Eye drops Arutimol: instructions for use in glaucoma

Arutimol refers to non-selective beta-1 and beta-2 adrenoreceptor blockers.

For him, internal sympathomimetic and membrane-stabilizing activity is uncharacteristic. In topical application in the form of eye drops, Arutimol reduces both normal and increased intraocular pressure due to inhibition of tear production.

On this page you will find all information about Arutimol: the full instruction on the application for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Arutimol. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antiglaucomial drug - beta-blocker.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Arutimol cost? The average price in pharmacies is at the level of95 rubles.

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Form of issue and composition

The medication is issued in the form of 5% and,% eye drops, in 1 ml of which contains:

• , or 5 mg timolol (in the form of hydro-maleate), respectively;
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• The following auxiliary components: sodium dihydrogen phosphate, disodium edetate dihydrate, sodium monohydrogenphosphate dodecahydrate, povidone, injection water and, as a preservative, benzalkonium chloride.

Droplets of 5 ml are realized in polyethylene bottles.

Pharmacological effect

According to the instructions, Arutimol is an anti-glaucoma drug that does not possess membrane-stabilizing and internal sympathomimetic activity. Eye drops Arutimol with local application reduce intraocular pressure. This is due to a reduction in the amount and formation of intraocular fluid. The drug does not affect the accommodation and the size of the pupil.

Timolol begins to act 20 minutes after application (instillation into the conjunctival sac). The optimal decrease in intraocular pressure occurs 1-2 hours after instillation and persists throughout the day.

Indications for use

The drug is used to reduce the increased ophthalmotonus (intraocular pressure) in patients with various forms of glaucoma, including the drug is indicated in such forms of glaucoma:

• Chronic occlusive glaucoma;
• Different types of open-angle glaucoma;
• Afakic glaucoma and other types of secondary glaucoma;
• The drug is also used to reduce intraocular pressure in patients with congenital glaucoma.

The dose of the drug and the duration of the course of treatment are determined by the attending physician individually for each patient.

Contraindications

Contraindication to taking the drug is:

• Chronic obstructive diseases of the upper respiratory tract (including bronchial asthma).
• Severe atrophic rhinitis.
• Dystrophy of the cornea.
• Atrioventricular block of II or III degree.
• Sinus bradycardia.
• Cardiogenic shock.
• Severe heart failure.
• Allergic manifestations with generalized skin rashes.
• Increased individual sensitivity to timolol and other auxiliary components of the drug.

Arutimol is administered with extreme caution to patients with severe cerebrovascular insufficiency, pulmonary insufficiency, chronic heart failure, hypoglycemia, diabetes mellitus, myasthenia gravis, thyrotoxicosis, and also in conjunction with other beta-blockers.

Application in pregnancy and lactation

Contraindicated the use of Arutimol during pregnancy and lactation (breastfeeding).

Instructions for use

Before the first use it is necessary to use the instruction and correctly to bring the lid-dropper into the working position. First it is tightly pressed to the vial and turned strictly clockwise. This is necessary in order for the special spike to puncture the dispenser. Then the cover returns to its original position.

In order for the drops to bring unquestionable benefit, you must follow certain rules when instilling the medicine:

1. The head is retracted.
2. The lower eyelid is pulled down.
3. One finger at the time of instillation closes the tear duct (this prevents the systemic exposure of thymol).
4. The bottle is turned over and dripped one drop into the conjunctival sac, it is impossible to touch the mucosa with a dispenser.
5. After instillation for a while, the head should be held back up - this facilitates a better distribution of the drops.

The instructions for use indicate that at the beginning of therapy, one drop of 0.25% or 0.5% of eye drops of Arutimol is injected into the conjunctival sac 2 times a day.

• With the normalization of intraocular pressure, the maintenance dose is 1 drop of 0.25% eye drops 1 time / day.

Treatment with arutimol is usually carried out for a long time. A break or change in dose is carried out only according to the prescription of the attending physician.

Side effects

When using the drug in patients, such local side effects were noted:

• visual impairment, inflammation of the eyelid and conjunctiva, keratitis, dry eye syndrome, increased lacrimation. In addition, in a few cases, the development of diplopia and blepharoptosis was noted.

With prolonged use of the drug, as well as with the use of high doses of the drug, it is possible to develop systemic side effects characteristic of beta1 and beta2-adrenoblockers, including:

1. From the side of the cardiovascular system: arrhythmia (possible development, both tachycardia and bradycardia), atrioventricular blockade, hypotension. In single cases, the development of heart failure, violations of cerebral circulation, cardiac arrest was noted.
2. From the respiratory system: shortness of breath, bronchospasm may develop in patients with bronchial asthma.
3. From the skin: allergic reactions in the form of skin rashes, hives, generalized exanthema.
4. From the central and peripheral nervous system: headache, dizziness, fatigue, irritability, apathy, depressive states.
5. In a few cases, nausea was noted.

The risk of side effects when using Arutimol in children is higher than in patients over 16 years of age. If side effects develop, the drug should be discontinued and consulted by your doctor.

Overdose

Overdose is possible when taking drops at doses much higher than recommended. There may be such effects:

• diarrhea;
• difficulty breathing, shortness of breath;
• nausea;
• headache and dizziness;
• vomiting;
• arrhythmia.

In such cases, it is necessary to rinse the eyes with plenty of clean water, the treatment will depend on the specific symptomatology.

special instructions

Before prescribing the medication in question, the patient should be warned about the need to visit the doctor regularly to measure eye pressure and examine the cornea.

• If the patient wears soft contact lenses, then the drug "Arutimol" is contraindicated to him, since the preservative, contained in the solution, can be deposited in lenses and have an adverse effect on the tissues of visual bodies. As for the hard contact lenses, before the instillation of the medicament and their re-installation, an interval of ¼ hour should be observed.
• Before the forthcoming surgical intervention with general anesthesia, the instillation of "Arutimol" should be stopped exactly in two days.

It is strictly forbidden to use two beta-blockers at the same time.

Drug Interactions

1. The action of Arutimol is enhanced by the simultaneous administration of drops containing adrenaline and pilocarpine.
2. When using drops that include epinephrine, the patients had a dilated pupil.
3. Arutimol can enhance the action of insulin and diabetes remedies. Therefore, careful monitoring of glucose during the treatment period is necessary.
4. When using drops and agents for the treatment of cardiovascular diseases, there may be an increase in side effects.
5. Before the operation, where anesthesia will be used, the patient should refuse to take drops in at least 2 days.
6. Arutimol can enhance the therapeutic effect of drugs aimed at relaxing skeletal muscles (with osteochondrosis and other diseases of the spine).

Reviews

Reviews about the drug among patients are favorable. "... I am treated with Arutimol for almost 2 years with interruptions. With his help, while maintaining intraocular pressure, although the doctor offers a laser correction. " In practice, Arutimol is often used in hemangiomas, especially in hemangiomas in infants in their primary manifestations and small in size.

Analogues

The following drugs are the analogues of Arutimol:

• By the active substance: Glautam, Niolol, Okuker, Okumed, Okumol, Okupres-E, Oftan, Timadren, TioGexal, Timolol, Timolol-Betalek, Tipololong, Oftan Timogel;
• On the mechanism of action: Azarga, Anaprilin, Betaxolol, Betalmik EU, Betoptik, Betofan, Ganforth, Duoprost, DuoTrav, Kombigan, Xalakom, Xonef, Xonef BK.

Before using analogues, consult your doctor.

Storage conditions and shelf life

List B. The drug should be stored out of the reach of children, protected from light at a temperature of no higher than 25 ° C. Shelf life - 3 years.

After opening the vial, the period of storage of eye drops is 6 weeks

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