Omez

Omez is an antiulcer medication that has a depressing effect on stimulating gastric acid secretion.

The effect manifests itself one hour after admission, reaches its maximums in about two hours and persists for a day. A single dose is quite effective, since it completely suppresses the increased secretion of hydrochloric acid.

Of all the generics of omeprazole Omega has proven to be highly effective, better tolerated and maximizing price-quality. Tablets the preparation is used inside not chewing. Duration of use and dosage of the drug depends on the disease.

Clinical and pharmacological group

H + -K + -ATPase inhibitor. Antiulcer drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Omez cost in pharmacies? The average price in 2018 is at the level of75 rubles.

Form of issue and composition

Omez - hard transparent gelatin capsules, colorless body, pink cover, marking with black "OMEZ" paint. The contents of capsules are granules of white or almost white color. Contour-cell packaging, cardboard box

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The capsules contain the active ingredient omeprazole, as well as additional substances: sodium dihydrogen phosphate, sucrose, sodium lauryl sulfate, purified water.

The drug is also available as a lyophilized powder, which is used to prepare the solution. It also includes the active ingredient omeprazole, as well as an auxiliary anhydrous sodium carbonate.

Pharmacological effect

Active substance Omeza has antiulcer action, reducing the level of basal and stimulated secretion. According to the instructions, the therapeutic effect of Omega does not depend on the nature of the stimulus.

Included in the composition of Omeza D domperidone has an antiemetic effect, increases the tone of the lower esophageal sphincter, and also accelerates the emptying of the stomach when this process slows down.

As a rule, the action of the drug occurs quickly, within the first hour after administration, and lasts no less than 24 hours.

Indications for use

What helps? Omega is prescribed for such diseases as peptic ulcer of the stomach and duodenum, reflux esophagitis, gastrointestinal ulcer, which originated in result of stress, pancreatitis, systemic mastocytosis, Zollinger-Ellison syndrome, with the appointment of complete eradication (eradication) of Helicobacter pylori.

Ulcer of the esophagus.
An ulcer of the stomach or duodenum, potentiated by the use of non-steroidal anti-inflammatory drugs.
Stress ulcer.
Gastroesophageal reflux.
Gastroesophageal reflux with esophagitis.
Gastroejunal ulcer.
Peptic ulcers of the stomach and duodenum.
Erosive-ulcerative esophagitis.
Zollinger-Ellison syndrome.
Pancreatitis.
Other diseases of the esophagus.
Systemic mastocytosis.

Also, the drug is prescribed as part of complex therapy to eliminate the erosive and ulcerative pathologies of the intestine and stomach, provoked by Helicobacter pylori.

Contraindications

The use of Omez is not prescribed:

During pregnancy and breast-feeding (lactation);
For children up to the age of 18;
Mechanical obstruction of the intestine;
Gastrointestinal bleeding;
When hypersensitivity to the constituent substances of the drug Omes.

The instruction warns of caution in the use of Omega in people with impaired renal and / or liver function.

Use in pregnancy and lactation

When pregnant and breast-feeding a child, treatment with this drug is not practiced.

Dosage and route of administration

In the instructions for use, it is indicated that the Omez is ingested, 30 minutes before meals, with enough water (the contents of the capsule can not be chewed).

If the patient is not able to swallow the whole capsule, you can mix its contents with slightly acidified liquid, juice or fruit puree. Do not dissolve the contents of the capsule in carbonated beverages or milk. The resulting mixture should be used inside immediately after preparation.

Dosage for adult patients:

1) With gastroesophageal reflux disease (GERD)Depending on the severity of the esophagitis appointed from 20 mg to 80 mg per day. The duration of the main course also depends on the severity of the esophagitis and is 4-8 weeks. Supportive therapy should be carried out at the lowest effective dose, incl. on demand, with intermittent courses. The duration of maintenance therapy is determined by the doctor.

2) With peptic ulcer of stomach and duodenum(including for the prevention of relapses) the drug is prescribed for 20 mg 1 time / day; patients who are resistant to treatment with other antiulcer drugs, Omez is prescribed in a dose of 40 mg / day. The course of treatment for duodenal ulcer is 2 weeks, if necessary - up to 4 weeks; with peptic ulcer of the stomach - 4-8 weeks.

3) In hypersecretory states(Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, multiple endocrine adenomatosis, systemic mastocytosis), the drug is prescribed in a dose of 60 mg; if necessary, increase the dose to 80-120 mg / day (in this case, the dose should be divided into 2-3 doses).

4) For eradication of Helicobacter pyloriIn infected patients with peptic ulcer of the stomach and duodenum according to the recommendations of the working group "Maastricht-4", Omez can be included in the following treatment regimens:

The first line (the standard triple scheme): Omega 20 mg 2 times / day + clarithromycin 500 mg 2 times / day + amoxicillin 1000 mg 2 times / day. To increase the effectiveness of therapy, it is possible to administer Omez in a dose of 40 mg (2 caps. 20 mg) 2 times / day (doubling the standard dose) and increasing the duration of the course from 7 to 10-14 days;
Second line (four-component): it is used when the standard triple therapy is ineffective, or when the penicillin group is intolerant. Bismuth titrate dicitrate (120 mg 4 times / day) in combination with the preparation Omega 20 mg 2 times / day, tetracycline (500 mg 4 times / day), metronidazole (500 mg 4 times / day) for 10 days;
The third line and other alternative therapies are prescribed based on the study of the individual sensitivity of Helicobacter pylori to antibacterial drugs.

5) To prevent and treat damage to the mucous membrane of the stomach and duodenum, caused by the intake of NSAIDs (NSAIDs-gastropathy), such as dyspepsia, mucosal erosion, peptic ulcer, for the prevention of Omez in a dose 20 mg daily for 30 minutes before breakfast during the entire course of NSAID treatment; with the purpose of treatment - in a dose of 20 mg 2 times / day or 40 mg 1 time / day for 4-8 weeks.

6) For the prevention of Mendelssohn's syndrome(aspiration pneumonitis) 40 mg once.

Dosage for children:

1) With duodenal ulcer caused by Helicobacter pylori, children over the age of 4, with a body weight of more than 20 kg, the drug is prescribed in a dose of 20 mg 1 time / day in combination with antibacterial (the recommended dose of omeprazole in the Helicobacter pylori eradication regimens in pediatric practice is 1-2 mg / kg / day).

2) With gastroesophageal reflux diseaseChildren over the age of 2 years, with a body weight of more than 20 kg, it is recommended to prescribe Omez in a dose of 20 mg 1 time / day 4-8 weeks (recommended The dose of omeprazole for the treatment of gastroesophageal reflux disease in pediatric practice is 0.7-3.3 mg / kg / day).

Special patient groups:

In patients with impaired renal function, dose adjustment is not required.

In patients with impaired liver function, bioavailability and omeprazole clearance are increased. In this regard, the therapeutic dose should not exceed 20 mg / day.

The metabolic rate of omeprazole in elderly patients is reduced, but dose adjustment is not required.

Side effects

Despite the fact that the drug is well tolerated by patients, physicians do not exclude the development of side effects from different organs and systems. It is about the appearance of:

Muscle weakness, myalgia;
Exudative erythema, a rash that resembles hives, itching, baldness;
Functional disorders of the liver, especially in patients with hepatitis;
Nausea, discomfort, abdominal pain, vomiting, diarrhea, changes in taste, stomatitis on the part of the organs of the gastrointestinal tract;
Symptoms of pancytopenia, leukopenia, thrombocytopenia and other pathologies of the hematopoiesis system caused by violations of blood indicators;
Depression, dizziness, headaches, insomnia, hallucinations, as well as increased excitability from the central nervous system, which are fixed in the presence of concomitant diseases.

Eruptions on the skin are most often due to an allergic reaction to the components of the drug. In severe cases, there may be more dangerous manifestations - anaphylactic shock, bronchospasm or Quincke edema.

Overdose

Symptoms of an overdose: arrhythmia, increased sweating, headache, nausea, dry mouth, confusion, visual impairment, agitation or drowsiness.

Treatment of an overdose consists of washing the stomach, taking activated charcoal and symptomatic therapy.

special instructions

Before using the drug, the patient should consult a doctor in the following cases:

in the presence of a previously diagnosed peptic ulcer of the stomach, severe liver disease accompanied by hepatic insufficiency, renal insufficiency, jaundice, previous surgical intervention on the gastrointestinal tract;
in the presence of anxiety symptoms (significant spontaneous decrease in body weight, repeated vomiting, vomiting with blood, a change in stool color (tarry stool - melena), impaired swallowing);
when there are new symptoms or changes in symptoms already existing on the part of the gastrointestinal tract;
when used concomitantly with one or more of the following drugs (clopidogrel, digoxin, ketoconazole, itraconazole, warfarin, cilostazol, diazepam, phenytoin, saquinavir, tacrolimus, clarithromycin, voriconazole, rifampicin, preparations of St. John's wort perfumed).

In the presence of any anxiety symptoms, such as significant spontaneous weight loss, frequent vomiting, dysphagia, vomiting with blood or melena, and with a stomach ulcer (or if suspected on gastric ulcer), the possibility of malignant neoplasm should be excluded, since treatment with Omez can lead to a smoothing of the symptoms and delay the diagnosis.

Decrease in secretion of hydrochloric acid in the stomach under the influence of proton pump inhibitors leads to an increase in the growth of normal intestinal microflora and can lead to a slight increase in the risk of intestinal infections caused by bacteria of the genus Salmonella spp., Campylobacter spp., and also bacteria Clostridium difficile.

Reducing acidity on the background of taking omeprazole can also lead to a decrease in absorption of vitamin B12 (cyanocobalamin).

With the simultaneous use of omeprazole with clopidogrel, a decrease in the antiplatelet effect of the latter is observed.

Patients with a risk of developing osteoporosis or fractures against it should be under appropriate clinical supervision, although a causal relationship between the use of omeprazole / esomeprazole with fractures against the background of osteoporosis has not been established.

There are reports of the emergence of severe hypomagnesemia in patients receiving proton pump inhibitors therapy, including omeprazole, more than one year. Patients receiving omeprazole therapy for a long time, especially in combination with digoxin or other drugs, which reduce the content of magnesium in the blood plasma (diuretics), requires regular monitoring of the magnesium content.

Impact on the ability to drive vehicles

During treatment with omeprazole, dizziness, drowsiness, and visual impairment may occur, so caution should be exercised when driving vehicles and the performance of other potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.

Impact on laboratory tests

A decrease in the level of hydrochloric acid secretion can lead to an increase in the concentration of chromogranin A (CgA), which affects the results of the examinations for the detection of neuroendocrine tumors. To prevent this effect, therapy with proton pump inhibitors should be suspended 5 days before the study of the concentration of CgA.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

Omeprazole and clarithromycin combined with oral intake mutually increase plasma concentrations of each other.
Omez enhances the inhibitory effect on the hematopoietic system of other drugs.
At simultaneous reception with antacid agents of interaction it is not noted.
With the simultaneous use of omeprazole can reduce the absorption of iron salts, ampicillin esters, ketoconazole and itraconazole.
Omez can increase the concentration and decrease the excretion of phenytoin, anticoagulants of indirect action (warfarin) and diazepam, which may require a reduction in the recommended doses of these drugs.
When applied simultaneously with omeprazole at a dose of 20 mg once a day, the plasma concentrations of the following substances did not change: theophylline, caffeine, diclofenac, metoprolol, ethanol, piroxicam, naproxen, cyclosporine, quinidine, propranolol, lidocaine and estradiol.

Reviews

We picked up some reviews of people who used the drug Omez:

Anton. I have high acidity, and this drug just saves me, to be honest. After a week of treatment it became much better. I no longer felt pain. (Sometimes spasms occur, but it's quite rare). And I really love to drink Coca-Cola, so I can not do without "Omez", if I do not want to earn myself an ulcer at such a young age. Well, while I accept.
Denis. "Omez" is a very good drug with a wide spectrum of action. It can be used for pain in the stomach and for heartburn. The doctor recommended taking two capsules a day in the morning and evening. Pain, heartburn disappeared. The general condition improved. An important factor is that the drug is not very expensive, I bought it for 157 rubles. Now he is constantly in my home medicine cabinet. Interestingly, in addition to it nothing had to be bought. Saw "Omez" and infusion of chamomile.
Maria. I suffer a lot of pain in the back, and constantly need to prick painkillers. And not an ordinary analgin, but ampoules like dekloberla. The stomach has gone to hell. You have to drink omez to protect your stomach a little. I use it exclusively for prevention, so I can not say anything about the treatment.

Analogues

On the basis of omeprazole, the following drugs are manufactured:

Gastrozole;
Omeprazole;
Ultop;
Ortanol;
Losek.

In addition, there are a number of medications with a similar effect on the body, but with a different composition. Among them:

Nexium;
Nolpaz;
Zulbeks;
De-nol;
Ranitidine.

Before using analogues, consult your doctor.

Which is better - Omez or Omeprazole?

It is difficult to say which of these drugs is better, since both drugs have the same therapeutic effect, has the same indications and the same active substance. The difference between medicines only in the auxiliary components and the manufacturer.

Omez is produced by an Indian pharmaceutical company, and Omeprazol is a Russian pharmaceutical company. In omeprazole, the active substance is present in the maximum amount, whereas in Omez there are auxiliary substances that soften the side reactions. Omeprazole produced in Russia is quite a budget price and is cheaper than Omega.

Omez is not original, but an analog preparation, which began to be produced as a replacement for an expensive Losek facility. Therefore, the active substance Omega slightly more slowly reaches the maximum concentration in the blood and is quickly excreted from the body.

Nolpaz or Omez?

The Nolpaz product has a similar effect, reducing the level of hydrochloric acid and relieving the symptoms of gastrointestinal diseases. Nolpase contains the active ingredient Pantoprazole. This medicine sometimes acts more quickly.

Omez or De Nol?

De Nol - antiulcer, which contains bismuth subcitrate. How to take Omez and De Nol depends on the severity and characteristics of the disease. But this should be done according to the scheme appointed by the doctor.

Storage conditions and shelf life

Store in a dry and inaccessible place for children at a temperature not exceeding + 25 ° C. The shelf life of the capsules is 3 years, and the lyophilizate for the preparation of the solution is 2 years.