Lidevin - a drug for the treatment of alcohol dependence

Lidevin is a drug designed to combat alcohol dependence, is used to treat and prevent relapses.

The drug has undergone numerous tests in drug treatment clinics and is recognized as safe for the human body of the drug.

Thanks to its action, aversion to alcohol is developed, which is a physiological barrier to the constant use of alcohol-containing beverages.

Clinical and pharmacological group

It is intended for the treatment of alcohol dependence.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Lidevin? The average price in pharmacies is at the level of1 300 rubles.

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Form of issue and composition

Medicinal form of Lidevin - tablets: round, flat-cylindrical, with a facet, white with a creamy shade (there may be inclusions), with a cross-shaped risk on one side (10 pcs. in a blister, 2 blisters in a cardboard bundle).

Active ingredients in 1 tablet:

• Disulfiram - 500 mg;
• Adenine (vitamin B4) mg;
• Nichirinamide (vitamin B3) mg.

Auxiliary components: microcrystalline cellulose, magnesium stearate, povidone and sodium carboxymethyl cellulose.

Pharmacological effect

Disulfiram when ingested begins its action: complete or partial blocking of acetaldehyde genase. As a result, the concentration of acetaldehyde rises.

Such processes in the body give the following result: a person feels nausea, malaise, blood rushes to the face, tachycardia develops, the osmotic pressure in the blood increases. Such feelings will haunt a person every time he drinks alcohol while taking a course of treatment.

The duration of Lidevin does not exceed 48 hours. That is, at this time after taking Lidevin tablets a person has a forced refusal of alcohol.

Indications for use

The main indication for the use of the tablet preparation Lidevin is the treatment and prevention of chronic alcoholism and subsequent relapses.

To determine whether a given medication should be taken to a patient, only a qualified narcologist doctor can. Independently use the drug in Lidevin tablets without consulting a doctor is strictly prohibited.

Contraindications

Absolute:

• Kidney disease;
• Neuritis of the auditory and optic nerve;
• Stomach ulcer in the phase of exacerbation;
• Violations of hematopoiesis;
• Glaucoma;
• Pulmonary tuberculosis;
• Emphysema of the lungs;
• Bronchial asthma;
• Diabetes;
• Malignant neoplasms;
• Thyrotoxicosis;
• Mental diseases;
• Pregnancy;
• Polyneuritis of various etiologies;
• Diseases of the cardiovascular system (in the stage of decompensation);
• Epilepsy and convulsive syndrome of any genesis;
• Severe hepatic impairment;
• Hypersensitivity to the components of the drug.

Relative:

• Stomach ulcer and duodenal ulcer in remission phase;
• Disulfiram (antabuse) psychoses in the anamnesis;
• Residual effects after cerebrovascular accident;
• Diseases of the cardiovascular system (in the compensation stage);
• The elderly are over 60 years of age.

With caution, Lidevin should be administered to patients with hypothyroidism, especially at the risk of a possible combination with alcohol.

Dosage and route of administration

The instructions for use indicate: Lidevin is appointed after a thorough examination of the patient and warning of the consequences and complications of therapy.

The dose of the drug is set at the rate of disulfiram and taken internally at 125-500 mg 2 times / day according to the individual scheme. After 7-10 days of therapy, a disulfiramalcoholic sample is taken (20-30 ml of 40% vodka after administration of 500 mg drug), with a weak reaction, the dose of alcohol is increased by 10-20 ml (the maximum dose is 100-120 ml). The sample is repeated after 1-2 days in the hospital and 3-5 days after an outpatient treatment, if necessary - with the correction of the doses of alcohol and / or the drug.

In the future, a maintenance dose of 125-200 mg / day can be used for 1-3 years.

Side effects

Manifestations that are associated with exposure to disulfiram are expressed in polyneuropathy of the lower extremities, metallic taste in the mouth, deterioration memory, asthenia, headaches, unpleasant odor in patients with a colostomy, optic neuritis, confusion, allergies to the skin, hepatitis.

Symptomatism, provoked by the mutual effect of ethyl alcohol with disulfiram: disorders of the neurological type, arrhythmia, risk of myocardial infarction, angina pectoris, insufficiency of the respiratory process, edema of the GM, cardiovascular collapse.

The symptomatology developing with long courses: psychosis, the probability of thrombosis in the GM, gastritis, exacerbation of polyneuritis, hepatitis.

Severe disorders of respiratory and cardiovascular functionality, convulsions, edema are possible with the intake of 40% alcohol in an amount of more than 50 - 80 ml. Urgently perform detoxification treatment, inject analeptics and conduct other therapy.

Overdose

According to doctors, there was no drug overdose for today. When taking Lidevin with alcohol in the amount of 50-80 ml in terms of 40% vodka, it is possible to seriously develop various disorders of the heart and vessels, breathing, swelling, seizures.

To eliminate symptoms of an overdose of Lidevin, analeptics are administered, detoxification, symptomatic treatment.

special instructions

It is necessary to warn patients about the possible consequences of concurrent use of alcohol or taking medications containing ethanol.

Drug Interactions

Combinations requiring caution:

1. Lidevin slows down the biotransformation of theophylline, therefore, with simultaneous use, a dose reduction of theophylline is required depending on the clinical symptoms and its concentration in the blood plasma.
2. With the simultaneous use of Lidevin and warfarin (or other oral anticoagulants) is increased risk of bleeding due to increased warfarin action (slowing biotransformation of the latter).
3. With the simultaneous use of Lidevin and tricyclic antidepressants, it is possible to intensify the reactions of alcohol intolerance, especially if patients take alcohol while taking Lidevin.
4. With the simultaneous use of Lidevin potentiates the sedative effect of benzodiazepines by inhibiting the oxidative pathway of metabolism of the latter, especially chlordiazepoxide and diazepam. The dose of benzodiazepine should be adjusted in accordance with clinical manifestations.

Unwanted combinations:

1. With simultaneous application of Lidevin and isoniazid, there may be a violation of behavior and coordination.
2. With the simultaneous application of phenytoin, the development of toxic effects of phenytoin (due to a slowing of its metabolism and an increase in the concentration in the blood plasma) is possible.
3. With simultaneous use with drugs from the group of derivatives of nitro-5-imidazole (metronidazole, ornidazole, seksnidazol, tinidazol), it is possible to develop delirious disorders, confusion.

With the simultaneous reception with alcohol, the reaction of intolerance develops (hot flushes, erythema, vomiting, tachycardia). Avoid taking drinks and medicines containing ethanol.

Reviews

We picked up some reviews of people taking the drug Lidevin:

1. George. Last year, I suffered a lot of stress because of the death of my parents, so I began to apply to the bottle. I could not stop, so I asked for help from the narcologist. He put me in the hospital and prescribed Lidevin tablets. I drank them neatly, because, according to reviews, they have a lot of risks, but I was carried away. For half a year I have not been drinking, and I'm not drawn to the bottle, I'm very happy.
2. Pauline. My elder brother is always drinking, he already has chronic alcoholism, the breakdowns are permanent, the binges continue all the time. I tried to give him Lidevin tablets, but they did not help him, only aggravated the state of the heart system. I'll have to code it, otherwise it will turn my life and my life into a real nightmare.
3. Lilya. There was a period in my life when I had to turn to a narcologist. After the beginning of treatment, the doctor told me about Lidevin and suggested that he try it, they say, this will enhance the effect of treatment. He explained that the drug is not at all harmless. But I still agreed. However before reception of a preparation I have passed or have taken place inspection, and it was found out, that at me two contraindications to reception. Unfortunately, we had to do without Lidevin, only on the strength of will. But I did it!!! And to you I wish the same!

Reviews of Lidevin as doctors and patients are currently ambiguous. Among them there are both positive and negative, but the first is still greater. The drug is quite effective against alcoholism, but many patients are afraid of contraindications and side effects.

Analogues

There are a lot of different medicines:

• Antabus;
• Disulfiram;
• Teturam;
• Esperal.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The medication is dispensed in prescription pharmacies, it should be stored in a place inaccessible to children, with an air temperature of not more than 25 ° C, the shelf life is 3 years.

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