;
  3. Subcutaneous;
  4. In the spinal cord (intraliumbalno).

In the first three cases, the patient can make injections of vitamin B12 on his own. Only with intralumbalnom introduction necessarily need the help of an experienced doctor.

According to the instructions, vitamin B12 is usually administered by 1 ml of solution per day for 2-3 weeks, followed by monitoring the amount of vitamin in the blood.

Instructions for the use of injections of vitamin B12 intramuscularly means injections into the gluteus muscle or thigh.

To do this, the site of the injection is wiped with alcohol, carefully cut off or break off the tip of the ampoule with a special ampoule knife, After that, the solution is drawn into the syringe and, raising the needle up, gently press the plunger of the syringe to squeeze out air. Then the needle quickly (it is possible with a slap) is injected into the injection site and the drug is slowly squeezed out of the syringe.

With intravenous administration, the procedure is similar, only the injection is made into the elbow vein, provided it is well visible.

According to the instructions, vitamin B12 to children is usually injected subcutaneously. Typical injection sites are buttocks, hips, shoulders.

Below in the photo shows some common vitamin B12 preparations in ampoules (manufactured by Moskhimpharmpreparat, Dalhimfarm, Darnitsa, etc.) - they are suitable for all types of injections:

There are also complex solutions for injections, containing together with cyanocobalamin also vitamins B1 and B6 (Neurobion, Neurorubin, etc.). They are usually assigned several in other situations than B12 alone.

Instructions for the use of certain tablets

Tablets and capsules with vitamin B12 are much easier to take than solutions for injections: they are taken after meals in quantities indicated by the doctor, or prescribed in the instructions. Typical indications for admission are nervous disorders, a decrease in hemoglobin level in the blood, a tendency to anemia, a loss of blood, some diseases of the digestive tract.

The most common formulations of this form of release are:

  • B12 from Solgar. 1 tablet is taken once a day during meals and resolves under the tongue.
  • B12 from NowFoods with additional folate content. Also applies 1 tablet a day.
  • Neurovitan is a preparation containing vitamins B1 and B6 in addition. It should be prescribed only by the attending physician.

Doses and rates of vitamin B12 consumption

The daily intake of vitamin B12 is:

  • 3 mcg per day for an adult;
  • , mcg per day for children under 1 year.

Accordingly, these norms and need to take drugs. It should be borne in mind that when using tablets or capsules, only a part of vitamin B12 is absorbed.

When using vitamin B12 in the form of injections, the doses are calculated accurately - digestibility is very high here, and the person should receive exactly as much vitamin as he needs.

For therapeutic purposes, in the treatment of certain diseases, increased doses of cyanocobalamin are sometimes used, up to 10-15 μg per day. Such treatment should be carried out under the supervision of a doctor and stop with the appearance of side effects and signs of hypervitaminosis.

Contraindications to use of B12 and possible side effects

Contraindications to the intake of vitamin B12 are quite numerous, but not too strict. For example, vitamin B12 is not recommended for:

  • propensity to thrombosis;
  • varicose veins and hemorrhoids;
  • erythrocytosis;
  • lactation;
  • angina pectoris;
  • oncological diseases.

It is interesting to note that pregnancy is also a contraindication to the use of vitamin B12, since very large amounts of it can have a teratogenic effect on the fetus. However, in the presence of severe anemia in the mother, careful use of vitamin B12 will nevertheless be necessary.

Contraindication to the use of vitamin B12 may be the simultaneous use of certain medications. For example, B12 does not work well with corticosteroid hormones and antituberculosis drugs.

It should be remembered that when taking vitamin B12, there may be side effects. Among them:

  • hives;
  • thrombosis of the blood vessels on the legs;
  • pulmonary edema;
  • heart failure;
  • an allergic reaction of any severity, up to anaphylactic shock.

In advance to predict, there will be such consequences, or not, it is impossible. Therefore, start taking vitamin B12 (especially in the form of injections) preferably under the supervision of a doctor, using reduced dosages and carefully following the sensations and reactions of your own organism.

about the various causes of vitamin B12 deficiency and what can it lead to?

How to make injections correctly, including yourself


A source:

Vitamin B12 in ampoules: instructions for use, for which it is needed, contraindications and side effects

Variants of the forms of release of this vitamin, than they differ. In what cases is an injection given, the calculation of dosage.

Vitamin B12 - an important element of life, which has the property of accumulating and gradually consumed in the body. Most often, its name refers to a group of elements that have a similar structure, functions and properties. When there is a shortage of these substances, B12 is used in ampoules, which is considered the most relevant form of release. In this case, the substance is administered by injection.

Generally speaking, the action of the element is aimed at solving a number of problems - regulation of the vascular and respiratory tone, production of nucleic acids, creation of new blood cells.


In case of deficiency, symptoms such as dizziness, weight loss, gastrointestinal lesions, and so on are possible.


Below we will discuss in more detail the role played by vitamin B12 in ampoules, what are the features of its use, what are the contraindications and the action.

Forms of Vitamin

Today cyanocobalamin (the second name of group B 12) is issued in several forms:

  • In ampoules. This option is the most popular because of the convenience of dosing and maximum efficiency for the body.
  • In tablets. Advantage - convenience of reception. Disadvantages - less rapid action, additional irritation of the walls of the digestive tract.
  • Spray(drops).

The last two forms are more convenient, because they do not imply such unpleasant injections to patients. On the other hand, B 12 in ampoules shows greater efficacy, it provides the fastest possible action.

It is worth taking into account one more thing - taking a vitamin in the form of tablets does not give the expected result in case of damage to the ileum.

In this situation, failures occur in the development of the Castle factor, and as a result, there are problems with the absorption of cyanocobalamin or another similar substance.

Indications for use

One of the main questions concerns the indications for taking this supplement. Many believe that it is allowed to be used for almost any disease. But this is not so.

Indications for use of vitamin B12:

  • Anemia. The use of an element to treat such a disease has become relevant since the first half of the last century. It is also used today to combat chronic manifestations of the disease and in the role of maintenance therapy.
  • Cirrhosis of the liver or its insufficiency. B12 is essential for the repair of cells and damaged tissues. This is achieved through accelerated cell metabolism.
  • Hepatitis. It is acceptable to use cyanocobalamin in the treatment of chronic hepatitis types A, B and C. Most often this substance is used almost in the role of the main remedy.
  • Alcoholism. The appointment is made at the stage of restorative or maintenance therapy.
  • Neuralgia. As practice has shown, B12 in injections is good for neuralgia of the ternary nerve.
  • Problems of the central nervous system. Most often they are manifested by different neurotic states, psychological disorders and depression.

In addition to the above, the element helps in solving a number of additional problems - infantile cerebral palsy, Down syndrome, peripheral system and so on.

In addition, the reception is useful when on a strict diet, in the case of dermatological diseases (eczema, psoriasis and others), with prolonged intake of medications and having problems with the gastrointestinal tract.

Contraindications and side effects

Before starting taking it is necessary to take into account the negative features that the vitamin possesses.

Treatment with the use of such a drug is prohibited in the following cases - with erythremia, thromboembolism, hypersensitivity, erythrocytosis.

In addition, the instructionprohibits taking in case of pregnancy and lactation.

There are also symptoms and diseases in which B12 should be taken with caution:

  • angina pectoris;
  • malignant and benign formations;
  • propensity to form blood clots and others.

Do not forget about the negative effects that are possible in the case of admission. It is worth noting the following side effects of the vitamin:

  • risk of weakness and dizziness;
  • headache;
  • tachycardia;
  • the appearance of problems with falling asleep;
  • increased excitement;
  • urticaria and others.

In the case of B12 injections, an overdose is possible (although this phenomenon is rare). Recognize it can on the following symptoms - thrombosis, heart failure, pulmonary edema. It is worth noting that with injections of this substance it is impossible to combine it in one syringe with riboflavin and bromide.

Instructions for use and dosage

Now it is necessary to pass to not less important nuances - in what volume this vitamin in ampoules should be accepted. It should be noted right away that the drug can be ingested, intraluminally, subcutaneously, intravenously and intramuscularly.

The dosage depends on the type of the disease and is prescribed by the doctor:

  • With Addison-Birmer anemia, the dosage is100-200 μg. Admission is carried out under the skin, once in 2 days.
  • In the case of funicular myelosis, as well as in case of a violation of CNS functions, the dosage is400-500 μgin a day. The first seven days are taken daily, after which there are small intervals. To increase the effectiveness of the course, folic acid is added.
  • In the case of iron deficiency or posthemorrhagic anemia, the dosage30-100 μg / reception. Frequency - 2-3 times during the week.
  • In the presence of failures in the peripheral and central nervous system, it is recommended to take200-500 μgevery two days. The duration of the course in this case is 14 days.
  • If there are injuries to the peripheral nervous system, the dosage -200-400 μg.
  • Particular attention is paid to the use of the drug in liver diseases. How to take vitamin B12 in this case? Here the daily rate is30-60 μg. The second option is acceptable, when 100 μg of supplement is taken every second day. The duration of the course is 25-40 days.
  • An element is also prescribed for radiation sickness, when its norm is60-100 μgper day. The course in this case has a duration of 20-30 days.

Dosage should be planned and taking into account the age of the patient. So, the daily portion is (for each of the ages):

  • up to 6 months mcg;
  • 7-12 months mcg;
  • 1-3 years mcg;
  • 4-10 years mcg;
  • 11-14 years mcg;
  • 15-17 years mcg;
  • from 18 years and more mkg.
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During lactation or pregnancy, the norm -, μg.

Separate instructions for use

One of the most important points is confirmation of vitamin deficiency. This point must be confirmed by appropriate diagnostics. As for the appointment, this procedure is only allowed to medical staff.

The entire stage of treatment under control is worth keeping parameters of the periphery of the blood:

  • So, after 5-8 days after the start of the course, it is worth checking the volume of reticulocytes, the concentration of Fe.
  • Every one or two weeks should be checked for the fact of the color index, the volume of Hb and erythrocytes.
  • As soon as the number of red blood cells reaches the level of 4, million / μl, one can expect to achieve remission. In this case poikilo- and anisocytosis disappears.
  • As soon as hematological remission is achieved, the blood composition is monitored every 4-6 months.

In the process of taking the supplement, special care should be taken by a group of patients who are prone to blood clots and angina pectoris, in the event of a future operation on the gastrointestinal tract or with pernicious anemia.

Preparations in ampoules

Above we considered the features of vitamin B12, the instruction to which you need to know and obey unconditionally. But we must not forget about the existence of several types of drugs, which may differ in composition. Among them:

  • Cyanocobalamin- B12 in the form of a liquid with the addition of sodium chloride. Ampoules have a volume of, and, mg. The solution is administered intravenously, intramuscularly, under the skin or intralumbly. With sclerosis and myelosis, the introduction is carried out in the spinal canal.
  • Neurobion- a remedy from the German manufacturer Merck. Admission is not recommended for breastfeeding, pregnancy, allergic reactions, at the age of 12 years. A feature of Neurobion is the combination of several vitamins - B12, B6 and B1.
  • Neurorubin- Another drug, which is issued in ampoule form, is considered an analogue of the previous one. It is used for some forms of sclerosis and anemia.
  • Vitagamma- a remedy from the Russian manufacturer. In addition to B vitamins (1, 6 and 12), the composition contains lidocaine, which relieves pain after injection. This drug is not recommended for use during pregnancy and children.

July 17, 2016

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Cyanocobalamin (Vitamin B12), SOLUTION FOR INJECTIONS (AMPULS)

Instructions for medical use

medicinal product

Cyanocobalamin(vitamin B12)


Cyanocobalamin (vitamin B12)

International Nonproprietary Name


Dosage form

Solution for injection, 2% and, 5%, 1 ml


1 ml of solution contains

active substance - cyanocobalamin (in terms of 100% substance), 0 mg 0 mg

auxiliary substances: sodium chloride, 0.1 M hydrochloric acid, water for injection.


Transparent liquid from slightly pink to bright red

Pharmacotherapeutic group

Stimulators of hemopoiesis. Vitamin B12 and folic acid. Cyanocobalamin and its derivatives. Cyanocobalamin

ATX Code B03BA01

Pharmacological properties


Absorption occurs throughout the small intestine, a small amount is absorbed in the large intestine.

In the ileum is connected with a special internal factor, which is produced by the cells of the fundus of the stomach and becomes inaccessible to the microorganisms of the intestine.

The complex in the wall of the small intestine transfers cyanocobalamin to the receptor, which transports it into the cell. In the blood, vitamin B12 binds to transcobalamins 1 and 2, which transport it into tissues. It is deposited mainly in the liver.


Connection with blood plasma proteins - 90%. The maximum concentration in the blood plasma after subcutaneous and intramuscular injection is achieved after 1 hour. From the liver is excreted bile in the intestine and again absorbed into the blood. The half-life in the liver is 500 days.


It is excreted at normal kidney function - 7-10% by kidneys, about 50% - with calves, and with reduced kidney function - 0-7% by kidneys, 70-100% with calves. Penetrates through the placental barrier, into breast milk.


Cyanocobalamin has a metabolic, hematopoietic effect.

In the body (mainly in the liver) is converted into a coenzyme form - adenosylcobalamin, or kobamid, which is an active form cyanocobalamin and is a part of numerous enzymes, incl. in the reductase reductase, restoring folic acid in tetrahydrofolic. Has a high biological activity.

Cobamamide participates in the transfer of methyl and other single carbonaceous fragments, so it is necessary for the formation of deoxyribose and DNA, creatine, methionine - a donor methyl groups, in the synthesis of lipotropic factor - choline, for the conversion of methylmalonic acid to succinic, which is part of myelin, for the utilization of propionic acid. It is necessary for normal hematopoiesis - promotes the maturation of red blood cells.

Promotes the accumulation in erythrocytes of compounds containing sulfhydryl groups, which increases their tolerance to hemolysis.

Activates the blood coagulation system, in high doses causes an increase in thromboplasty activity and prothrombin activity. Reduces the concentration of cholesterol in the blood.

Has a beneficial effect on the function of the liver and nervous system. Increases the ability of tissues to regenerate.

Indications for use

- hypo and vitamin B12 vitamin deficiency (Addison-Birmer disease, alimentary macrocytic anemia)

As part of complex therapy

- iron deficiency, posthemorrhagic, aplastic anemia and anemia caused by toxic substances and / or drugs

- chronic hepatitis, cirrhosis, liver failure

- alcoholism

- prolonged fever

- polyneuritis, radiculitis, neuralgia (including trigeminal neuralgia), traumatic nerve damage, diabetic neuritis, funicular myelosis, amyotrophic lateral sclerosis, cerebral palsy, Down's disease

- skin diseases (psoriasis, photodermatosis, herpetiform dermatitis, atopic dermatitis)

With the preventive purpose of

- the appointment of biguanides, paraaminosalicylic acid, ascorbic acid in high doses

- pathology of the stomach and intestines with impaired absorption of cyanocobalamin (resection of part of the stomach, small intestine, Crohn's disease, celiac disease, malabsorption syndrome, sprue)

- malignant formations of the pancreas and intestines

- radiation sickness

Dosing and Administration

Enter intramuscularly, subcutaneously, intravenously and intraljumbally.

Subcutaneously, with anemia associated with vitamin B12 deficiency, enter, mg once every 2 days, with Addison-Birmer anemia with the phenomena of funicular myelosis and macrocytic anemia with lesions of the nervous system - by, mg or more per injection in the first week daily, and then at intervals of up to 5 - 7 days. At the same time, folic acid is prescribed.

With posthemorrhagic and iron deficiency anemia appoint, 3, mg 2 - 3 times a week, with aplastic anemia in childhood and in preterm - 3 mg per day for 15 days.

In diseases of the central nervous system (amyotrophic lateral sclerosis, encephalomyelitis, etc.)

) and neurological diseases with pain syndrome are administered in increasing doses from, to, mg per injection, and with improvement of the condition - by, mg per day, treatment course up to 2 weeks.

When traumatic lesions of peripheral nerves are prescribed for, mg once every 2 days for 40-45 days.


When hepatitis and cirrhosis of the liver is administered (adults and children) to, 3, 6 mg per day or, per mg every other day for 25-40 days.


With sprue, radiation sickness, diabetic neuropathy and other diseases, it is usually prescribed by, 6 mg daily for 20-30 days.

For the treatment of funicular myelosis, amyotrophic lateral sclerosis, multiple sclerosis, sometimes injected into the spinal canal, 15 3 mg, gradually increasing the dose to, 5 mg.

Children of early age with alimentary anemia and premature infants are injected subcutaneously at 30 mcg per day for 15 days. In dystrophies in young children, Down's disease and child cerebral palsy subcutaneously at 15-30 mcg every other day.

Side effects

- allergic reactions, itching, skin rashes

- mental agitation, headache, dizziness

- cardialgia, tachycardia

- diarrhea

- hypercoagulation, violation of purine metabolism in the application of high doses


Hypersensitivity to the drug components

- thromboembolism

- erythremia, erythrocytosis

- pregnancy and lactation period

Drug Interactions

It is not recommended to inject vitamins B12, B1, B6 together (in one syringe), as the cobalt ion contained in the cyanocobalamin molecule helps to destroy other vitamins. It should also be borne in mind that vitamin B12 can enhance the allergic reactions caused by vitamin B1.

Pharmaceutically incompatible with ascorbic acid, heavy metal salts (inactivation of cyanocobalamin), thiamine bromide, pyridoxine, riboflavin.

Aminoglycosides, salicylates, antiepileptic medicines, colchicine, potassium preparations reduce the absorption of cyanocobalamin. Chloramphenicol reduces the hemopoietic response. Cyanocobalamin can not be combined with drugs that increase blood coagulability.

special instructions

Cyanocobalamin deficiency should be confirmed diagnostically prior to prescribing, as it can mask a deficiency of folic acid.

Do not administer vitamin B12 for acute thromboembolic disease. Be careful in individuals prone to thrombosis, with angina (in smaller doses, up to 100 μg per injection). It is necessary to monitor blood coagulability.

During the period of treatment it is necessary to monitor the parameters of peripheral blood: on the 5th-8th day of treatment the number of reticulocytes is determined. The number of erythrocytes, hemoglobin and color index should be monitored for 1 month 1-2 times a week, and then - 2-4 times a month.

In the case of leuko- and erythrocytosis, the dose of the drug should be reduced or temporarily discontinued, taking care when prone to thrombosis.


Remission is achieved with an increase in the number of red blood cells to 4, million / mm, when the normal size is reached erythrocytes, the disappearance of aniso- and poikilocytosis, the normalization of the number of reticulocytes after the reticulocytic crisis.


After achieving hematologic remission, peripheral blood monitoring is performed at least once every 4 to 6 months. There are separate indications of the possible teratogenic effects of B vitamins in high doses.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Given the side effects of the drug should be careful when managing transport and work that requires concentration.


Symptoms - increased side effects of the drug

Treatment is symptomatic.

Form of production and packaging

1 ml per neutral glass ampoules for syringe filling or imported, or ampoules sterile for syringe filling imported, with a break point or a ring of fracture.

Each label is labeled with label paper or writing paper.

For 5 or 10 ampoules are packed in a contour mesh box made of a polyvinylchloride film and aluminum foil, or imported.

Contoured cell packs along with approved instructions for medical use in the state and Russian languages ​​are placed in boxes of cardboard or corrugated cardboard.

In the group package by the number of packages, the approved instructions for medical use in the state and Russian languages ​​are put.

Storage conditions

Store in a dry, dark place at a temperature of no higher than 30 ° C.

Keep out of the reach of children!

Shelf life

3 years

Do not use after expiry date.

Conditions of leave from pharmacies

On prescription

Name and country of the manufacturing organization

JSC "Khimfarm the Republic of Kazakhstan,

in Shymkent, Rashidov, 81

Name and country of the holder of the registration certificate

JSC "Himpharm the Republic of Kazakhstan

The address of the organization that accepts on the territory of the Republic of Kazakhstan claims from consumers on the quality of products (goods)

JSC "Himpharm Shymkent, Republic of Kazakhstan, 160019

ul. Rashidov, 81

Phone number 7252 (561342)

Fax number 7252 (561342)

E-mail address [email protected]

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