Eye drops Indomethacin: when and how to apply

Indomethacin is a medicinal substance from the group of non-steroidal anti-inflammatory drugs (NSAIDs). Preparations with indomethacin have anti-inflammatory, analgesic and antipyretic effects. The medicine is available in the form of tablets, suppositories, eye drops, solutions in ampoules, ointments and gels for external use.In this article, we will consider the features of the use of eye drops Indomethacin.

Description of the preparation

The Latin name of the substance Indomethacinum (genus. Indomethacini)

Eye drops Indomethacin has anti-inflammatory and analgesic properties. They are used for the treatment and prevention of ocular inflammatory processes of various origins, for operations on cataracts, as well as for the prevention of postoperative complications.

Pharmacological action and group

Indomethacin is a non-steroidal anti-inflammatory solution that effectively removes inflammation and pain due to reducing the synthesis of prostaglandins, substances that affect the formation and maintenance of the inflammation focus and the development of painful sensations.

The main mechanism of the drug is the inhibition of the synthesis of prostaglandins, which play an important role in the pathogenesis of inflammation and pain.

The drug with a single instillation for several hours is determined in the anterior chamber of the eye. In the systemic bloodstream penetrates insignificantly.

Eye drops Indomethacin penetrate the anterior chamber of the eye. After a single instillation is determined in the moisture of the anterior chamber for several hours. Systemic absorption is low.

Indications and contraindications for use

In ophthalmology, eye drops of Indomethacin are used with the following indications:

• Inhibition of miosis during surgery for cataracts;
• Inflammatory process caused by surgery;
• Prevention and treatment of cystoid macular edema of the retina after surgical removal of cataracts;
• Treatment and prevention of inflammatory processes of the eyeball;
• Noninfectious conjunctivitis.

Contraindications

The drug Indomethacin is contraindicated:

• With an increase in individual sensitivity to the active substance of the drug or to any of the auxiliary ingredients that form part of this dosage form of the drug;
• Patients in whom acetylsalicylic acid or other non-steroidal anti-inflammatory drugs provoke the development of asthma attacks, the appearance of urticaria rash, acute rhinitis, etc.

With care Indomethacin should be used in the following pathologies:

• Epithelial herpetic keratitis (including in the anamnesis);
• Diseases that cause a clotting disorder (including hemophilia, lengthening bleeding time, a tendency to bleeding).

Application of the drug during pregnancy and lactation

Nonsteroid drugs, including Indomethacin, increase the number of cases of labored births, cause delay in the onset of labor and delivery, and a decrease in the number of surviving pups.

Currently, there are no accurate studies in pregnant women confirming the safety of this dosage form of this drug during pregnancy and breastfeeding.Indomethacin can be used in the first 5 months of pregnancy in the event that the intended benefit to the mother exceeds the possible risk to the fetus.Starting from the sixth month of pregnancy, the drug should not be used, as this can lead to impaired vascular function and kidney function in the fetus.

This drug penetrates into the mother's milk, so you should stop breastfeeding. breastfeeding during treatment with Indomethacin or to avoid its use during the breast feeding.

Indomethacin penetrates into breast milk, so you should stop breastfeeding for the duration of treatment or avoid the use of the drug during breastfeeding.

Restrictions on the use

In ophthalmology, eye drops are used only in the following cases:

• Epithelial herpetic keratitis;
• Pregnancy;
• Children's age (up to 14 years).

Indomethacin is not recommended for use:

• With increased sensitivity to the active ingredient;
• In case of gastric ulcer and duodenal ulcer in the phase of exacerbation;
• In patients with the "aspirin triad" (eosinophilic rhinitis, recurrent polyposis of the nose, hyperplastic sinusitis);
• With violations of the liver or kidney function, severe forms of chronic heart failure, arterial hypertension, pancreatitis.

Patients who use contact lenses should be extremely cautious and make instillations of the solution 5 minutes after removal of contact lenses.

In the presence of an infection or the threat of its development, concomitantly with Indomethacin, local antibacterial treatment is prescribed.

In the period of treatment with eye drops Indomethacin should be careful when driving vehicles and occupations other potentially hazardous activities requiring increased concentration and speed of psychomotor reactions.

Mode of application

Mode of dosing of eye drops Indomethacin: to inhibit the previous operation in the conjunctival sac Bury 1 drop in the affected eye 4 times for 2 hours (with an interval of 30 minutes) and 1 drop - 45 minutes before operation.For prophylaxis of cystic edema of the macula after the operation: 1 drop in the conjunctival sac 3-4 times a day for 1 month after the operation. Other indications: 1 drop 3-4 times a day for 1-4 weeks.

Avoid contact with medicinal solution on mucous membranes and open wounds.

Possible complications caused by the drug

The most common side effects are with the ophthalmic indomethacin:

• Nausea, vomiting, pain in the upper abdomen;
• Exacerbation of peptic ulcer;
• Gastrointestinal bleeding;
• Rectal bleeding;
• Toxic hepatitis;
• Constipation;
• Arterial hypertension;
• Heart rhythm disturbances.

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Very rarely occur the following violations:

• Hypoplasia of bone marrow;
• Aplastic anemia;
• Autoimmune hemolytic anemia;
• Agranulocytosis;
• Thrombocytopenia;
• Violation of the function of platelets;
• Fluid retention (edema);
• Hyperglycaemia;
• Pulmonary edema.

Indomethacin can cause serious complications in elderly patients, as well as in diseases of the liver, kidneys, digestive system in the past, arterial hypertension, heart failure, immediately after serious surgical interventions, with parkinsonism, epilepsy.

Before you start using eye drops Indomethacin, tell your doctor about other medications that you are taking.

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conclusions

Eye drops Indomethacin is a very effective drug used in ophthalmology as an anti-inflammatory and analgesic. The drug is a safe remedy if applied in accordance with the rules and recommendations specified in the instructions.

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