Sofradex

Drops Sofraks is a drug for topical application in ENT practice, which has a pronounced anti-inflammatory and antibacterial effect.

The drug Sofradex has a bactericidal and antibacterial action of a wide spectrum due to gramicidin and framicetin, is active against such Gram-positive and Gram-negative microorganisms.

Anti-inflammatory, anti-allergic and antipruritic effect has a glucocorticoid - dexamethasone. As a result of instillation into the eye, pain sensations, burning sensations decrease, there is photophobia, lacrimation and other symptoms characteristic of pathological processes caused by the corresponding pathogens.

Clinical and pharmacological group

The drug with antibacterial and anti-inflammatory action for topical application in ophthalmology and ENT-practice.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Sofradex cost in pharmacies? The average price is at the level of350 rubles.

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Composition and form of release

Drops of Sofradex are intended for administration to the eyes and ears. Therefore, "ear drops Sophradex" - this is the same as "eye drops Sophradex".

Composition:

• Framicetin (5 mg) is an antibiotic that actively affects bacteria of staphylococcus, dysentery and other harmful microorganisms (except those that can live in airless space).
• Gramicidin (50 mg) - acts as an additional support for Framichetin. The component itself is not expensive, but necessary for the complex treatment of bacterial and infectious diseases.
• Dexamethasone (500 mg) is a special hormone necessary for the suppression of inflammatory processes. In addition to the main function, it helps to remove allergic reactions, swelling and itching.
• Additional substances that do not have a medical effect.

pharmachologic effect

The drug Sofraks is combined, and has the following therapeutic effects:

1. Antibacterial action.
2. Anti-inflammatory effect.
3. Antiallergic effect.

Drops and ointment Sofreks contain two antibiotics - Framicetin and gramicidin, from the group of aminoglycosides. These antibiotics effectively destroy a wide range of pathogenic microorganisms that cause infectious and inflammatory diseases of the ears and eyes. Framicetin destroys a large number of Gram-positive bacteria, including Staphylococcus aureus, which is a conditionally pathogenic microbe, often causes inflammatory lesions of various organs, and it is rather difficult is cured. Also, framicetin has a harmful effect on the main gram-negative microorganisms - E. coli, dysentery, proteus, etc. Resistance to this antibiotic is produced very slowly. Framicetin does not kill streptococci, fungi and microbes that can live in anoxic environment (anaerobic). The second antibiotic of Софрадекса - грамицидин, increases a spectrum of action Фрамициетина, especially well working concerning the staphilococcuses difficultly giving in to therapy.

The third component of the ointment and drops of Sofredex is the glucocorticoid hormone dexamethasone, which has the property of suppressing inflammatory reaction, reduce the production of substances that stimulate inflammation, and reduce the degree of permeability of the wall capillaries. In addition, dexamethasone has the property of suppressing allergic reactions and itching. Also, dexamethasone removes puffiness, improving nasal breathing, hearing and vision.

Sofradeks when injected into the eyes removes pain syndrome, eliminates burning, lacrimation and photophobia. And the introduction of the drug in the ears can eliminate redness of the skin, tenderness, itching, burning in the external auditory canal and sensation of a stuffy ear.

Indications for use

The indications are the following bacterial diseases:

1. External catarrhal or purulent otitis.
2. Bacterial conjunctivitis (inflammation in the surface of the eye).
3. Inflammation of the eyelid and its margins.
4. Keratitis and iridocyclitis (inflammatory changes in the cornea, iris and in the ciliary body of the eye).
5. Scleritis or episcleritis (when the skin itself or the outer layers of the opaque membrane of the eye is inflamed).
6. Infected with bacteria eczematid skin of the eyelids (characterized by the appearance of itching, burning and moknutiya on the skin of the century).

Contraindications

Before starting treatment, you should carefully read the instructions to the drug, since the drops of Sophradex have a number of contraindications and limitations to use:

• keratitis caused by the herpes virus;
• glaucoma (increased intraocular pressure);
• perforation of the tympanic membrane;
• pregnancy and the period of breastfeeding;
• individual intolerance to the components of the drug;
• eye and ear diseases of viral and fungal nature - in this case the drug will simply not be effective;
• tuberculosis;
• trachoma;
• violation of the integrity of the mucous membrane of the eye;
• children under 2 years.

With special care, the drug Sofraksek is prescribed for children of younger preschool age, since long-term and uncontrolled use of drops can lead to the development of systemic side effects, in particular from the side adrenal glands.

Intended use for pregnancy and lactation

To date, no experiments have been conducted to establish the negative effect of the antibiotic on the course of pregnancy and child development. It is known that the drug is capable of diffusing through the placental barrier and into breast milk. Therefore, pregnant women and women during lactation are prohibited from taking this medication.

If there is an acute need for breastfeeding, you need to stop breastfeeding. It is important: the active ingredients included in the composition adversely affect the microflora of the baby's intestines and can lead to the formation of extensive pathological processes.

Dosage and route of administration

As indicated in the instructions for use, ear drops Sophradex should be instilled in the outer part of the auditory meatus by 2-3 drops. 3-4 times a day, or - you can lay a gauze pad, moistened with a solution.

The drops in the ears of Sofradex are applied no more than 7 days, except for cases of visible positive dynamics. It should be remembered that GCS mask hidden infections, long-term use of antimicrobial agents promotes the development of stable flora and superinfections.

For instillation into the eye

In case of eye diseases: for a mild infection, 1-2 drops of the drug are injected into the conjunctival sac of the eye every 4 hours. In the case of a serious infectious process, the drug is instilled every hour. As the inflammatory phenomena decrease, the frequency of instillations of the drug decreases.

Side effect

As a rule, the drug Sophradex is normally tolerated by patients. After instillation of the drug in individuals with increased individual sensitivity, local side effects may develop:

• burning;
• itching;
• pain;
• impaired sensation (blunting of hearing or blurring of vision).

These side effects are not dangerous and do not require the withdrawal of treatment with the drug and go on their own in 15 minutes.

Overdose

Overdosage of the drug Sophraidex is possible in case of using drops for more than 7 days and its symptoms are due to the addiction to dexamethasone. In this case, there is an increase in all of the above-described side effects, a violation of the adrenal function.

At the first signs of an overdose, the drug is withdrawn and treated by a doctor. If necessary, specialists will prescribe symptomatic treatment.

special instructions

Local GCS should never be used in patients with eye hyperemia of unknown eliology. Inadequate use of the drug may lead to significant visual impairment.

With prolonged use of the drug, as with long-term use of other antimicrobial means, the development of superinfections caused by drug-resistant microorganisms, including fungi.

Prolonged instillation of the drug in the eye can lead to thinning of the cornea with the development of its perforation, as well as an increase in intraocular pressure. Treatment with drugs containing corticosteroids should not be repeated or prolonged without regular monitoring of intraocular pressure, eye examination for cataract development or secondary infections.

The duration of the drug should not exceed 7 days, except in cases of obvious positive dynamics of the disease, because long-term use of GCS, which enters into its composition, can mask hidden infections, and the long-term use of antimicrobial agents - contribute to the development sustainable flora.

Framicetin sulfate, which is part of the drug, is an antibiotic from the group of aminoglycosides, development of nephro- and ototoxic effects in systemic application or local application to an open wound or damaged skin. These effects depend on the dose and are increased and renal or hepatic insufficiency. Although the development of these effects was not observed when instilled in the eye, the possibility of their occurrence in the case of topical application of high doses of the drug in children should be taken into account.

Patients who, after instillation in the eye of the drug temporarily lost clear vision, is not recommended immediately after instillation drug to drive a car or work with complex machinery, machines or some other complex equipment that requires clarity view.

The bottle must be closed after each use. Do not touch the tip of the pipette to the eye. After opening the vial, the drug should be used within 1 month.

Interaction with other drugs

Do not use framicetin sulfate along with other antibiotics that have ototoxic and nephrotoxic effects (streptomycin, monomycin, kanamycin, gentamicin).

Reviews

Otolaryngologists and ophthalmologists positively characterize this drug, paying special attention not only to its effectiveness, but also to the lack of a large list of side effects.

It is acceptable to prescribe to younger patients, but the treatment course requires increased attention of parents and doctors for the general condition of the child.

Analogues

The drug has a balanced combination of components, such drugs are not produced. It is possible to use drugs similar in clinical effect:

• Candybiotic.
• The otinum.
• Otypaks.
• Fugentin.
• Otofa.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

The drug should be stored in a cool dark place, away from children. Shelf life of the drug is 24 months from the date of production, which is indicated on the packaging, subject to the rules of storage.

The open vial should be kept in the refrigerator for no longer than 28 days from the date of opening. At the end of this period, the medicine is poured and, if necessary, a new bottle is printed.

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