Solution and tablets Dicinon: instructions for use

Dicycin is a hemostatic drug, a remedy for preventing and stopping bleeding.

The mechanism of action is due to the effect on the first stage of the hemostasis process (interaction between the endothelium and platelets). Suppresses the decomposition of mucopolysaccharides of the vascular wall (anti-hyaluronidase activity), and normalizes permeability in pathological processes. The medication acts haemostatically due to an increase in the rate of primary clot formation.

On this page you will find all information about Dicinon: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used tablets Dicinon. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Hemostatic drug. Activator of thromboplastin formation.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Dicinon cost? The average price in pharmacies is at the level of430 rubles.

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Form of issue and composition

The preparation is prepared in tablet form for 250 mg (in a package of 100 pieces) and in the form of a solution for injections in a dosage of 2 ml in an ampoule (50 or 10 per pack).

• The active substance is etamzilate, 250 mg per tablet and 2 ml ampoule.

Additional substances are:

• for injections: injection water, sodium metabisulphite, sodium hydrogen carbonate.
• for tablets: povidone, corn starch, citric acid, lactose, magnesium stearate.

Pharmacological effect

The active ingredient of Dicinone is ethazylate.

The drug has a homeostatic effect (stops or reduces bleeding), which is due to the ability of the drug to activate with the damage of small vessels formation of thromboplastin (formed at the initial stages of the process coagulation). The use of Dicinone allows to increase the formation of mucopolysaccharides (protect protein fibers from injury) large mass in the walls of capillaries, normalize the permeability of capillaries, increase their stability, improve microcirculation.

Dicycin does not have the ability to increase blood clotting and cause vasoconstriction, and also does not promote formation of thrombi. Dicinone begins to act 1-2 hours after oral administration and 5-15 minutes after the injection. The therapeutic effect of Dicinone is observed for 4-6 hours.

Indications for use

What helps? Dicinone is used to prevent and stop parenchymal and capillary bleeding in otolaryngology in surgical treatment (tonsillectomy, ie removal of tonsils, microsurgical operations on the ear, etc.).

Also, the use of the drug is indicated in such cases:

1. In operative gynecology;
2. With surgical interventions in ophthalmology (keratoplasty, removal of cataracts and treatment of glaucoma);
3. In dentistry with surgical interventions (removal of cysts, extraction (removal) of teeth);
4. In urgent surgery to stop intestinal and pulmonary hemorrhages, in neurology - with progressive ischemic stroke;
5. With hemorrhagic diathesis and diseases of the blood system.

Contraindications

• thromboembolism,
• acute porphyria,
• glucose-lactose deficiency,
• thrombosis,
• hypersensitivity of the patient to at least one of the components of the drug, as well as to sodium sulfite,
• hemoblastosis in children, including myeloblastic and lymphoblastic leukemia, osteosarcoma.

With caution, the drug is prescribed if the patient has previously suffered a thrombosis, as well as hemorrhages against the background of taking anticoagulants.

Application in pregnancy and lactation

The use of the drug in pregnancy is permissible only in cases when the benefit of its use for the mother exceeds the risk of possible complications for the fetus.

When Dicinon is appointed during lactation, breastfeeding should be temporarily stopped.

Instructions for use

The instructions for use indicate that Dicinone is available in the form of a solution for intravenous and intramuscular injections and in the form of tablets intended for oral administration. It is also possible for local application of Dicinone by applying a tampon impregnated with a solution to the wound. One ampoule and one tablet contain 250 mg of etamzilate.

Instructions for tablets:

1. The optimal daily intake for adults is 10-20 mg / kg body weight, divided into 3-4 doses. In most cases, a single dose is 250-500 mg 3-4 times / day. In exceptional cases, a single dose can be increased to 750 mg 3-4 times / day.
2. With a menorrhagia, 750-1000 mg / day is prescribed starting from the 5th day of the expected menstruation to 5 days of the next menstrual cycle.
3. In the postoperative period, the drug is prescribed in a single dose of 250-500 mg every 6 hours until the risk of bleeding disappears.
4. Children are prescribed in a daily dose of 10-15 mg / kg in 3-4 divided doses.

Solution for IM and / or injection:

1. The optimal daily dose for adults is 10-20 mg / kg, divided by 3-4 in / m or IV (slow) injection.
2. Adults during surgical interventions prophylactically injected in / in or / m 250-500 mg for 1 hour before the operation. During the operation, I / O injected 250-500 mg, the introduction of this dose can be repeated again. After the operation, 250-500 mg is administered every 6 hours until the risk of bleeding disappears.
3. For children, the daily dose is 10-15 mg / kg body weight, divided into 3-4 injections.
4. In neonatology: Dicinone is given in / m or IV (slowly) at a dose of 12.5 mg / kg (0.1 ml = 12.5 mg). Treatment should be started within the first 2 hours after birth.
5. If Dicinone is mixed with saline, it should be administered immediately.

Side effects

The use of dicinone in a number of cases can cause the following side effects: severity in the epigastric region (upper abdominal walls), heartburn, blood vessel face overflow, headache, dizziness, numbness of the legs, allergic reactions, lowering of the arterial pressure.

Overdose

No data available. Symptomatic treatment is recommended.

special instructions

1. Before starting treatment, other causes of bleeding should be ruled out.
2. When there is a color solution for the / m and / in the introduction, it can not be used.
3. The solution for intravenous and intravenous administration is intended only for use in hospitals and clinics.
4. Solution for IM and / or injection can be applied topically: a sterile swab or gauze pad impregnated with a solution and applied to the wound (eg, skin graft, tooth extraction).
5. One Dicinone tablet contains 60.5 mg of lactose (the maximum daily dose of lactose should not exceed 5 g). Do not prescribe the drug to patients with congenital glucose intolerance, lactase deficiency lapp (lactase deficiency in some nationalities of the North) or malabsorption syndrome glucose-galactose.

Drug Interactions

1. The drug can be combined with aminocaproic acid and menadione sodium bisulfite.
2. Dicinone is also incompatible with sodium bicarbonate solution for injection and sodium lactate solution.
3. As a solution, the drug is pharmaceutically incompatible (in one syringe) with other drugs.
4. Introduction at a dose of 10 mg / kg body weight 1 hour prior to the administration of dextrans prevents their antiaggregant effect. Introduction Dicycin after the administration of dextran does not have a hemostatic effect.

Reviews

We picked up some feedback from people about the Dicinon drug:

1. Misha. Dicycin solution was unknown to me until I went to the dentist to remove the tooth. I broke it under the root, so there was a lot of blood. The doctor stopped the bleeding with a solution of this medicine, and then carried out the necessary manipulations. I'm surprised that a simple "vodichka" saved me from a significant loss of blood.
2. Larissa. To me, this drug in due time helped to stop bleeding. While they were investigating the cause and origin of the breakthrough bleeding, dicinone was prescribed. Side effects during the admission and after I was not observed, bleeding for 6-7 days ceased, then ceased taking dicinone. So as an emergency medicine - he helped me a lot, I also know that it is used during pregnancy if necessary.
3. Anastasia. At the moment dicinone is a necessity for me. From an early age I suffer from heavy nosebleeds. Over the past seven years, this drug always lies in my medicine chest in the form of a solution. Often, I have to inject the drug myself, intramuscularly 2 or 4 ml (1-2 ampoules) to provide first aid. Dicycin acts quickly and effectively. Suitable for complex therapy with vikasol. When intramuscular introduction of painful sensations there. No adverse events were detected.
4. Natalia. The medicine Dicinon helped me with a lot of menstruation. They and so all life were plentiful, and after 40 have still amplified. Because of this, I started anemia, had a bad feeling, pressure jumped. The doctor prescribed a pill that I drank five days before the onset of menstruation and the first five days after. It helped - the menstrual cycle and volume were normalized.

Analogues

Analogues Dicinon according to the principle of action:

• Etamsylate;
• Mononayn;
• Octanein F;
• Octanate;
• Protamine sulfate;
• The Revolade.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep the medicine in a place protected from light and moisture (for tablets), inaccessible to children, where the temperature does not exceed 25 ºС. Shelf life and solution in ampoules, and tablets is 5 years.

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