Tempalgin

Tempalgin (metamizole sodium + tempidone) is a combined non-narcotic analgesic drug.

Used for pain syndrome of various etiologies, as well as for elevated body temperature. Effective for headaches. Given the diversity of pathogenetic mechanisms of development of headaches, when they are stopped, a wide arsenal of medicinal products drugs, including narcotic drugs, NSAIDs, psychotropic drugs, drugs that improve the blood supply of nervous tissue.

The duration of continuous daily intake of the drug is limited to five days. If you need to increase the duration of the medication course, you should consult a doctor.

Clinical and pharmacological group

An analgesic-antipyretics of a combined composition.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does Tempalgin cost in pharmacies? The average price is at the level of120 rubles.

Composition and form of release

Tempalgin is available in the form of coated tablets: biconvex, round, green (10 pieces in blisters, in a cardboard bundle of 2 or 10 blisters).

Composition of 1 tablet:

• active ingredients: metamizole sodium - 500 mg and tempidone (triacetonamine 4-toluenesulfonate) - 20 mg;

• auxiliary components: MCC (microcrystalline cellulose), crospovidone (povidone K25), talc, wheat starch, magnesium stearate;
• film shell: Opadry II green 85 F 21526 (talc, macrogol 3350, partially hydrolyzed polyvinyl alcohol, quinoline yellow (E104) aluminum varnish, brilliant blue (E133) FCF aluminum varnish, titanium dioxide (E171).

pharmachologic effect

Tempalgin tablets belong to the clinical and pharmacological group of medicinal combined agents with pronounced analgesic and anti-inflammatory effect. Active components of the drug - metamizole and tempidone in the complex allow you to quickly cope with the pain syndrome, reduce the elevated body temperature, eliminate inflammation.

The mechanism of action of the drug is due to its composition. Metamizone refers to analgesics, suppresses the synthesis of prostaglandins, which take part in the inflammatory reaction. Also, this agent inhibits the formation of pyrogens, normalizes the cell membranes. Tampidone in the tablets affects the central cholinergic receptors, relieves tension, a sense of fear, negative emotions. The presence of this component in the drug enhances the action of the analgesic, thereby providing a high effect after taking the drug.

After taking the Tempalgin pill, the active ingredients are quickly absorbed by the gastrointestinal tract, penetrate into the blood flow, are evenly distributed in the tissues, affecting the inflammatory process and pain syndrome. The drug is metabolized in the liver, excreted in the urine.

Indications for use

Reception of tablets Tempalgin is indicated in pathological conditions in which it is necessary to achieve the therapeutic effects of these medicines:

1. Pain syndrome in patients with increased excitability of the nervous system (migraine, pain during menstruation, dental pain, headache, neuritis, neuralgia, joint and muscle pain, pain with injuries, wounds, burns, etc.);
2. Renal, hepatic or intestinal colic (in combination with antispasmodics);
3. Anesthesia before dental manipulation;
4. Pain in the postoperative period;
5. Pain after invasive diagnostic procedures;
6. Increase in body temperature in viral and infectious-inflammatory diseases.

Contraindications

Absolute:

• children's age till 14 years;
• period of pregnancy;
• the period of breastfeeding;
• chronic heart failure;
• marked renal and / or liver failure;
• oppression of hemopoiesis (leukopenia, granulocytopenia, infectious or cytostatic neutropenia, agranulocytosis);
• aspirin bronchial asthma;
• low blood pressure (systolic pressure less than 100 mm Hg. item);
• deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• hypersensitivity to metamizole sodium, tempidone, auxiliary components of the drug or other derivatives of pyrazolone.

Relative (Tempalgin is used with caution):

• kidney diseases (glomerulonephritis, pyelonephritis, including in history);
• predisposition to arterial hypotension;
• moderate renal and / or hepatic insufficiency;
• bronchial asthma;
• prolonged abuse of alcohol.

Intended use for pregnancy and lactation

Tempalgin during pregnancy is prescribed with caution. During the I and III trimester the drug is contraindicated, because tranquilizing component (triacetomin), ingesting in its composition, can easily penetrate through the placental barrier into the blood and brain of the fetus. This substance can cause irreparable harm to the brain of the future baby.

It is not recommended to take Tempalgin and to treat the pain syndrome in nursing mothers.

Dosage and route of administration

As indicated in the instructions for use of the tablet, Tempalgin is taken orally, without chewing, with a sufficient amount of liquid, during or after a meal.

• Adults appoint 1 tablet. 1-3 times / day, with insufficient effectiveness, you can take another 1 tab. The maximum single dose is 2 tablets, the maximum daily intake is 6 tablets. Duration of reception - no more than 5 days.

An increase in the daily dose or an increase in the duration of treatment is possible only under the supervision of a physician.

Side effects

Adverse reactions of the body after taking the drug are extremely rare, but in single cases the following symptoms may appear:

• anemia;
• discomfort, abdominal pain;
• heart rhythm disorder;
• nausea, vomiting;
• a decrease in blood pressure;
• cyanosis of the skin.

The appearance of such a symptom is the reason for the withdrawal of the drug. Many doctors claim that the risk of side effects increases if, during the course of taking the medicine a person does not comply with the permissible dose or takes the pill if there is a history of contraindications.

Overdose

When an overdose sharply increases the likelihood of side effects. In addition, nausea and vomiting, ataxia and impaired consciousness, paralysis of the respiratory muscles and hemorrhagic syndrome may appear. As a treatment, gastric lavage, the use of laxatives and activated charcoal are used, symptomatic therapy is necessarily performed.

special instructions

Before you start using the drug, read the special instructions:

1. Do not drink alcohol while taking this medication.
2. The use of the drug in patients receiving cytotoxic drugs should be performed only under the supervision of a doctor.
3. With prolonged (more than 7 days) taking the drug, you need to monitor the blood picture and the functional state of the liver.
4. It is inadmissible to use Tempalgine to relieve acute pain in the abdomen (until finding out the cause).
5. Radiocontrast preparations, colloidal blood substitutes and penicillin should not be prescribed with metamizole sodium.
6. Against the background of the use of metamizole sodium, the development of agranulocytosis is possible, in connection with which, when an unclear genesis of temperature rise, chills, pain in the throat, difficulty swallowing, stomatitis, as well as in the development of the phenomena of vaginitis or proctitis, drug withdrawal is necessary.

In connection with the anxiolytic effect of the drug during the period of Tempalgina intake, one should refrain from practicing potentially Dangerous activities that require increased attention and speed of psychomotor reactions.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Tempalgin enhances the effects of ethanol.
2. Sedatives and tranquilizers increase the analgesic effect of the drug.
3. With simultaneous use of thiamazole and cytotoxic drugs increase the risk of developing leukopenia.
4. With the simultaneous use of metamizole sodium with cyclosporine, the concentration of the latter in the blood plasma decreases.
5. Simultaneous application of Tempalgine with chlorpromazine or other phenothiazine derivatives may lead to the development of severe hyperthermia.
6. With the simultaneous use of barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole sodium.
7. The simultaneous use of metamizole sodium with other non-opioid analgesics, tricyclic antidepressants, oral contraceptives, allopurinol can lead to a mutual enhancement of toxic effects.
8. Metamizole sodium, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, GCS and indomethacin, increases their effect.
9. Codeine, histamine H2-receptor blockers and propranolol slow the excretion of metamizole sodium and enhance its effect.

Reviews

We offer you to read reviews of people who used Tempalgin tablets:

1. Olga. I took Tempalgin uncontrollably, with headaches, with menstrual pains. Approximately 10-20 tablets per month. Eventually, I developed thrombocytopenia. The platelet count in the blood dropped to 30 at a rate of 150-450. On the body began to appear bruises. First they searched for the cause, handed over all sorts of blood tests for viruses (HIV, hepatitis), a complete examination of the body. In the end, you just need to eat less of any tablets. Although they helped well.
2. Svetlana. Tempalgin should not be used by those with an allergy to analgin. I trusted the pharmacist, who said that there was no analgin with the composition of the drug, although I doubted it. Has accepted and there was an allergy, as well as on analginum. Observed symptoms of allergy: severe itching from the palms, then all over the body, redness, temperature.
3. Elena. Quite the same budget, as for me, an anesthetic drug. And most importantly, very effective. I apply basically in the period of critical days - one tablet for 12 hours is quite enough. When severe spasms these days, then within an hour I can drink a few pills and everything passes. In this application, she did not notice any side effects. Another time the tooth was very sick. Saw tempalgin paired with potent drugs in order to less load on the body from these drugs. And she also did not notice any side effects from such an application, but she only received quick help.

Analogues

Structural analogs for the active substance:

• Tempaldol;
• Tempanal;
• Tempanginol;
• Tempimed;
• Metamizol sodium + Triazitonamin-4-toluenesulfonate.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Store the drug in a dry place, at a temperature of no higher than 25 ° C. Shelf life - 4 years.

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