Chlorhexidine Bigluconate

Chlorhexidine is a widely used antiseptic that is intended for topical external application.

The drug has an effect on gram-negative and gram-positive bacteria, eliminating the development of the inflammatory process in the tissues of the body. It has stable properties. After use, it retains its activity, and for a long time it provides a bactericidal effect. This is one of the most common and safe means. The solution is capable of stopping the activity of many grammus and gramminus pathogens.

It is allowed for use during pregnancy, it is possible to treat wounds for children, apply in gynecology, dentistry for mouth and throat rinsing, venereal practice.

Clinical and pharmacological group


Terms of sale from pharmacies

Can buywithout a doctor's prescription.


How much is Chlorhexidine bigluconate in pharmacies? The average price is at the level of20 rubles.

Composition and form of release

The name is Chlorhexidine (Chlorhexidine). It is available in the form of a solution for external use of 0.05% and 20%. And also in the form of candles, gels, sprays and ointments.

  • A solution of 0.05% Chlorhexidine is provided in a polymer bottle with a nozzle or glass bottles of 100 ml. Packaging for the drug is used cardboard type. In such a cardboard box there is 1 bottle.

A solution of 20% of Chlorhexidine is available in polymer bottles with a cap of 100 or 500 ml.

Pharmacological effect

On microorganisms Chlorhexidine bigluconate - it is this salt is used as an antiseptic - acts differently, and it depends on the type of microbes.

  1. Mushrooms. The effect of the drug on pathogenic and opportunistic fungi is very similar to the effect exerted on bacteria. Destroying the cell wall, the antiseptic penetrates into the cytoplasmic membrane of the fungus and irrevocably destroys the cell.
  2. Bacteria. A positively charged molecule of Chlorhexidine binds to the bacterial cell wall that has a negative charge. As a result, destabilization and damage to the cell wall occurs. Interestingly, this process takes only about 20 seconds. However, the role of antiseptics does not end there. The drug penetrates into the cell and attacks the internal cytoplasmic membrane of the bacterium, as a result of which the contents simply flow into the cytoplasm. The cell is dying. Chlorhexidine bigluconate of high concentration can cause solidification or congealing of the cytoplasm.
  3. Biofilm. This is a complex set of microorganisms growing on a solid organic (eg, plaque) or inorganic surface. Biofilms are characterized by structural heterogeneity, genetic diversity and complex interactions within the conglomerate. The matrix protects the cells inside it, which causes a special resistance of microorganisms of biofilms to antibacterial drugs. Most antiseptics are not able to act inside the complex structure of the biofilm. Chlorhexidine broke out of a harmonious number of impotent kinsmen and in which he proved his exceptional abilities. The drug can prevent the adhesion (adhesion) of microorganisms to a solid surface, which stops the growth and development of biofilms.
  4. Other microorganisms. Unlike many antiseptic agents, the solution of Chlorhexidine demonstrates high efficiency against other microbes, for example, bacterial spores and protozoa. It is also assumed that it also acts against viruses covered by an additional coat: the herpes simplex virus, HIV, cytomegalovirus, influenza virus. Unsecured viruses are resistant to Chlorhexidine. These include the agents of ARVI rotavirus, adenovirus and enteroviruses.

Indications for use

Chlorhexidine bigluconate is intended for therapeutic interventions in the fight against pathologies caused by pathogens susceptible to its action:

A solution of 0.1% (0.05 and 0.2):

  • is prescribed for prophylactic purposes after surgical interventions and with injuries in dentistry, laryngotorinological organs.
  • when disinfected damaged mucous membranes of the mouth and genitals.
  • treatment of integument to prevent infection after manipulation in surgical, obstetrical practice and in gynecology.
  • as an antiseptic in wound areas, scratches, abrasions, cuts and burns.
  • to protect against viruses that penetrate the urethrogenital system.
  • for gargling.

Solution 0, 5%:

  • for the treatment of surfaces, instruments and instruments for medical use in a pre-heated condition up to 750 ° C.

A solution of 1%:

  • preventive measures for burn injuries of the epidermis.
  • for disinfecting and cleaning the hands of doctors and personnel before the operation.

There is also a solution with a concentration of 5 and 20% for the formulation using alcohol, glycerin or water.


Chlorhexidine 0.05% can not be used:

  • for the treatment of patients with dermatitis;
  • for disinfection after operations on the central nervous system and auditory canal;
  • for the treatment of ophthalmic diseases;
  • simultaneously with other antiseptics.

With caution, the drug is used in childhood.

Intended use for pregnancy and lactation

The drug Chlorhexidine, if necessary, can be used to treat pregnant women. During the clinical trials, there was no teratogenic or embryotoxic effect drug on the child's body, even if the solution is used in the first weeks of pregnancy.

Chlorhexidine solution can be used by pregnant women immediately 1-2 weeks before childbirth with the purpose of sanation of the birth canal and treatment of colpitis, vaginitis, thrush.

The drug Chlorhexidine Bigluconte can be used externally and locally to nursing mothers. For this, it is not necessary to interrupt lactation.

Dosage and route of administration

As indicated in the instructions for use. Chlorhexidine bigluconate solution is applied topically, topically.

Solution for topical and topical application , %, solution for external use , 5%

To the affected surface of the skin or mucous membranes of the oral cavity, urogenital organs by irrigation or a tampon, 5-10 ml of the drug is applied and left for 1-3 minutes. Multiplicity of application - 2-3 times a day.

For the prevention of sexually transmitted diseases, the contents of the vial by means of a nozzle are inserted into the vagina women (5-10 ml) or in the urethra to men (2-3 ml), women (1-2 ml) for 2-3 min. For 2 hours after the procedure, it is recommended not to urinate. Also, the preparation should treat the skin of the genital organs, pubis, inner thighs.

Solution for topical and topical application 0.5%

5-10 ml of the preparation in the form of rinses, appliqués or irrigation are applied to the affected surface of the skin or mucous membranes and left for 1-3 minutes. Multiplicity of application - 2-3 times a day.

Medical equipment and work surfaces are treated with a wetted solution with a clean sponge or by soaking.

Solution for topical and topical application 1%

The skin of the postoperative wounds is treated with a solution by means of a clean swab.

Before treatment with the drug, the surgeon's hands are thoroughly washed with soap and wiped dry, after which they are washed with 20-30 ml of the solution. Postoperative wounds are treated with a clean swab.

Work surfaces and a medical tool are treated with a wetted solution with a clean sponge or by soaking.

Solution for topical and topical application 5%

Dilution of the concentrate is carried out proceeding from the calculation of the concentration of the prepared solution.

Adverse Reactions

When used in the treatment of Chlorhexidine Bigluconate in some patients, the following side effects were noted:

  • dry skin;
  • itching of the skin;
  • the appearance of a rash;
  • dermatitis;
  • photosensitivity.

With prolonged use of mouth rinsing and irrigation, taste sensations can change, tartar appears, and discoloration of teeth is noted.


If the instructions are followed, an overdose of chlorhexidine is excluded. If a person accidentally swallows the drug, immediately wash the stomach using milk, a raw egg, gelatin or soap.

special instructions

It retains activity in the presence of impurities of blood and organic substances. Do not allow chlorhexidine to enter the eyes (except for a special dosage form intended for eye washing), as well as contact with the medullary membranes and the auditory nerve.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

  1. Ethyl alcohol enhances the bactericidal effect.
  2. It does not combine with anionic compounds, in particular with soap.
  3. It does not combine with chlorides, carbonates, phosphates, sulfates, borates, citrates.
  4. Under the influence of the agent, the sensitivity of microorganisms to the influence of neomycin, kanamycin, chloramphenicol, cephalosporin increases.
  5. If the pH of the medium is greater than 8, a precipitate forms. If hard water is used in the preparation of the solution, its bactericidal effect decreases.


We offer you to read reviews of people who used Chlorhexidine Bigluconate:

  1. Ulyana. I have been using chlorhexidine for a very long time, the main purpose of the application is skin treatment. At me problem type, often there are spots and rashes. Every evening I rub my face with a solution of 0.05% and apply the cream. I like that the product quickly dries the pimples and prevents them from spreading further. All my girlfriends are also so enjoy, happy.
  2. Victoria. A good tool for disinfection, especially after squeezing and opening pimples, because it does not paint and does not burn. Some of them get rid of pimples completely, but Metgil is happy with me. And to wipe the face in the summer in a heat it is possible hlorgeksidinom for prophylaxis of spots.
  3. Alexander. Last week, I was removed a tooth. Until the crown was placed, they said to leave to healing and once a day gently rinse the mouth with Chlorhexidine to kill a possible microflora and not carry another infection. The drug is a bit bitter, but it does not cause unpleasant feelings and discomfort when used. I'll rinse it for the third day, it's kind of healing.


There are no analogues. In most cases, you can use Miramistin as an analogue.

Which is better: Chlorhexidine or Miramistin?

Many people are convinced that these are the same medicines. In fact, they really belong to the same class of antiseptic drugs. What is the difference between Chlorhexidine and Miramistin is in the active substances contained in the preparations.

Miramistin is not a complete analog of Chlorhexidine. It has a pronounced antifungal and antiviral effect. Therefore, there are some differences in the indications for the use of this drug. Miramistin is not contraindicated in people with dermatitis.

Shelf life and storage conditions

Store the vial with solution in a place protected from light away from children at a temperature of no higher than 30 degrees. Shelf life of the drug is 2 years from the date of manufacture, after opening the bottle the solution should be used within 6 months.

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