Tranexam with bleeding: Instructions for use

Traneksam is a medicinal product used to stop and prevent bleeding of various etiologies.

The drug has a local and general hemostatic effect in bleeding associated with increased fibrinolysis (platelet pathology, menorrhagia). Additionally, tranexamic acid in Tranexam is characterized by effective antiallergic, anti-inflammatory, anti-infective and antitumor actions based on the inhibition of active peptides taking part in inflammatory and allergic reactions.

Produced in the form of tablets and a solution for injections (injections), the main active substance is tranexamic acid.

Clinical and pharmacological group

Tablets have antifibrinolytic, hemostatic, anti-allergic and anti-inflammatory effects.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Tranex in pharmacies cost? The average price is at the level of270 rubles.

Composition and form of release

Produced Traneksam in the form of tablets and a solution for the introduction of a vein. Tablets with an active component content of 250 and 500 mg are packaged in contour cells of 10 pieces, 1, 2, 3, 5 cells per package.

• Each tablet contains 250 mg or 500 mg of active ingredient Tranexamic acid, and a number of auxiliary components are also included in the preparation.

pharmachologic effect

Tranexam is an inhibitor of fibrinolysis, a hemostatic drug. This agent inhibits the conversion of plasminogen to plasmin.

Tranexamic acid with bleeding due to fibrinolysis shows systemic and local hemostatic effect. In addition, it has antiallergic, anti-inflammatory, antitumor and anti-infective effects, which are based on suppression of the formation of active peptides, which take part in inflammatory and allergic reactions.

The potentiating effect of tranexamic acid on the analgesic activity of opiates and its own analgesic activity is confirmed experimentally.

When ingestion absorbs up to 50% of the drug, the maximum concentration is achieved after three hours. It binds to plasma proteins, penetrates through the placental barriers, is excreted in breast milk at a concentration of 1%. Valid for 17 hours in tissues, 7-8 hours in plasma. If there is a violation of the kidneys, there is a risk of accumulation of the active substance. With intravenous administration, the analgesic activity of the drug was confirmed.

Indications for use

The drug is administered to patients for the treatment or prevention of disorders of the circulatory system, namely:

• Bleeding or risk of their development with increasing generalized fibrinolysis: manual detachment, postpartum haemorrhage, malignant tumors of the prostate and pancreas, liver disease, surgical interventions on the thorax, leukemia.
• Bleeding or risk of their development with increased local fibrinolysis: hematuria, gastrointestinal, uterine (including von Willebrand disease and other coagulopathies) and nosebleeds, as well as bleeding after prostatectomy, conization of the cervix in carcinoma, tooth extraction in patients with hemorrhagic diathesis.

Tranexam in capsules is also used for such diseases:

• Bleeding during pregnancy;
• Allergic diseases (allergic dermatitis, eczema, urticaria, toxic and medicinal rash);
• Hereditary angioedema;
• Inflammatory diseases (aphthae of the oral mucosa, stomatitis, pharyngitis, tonsillitis, laryngitis).

A solution for intravenous administration is also used in the following cases:

• Operations on the bladder;
• Surgical interventions for systemic inflammatory reactions (pancreatic necrosis, sepsis, peritonitis, severe or moderate gestosis, shock of various etiologies and other critical conditions).

Traneksam with uterine bleeding

There are many cases where uterine bleeding caused iron deficiency, which is also a threat to human health and life. Therefore, in uterine bleeding, hemostatic tablets are prescribed, including Tranexam. Of course, without the doctor's appointment, this should not be done, since it is important to establish the causes of the violation, which can be very different.

Contraindications

Absolute:

• subarachnoid hemorrhage;
• hypersensitivity to the components of the drug.

Relative (Tranexam is used with caution):

• thrombosis (myocardial infarction, thromboembolic syndrome, deep vein thrombophlebitis);
• thrombohemorrhagic complications (in combination with indirect anticoagulants and heparin);
• kidney failure;
• hematuria from the upper parts of the urinary tract;
• violation of color vision.

Intended use for pregnancy and lactation

The drug Traneksam during pregnancy is prescribed to women according to the indications, only if the benefit to the mother exceeds the possible risks to the fetus. Treatment is prescribed at the lowest effective dose, while constantly monitoring the blood test.

During clinical trials, there was no teratogenic and embryotoxic effect of Tranexam on the fetus, but the drug easily penetrates the placental barrier.

The use of the drug during breastfeeding is not recommended. If necessary, lactation should be discontinued in order not to harm the child.

Dosage and route of administration

As indicated in the instructions for use Traneksam tablets are:

• With repeated nasal bleeding three times a day for 1.0 g for 7 days;
• With uterine bleeding, 1.0 g every six hours for three days;
• After extraction of the tooth in patients with hemorrhagic diathesis to prevent secondary bleeding, Tranexam in tablets is administered at a rate of 25 mg / kg 4 times a day for a week;
• For the treatment of hereditary angioedema, the drug is prescribed courses or continuously 1.0 g twice daily;
• In the postoperative period, 1.5 g three times a day for 10 to 14 days.

Traneksam for intravenous drip or jet infusion is usually used to stop massive bleeding, as well as bleeding that occurs during surgery. Before removal of the tooth, patients with impaired blood coagulability of the drug are also administered intravenously, and after extraction, Tranexam is given in tablets.

Side effects

Against the background of drug treatment in ampoules and tablets may appear:

• an allergy that is manifested by a rash, itchy skin and hives;
• thromboembolism and thrombosis;
• loss of appetite until anorexia, loose stools, heartburn, nausea and vomiting;
• vertigo, drowsiness, color perception disorder and color vision.

When prescribing the drug in ampoules, the following undesirable reactions can occur:

• increased heart rate;
• chest pains;
• pressure drop.

Overdose

Data on drug overdose are not provided.

special instructions

Before the start of Tranexam and during treatment, regular examinations of the ophthalmologist are recommended for the diagnosis of visual acuity, eye fundus, color perception.

During pregnancy, the drug is used with caution (contraindications are necessarily taken into account). When prescribing tranexamic acid to pregnant and lactating people, it must be taken into account that this substance is able to pass through the placental barrier and enter the breast milk.

Interaction with other drugs

With simultaneous application with hemocoagulase and haemostatic agents, thrombus formation can be activated.

Tranexam solution is pharmaceutically incompatible with urokinase, blood products, tetracyclines, diazepam, dipyridamole, hypertensive drugs (metformin bitartrate, deoxyepinephrine hydrochloride, norepinephrine) and solutions containing penicillin.

Reviews

We offer you to get acquainted with the opinions of women who used the drug Traneksam:

1. Marina. The bleeding started at the first menstruation after childbirth, could not stop either dicinone or vibrocil, and oxytocin also did not help. The doctor attributed to the tranecks a dose of 250 mg 2 tablets 2 times a day for four days. Has stopped for two receptions of a medicine, but in connection with hormonal infringements the bleeding has renewed. Now I take hormonal pills... help.
2. Galina. I accept traneksam 4 days as prescribed by a doctor, after radiokonizatsii cervix. The bleeding has decreased already on the 2nd day, on the 4th, it can be said, almost ceased. But the side effects began, a sense of prostration. I think to reduce the dosage and quietly stop taking earlier.
3. Irina. Very good hemostatic. With gynecological bleeding, Vikasol does not help, and Traneksam manages.

Analogues

Structural analogs for the active substance:

• Tranexamic acid;
• Transacha;
• Troxaminate;
• Exacil.

Analogues for the pharmacological group (inhibitors of fibrinolysis):

• Amben;
• Aminocaproic acid;
• Aprotex;
• Aprotinin;
• Aeros;
• Vero Narkap;
• Gordoks;
• Gumbix;
• Inhistril;
• Contrikal;
• Pamba;
• Polycapra;
• Trasilol 50, 00;
• Traskolan.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Tablets should be stored at a temperature of no higher than 30 degrees, ampoules - 25 degrees. Shelf life of the tablets is 36 months, ampoules - 24 months.

Self-medication is inadmissible only the doctor can choose an appropriate dosing regimen.

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