Zinnat: instructions for use for children and adults

Zinnat is an antibiotic of the 2nd generation of a broad spectrum of action, which belongs to the group of cephalosporins.

A medicament is used to treat bacterial infections caused by microorganisms sensitive to the active substance of the preparation.

On this page you will find all information about Sinnat: complete instructions for use for this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Zinnat. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Cephalosporin II generation.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Zinnat? The average price in pharmacies is at the level of240 rubles.

Form of issue and composition

The drug is available in tablets and granules. Tablets in a film coat can contain from 125 to 500 mg of the active component - cefuroxime axetil. The drug is delivered in 5 or 10 pcs. in blisters, in a package of 1 or 2 blisters. Zinnat is sold in granules for the preparation of a suspension for oral administration in a 100 ml vial.

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Active ingredient: each tablet contains cefuroxime as an active ingredient in the form of cefuroxime axetil in a dose of 125 mg or 250 mg.
Other ingredients: microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, hydrogenated vegetable oil, silicon colloidal dioxide, methylhydroxypropylcellulose, propylene glycol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, dangerous white.

In appearance, granules of irregular shape in the form of grains, not larger than 3 mm. When diluted, a suspension with a fruity odor is obtained.

Pharmacological effect

Bacteriostatic (suppresses the reproduction of bacteria) and bactericidal (causes the death of bacteria), the properties of Zinnat are due to its ability to disrupt the synthesis of the cell wall of the microorganism.

The active substance of Zinnat is cefuroxime, which shows activity against most Gram-positive and Gram-negative aerobic bacteria. The absorption process from the gastrointestinal tract is significantly accelerated if the Zinnat antibiotic is taken simultaneously with food.

The maximum concentration of the drug in the blood can be observed after 2-3 hours after application of the drug. Zinnat is excreted by the kidneys unchanged.

Indications for use

What helps? Treatment of Zinnat is effective for infectious and inflammatory diseases caused by microorganisms that are sensitive to the drug:

urinary tract infection (pyelonephritis, cystitis, urethritis);
infections of the skin and soft tissues (furunculosis, pyoderma, impetigo);
gonorrhea, acute uncomplicated gonorrhea urethritis and cervicitis;
upper respiratory tract infections, ENT organs (sinusitis, tonsillitis, pharyngitis, otitis media);
infection of the lower respiratory tract (acute bacterial bronchitis and exacerbation of chronic bronchitis, pneumonia);
Lyme disease treatment at an early stage and prevention of late stages of the disease in adults and children over 12 years of age.

Cefuroxime is also available as a sodium salt (Zinacef preparation) for parenteral administration. In the framework of the stepwise therapy, the transition from the parenteral form to the oral form of cefuroxime is recommended.

Contraindications

According to the instructions, Zinnat is contraindicated in patients with an allergic reaction to the drugs of the penicillin group, with hypersensitivity to cephalosporin, bleeding and gastrointestinal diseases, as well as during pregnancy and lactation.

Also, the medicinal product is not prescribed for children under the age of three months.

Application in pregnancy and lactation

There is no data on the ongoing studies of the effect of the antibiotic on the fetus. Therefore, it is not desirable to use it during pregnancy, especially in the first trimester. In some cases, Zinnat may be prescribed to pregnant women, but only with greater benefit to the mother's health than a possible risk to the child.

Breastfeeding should be interrupted for the duration of therapy with Zinnat, as cefuroxime is excreted in breast milk.

Instructions for use

The instructions for use indicate that Zinnat should be taken during or immediately after meals. The course of treatment and dose is chosen by the attending physician individually in each case.

When treating severe infections of the lower respiratory tract or otitis media:

Adults 500 mg twice a day;
children 3-6 months 60-90 mg 2 times a day;
children 6 months - 2 years 90-180 mg 2 times a day;
children 2-12 years 180-250 mg 2 times a day.

In the treatment of lower respiratory tract infections of mild and moderate severity:

Adults 250 mg twice a day;
children 3-6 months 40-60 mg 2 times a day;
children 6 months - 2 years 60-120 mg 2 times a day;
children 2-12 years of age 125 mg twice a day.

With pyelonephritis:

Adults on 250 mg 2 times a day.

When treating uncomplicated gonorrhea:

Adults appoint 1 g once.

When treating infections of the genitourinary system:

Adults 125 mg twice a day.

The average course of treatment with the drug is 5-7 days.

Side effects

The instructions to Zinnat indicate that the agent can cause side effects from some body systems, namely:

Eosinophilia, hemolytic anemia, thrombocytopenia, neutropenia and leukopenia (hematopoiesis system).
Headache (central nervous system).
Nausea, diarrhea, vomiting, jaundice, a temporary increase in hepatic enzyme activity and pseudomembranous colitis (digestive system).

Also, Zinnat can cause allergic reactions - whey, skin rash, fever, hives, Stevens-Johnson syndrome, anaphylaxis, erythema multiforme and toxic epidermal necrolysis.

Overdose

Overdose of cephalosporins can cause an increase in the excitability of the brain with the development of seizures. The serum level of cefuroxime can be reduced by hemodialysis and peritoneal dialysis.

special instructions

During treatment it is recommended to periodically monitor the functioning of the kidneys.
5 ml of the suspension contains 0.5 XE, which should be considered when prescribing the drug with diabetes mellitus.
Tablets are not assigned to patients who have difficulty swallowing, since they can not be broken or chewed.
The drug with extreme caution is prescribed in the presence of an anamnesis of an allergic reaction to beta-lactam antibiotics.

Zinnat may cause dizziness and headache, so caution should be exercised when managing transport or other mechanisms, or completely abandon the work, which requires increased concentration and attention.

Drug Interactions

The administration of Zinnat does not affect the quantitative determination of creatinine by the alkaline-picrate method.
As a result of the ferrocyanide test, a false negative result is possible to determine the level of glucose in the blood and in the plasma is desirable to use hexokinase or glucose oxidase methods.
Zinnat can affect the state of the intestinal microflora, and this leads to a decrease in the reabsorption of estrogens. As a result, the effect of hormonal oral combined contraceptives decreases.
With simultaneous application with loop diuretics, tubular secretion, renal clearance, increased concentration of cefuroxime in plasma, as well as its half-life.
When taken simultaneously with diuretics and aminoglycosides, the likelihood of developing nephrotoxic effects increases.

Bioavailability of cefuroxime may decrease with simultaneous administration of drugs that reduce the acidity of gastric juice. Such drugs level out the effect of increasing the absorption of medication when taken after a meal.

Reviews

We picked up some feedback from people about Zinnat:

Nastya. Zinnat is an excellent new generation antibiotic. The child was 3.5 years old, the temperature was 39.3 every 6 hours, there was no coughing and sneezing, the pediatrician prescribed, immediately on the next day the improvement in the face of the child. I advise you not to be afraid of anything !!!!
Victoria. My son was sick heavily. It started with Orvi, ended with bronchitis with a very high continuous temperature. Assigned zinnat in the form of a syrup from granules. Tear is terrible. They switched to zinnat tablets and normally drank the course, recovered very quickly.
Oksana. My doctor prescribed the drug Zinnat to my children with ARVI. I read the reviews, bought granules for 400 rubles. Since this is an antibiotic, I bought Norbokakt for the normalization of the intestinal microflora. The instructions marked the course of treatment in 5 days, as the doctor prescribed us. At illness or disease the antibiotic has helped or assisted - illness has departed, but to take a great interest in a strong agent it is not necessary.

Analogues

If necessary, Zinnat can be replaced with another antibiotic with the same composition:

Aksetin;
Axosafe;
Antibioksim;
Acenoveis;
Zinatsef;
Zinoxymor;
Ketoceph;
Ksorim;
Proxim;
Super;
Cetil Lupine;
Cefroxime J;
Cefurabol;
Cefuroxime;
Cefuroxime sodium;
Cefuroxime sodium is sterile;
Cefuroxime axetil;
Cephus.

In some cases, it is required to replace the antibiotic with another that has a similar effect, but contains another active substance. Suprax can be used to treat similar diseases. However, there are other medicines:

Clacid is an antibiotic related to macrolides. The active substance is clarithromycin. According to the testimony he crosses with Zinnat. Children younger than 12 years are prescribed a drug at a rate of 7.5 mg per kilogram of body weight per day. In severe cases, the dose doubles. The reception takes place 2 times a day.
Sumamed is an antibiotic, the active substance in which is Azithromycin. The indications for use are the same as for Zinnat, but it can also be used to treat peptic ulcer. The drug is prescribed for children over 3 years for a single daily intake of 10 mg per kilogram of body weight.
Augmentin - contains 2 active substances: amoxicillin and clavulanic acid. It is prescribed to babies from 4 months of life. It is not resistant to beta-lactamases, therefore it is used to control microorganisms that do not produce these enzymes.

Before using analogues, consult your doctor.