Cefotaxime

Cefotaxime is a highly effective bactericidal medication (third generation cephalosporin antibiotic) for parenteral use.

It is effective in combating pathogenic microorganisms in the genitourinary system, as well as in internal and respiratory organs. Often such an antibacterial agent is prescribed for the treatment of patients suffering from immunodeficiency.

Cefotaxime is available as a powder for injections. The package contains only one bottle for a single dose. You have already realized that cefotaxime is used only in the form of injections. It does not just stop the multiplication of pathogenic microbes, this drug destroys the causative agent of the disease. Cefotaxime is active against a large number of pathogenic microorganisms.

Clinical and pharmacological group

Cephalosporin III generation.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Cefotaxime cost in pharmacies? The average price is at the level of130 rubles.

Composition and form of release

Powder for the preparation of solution for injection: from pale yellow to white (500 or 1000 mg powder in a glass bottle of 10 ml, 1 bottle in a cardboard box).

Composition of 1 bottle of powder: sodium cefotaxime is sterile (equivalent to 500 or 1000 mg of anhydrous cefotaxime).

Pharmacological effect

Semisynthetic antibiotic. The active ingredient refers to the third generation cephalosporins used parenterally. The drug is active against gramnegative and gram-positive flora, resistant to the effects of sulfonamides, aminoglycosides and Penicillin. The mechanism of antimicrobial action is based on the suppression of transpeptidase activity by blocking peptidoglycan.

After intramuscular injection, the maximum concentration is recorded after 30 minutes. 25-40% of the active substance binds to plasma proteins. Bactericidal effect lasts 12 hours. In the gallbladder, bone tissue, myocardium, soft tissues, an effective concentration of the active substance is created.

Indications for use

Indications for the use of Cefotaxime are infections that cause drug-sensitive microorganisms (most often - Gram-negative), namely infections:

1. Kidney and urinary tract;
2. Respiratory tract;
3. Bones and soft tissues;
4. Throat, ear and nose;
5. Abdominal cavity.

Also, Cefotaxime, according to the instructions, is prescribed for treatment:

1. Infectious and inflammatory diseases of the pelvic organs;
2. Septicemia, endocarditis and meningitis;
3. Wound and burn infections;
4. Gonorrhea.

Contraindications

Absolute contraindication to the use of the drug is increased sensitivity to cefotaxime, as well as to other cephalosporins.

Absolute contraindications for drug forms containing lidocaine as a solvent:

• increased sensitivity to lidocaine or other local anesthetics of the amide type;
• intracardiac blockade (in cases where the pacemaker is not installed);
• severe heart failure;
• intravenous administration;
• age to 2.5 years (intramuscular injection).

Relative contraindications:

• allergic reactions to penicillins in the anamnesis (risk of developing cross-allergy);
• joint administration with aminoglycosides;
• renal insufficiency.

Intended use for pregnancy and lactation

In very rare cases, the use of Cefotaxime pregnant or lactating women is allowed. The drug is used if the expected positive effect is several times greater than the risks. The need for the use of the drug in this or that state of the body is determined exclusively by a qualified specialist.

Dosage and route of administration

Instructions for the use of Cefotaxime in adults: every 4-12 hours intramuscularly or intravenously administered 1-2 grams. In pediatric practice, injections of Cefotaxime are also prescribed. Instructions for use for children weighing less than 50 kg: 2-6 times a day, 50-180 mg / kg is administered. How many days to prick an antibiotic is determined by the treating doctor, taking into account the underlying disease, the general reaction of the organism, the concomitant pathology. Tablets are not available.

How to dilute Cefotaxime for intravenous injection: 1 g of powder diluted in 4 ml of sterile water, inject slowly 3-5 minutes.

How to dilute Cefotaxime with Novocaine: 1 g of powder diluted in 4 ml of novocaine, injected slowly.

Than to plant a powder? As a solvent, sterile water, lidocaine and Novocaine can act. The last two substances are used for anesthesia. the injections of Cefotaxime are rather painful.

Adverse Reactions

According to reviews, Cefotaxime causes the following adverse reactions:

1. Blood coagulation system: hypoprothrombinemia.
2. Urinary system: interstitial nephritis.
3. Allergies: eosinophilia, skin rash and itching. According to reviews, Cefotaxime can rarely cause angioedema.
4. Hemopoietic system: thrombocytopenia, leukopenia, hemolytic anemia, neutropenia (only with prolonged use of Cefotaxime in high dosages).
5. Digestive system: diarrhea, nausea, vomiting, hepatitis, cholestatic jaundice, pseudomembranous colitis, transient increase in hepatic transaminase activity.
6. Local side reactions: with intravenous injection - phlebitis, with intramuscular - pain at the injection site.

In addition, Cefotaxime according to reviews can cause candidiasis, due to the chemotherapeutic effect of the drug.

Overdose Symptoms

If the recommended dose is exceeded or the dose is incorrectly calculated, the patient may develop signs of overdose, which are clinically manifested by an increase in the described side effects, a violation of the liver and kidney function.

Treatment of an overdose consists in the immediate cessation of therapy, hemodialysis, the introduction of enterosorbents. If necessary, the patient is symptomatically treated.

special instructions

Before you start using the drug, read the special instructions:

1. When treating the drug for more than 10 days, monitoring of the peripheral blood pattern is necessary.
2. During treatment with cefotaxime, it is possible to obtain a false positive sample of Coombs and a false positive urine reaction to glucose.
3. Patients who had a history of allergic reactions to penicillins, may have increased sensitivity to cephalosporin antibiotics.
4. In the first weeks of treatment, pseudomembranous colitis can occur, which is manifested by severe prolonged diarrhea. At the same time, stop taking the drug and prescribe adequate therapy, including vancomycin or metronidazole.
5. During treatment, you can not drink alcohol, since there may be effects similar to the action of disulfiram (hyperemia face, stomach and stomach spasms, nausea, vomiting, headache, lowering blood pressure, tachycardia, dyspnea).

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Pharmaceutically incompatible with solutions of other antibiotics in one syringe or dropper.
2. Cefotaxime increases the risk of bleeding when combined with antiplatelet agents, NSAIDs.
3. The risk of kidney damage increases with the simultaneous administration of aminoglycosides, polymyxin B and "loop" diuretics.
4. Drugs that block tubular secretion, increase plasma concentrations of cefotaxime and slow its elimination.

Patient Reviews

We offer you to read reviews of people who used Cefotaxime:

1. Dmitriy. He was treated with cefotaxime from one unpleasant infection. I can say that the drug is really effective. At me, the truth, from it or him the first days the head hurted or was ill; was sick and was turned a little bit. But then everything went by itself. I treated nothing specially. And my infection was cured pretty soon and successfully. I no longer suffer from these symptoms and are very happy about it. Now I behave more circumspectly in some cases. Caution in fact never hurts.
2. Antonina. In the hospital, they pierced 10 days (the child was 3 months old). It seems to be an improvement. But the whole year they ached, intestines, colds. As a result, exactly a year later, the hospital again. One day, they injected 2 times. The child poured out, stopped urinating. Refused. Have appointed or nominated amikatsin. The result is much better. I think if it were originally pierced with amikacin, the result would be better.
3. Alexander. My daughter was 3 years old, the temperature was kept for a week, the temperature fell after the first injection, the course was prescribed for 7 days, on the 8th I accidentally did an extra injection... and then started: urticaria, the temperature rose, the joints swelled and ached, the child did not walk at all, then periodically, was diagnosed: allergic arthritis. While we are being treated, what will happen next... time will tell if the child is sorry. So here: one treats, the other is crippled.

Analogues

Structural analogs for the active substance:

• Intrataxime;
• Kefotex;
• Clafhorn;
• Claforan;
• Clafotaxime;
• Liphoran;
• Oritax;
• Ortaxime;
• Resibelact;
• Spirozin;
• Tax-o-bid;
• Taltsef;
• Tarcephoxime;
• Tirotax;
• Cetax;
• Cefabol;
• Cefanthral;
• Cefosin;
• Cefotaxime Lek;
• Cefotaxime sodium;
• Cefotaxime Sandoz;
• Cefotaxime Vial;
• Cefotaxime sodium salt.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Storage of the product must be carried out in a dry place, do not allow direct sunlight and excess temperature in the storage place to more than 25 ° C. Keep the drug out of the reach of children.

The shelf life of Cefotaxime is 2 years from the date of manufacture.

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