What is omeprazole for: instruction, price and analogy

Omeprazole is an effective modern preparation used for the treatment of gastric erosions, certain types of gastritis and peptic ulcer with high acidity.

The active substance of the drug successfully fights with various inflammatory processes in the gastrointestinal. Only getting into an acidic stomach environment, the drug manifests its properties - reduces the effect of acids on the walls organs, restores the acid-base balance of gastric juice, reduces the symptoms of diseases.

After taking this medication, patients not only improve their health, but also reduce the risk of getting sick again. The first action is felt for an hour and lasts for 24 hours.

Clinical and pharmacological group

H + -K + -ATPase inhibitor. Antiulcer drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is omeprazole in pharmacies? The average price is at the level of35 rubles.

Form of issue and composition

In the pharmacy network, the drug omeprazole is sold in tablets, capsules and solutions for intravenous administration.

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Intestinal capsules contain 10 mg or 20 mg of the main active ingredient - omeprazole (7 capsules in a blister pack, in the bundle there can be from 1 to 4 blister plates); Some manufacturers pack capsules in polymer cans of 30 or 40 pieces;
Tablets MAPS (pellets), coated with 10 mg, 20 mg or 40 mg of active substance (№ 7, 14, 28);
Powder for infusion solutions in bottles of 40 mg (5 bottles per package).

Pharmacological effect

Omeprazole is a proton pump inhibitor that reduces the production of hydrochloric acid by inhibiting the H + / K + -ATPase of parietal cells in the stomach. The drug is a prodrug that is activated in the acidic biosena of the secretory tubules of the parietal cell of the gastric mucosa.

As a result of the drug, basal and stimulated secretion is reduced regardless of the nature of the stimulus. After taking omeprazole in a dose of 20 mg antisecretory effect manifests itself within the first hour (maximum after 2 hours). During the day 50% of maximal secretion is inhibited. As a result of a single administration, rapid effective suppression of night and daytime gastric secretion is provided, reaching a maximum after 4 days of therapy and disappearing in 3-4 days after the end of admission.

With duodenal ulcer after taking omeprazole at a dose of 20 mg for 17 hours, intragastric pH is maintained at level 3.

Indications for use

Omeprazole: what heals and what are they prescribed for? The agent is indicated for the treatment and prevention of pathology of the digestive tract. Indications for the use of omeprazole Acrya are no different from the indications, which are listed in the omeprazole annotation, produced by another pharmaceutical company (Sandoz, Gedeon Richter Plc., STADA CIS, etc.).

The drug is effective in the following cases:

For the treatment of Zollinger-Ellison syndrome;
In the combined treatment of polyendocrine adenomatosis;
As a course of treatment endoscopically confirmed erosive esophagitis;
To eliminate uncomplicated heartburn, which lasts more than 2 days during the week;
For the treatment of gastropathies, which were formed from the use of non-steroidal anti-inflammatory drugs;
For relief of manifestations of gastroesophageal reflux (throwing of gastric contents into the lower part of the esophagus);
In the complex treatment of the active phase of stomach ulcer and duodenal ulcer associated with Helicobacter pylori infection;
Prophylactically, to prevent recurrence of chronic duodenal ulcer, aspirin and stress ulcer disease;
To correct hypersecretory disorders in the upper part of the digestive tract.

Contraindications

With caution appoint a group of patients with renal or hepatic insufficiency. The instructions for the use of omeprazole indicated absolute contraindications to treatment:

Pregnancy;
Lactation;
Childhood;
Hypersensitivity.

Use in pregnancy and lactation

Omeprazole is not recommended for pregnant women. Contraindicated taking the drug in the first three months of pregnancy, as its use can disrupt the development of the fetus or lead to serious violations.

In other cases, if this medicine is prescribed, it is very rare and very cautious if the effect from it will be much greater than the harm, that is, the risk must be justified.

Dosage and route of administration

The instructions for use indicate that omeprazole capsules are taken orally, usually in the morning, without chewing, with a small amount of water (just before meals).

For the prevention of recurrences of peptic ulcer - 10 mg once a day.
With Zollinger-Elisson syndrome - usually 60 mg once a day; if necessary, increase the dose to 80-120 mg / day (the dose is divided into 2 divided doses).
With exacerbation of peptic ulcer, reflux esophagitis and gastropathy caused by the intake of NSAIDs - 20 mg once a day. For patients with severe reflux esophagitis, the dose is increased to 40 mg once a day. The course of treatment for duodenal ulcer is 2-4 weeks, if necessary - 4-5 weeks; with peptic ulcer stomach, with reflux-esophagitis, with erosive-ulcerative lesions of the gastrointestinal tract caused by the intake of NSAIDs - within 4-8 weeks. Reduction of symptoms of the disease and cicatrization of the ulcer in most cases occurs within 2 weeks. Patients who have not had complete cicatrization of the ulcer after a two-week course should continue treatment for 2 more weeks. Patients who are resistant to treatment with other antiulcer drugs are prescribed 40 mg per day. The course of treatment for duodenal ulcer is 4 weeks, with peptic ulcer and reflux esophagitis 8 weeks.

For the eradication of Helicobacter pylori, one of two therapies is used:

"Triple" therapy: 20 mg of omeprazole, 500 mg of clarithromycin and 1000 mg of amoxicillin 2 times a day; or 20 mg of omeprazole, 250 mg of clarithromycin and 400 mg of metronidazole 2 times a day; or 40 mg of omeprazole once a day, 400 mg of metronidazole and 500 mg of amoxicillin 3 times a day. Course duration - 1 week;
"Double" therapy: 20-40 mg of omeprazole and 750 mg of amoxicillin 2 times a day; either 40 mg 1 time per day and 500 ml and 500 mg of clarithromycin 3 times a day or 750-1500 mg of amoxicillin 2 times a day. Duration of the course is 2 weeks.

For hepatic insufficiency appoint 10-20 mg once a day (with severe liver failure, the daily dose should not exceed 20 mg); if there is a violation of kidney function and in elderly patients, correction of the dosing regimen is not required.

Omeprazole for heartburn

Omeprazole effectively removes the phenomenon of heartburn with various diseases of the gastrointestinal tract. However, his independent reception is allowed only as an exception, as an emergency aid. Its dose in this case should not exceed 10 mg per day. The therapeutic effect of omeprazole develops after 4-5 days, and the full course of treatment should not exceed 14 days. Repeat treatment with omeprazole can be no earlier than 4 months.

If, at the end of the treatment, heartburn returns, it is necessary to consult a doctor for advice and examination. The same should be done with frequent heartburn, especially if they are observed more than 2 days a week. In this case, appropriate treatment with omeprazole in appropriate dosages will be prescribed.

Side effects

As a rule, the drug is well tolerated. The exception is a long period of application - more than two months, but doctors do not prescribe medicine for such a long time, the optimal course of treatment is 30 days. After a break, you can resume use for preventive purposes.

The main adverse reactions that may occur with incorrect use of omeprazole, they consist of the following symptoms:

Musculoskeletal: rarely develop myasthenia gravis, arthralgia, myalgia.
The system of hematopoiesis: rarely - leukopenia, agranulocytosis, thrombocytopenia, pancytopegia.
Allergic reactions: angioedema, hives, fever, bronchial spasm, anaphylactic shock.
Skin: In rare cases - skin itch or rash, photosensitization, exudative erythema multiforme, alopecia.
Organs of digestion: abdominal pain, diarrhea or constipation, nausea and vomiting, flatulence. Rarely activation of liver enzymes is increased, there is a taste distortion, stomatitis, dryness of the mucous membranes of the mouth. In patients with severe liver diseases, hepatitis may develop.
Nervous system: With concomitant somatic diseases in severe form, dizziness, headaches, depressive states, agitation. In patients with severe liver diseases, encephalopathy is possible.
Other: rarely visual impairment, swelling of the extremities, malaise, increased sweating, gynecomastia, formation of benign gastric glandular cysts reversible in long-term treatment.

Overdose

The instruction describes the symptoms of an overdose when the medicine is misused. There may be a headache, nausea, drowsiness. There is confusion, visual impairment, tachycardia.

If any of the above symptoms occur, seek medical attention immediately. He will prescribe symptomatic treatment - that is, will eliminate the consequences as they arise. Omeprazole is absorbed into the blood for an hour - that is, dialysis is not effective.

special instructions

Before the start of therapy, it is necessary to exclude the presence of a malignant process (especially with a stomach ulcer), as treatment, masking the symptoms, can delay the establishment of the correct diagnosis.

Admission simultaneously with food does not affect its effectiveness.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

No interaction with concomitant antacids was noted.
It can reduce the absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (omeprazole increases the pH of the stomach).
Increases the inhibitory effect on the hemopoietic system and other medicines.
At the same time, long-term use of omeprazole at a dose of 20 mg once a day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not lead to a change in their plasma concentration.
Being inhibitors of cytochrome P450, it can increase the concentration and reduce the excretion of diazepam, anticoagulants of indirect action, phenytoin (drugs, which are metabolized in the liver via cytochrome CYP2C19), which in some cases may require a reduction in the doses of these drugs. Can increase the concentration of clarithromycin in the blood plasma.

Reviews

We picked up some reviews of people who used the drug Omeprazole:

Sergei. I know this drug very well. Having earned myself a gastritis, I began to suffer from constant heartburn. And whatever I take, everything is useless - heartburn if and passed, then for a short time. Then I was advised to try omeprazole. One capsule in the morning natoschyak and the whole day without heartburn. Already for four years I have only been saving myself.
Igor. Gastritis has earned many years ago, a disease of nerves. He treated tablets different when it was already quite unbearable. What to drink once again did not know, went to the doctor, discharged omeprazole. Weakly believed that he had such a lasting effect, but the pain was removed for a long time. Took a month, but for half a year does not bother.
Olga. Omeprazole helps me very well for heartburn. I used to take ranitidine, it also very quickly and relieves heartburn, but my hair falls out heavily, so I switched to omeprazole. Of side effects, there is sometimes swelling and increased gas formation.

Analogues

In view of the fact that the drug is very effective and in demand, more and more different analogues can be found every year. All of them have different costs - if you are trying to buy a drug cheaper, consult a pharmacist.

The most famous synonyms of omeprazole are: