Good evening, dear readers! Since I work as a paramedic in the office of medical prevention in the polyclinic of the Unitary Hospital "Nekhaevsky CRH" and almost all residents of the village know me, on the street quite often people ask about how to treat inflammatory diseases of the most different localization and which antibiotic is the most effective in this regard. Of course, the appointment of a citizen in the treatment of antibiotics should be taken by a doctor - a district therapist or surgeon. Just the patient comes to the reception. .. and all the cases!
Otherwise, uncontrolled self-use of antibiotic drugs will lead to the fact that even the best antibiotic will lose its effectiveness and relevance, since its frequent use leads to the development of immune protection in pathogenic microbes. Then we have to look for new antimicrobial agents, and this is not always possible.
CONTENTS
Azithromycin, what is this antibiotic?
People often ask about what is Azithromycin. Indeed, this thing is still very effective in the treatment of inflammatory reactions of pathogenic microflora - angina, osteomyelitis, periodontitis, prostatitis and diseases of the female sexual sphere and others, including diseases of the ENT area. Because it is well accumulated in the bones and penetrates into hard-to-reach areas of the body, where it "holds a reserve" holds microbes.
I warn you right away, this drug "does not take" the viruses. So with the flu, ARVI - it is useless, except that it is then appropriate to treat complications after the transfer of viral infections.
Let's talk today about the pharmacological properties of Azithromycin and how to take this antibiotic in the treatment of inflammatory diseases.
Azithromycin helps with infectious inflammatory diseases .It is a semisynthetic antibiotic that is a subclass of azalides, which differs slightly in structure from classical macrolides.
First obtained in 1980 by the pharmaceutical company Pliva. In Eastern Europe, the drug was licensed and sold under the name Sumamed , and in the Western - Supraks .
Immediately I can not restrain my emotions - the prices for Sumamed are stunned compared to our domestic version, which is simply called "Azithromycin" and differs not in that at times, but in 10 times. For the same money you can buy at the pharmacy or 1 package Sumamed, or 10 packages of Azithromycin. The effect will be the same. But you can buy something else from the tablets, save money.
Azithromycin: formulation, formulation, packaging
The antibiotic is available in capsules of 3 or 6 pcs. One capsule contains azithromycin( active substance) 500 mg, and sometimes 250 mg.
Therefore, be careful if you need 6 days of admission to the course and you are an adult, then take 2 packs of 500 mg( where three capsules in 1 pack).When you ran into a dosage of 250 mg, and you are an adult, then in one session you will need to take 2 capsules( 250 mg each), instead of 1( 500 mg each).And for 6 days of admission you will need to buy 4 packs of 3 capsules( 250 mg each).
The capsules themselves have a hard gelatin shape and white color. Their contents are white powder, sometimes with a yellowish tinge.
In addition to the active ingredient in the composition there are microcrystalline cellulose, povidone, magnesium stearate, sodium lauryl sulfate, lactose. The sheath itself is made of titanium dioxide and gelling agents.
Manufacturer of domestic antibiotic in Russia - LLC "Production of medicines", "MOSHIMFARMPREPARATY".
Azithromycin, what are the indications for use?
The use of capsules is advisable for infectious diseases of the respiratory system, skin and soft tissues, as well as the reproductive and genitourinary system. A drug is prescribed for bacterial involvement of ENT organs or for dermatological problems of bacterial nature.
Can be prescribed for the treatment of gastrointestinal diseases caused by specific types of bacteria. It is advisable to appoint only in a situation where the disease was caused by susceptible azithromycin microorganisms:
- angina,
- sinusitis,
- tonsillitis,
- scarlet fever,
- flu and cold,
- erysipelas,
- impetigo,
- urethritis,
- Lyme disease and others.
Contraindications to the use of
The drug is contraindicated in the lactation period and for children under 12 years in the form of capsules or persons with a weight less than 45 kg. You can not prescribe Azithromycin for patients who have an increased level of sensitivity to macrolits, with renal or hepatic insufficiency.
Mechanism of action of antibiotic
Semisynthetic antibiotic acts on the extracellular and intracellular pathogens. It is active against mycoplasmas, ureaplasmas, endobacteria and some other microorganisms. The mechanism of antimicrobial action is associated with a violation of the structure of the protein in bacterial cells. Because of this, their growth and reproduction slow down.
The drug is well absorbed, acid resistant. Bioavailability after a single dose of 500 mg is slightly less than 40%.The maximum concentration is achieved in 2.5 hours and is 0.4 mg / l. In tissues, the concentration is significantly greater than in the serum of the biological fluid.
Concentration in foci of infection is higher by 24-34% than in healthy cells. It depends on the degree of the inflammatory process. The focus remains in the correct concentration for 5-7 days after the last dose.
Azithromycin: instruction on the use of antibiotic
You can take medicine for treatment only once a day. This is one of its main advantages. It is prescribed an hour before meals or 2 after eating.
Without compliance with this rule, the level of absorption is slowed down, since undigested food prevents the complete absorption of the active substance.
For infections on the first day, 500 mg is prescribed for a single dose. From 2 to 5 it is enough to drink one tablet of the drug for 250 mg. If the treatment schedule is not more than three days, then capsules of 500 mg are usually prescribed. With ulcerative lesions of the gastrointestinal tract, an antibiotic is prescribed as part of complex therapy in a single dose of 1000 mg. Children weighing more than 45 kg and age more than 12 years, the drug is prescribed by the same rules as adults.
Possible side effects of
The action of the medicine may adversely affect the operation of different systems. On the cardiovascular side, there is increased heart rate, chest pain, headaches and drowsiness. From the digestive tract is observed flatulence, nausea, diarrhea, vomiting.
Children can develop candidiasis of the oral cavity with intravenous administration. On the part of the genitourinary system, candidiasis and nephritis may appear.
Allergic reactions are presented:
- rash,
- with Quinck edema,
- bronchospasm,
- by photosensitization.
When injected into a vein, not only the bronchospasm can be noted, but also the development of pain at the injection site.
Video on how to take Azithromycin
From this video you will learn the doctor's opinion about the effectiveness, side effects, form, dosage of Azithromycin.
What happens when I overdose?
The extreme effects are vomiting, temporary hearing loss and diarrhea. Treatment in all cases is symptomatic.
Special instructions
Women in pregnancy are prescribed exclusively for acute need, when the benefits of treatment are higher than the risks for the fetus. Azithromycin penetrates the placenta. When used during lactation, the doctor will offer to stop breastfeeding until the medicine has completely expired.
For children under 12 years of age, a medicine in the form of capsules is prohibited. In case of taking an antibiotic, the missed pill should be taken as soon as possible. All other doses are taken with an interval of 24 hours.
Given the potential for side effects from the CNS, care should be taken when controlling the car. It is not recommended to take medicine for those who have abnormalities in the liver and kidneys. It is not recommended to mix with alcoholic beverages.
Drug Interaction
With the simultaneous administration of aluminum and magnesium-containing antacids, the absorption of azithromycin is slowed. The component itself slows the excretion of indirect anticoagulants. Weakening the effectiveness of treatment can cause lincosamines, indirect anticoagulants. Complete pharmaceutical incompatibility is noted with Heparin.
Reviews and comments of readers about the drug
Many people say that this is one of the best antibiotics. He has a selective effect, accumulates in the hearth of inflammation. Due to this, the treatment time is shorter. Assign it for bronchitis and pneumonia, other serious bacterial infections. The domestic market is more often sold under the name Sumamed, but the Azithromycin itself costs five to ten times cheaper.
The drawbacks are that it kills a useful microflora, like any other antibiotics. Therefore, after treatment requires the restoration of normal microflora with the help of additional medications.
The drug is also effective in the fight against serious infections. Users note that after the course, the improvement of the state comes quickly enough. Due to the shorter duration of treatment, the risk of developing dysbiosis and thrush of the mucous membranes is reduced.
Effective treatment with a drug of prostatitis and a venereal disease like gonorrhea( "gonorrhea") is known.
Price for Azithromycin
The price is less for Azithromycin in 250 mg capsules. In this case, you can buy at a price of 39 rubles. Depending on the manufacturer can reach up to 120 rubles. Pills with active substance azithromycin in 500 mg have a cost of 80 to 240 rubles.
Analogues of the preparation
Azithromycin monohydrate, Vero-Azithromycin.
More cheap analogs
Azithromycin-AKOS, Azithromycin, Azithromycin dihydrate
Synonyms
- Azivok,
- Azitral,
- Z-factor,
- Sumazid,
- Sumamed,
- Sumamecin,
- Chemomycin,
- EcoMed.
Conditions for dispensing from pharmacies
Sold only by prescription, although it is possible in some pharmacies to be released without it.
Shelf life and storage conditions
The medicine package should be stored in a dry and dark place at a temperature of 25 degrees. Shelf life of this antibiotic is 3 years.
Publication source: revision of article http: //gidmed.com/otorinolarintologija/ lekarstva-lor / azitromitsin.html
