Tetracycline tablets

Tetracycline is a broad-spectrum antibiotic with bacteriostatic action.

The drug destroys Gram-positive and Gram-negative bacteria. Widespread use of tetracycline has been used as a drug for the treatment of various purulent skin diseases (incl. furunculosis, acne), inflammatory processes of the respiratory tract (angina, bronchitis, pneumonia, etc.) and the genitourinary system (gonorrhea, syphilis, etc.).

It has various dosage forms: oral tablets, ointment for external use. Used to treat infectious diseases, the causative agents of which are pathogenic bacteria sensitive to the action of the drug.

Clinical and pharmacological group

Antibiotic of a wide spectrum of action.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does tetracycline cost in pharmacies? The average price is at the level of100 rubles.

Composition and form of release

Tablets Tetracycline have a pink color, a round shape and a biconvex surface. The main active substance of the drug is tetracycline, its content in one tablet is 100 mg. It also includes additional components, which include:

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Calcium stearate.
Macrogol.
Titanium dioxide.
Polyvinyl alcohol.
Microcrystalline cellulose.
Talc.
Croscarmellose sodium.

Tablets are packaged in a blister pack of 20 pieces. Cardboard pack contains 1 blister with tablets, as well as instructions for using the drug.

pharmachologic effect

By classification, this drug is included in the antibiotics of the tetracycline group. It is active against many gram-positive microbes: Clostridium spp., Staphylococcus spp., Listeria spp., Streptococcus pneumoniae, Bacillus anthracis, Actinomyces israelii. In addition, this agent can be used against many gram-negative microorganisms: Haemophilus ducreyi, Salmonella spp., Acinetobacter spp., Yersinia pestis, Haemophilus influenzae, Bartonella bacilliformis, Borrelia burgdorferi, Enterobacter spp., Bordetella pertussis, Klebsiella spp., Vibrio fetus, Shigella spp., Francisella tularensis, Vibrio cholerae, Rickettsia spp., Escherichia coli, Brucella spp.

The drug is also active in Chlamydia psittaci, Treponema spp., Calymmatobacterium granulomatis, Chlamydia trachomatis, Mycoplasma pneumoniae.

The degree of absorption of the drug when administered on an empty stomach is 75-77%, in case of application during food absorption decreases. With plasma proteins, the active substance binds to 55-65%. When administered orally, the maximum plasma concentration is noted after 2-3 hours. It gradually decreases over a period of 8 hours.

Getting into the body, the active substance accumulates in the liver, lungs, kidneys, as well as in organs that are characterized by a developed reticulo-endothelial system. The content of bile is about 5-10 times greater than in the serum. Tetracycline hydrochloride also accumulates in bone tissue, dentin, tissues of tumors, enamel of milk teeth. Penetrates through the placental barrier and into milk during lactation.

The elimination half-life is 6-11 hours. For 20-50% the drug is excreted through the intestine.

Indications for use

The official instruction on the use of tablets Tetracycline indicates that they are effective in the following pathologies:

All infectious diseases caused by drug-susceptible pathogens.
Intestinal amoebiasis, cholera, anthrax, brucellosis, rickettsiosis, syphilis, tularemia, trachoma, yaws, listeriosis, uncomplicated gonorrhea, plague, inguinal granuloma, chlamydia, psittacosis, actinomycosis, etc.
Infections of the skin, bones, soft tissues, mucous membranes (gingivitis, stomatitis, including ulcerative necrotic), acne, carbuncles, furunculosis, suppuration of skin, conjunctivitis.
Bacterial infections of the respiratory, urinary tract.

Contraindications

Film-coated tablets:

leukopenia;
children's age till 8 years;
second and third trimesters of pregnancy;
the period of breastfeeding;
increased individual sensitivity to the components of the drug.

Tetracycline in the form of tablets with caution is prescribed to patients with renal insufficiency.

Dosage and route of administration

As indicated in the instructions for use, Tetracycline tablets are taken orally by washing with a large amount of liquid.

Adults, as a rule, are prescribed 4 times a day for 0.25-0.5 g or 2 times a day (every 12 hours) for 0.5-1 g. The maximum dose is 4 g per day. Children from 8 years are prescribed 4 times a day (every 6 hours) at 6.25-12.5 mg / kg or every 12 hours at 12.5-25 mg / kg.

In uncomplicated gonorrhea, the drug is prescribed in the initial single dose of 1.5 g, after which for 4 days every 6 hours, 0.5 g (total dose - 9 g).
In the treatment of acne Tetracycline is used at 0.5-2 g per day. When the condition improves (usually after 3 weeks), the dose is gradually reduced to a maintenance dose of 0.125-1 g. Adequate remission of acne can be achieved with intermittent therapy or taking the drug every other day.
With early syphilis for 15 days should be taken every 6 hours for 0.5 g of tetracycline, with late syphilis drug taken within 30 days.
In the treatment of brucellosis for 3 weeks every 6 hours shows the intake of 0.5 g of tetracycline simultaneously with intramuscular injection of 1 g of streptomycin (during the first week - every 12 hours, during the second week - 1 time per day).
In uncomplicated urethral, rectal and endocervical infections caused by Chlamydia trachomatis, the drug in a dose of 0.5 g should be taken 4 times a day for at least 7 days.

Side effects

Possible adverse reactions:

CNS: headache, increased RF pressure, dizziness;
urinary system: azotemia, hypercreatininaemia;
hemopoiesis: hemolytic anemia, neutropenia, thrombocytopenia, eosinophilia;
organs of the digestive system: dysphagia, hypersensitivity of the papillae of the tongue, blunting of hunger, diarrhea, glossitis, gastritis, hepatotoxic action, pancreatitis, enterocolitis, vomiting, nausea, esophagitis, stomach and duodenal ulcers, increased liver transaminase activity, dysbacteriosis;
allergy and immunopathological reactions: skin hyperemia, Quincke's edema, maculopapular rash, systemic lupus erythematosus, anaphylactoid reactions, photosensitivity;
other: superinfection, hypovitaminosis B, discoloration of the enamel of the infant teeth, candidiasis, stomatitis.

Overdose

Exceeding the recommended therapeutic dosage of tablets Tetracycline is accompanied by nausea, vomiting, the appearance of blood in the urine (hematuria). In this case, after a preliminary washing of the stomach, intestine, and also the intake of intestinal sorbents (activated charcoal), a symptomatic therapy in a medical hospital, since there is no specific antidote for tetracycline.

special instructions

Before you start using the drug, read the special instructions:

The use of tetracycline in children during the development of teeth can lead to an irreversible change in their color.
During the treatment for the prevention of hypovitaminosis should be used vitamins B, K, brewer's yeast.
With prolonged use, it is necessary to periodically monitor the functions of the kidneys, liver, and hematopoiesis.
Tetracycline should not be taken concomitantly with milk and other dairy products. at the same time, absorption of the antibiotic is impaired.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

With the simultaneous use of tetracycline with retinol may develop intracranial hypertension.
When used simultaneously with colestyramine or colestipol, there is a violation of absorption of tetracycline.
Preparations containing metal ions (antacids, preparations containing iron, magnesium, calcium) form with tetracycline inactive chelates, in connection with which it is necessary to avoid their simultaneous appointment.
It is necessary to avoid the combination with penicillins, cephalosporins, which have bactericidal action and are antagonists of bacteriostatic antibiotics (including tetracycline).

Reviews

We offer you to read reviews of people who used the drug Tetracycline:

Kostya. A good antibiotic, when a cough or sore throat appears, it helps, just do not drink it and keep it in my mouth until it completely dissolves, I swallow this bitterness, but only the red tablets prompted my mother-in-law.)
Lyudmila. As soon as my skin spoils and jumps up some muck, I immediately smear with tetracycline, inflammation it becomes less, and in a day the terrible white rod disappears, which frightens everyone. Of all the ointments that I tried this one showed the best result! Be sure to buy it again. It also helps to lighten the pigment spots a little.
Paul. Tetracycline is a very common and quite famous antibiotic. I remember him from childhood. I was about ten when I first fell ill with pneumonia. As now I remember that I was prescribed tetracycline. There were other drugs, but I unfortunately can not recall their names. To drink tetracycline in tablets was difficult - they are very bitter, but the end result was positive. As far as I know, tetracycline is in many ways superior to other antibiotic drugs.

Analogues

Structural analogs for the active substance:

Tetracycline-AKOS;
Tetracycline-LekT;
Tetracycline hydrochloride.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Store in a dark place at a temperature of: not more than 15 ° C (ointment eye); 20-25 ° C (tablets and ointment for external use). Keep away from children.

Shelf life - 3 years.