Orthophene

Orthofen is a medical device used for various diseases of the musculoskeletal system. In addition to anti-inflammatory and analgesic actions, it also has a small antipyretic effect.

Penetrates into the blood plasma and synovial fluid of the joints, where it exerts its effect. Diclofenac, included in its composition, today is the "gold standard" for the treatment of diseases and injuries of the musculoskeletal system.

This status of this medication is explained not only by its quick painkiller and anti-inflammatory effect, but also the results of studies proving its relative safety in comparison with other representatives of NSAIDs.

Used to treat rheumatoid and some types of reactive arthritis and other diseases of the osteoarticular system, as well as the consequences of injuries.

Clinical and pharmacological group

NSAID, a derivative of phenylacetic acid.

Conditions of leave from pharmacies

Tablets and ointment are sold without a doctor's prescription.

Price list

How much does Orthofen cost in pharmacies? The average price is at the level of50 rubles.

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Form of issue and composition

Orthofen is produced in several dosage forms, namely:

In tablets of 25 mg.
In the form of ointment or gel 2%, for external use.
In the form of an ampoule solution, for intramuscular injection.

The active ingredient of Orthophene is sodium diclofenac:

1 tablet: 0.025 g;
1 ml of solution: 0.025 g;
1 g of ointment: 0.02 g;
1 g of gel: 0.05 g.

Auxiliary components of the gel: propylene glycol, ethanol 95%, hyethellosis, purified water.

Pharmacological effect

Orthophene is indicated for the treatment of various diseases of the musculoskeletal system. The mechanism of action is built on the oppression of the production of substances that cause inflammation and pain. The advantage of the drug is that it acts at the cellular level, suppressing the synthesis of the enzyme (COX-1), responsible for the production of inflammatory mediators.

As with osteochondrosis, and with many degenerative diseases of the joints, a powerful inflammatory process develops in connection with the destruction of the cartilaginous tissue, which leads to painful sensations. The use of Orthophene is indicated in such painful conditions, as it blocks the development of inflammation, thereby reducing pain.

Indications for use

on the accompanying instructions to Orthofen, the use of medication is indicated for symptomatic therapy of degenerative and inflammatory lesions of the musculoskeletal system:

Gout;
Osteoarthritis;
Arthritis - juvenile chronic, rheumatoid, psoriatic;
Osteoarthritis;
Ankylosing spondylitis;
Periarthropathy.

Orthofen is also recommended for reduction or relief of pain in the background:

Neuralgia;
Algodismenorea;
Toothache;
Radiculitis;
Ishialgia;
Myalgia;
Ossalgia;
Headaches (migraines);
Lumbago;
Tendovaginitov;
Arthralgia;
Proctitis;
Adnexitis;
Renal and biliary colic.

Assign Ortophen, according to the instructions, also to reduce the pain syndrome with: postoperative and post-traumatic lesions (dislocations, sprains, bruises); combined treatment of infectious diseases of the ENT organs: otitis, tonsillitis, pharyngitis; excessive physical exertion, which provoked pain in the muscles and joints.

In ophthalmic practice, medicament is used when:

Therapy of non-infectious conjunctivitis;
Cataract surgery to inhibit miosis;
Post-traumatic inflammation of the eyeballs.

And also for the prevention of cystoid macular edema during removal and implantation of the lens.

Contraindications

Orthofen is not used for "aspirin" asthma, with intolerance to diclofenac, with a variety of disorders of the blood coagulation system, with hematopoiesis, with the "aspirin" triad (recurrent polyposis of nose, paranasal sinuses is combined with bronchial asthma and intolerance to acetylsalicylic acid, medicines pyrazolone series), with pregnancy, erosive and ulcerative lesions in the digestive tract, with hemophilia, breastfeeding, anemia, leukopenia, a tendency to bleeding, lengthening of the bleeding period, children up to the age of 6 years.

With puffiness, alcoholism, renal and hepatic insufficiency, arterial hypertension, erosive-ulcerative lesions of the digestive system system, with a decompensated form of chronic heart failure, with anemia, bronchial asthma, diabetes, postoperative period, with acute induced hepatic porphyria and elderly patients Orthofen is administered with caution.

Use in pregnancy and lactation

Use in pregnancy and lactation is only possible if the intended benefit to the mother exceeds the potential risk to the fetus or child.

Dosage and route of administration

The instructions for use indicate that the exact doses of Orthophene are set individually.

In tablets, adults are usually prescribed 25-50 mg 2-3 times a day. The highest permissible daily dose is 150 mg. Take the pill should be on an empty stomach, swallowing whole, with enough water.
In the form of a solution, the drug is usually used to treat acute conditions and relieve the exacerbation of the chronic process - 75 mg in the form of a single intramuscular injection (deep into the gluteus muscle). Then the patient is transferred to Orthofen tablets.

Children dose determined depending on their weight - 2 mg per kilogram of body weight.

In the form of ointment and gel, the drug is applied to the affected area 2-4 g 3-4 times a day.

The duration of treatment in each case is determined individually for each patient, depending on the indications, the drug formulation used and the effectiveness of the therapy.

Side effects

The use of Orthophene can be accompanied by side effects that affect pratically all the systems of the body:

Kidneys: edema, proteinuria, renal failure, nephritis, medullary necrosis, etc.
Gastrointestinal tract: nausea, diarrhea, constipation, vomiting, erosive gastritis, peptic ulcer, melena and HCC, glossitis, pancreatitis, etc.
Liver and biliary tract: jaundice, liver failure, hepatitis, elevation of liver enzymes, etc.
Heart: chest pain, increased blood pressure, palpitation, heart attack, etc.
CNS: dizziness, sleep disturbances, ringing in the ears, blurred vision, headache, distortion of taste, memory impairment, acute violation of cerebral blood circulation.
Other side effects: asthma, anemia, depression, impotence, post-injection abscess.

The most common complications of treatment on the part of the digestive system (NSAIDs-gastropathy), however, that, according to doctors, most of the above side effects of Orthofen is extremely rare.

Ointment for external use 2%, gel for external use 5%

Rarely: burning, itching, rash, redness;
Perhaps: with prolonged use and / or application to large areas of the body - the emergence of systemic side effects against the background of the resorptive effect of diclofenac.

Overdose

Information on cases of overdose with the use of cream is not.

Tablet form: nonspecific symptoms of poisoning, like vomiting (and what it is dangerous for poisoning, read in article Vomiting with blood), gastric bleeding, diarrhea, dizziness, ringing in the ears, loss of consciousness and convulsions.

There is no specific antidote. The patient is prescribed symptomatic treatment, including enterosorbents reception, alkaline drink and means causing forced diuresis (artificial urination stimulation). In parallel, correction of disorders from the gastrointestinal tract, as well as special measures to eliminate arterial hypertension, seizures and respiratory depression.

special instructions

Before you start using the drug, read the special instructions:

It is not recommended for use in children under the age of 6 years.
During the period of treatment with dosage forms for systemic use, alcohol consumption is not recommended.
With special care apply for diseases of the liver, kidneys, gastrointestinal tract in anamnesis, dyspeptic phenomena, bronchial asthma, arterial hypertension, heart failure, immediately after major surgical interventions, as well as in elderly patients.
Rectal use in patients with anorectal disease or anorectal hemorrhage in the anamnesis is not recommended. Outer should be used only on intact skin areas.
With the history of allergic reactions to NSAIDs and sulfites, diclofenac is used only in urgent cases. In the process of treatment, systematic monitoring of liver and kidney function, and peripheral blood patterns are necessary.
Avoid contact with diclofenac in the eyes (with the exception of eye drops) or mucous membranes. Patients using contact lenses should use eye drops no earlier than 5 minutes after removing the lenses.

During the treatment period, the speed of psychomotor reactions may decrease. If vision deteriorates after application of eye drops, do not drive and engage in other potentially hazardous activities.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

Antibacterial agents of quinolone derivatives - there are separate reports on the development of seizures in patients who received concurrently derivatives of quinolone and diclofacac.
NSAIDs and GCS - with simultaneous systemic use of diclofenac and other systemic NSAIDs or GCS may increase the incidence of adverse events (in particular, the gastrointestinal tract).
Anticoagulants and antiaggregants - it is impossible to exclude an increased risk of bleeding with the simultaneous use of diclofenac and with the drugs of these groups.
Selective serotonin reuptake inhibitors may increase the risk of developing gastrointestinal bleeding.
Hypoglycemic drugs - can not exclude the cases of both hypoglycemia and hyperglycemia, which necessitated a change in the dose of hypoglycemic drugs against diclofenac.
Powerful inhibitors of CYP2C9 - with the co-administration of diclofenac and potent inhibitors of CYP2C9 (such as voriconazole), an increase concentration of diclofenac in the blood serum and strengthening of systemic action caused by inhibition of diclofenac metabolism.
Lithium, digoxin - it is possible to increase the concentration of lithium and digoxin in plasma curvature. It is recommended to monitor the concentration of lithium, digoxin in the blood serum.
Diuretic and antihypertensive agents - with simultaneous use with diuretics and antihypertensive drugs (eg, beta-adrenoblocker, ACE inhibitors), diclofenac may reduce their hypotensive effect.
Ciclosporin - the effect of diclofenac on the activity of prostaglandins in the kidneys can enhance the nephrotoxicity of cyclosporine.
Drugs that can cause hyperkalemia are a joint use of diclofenac with potassium-sparing diuretics, cyclosporine, tacrolimus and trimethoprim can lead to an increase in the level of potassium in the blood plasma (in the case of such a combination, this indicator should often be monitored).
Methotrexate - with diclofenac for 24 hours before or within 24 hours after taking methotrexate, it is possible to increase the concentration of methotrexate in the blood and increase its toxic effect.
Phenytoin - it is possible to increase the effect of phenytoin.

Reviews

We picked up some reviews of people who used the drug Orthofen:

Vera. I was helped, the second day I drink and strong pains in my knee died down. In the morning and in the evening 2 tablets. Only take after meals so that the stomach does not hurt.
Victor. At me from it pobochka has arisen, the stomach has strongly hurt or be ill; be sick, the stomach twisted. but Orthophen pain really removed. But one thing ceased to hurt, the beginning of another ((
Alina. My husband has very strong and often aching joints. He used to smear ointments with various ointments: both expensive and cheap. Everything gave a temporary effect. And once in a drugstore he was offered orthotic pain in joints. The medicine immediately helped. Of course it's obezbalivayuschee. We were told that you need to drink a course - 3 weeks, then take a break and take it only with pain. With severe pain after a couple of months, the course of taking the drug should be repeated. For three weeks of taking the medicine, the pains went away and then appeared less often. I also want to note that the price for orthophene is quite low, which makes it affordable for everyone.
Lydia. A good drug. Quickly relieves pain in joints. But pobochka... Not only that the stomach or belly hurted or was ill; was sick constantly while accepted, so also the gastroenterologist has forbidden to accept it or him when has addressed in occasion of an indigestion in a stomach. He said that there is erosion and such a plan preparations with diclofenac are banned. I had to put Orthophen aside and learn to live with pain in my lap. And I live 🙁

Analogues

On the pharmaceutical market of our state there is a huge choice of analogues of Orthofen (list):

Diklak,
Voltaren,
Dicloran,
Diklogen,
Sanfinak,
Diclomax,
Diclofenac,
Naklofen,
Orthofer,
Feloran,
Dicluberl,
Revmavek.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store in a dry place, protected from light, out of reach of children, at a temperature of 15-25 ° C. Shelf life 3 years. After the expiration date the preparation is not suitable for use.