Chloropyramine

Chloropyramine is an antiallergic drug from the group of histamine H1 receptor blockers.

It has a pronounced anti-allergic, antipruritic and sedative effect. It is used for the treatment of allergic rhinitis, conjunctivitis, dermatoses and other allergic diseases.

Its more popular analogue is the "brand" drug of suprastin, but also under its generic name, consonant with the incoming in its composition pharmacologically active substance, the drug can also be found on the shelves of domestic pharmacies.

Clinical and pharmacological group

The blocker of histamine H1 receptors. Anti-allergic drug.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much is Chloropyramine in pharmacies? The average price is at the level of125 rubles.

Composition and form of release

Chloropyramine is produced in two forms: as a solution for intramuscular and intravenous administration, as well as tablets.

The solution for intravenous and intramuscular administration is a clear liquid with a hardly noticeable greenish or yellowish tinge with a characteristic odor. In each of the ampoules with the solution contains an active substance, the mass of which is 20 mg. There are packages of five or ten ampoules.
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The active ingredient in the tablets of Chloropyramine is 25 mg each. In the package - 20 pieces of tablets.

Pharmacological effect

Chloropyramine is capable of blocking histamine H1 receptors and m-cholinergic receptors, and its antipruritic, sedative, antiallergic, anticholinergic, spasmolytic and hypnotic effects.

Chloropyramine weakens the spasmodic activity of histamine against the smooth muscles of the bronchi and intestines, thereby reducing its hypotensive effect and its effect on vascular permeability. The drug also helps prevent the development of allergic reactions of immediate type and facilitate their flow.

It is characterized by a high rate of absorption, so the maximum concentration of the drug is reached within two hours after ingestion. The therapeutic effect lasts from four to six hours.

Indications for use

What helps? Chloropyramine is effective in treating a number of diseases:

conjunctivitis and allergic rhinitis;
hay fever and pollen;
angioedema;
angioedema;
dermatoses of an allergic type;
serum sickness;
allergic reactions to insect bites;
allergy to medicines.

Contraindications

The drug can not be used in the following cases:

hypersensitivity to the components of the drug;
children younger than 1 month;
in the presence of acute attacks of bronchial asthma;
with hyperplasia of the prostate;
in case of peptic ulcer disease exacerbation;
during pregnancy and during the lactation period.

In some cases, the use of chloropyramine is not contraindicated, but it should be taken with maximum caution:

with a delay in urine;
when taking medications that depress the functions of the central nervous system;
with ulcer of the stomach or duodenum;
in the presence of heart disease or liver failure;
in old age.

Intended use for pregnancy and lactation

Chloropyramine is contraindicated in pregnancy and lactation.

Dosage and route of administration

As indicated in the instructions for use, chloropyramamine is used iv or IM.

Adults prescribe 20-40 mg / day (the contents of 1-2 ampoules).
Treatment in children begins with a dose of 5 mg (0.25 ml). In the future, the dose is increased depending on the age of the child.
Children aged 1-12 months - 5 mg (0.25 ml).
Children aged 1-6 years - 10 mg (0.5 ml).
Children aged 7-18 years - 10-20 mg (0.5-1 ml).

The daily dose should not exceed 2 mg / kg of body weight.

In severe allergy, treatment should begin with an injection form of chloropyramine. First it is injected / slowly, then goes to the / m introduction and in the final phase of treatment they switch to taking the pills inside. The terms of treatment are set individually depending on the clinical symptoms and the patient's condition.

Elderly, emaciated patients: the use of the drug chloropyramine requires special care, tk. In these patients, antihistamines often cause side effects (dizziness, drowsiness).

Patients with impaired liver function: a dose reduction may be required due to a decrease in the metabolism of the active component of the drug in liver diseases.

Patients with impaired renal function: it may be necessary to change the regimen of the drug and reduce the dose due to the fact that the active component is mainly released through the kidneys.

Adverse Reactions

Against the background of the use of a solution or tablets of Chloropyramine, it is possible to develop negative pathological reactions from various organs and systems:

The organ of vision is increased intraocular pressure, reduced visual acuity.
Nervous system - drowsiness, dizziness, lethargy, general weakness, impaired coordination of movements, headache, euphoria (unmotivated mood increase). Children may experience anxiety, irritability, and increased motor activity.
Cardiovascular system - decrease in the level of systemic arterial pressure (arterial hypotension), which more often occurs in the elderly, a violation of the rhythm of contractions of the heart (arrhythmia), the rapidity of heartbeats.
The digestive system - nausea, periodic vomiting, dry mouth, constipation or diarrhea, a change in appetite with its increase or absence.
Blood and red bone marrow - a decrease in the number of leukocytes (leukopenia), granulocytes (agranulocytosis) per unit volume of blood.

When there are signs of development of negative pathological reactions after the beginning of the use of tablets or solution for the parenteral administration of Chloropyramine, the doctor in charge must decide whether to cancel or correct the dosage.

Overdose

The use of chloropyramine and analogues of the drug in an inappropriate amount can cause an overdose, the symptoms of which are as follows:

In adults, there may be a state of inhibition and depression, or CNS excitation, in rare cases - hallucinations, coordination disorders, lack of pupillary response to light, hyperthermia.
In children, an overdose manifests itself in the form of anxiety, the appearance of hallucinations, athetosis, ataxia, convulsions, mydriasis, pupillary real estate, facial hyperemia, hyperthermia. In rare cases - a coma, collapse.

Treatment involves systematic therapy, which includes the administration of phenamine, caffeine, antiepileptic drugs, as well as resuscitation together with ventilation. There is no specific antidote.

special instructions

Before you start using the drug, read the special instructions:

During treatment, it is unacceptable to drink alcoholic beverages.
Taking the drug at night can increase the symptoms of reflux esophagitis.
When combined with ototoxic drugs, chloropyramine can mask the early manifestations of ototoxicity.
Antihistamines can distort the manifestation of the reaction in the setting of skin allergological tests, therefore, a few days before the scheduled test, the drug should be discontinued.
If during prolonged use of the drug there is a causeless increase in body temperature, laryngitis, pale skin, jaundice, ulceration of the oral mucosa, the appearance hematomas, unusual and difficult to stop bleeding, it is necessary to see a doctor, since prolonged therapy with antihistamines can lead to violations of hemopoiesis.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

Caffeine and phenamine reduce the depressant effect on the central nervous system.
Simultaneous use with ethanol is not recommended (risk of severe CNS depression).
Tricyclic antidepressants and MAO inhibitors increase m-cholinoblocking and inhibitory effects on the central nervous system.
Strengthens the effect of drugs for general anesthesia, hypnotics, sedatives, tranquilizers, m-holinoblokatorov, opioid analgesics, local anesthetics.

Reviews

We offer you to read reviews of people who used Chloropyramine:

Marina. Suffered from a severe allergic reaction to pollen in the spring, for a long time could not pick up the drug. The doctor advised Chloropyramine in ampoules. It helped immediately, there were no side effects. Now I'm drinking pills. Previously, choking, as the whole sky swelled, it became difficult to breathe. The new drug made me feel all the colors of spring.
Irina. This drug helped me partially. Discharge on the mucosa decreased, it became easier to breathe. But the action of the drug was enough for less than a day, it had to be taken quite often. In addition, an unpleasant dryness appeared on the nasopharyngeal mucosa. Simultaneously with the preparation, I used washing of the nasal mucosa with a light saline solution. Perhaps it is in my body such an ambiguous reaction to the drug.
Maksim. The injection saved my friend, after a bite of a bee in the dacha there was a strong allergic reaction, the swelling did not allow him to breathe normally, we were afraid that the ambulance would not be in time. In the medicine cabinet there was a drug in ampoules, it was bought just in case. We made an emergency injection. A friend came to himself, the ambulance doctors said that the bill then went for a minute.

Analogues

The medication may not be appropriate, causing an individual reaction. Then the doctor will recommend an analogue that effectively replaces the original remedy. Among antihistamines with the same active substance:

Suprastin. It has the form of tablets, fluids for administration. Has anti-allergic and anti-histamine action.
Chloropyramine hydrochloride. It is available in the form of a solution for injection. The drug is suitable for allergy treatment.
Chloropyramine-ESCOM. Release form: injection. Antihistamine.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Shelf life of tablets and solution for parenteral administration of Chloropyramine is 3 years from the date of manufacture. They should be stored only in the original factory packaging, dark, dry, inaccessible to children at an air temperature of not more than 25 ° C.

Do not freeze the solution.