Spregal

Spregal is a medicinal product used in dermatological practice for the therapy of demodectic and scabies.

Contains several active ingredients: piperonyl butoxide and esdepalletrin. Both are endowed with insecticidal properties. Esdepalletrin is a specific poison that affects membranes, nerve cells of insects. Piperonil helps to enhance the effect of the drug. Along with this, auxiliary substances were added to the aerosol composition: ethyl alcohol, esbiol, diethylene glycol, oleic ether.

After 24 hours after using the drug, the concentration of its components in the blood plasma is minimal, and in some cases is not determined. 48 hours after application of Spragal, no traces of its components in the blood plasma of the patient are detected.

Clinical and pharmacological group

The drug for the treatment of scabies.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does Spregal cost in pharmacies? The average price in 2018 is at the level of1 000 rubles.

Composition and form of release

Produced in the form of an aerosol in pressurized cylinders. The principle of Spragal's action is based on the destruction of parasites that cause scabies, insecticidal substances with the support of auxiliary components:

• esdepalletrin (the main poison);
• piperonyl butoxide (as the poison acts weakly, but significantly enhances the effect of esdepalletrin);
• ethanol;
• diethylene glycol;
• esbiol;
• oleic ester.

Such a composition allows the agent to be absorbed into the skin quickly after application with minimal losses in the form of vapors. At the same time, the maximum concentration of the main active substances is achieved 2 hours after application, and after two day (48 hours) Spregal is completely eliminated from the body, it is not detected in the samples of the biomaterial in patients.

pharmachologic effect

The action of the neurotoxic poison of the esdepalletrin consists in violation of the transport of sodium, potassium, through the membrane of the magnesium insect cell, calcium, the violation of the equilibrium of cations in the cell and the intercellular environment. The components of the drug penetrate the body through the skin, after 2 hours after treatment, the maximum concentration of the drug in the blood is reached.

A day after application to the skin, Spragal components are found in trace amounts. Completely the drug is excreted from the body after two days.

Indications for use

Spragal is intended for the treatment of scabies of any localization in adults and children, including:

• nodular;
• scabies of "cleanliness";
• pseudotypes;
• typical;
• Norwegian and others.

Also use it for itching bather and demodectic.

Evaluation of the effectiveness of scabies treatment

This test was conducted by the Central Dermatovenerologic Research Institute of the Ministry of Health of the Russian Federation.

The trial involved 29 patients aged 3-74 years (12 women, 11 men, 6 children). The duration of the disease was from 3 days to 5 months. All patients, and people living with them, had characteristic scabies symptoms. One of the main symptoms - the presence of itch moves on the ground, typical for scabies (hands, forearm, abdominal region, thighs, buttocks, genitals).

After taking the shower, the spray was sprayed all over the skin from top to bottom, then changed clothes and bedding. After 12 hours, the subjects again took a shower and put on clean clothes. The results of the tests showed clinical recovery in all patients. There were no side effects or complications. Two children felt slight burning and itching for 5-7 days after the procedure. In 4 patients for 10-12 days, signs of nodular scabies accompanied by edema and itching were found. They were prescribed antipruritic drugs (chloropyramine, clemastine, loratadine) and steroid gels in combination with neutral creams.

With regular examinations of subjects during the following month, there were no complications associated with the treatment with the drug spregal. Complete disappearance of the rash in all patients was recorded at 5-8 days after a single procedure. Before and after the test, tests for itching, blood and urine tests were performed. The tolerability of the drug was good.

The results of the study made it possible to conclude that the drug is highly effective and safe. In comparison with other drugs used in medical practice, scabies (benzyl benzoate, sulfuric ointment, solution according to Demjanovich etc.), spray spregal has a therapeutic effect at any stage of the disease, destroying adult mites, larvae and eggs. In this case, a positive effect was observed in both adults and children in a single procedure. Spregal is convenient to use, it is normally tolerated by all groups of patients, it does not provoke adverse reactions and complications. One bottle is enough to treat 2-4 persons.

Contraindications

• bronchial asthma;
• bronchitis accompanied by bronchial obstruction;
• lactation;
• intolerance of the constituents of the drug.

In the first two cases, the drug is contraindicated for use only in the form of a spray. In this case, it is possible to treat the skin with a tampon impregnated with a spragal.

Intended use for pregnancy and lactation

It can be taken during pregnancy, only on condition that the expected benefit exceeds the possible risk. When lactating, Spragal does not apply.

Dosage and route of administration

As indicated in the instructions for use, treatment with the drug is preferably started in the evening (after 18-19 hours) to allow Spregal to act overnight. After applying the drug should not be washed. Before use, shake the canister thoroughly. By spraying the drug is carefully applied to the surface of the body (except the skin of the face and head) at a distance of 20-30 cm from the skin surface.

The drug is first applied to the trunk, and then to the limbs (the treated areas begin to shine). Particularly carefully the drug is applied between the fingers of the hands, feet, underarms, perineum, on all folds and affected areas and left on the skin for 12 hours. After 12 hours, wash thoroughly with soap and wipe.

As a rule, a single application of Spregal is sufficient.However, it should be borne in mind that even in the case of treatment effectiveness, itching and other symptoms may occur for another 8-10 days. If symptoms persist after this period, you can apply the drug again.

When treating children and newborns during the spraying of the drug, it is necessary to cover the nose and mouth with a napkin; In the case of changing diapers, the whole buttock zone needs to be re-processed. When localized scratching on the face, they are treated with a cotton swab dampened with Spregal.

Side effect

In some cases, the manifestation of local reactions (a slight burning sensation, which itself passes after a while) is possible.

Overdose

No cases of drug overdose have been reported.

special instructions

Before using, read the special instructions:

1. The drug should be sprayed in a well-ventilated area.
2. One bottle of the drug Spregal is enough to treat 3-4 people.
3. To avoid secondary infection, you must treat the bed and clothes.
4. Avoid contact with eyes and mucous membranes. In case of accidental contact with eyes, rinse thoroughly with warm water.
5. The drug is contraindicated in bronchial asthma, obstructive bronchitis only because of the aerosol form. In this case, it is possible to apply the drug on the skin with a cotton swab dampened with Spregal.

Interaction with other drugs

Data on the drug interaction of Spregal with other topical drugs are not described, but if the patient needs to put on the skin some kind of ointment or cream, you should do this after taking a shower and flushing the Spregal from the surface of the skin.

Reviews

We offer you to read reviews of people who used the drug Spregal:

1. Andrei. This is an excellent external tool, although there are many other substitutes that are cheap. Yes, medicine is expensive, but effective! Once I suffered, treated the whole body, and after 12 hours any manifestations of the disease disappear. For example, I did not need to spray for the second time. To prevent secondary infection, I processed the apartment.
2. Nastya. I work with money and I know what scabies are. It used to be treated with benzyl benzoate, but it takes a long time. The pharmacy advised spregal spray. At night it was processed, barely waited in the morning (everything burns and itches), drank a tablet of suprastin for relief of symptoms. I washed and decided to repeat the treatment and this was a big mistake for me! After 5 minutes after treatment, I began to grow numb and tingle my lower lip (my face did not work, only the body and neck), then my jaw became dumb and swelled.... and then I realized that this is not just an allergic reaction, it starts guarding the quincy! But I was lucky because I had previously drunk suprastin and I have not gone further than these symptoms... By the way, I do not suffer from any allergies. Be careful when re-processing! Although in general, the remedy has helped.
3. Marina. Demodecosis was with my daughter. At first there were small rashes on the cheeks, and then they covered the entire face. It looked terrible. Treated with various ointments. They helped little. Doctors advised to switch to hormonal medications. Decided to abstain. At the thematic forum I read about Spregal. Have decided to try. Of course, they were treated for a long time. More than a month. However, the result is obvious. The number of acne has decreased significantly, and there are no new rashes for a long time. We continue the therapy.

Analogues

If, for some reason, the use of Spregal became impossible, for example, because of the allergy or high cost of the drug, you can use one of the analogs. Please note that you do not need to choose a substitute drug yourself, it is better to ask advice from your doctor. The main analogues of Spregal:

• Benzyl benzoate (costs no more than 50 rubles);
• Permethrin (costs about 150 rubles);
• Esdepalletrin (costs around 700 rubles);
• A-Par (costs about 650 rubles).

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Store in a dark place inaccessible to children at room temperature. Shelf life - 24 months.

Caution - the liquid in the bottle is under pressure. The temperature of the cylinder should not exceed 50 degrees. It is forbidden to pierce or burn even empty vials. Do not spray on a flame, or on a hot metal. Use and store at a safe distance from heaters and electrical appliances.

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