Tolmoreyson

Tolperisone is a muscle relaxant of the central mechanism of action.

Has a membrane-stabilizing effect, inhibits the conduction of nerve impulses in primary afferent fibers and motor neurons, which leads to blocking of spinal mono- and polysynaptic reflexes. The drug is used for the complex treatment of diseases accompanied by muscle spasms, limb contracture and skeletal muscle hypertonicity.

After ingestion, tablets are rapidly absorbed in the small intestine, reaching a maximum concentration after 30-60 minutes.

Clinical and pharmacological group

Miorelaxant of central action.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Tolperisone cost in pharmacies? The average price is at the level of240 rubles.

Composition and form of release

Tolperisone is released only in the oral dosage form in two dosages: 50 mg and 150 mg. Tablets have a round shape and white color, when the package is opened, a characteristic smell is felt.

As an active ingredient in production, it is used tolperisone hydrochloride - muscle relaxant, whose mechanism of action has not been fully studied at the moment.

pharmachologic effect

Tolperisone-OBL is a drug of muscle relaxant action. It exhibits oppressive selective activity in relation to the caudal section of the reticular formation of the brain, has holinoblocking effects of central action.

It does not affect the peripheral nervous system, has a mild vasodilating and spasmolytic effect.

When taken orally, the absorption of the drug, due to the coating of tablets, occurs in the small intestine. The drug has 17-20% bioavailability.

TCmax in the blood is detected after a passage of 30-60 minutes. Metabolism occurs in the kidneys and liver. T1 / 2 for about 150 minutes. In the form of metabolites, almost the entire drug is excreted in the urine (99%).

Indications for use

Indications for use of the drug are due to the Tolperisone's affiliation to the group of central muscle relaxants. Conditions that serve as an excuse for medication use:

1. The course of restorative therapy after traumatology and orthopedic operations.
2. Children's cerebral palsy (Little's disease) and other encephalopathies with simultaneous muscular dystonia.
3. Therapy of muscle spasms and increased tone, muscle contractures that occur against the background of locomotor disorders apparatus (arthrosis of large joints, arteries, spondylosis lumbar and cervical syndromes of spondylarthrosis).
4. As part of the combined treatment of obliterating vascular pathologies (Raynaud's disease, obliterating atherosclerosis, obliterating thromboangiitis, diabetic angiopathy).
5. Therapy of constantly increased muscle tone and spasmodic attacks of the striated muscles, resulting from diseases of the central nervous system (multiple sclerosis, myelopathy, stroke, encephalomyelitis, defeat of pyramidal pathways).
6. Pathologies resulting from a disorder of vascular innervation (intermittent angioedema dysbasia, atherosclerotic acrocyanosis).

Contraindications

Tablets of the drug have some contraindications, so it is important to study the instructions before starting therapy. Contraindications to the use of the drug are:

• age in children under 3 years;
• individual intolerance to the components of the drug;
• myasthenia gravis.

Intended use for pregnancy and lactation

During the period of breastfeeding and pregnancy, the drug should not be taken.

Dosage and route of administration

As indicated in the instructions for use of the tablet, Tolperisone should be taken orally after meals: swallow whole, not breaking and chewing, and drink plenty of water. When taking the drug on an empty stomach, its bioavailability decreases.

The initial dose is 50 mg 3 times a day, then it is gradually increased to 150 mg, saving three meals a day.

Side effects

Against the background of taking the drug in patients with increased individual sensitivity, the following side effects may develop:

• from the side of the nervous system - headaches, weakness, dizziness;
• from the side of the cardiovascular system - lower blood pressure, dyspnea, arrhythmia;
• allergic reactions - urticaria, skin itching, hyperemia, bronchospasm, development of angioedema, anaphylactic shock;
• on the part of the organs of the digestive canal - the appearance of an unpleasant aftertaste in the mouth, nausea, vomiting, stomach pain, stool, bloating and increased gas production.

As a rule, these side effects are poorly expressed and immediately go away after reducing the dose of the drug. If one or more side effects occur, the patient should consult a doctor.

Overdose

Cases of overdose Tolperizonone were fixed rarely. The main symptom of pathology in patients was oppression of the respiratory function against the background of disorders in the work of the heart: lowering blood pressure, arrhythmia, rapid pulse.

The drug does not have a specific antidote, so the patient should be assisted in a hospital. Before the arrival of an ambulance, it is allowed to wash the stomach with a warm saline solution followed by sorbents (Smecta, Neosmectin, Enterosgel).

special instructions

Before you start using the drug, read the special instructions:

1. Women who have a history of indicating allergies or hypersensitivity reactions to other medicines are at higher risk.
2. Increased caution should be observed in the case of a known hypersensitivity to lidocaine, since it is possible to develop cross reactions.
3. Frequent side effects of the drug are hypersensitivity reactions, which can manifest from light skin to severe systemic, including anaphylactic shock. Symptoms of an allergic reaction are rash, redness, itching, urticaria, Quincke's edema, shortness of breath, arterial hypotension, tachycardia.
4. It is necessary to warn patients that they are attentive to the occurrence of any possible symptoms of hypersensitivity. If they develop, immediately discontinue the drug and consult a doctor. After a hypersensitivity episode, the repeated administration of tolperisone is prohibited.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Bioavailability of tolperisone decreases with fasting.
2. With the simultaneous use of other central muscle relaxants, the dose of tolperisone should be reduced.
3. Tolperisone enhances the effects of non-steroidal anti-inflammatory drugs, niflumic acid, therefore, for their combined use, dose adjustment may be required.
4. Tolmirezon with simultaneous application can increase the blood levels of drugs that are metabolized primarily with the participation of isoenzyme CYP2D6, such as desipramine, venlafaxine, metoprolol, tolterodine, perphenazine, dextromethorphan, thioridazine, nebivolol, atomoxetine.
5. Significant induction or inhibition of other CYP isoenzymes (CYP1A2, CYP2C9, CYP2C8, CYP2C19, CYP2B6, CYP3A4) was not detected in laboratory experiments.
6. With the combined use of CYP2D6 isoenzyme substrates and / or other drugs, an increase in tolperisone exposure is not expected.

Reviews

We offer you to familiarize yourself with the opinions of people who used the drug Tolperisone:

1. Paul. Peel Tolizor a month ago. Was pleasantly surprised how quickly he coped with the pain and spasms in the lower back. An excellent product and the price is acceptable.
2. George. I was prescribed this drug as a result of constant acrocyanosis, which developed due to heart problems. I took the pill according to how the doctor prescribed. Gradually I could forget about acrocyanosis. Plus, the doctor noted improvement in the state of the vessels that I have under the eye of diabetes.
3. Alexander. In my youth, I was very keen on that bodybuilding. I was constantly chasing the buildup of muscle mass and the constant increase in weights in the gym. As a result, some time ago, I began to suffer from muscle spasms. After the course of Tolperizon, spasms passed. However, when taking pills all the time I wanted to drink water.

Analogues

Analogues of the drug are represented by the following drugs:

• Midokalm;
• Baclosan;
• Sirdalud;
• Liorasel;
• Tizanil;
• Tisaloud;
• Tizanidine;
• Tolperisone.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Keep tablets Tolperisone in a place inaccessible to children, at a temperature of no higher than 25 degrees. The shelf life of the tablets is indicated on the packaging and is 3 years from the date of manufacture. Do not use the drug at the end of the expiration date.

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