Prick of the Don for joints: instructions for use

Dona is a medicinal preparation that stimulates the regeneration of cartilaginous tissue.

Has anabolic, anti-catabolic, anti-inflammatory, analgesic and chondroprotective effect. It stimulates the processes of synthesis of mediators and nutrients necessary for the restoration of damaged tissues (including calcium), facilitates their deposition in the region of the joints. This leads to inhibition of inflammatory and degenerative processes and relieves pain symptoms.

On this page you will find all information about the Don: complete instructions on how to use this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied injections of Don. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Chondroprotector.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much do dona prizes in pharmacies cost? The average price for 1 package (6 ampoules) starts from 1450 rubles to 1800, the price for a powder also varies from 1350 to 1650 rubles. It is expensive enough at first glance, but the effect is also promised.

Form of issue and composition

Produce the drug in the following variations:

1. Powder for solution for oral administration (1.5 g in bags, in a pack of cardboard 20 or 30 packets);
2. The tablets covered with a film cover: oblong form, white color; On the cross-section, two layers are visible: the outer white and internal - white with a brownish hue (in polyethylene bottles of 60 or 180 pcs., in a pack of cardboard 1 bottle);
3. Solution for intramuscular administration: colorless or light yellow, transparent (2 ml each in ampoules of transparent light-shielding glass, in a pack of cardboard 6 ampoules in a PVC tablet complete with 6 ampoules of solvent in a PVC plate).

Active substance: glucosamine (in the form of sulfate):

• 1 tablet 750 mg;
• 1 packet with powder - 1500 mg;
• 1 ml of the solution - 200 mg.

The solvent applied to the solution (colorless transparent liquid) consists of water for injection and diethanolamine.

Pharmacological effect

Stimulator of cartilage tissue regeneration, has anti-catabolic, anabolic, chondroprotective, analgesic, anti-inflammatory action. The active substance of Dona - glucosamine sulfate, is an amino saccharide with a low molecular weight, a natural component of the articular cartilage. Glucosamine activates the synthesis of proteoglycans of synovial fluid by cells of the cartilaginous tissue (hyaluronic acid and glucosaminoglycans), inhibits enzymes that cause the destruction of cartilage tissue (phospholipase A2, collagenase, etc.), inhibits the formation of superoxide radicals, reduces the activity of lysosome enzymes.

Due to the action of glucosamine, the drug initiates the processes of sulfur fixation in the formation of chondroitinsulfuric acid and has a positive effect on the processes of normal calcium deposition in bone tissue, and also prevents the formation of glycosaminoglycans that cause non-steroidal PVA to break, and protects the chondrocytes from the damaging effects of corticosteroids. In the formation of glycosaminoglycans and in the course of normal metabolic processes, sulfo groups participate, and sulfoesters in side chains in the composition of proteoglycans, participate in the preservation of the elasticity of the cartilaginous tissue, contributing to the retention of water in it.

Dona, replenishing the endogenous deficiency of glucosamine, increases the permeability of the joint capsule and promotes restoration of normal enzymatic processes in cells of articular cartilage and synovial membrane

Indications for use

What helps? The main indications for prescribing the drug are the following:

1. Primary and secondary osteoarthritis;
2. Shoulder-humeral periarteritis;
3. Chondromalation of patella;
4. Osteoarthritis of the intervertebral space;
5. Treatment of osteortrosis of different localization (hip, spondylarthrosis, osteochondrosis, knee arthrosis, wrist and others).

Contraindications

Drug preparation in the form of injections can not be administered in the following situations:

1. Complex functional changes in the kidneys and liver;
2. Epileptiform cramps;
3. Children up to 12 years;
4. Acute congestive heart failure and changes in cardiac conduction;
5. Pregnancy and lactation;
6. High sensitivity to lidocaine and glucosamine.

Care must be taken when using this medication if the patient has an allergic reaction to mollusks, shrimps.

Application in pregnancy and lactation

Due to the lack of sufficient data on the efficacy and safety of the use of the drug in pregnant and lactating women, taking the medication in this period is contraindicated.

The medication should be discontinued in women who have fertility problems and undergo a special examination.

Instructions for use

The instructions for use indicate that the Don solution for intramuscular injection is used as follows: the ampoule of the preparation in one syringe is mixed with the ampoule of the solvent. Enter deep intramuscularly three times a week for 1-1.5 months.

To increase the effectiveness of treatment, it is advisable to combine the parenteral administration of Don with oral administration of the drug.

Pills:

• Take at the same time with a meal of 1 or 2 pieces three times a day.

Powder:

• Take in before meals in 30 minutes, first dissolving 1 packet in a glass of water once a day for 1-3 months. The second course is 2 months later.

Side effects

As a rule, Dona is well tolerated.

In some cases during the therapy can develop flatulence, gastralgia, diarrhea, nausea, constipation, drowsiness, headache, allergic reactions (in the form of erythema, urticaria and itching).

When applying Dona in the form of a solution for injection, because of the lidocaine included in its composition, it is possible to develop nausea, vomiting, drowsiness, diplopia, dizziness, headache, numbness of the oral mucosa and tongue, tremor, disorientation, euphoria, cardiac conduction disorders.

Overdose

Cases of overdose are unknown. However, if an overdose occurs, treatment should be symptomatic, aimed at restoring the water-electrolyte balance.

special instructions

When using Dona in patients with severe renal and hepatic insufficiency, as well as impaired glucose tolerance, medical supervision is necessary.

With caution should take the drug for diabetes and bronchial asthma.

Drug Interactions

The drug enhances the effect of adrenoblockers, glucocorticosteroids, MAO inhibitors, hypnotics and sedatives, coumarin anticoagulants.

Reduces - Chloramphenicol, semi-synthetic penicillins.

Reviews

We picked up some people's comments about the drug Don:

1. Tamara. To me of 60 years, last years five I am excruciated with an arthrosis, pains in knees. The doctor prescribed injections of Don, a course twice a year. The pains have decreased, now I can at least rise to the 4th floor without help
2. Anna. Delivered 11 injections while and drank 20 powders, there are still 7 injections. I want to be treated for two or three months, I have coke-arthrosis 2st. While I can not say anything about the result, probably a little time has passed.
3. Irina. Very good drug, came to him by trial and error. Prior to that, I took other chondroprotectors, but did not notice a special effect. C bottom is different, I really forget about the fact that I have painful joints. I have been taking courses for 4 years as needed (approximately 2 times a year).
4. Natalia. I finish the third pack of injections and drink the second pack of powder, the only shift is pain with TBS, but my knees terribly hurt, perhaps from them, perhaps in itself another disease. But I want to drink powder for another three months, because the terrible severity in the joints and stiffness. At me koksartroz 2st.

Analogues

Analogues of the drug Don in injections for pharmacological properties are: Yunium, Elbona, Chondroxide Maximum, Pharmaskin TGK, Sustilac, Glucosamine Sodium Chloride Sulfate, Glucosamine Sulphate 750, Glucosamine Hydrochloride, Glucosamine, Aminoarthrin.

Before using analogues, consult your doctor.

Storage conditions and shelf life

According to the instruction, Don should be stored at a temperature of no more than 25 ° C in a place inaccessible to children. Shelf life of the solution for the / m introduction of 2 years, tablets and powder - 3 years.

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