Tiogamma

Thiogamma - a drug that regulates lipid and carbohydrate metabolism.

According to the instructions, the drug is a metabolic drug. The alpha-lipoic acid contained in it is an endogenous antioxidant that binds free radicals. The use of the drug increases the glycogen content in the liver, lowers the level of glucose in the blood, helps to overcome insulin resistance.

Alpha-lipoic acid normalizes the function of the liver, regulates lipid and carbohydrate metabolism, stimulates the exchange of cholesterol.

Clinical and pharmacological group

The drug regulating lipid and carbohydrate metabolism.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Tiogamma cost in pharmacies? The average price is at the level of800 rubles.

Composition and form of release

Medicinal forms of Thiogamma:

• The tablets covered with a cover: oblong, biconcave, light yellow color with impregnations of white and yellow color of varying intensity, with risks on both sides; on the cross-section, the core of light yellow color (10 pcs. in blisters, in a cardboard bundle of 3, 6 or 10 blisters);
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• Solution for infusions: clear, light yellow or yellowish green (50 ml each in dark glass bottles, closing rubber stoppers, which are fixed with the help of aluminum caps, in a carton pack of 1 or 10 bottles);
• Concentrate for the preparation of a solution for infusions: transparent, yellowish green (20 ml each in dark glass ampoules with a white dot, 5 ampoules in cardboard pallets, in a cardboard bundle 1, 2 or 4 pallets complete with a pendant light-protective case made of black polyethylene).

The active substance of the preparation is thioctic acid (in the form of a meglumine salt):

• 1 tablet - 600 mg;
• 1 ml of solution - 12 mg;
• 1 ml of concentrate - 30 mg.

Excipients of tablets: hypromellose, silicon colloidal dioxide, croscarmellose sodium, lactose monohydrate, simethicone (dimethicone and silicon colloidal dioxide in a ratio of 94: 6), microcrystalline cellulose, talc, magnesium stearate.

The composition of the tablet shell: hypromellose, sodium lauryl sulfate, macrogol 6000 and talc.

Auxiliary components of the infusion solution and concentrate: Macrogol 300, meglumine (for pH correction) and water for injections.

pharmachologic effect

The active substance is an endogenous antioxidant that binds free radicals. Thioctic acid in the body is formed during oxidative decarboxylation of α-keto acids. It takes the form of coenzyme of mitochondrial multienzyme complexes in the oxidative decarboxylation of pyruvic acid and α-keto acids. Reduces blood glucose and increases glycogen in the baking, helps to overcome insulin resistance.

Thioctic acid regulates lipid and carbohydrate metabolism, cholesterol metabolism, improves liver function and trophic neurons. Also, when poisoning with salts of heavy metals and other intoxications, Tiogamma has a detoxifying effect.

Patients suffering from diabetes mellitus on the background of therapy improves endoneural blood flow, increases the level of glutathione to physiological indicators, which improves the functional state of peripheral nerve fibers in diabetic neuropathy.

After ingestion, the drug quickly and almost completely absorbed from the digestive tract. With simultaneous intake with food, the absorption of thioctic acid decreases. The maximum concentration of the drug is observed in half an hour after its administration. Bioavailability of the drug can vary from 30 to 60%. Passing through the liver, thioctic acid undergoes metabolism. The drug is excreted through the kidneys, the elimination half-life is 25 minutes.

Indications for use

Thiogamma in tablets or droppers is prescribed for patients for the complex treatment of polyneuropathies of various origins, in particular diabetic genesis and against the background of alcohol intoxication.

Contraindications

The drug should not be used with hypersensitivity to its components, patients under the age of 18, pregnant and lactating women. Tablets are also contraindicated in the presence of the following diseases:

• Glucose-galactose malabsorption.
• Deficiency of lactase.
• Hereditary intolerance to galactose.

Before using the analogs and the drug itself, you should consult your doctor.

Intended use for pregnancy and lactation

During lactation and pregnancy, the use of the drug is contraindicated because of the possible effects on the child.

Dosage and route of administration

As indicated in the instructions for use, Thiogram tablets are taken on an empty stomach, without chewing, with a small amount of liquid.

• Assign inside of 600 mg (1 tab.) 1 time / day.

The duration of the course of treatment is 30-60 days, depending on the severity of the disease. It is possible to repeat the course of treatment 2-3 times a year.

Side effects

The drug is generally well tolerated, and unwanted reactions rarely occur.

Possible side effects associated with taking tablets:

• Digestive system: abdominal pain, nausea, vomiting, diarrhea;
• Central nervous system: transformation or violation of taste sensations;
• Endocrine system: a decrease in blood glucose, due to improved digestion and accompanied by signs of hypoglycemia: increased sweating, headache, dizziness, visual disturbances;
• Allergic reactions: itching, urticaria, skin rash, systemic reactions (in severe cases - the development of anaphylactic shock).

Overdose

When an overdose of thioctic acid, the following symptoms occur: headache, nausea and vomiting. With the intake of 10-40 g of Thiogamma in combination with alcohol, there were cases of severe intoxication, even to death.

In acute overdose of the drug there is a confusion of consciousness or psychomotor agitation, accompanied, as a rule, by lactic acidosis and generalized convulsions. Cases of hemolysis, rhabdomyolysis, hypoglycemia, bone marrow depression, disseminated intravascular coagulation, multiorgan failure and shock are described.

Treatment is symptomatic. There is no specific antidote of thioctic acid.

special instructions

Before you start using the drug, read the special instructions:

1. One tablet of Tiogamma 600 mg contains less than 0.0041 XE.
2. Patients with rare hereditary intolerance to fructose, glucose malabsorption / galactose syndrome, or glucose isomaltase deficiency should not take Thiogamma.
3. Patients with diabetes mellitus during the treatment with Thiogamma, especially at the beginning of therapy, need to monitor blood glucose levels. In some cases, it may be necessary to adjust the dose of insulin or an oral hypoglycemic drug in order to avoid the development of hypoglycemia.
4. Patients taking the drug Tiogamma should refrain from drinking alcohol. Alcohol consumption during therapy with Thiogamma reduces the therapeutic effect and is a risk factor that contributes to the development and progression of neuropathy.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Ethanol and its metabolites weaken the action of thioctic acid.
2. Thioctic acid enhances the anti-inflammatory effect of GCS.
3. With the simultaneous administration of thioctic acid and cisplatin, cisplatin is less effective.
4. With the simultaneous use of thioctic acid and insulin or oral hypoglycemic drugs, their effect may be enhanced.
5. Thioctic acid binds metals, so it should not be prescribed simultaneously with preparations containing metals (for example, preparations of iron, magnesium, calcium) - the interval between doses should be at least 2 hours.

Reviews

We offer you to familiarize yourself with the opinions of people who used the drug Tiogamma:

1. Eugene. From diabetes I take, in the morning during a meal, Diabeton MB 60mg (there is a risk, I divide it in half, it turns out cheaper than taking 30 mg) and at night Merviform (Glucophage 1000 mg - we have 370 rubles. it is long-lasting. If you follow a diet for carbohydrates, sugar is within normal limits.
2. Alexey. Against the background of my addiction to alcohol, I started polyneuropathy, my hands trembled, I began to suffer from frequent changes in mood. Doctors said that you must first recover from alcoholism, and then eliminate the consequences. At the second stage of therapy I began to take a solution of Tiogamma. He effectively copes with the problem of neuropathy, I began to sleep better.
3. Larissa. From a friend in cosmetology, I heard advice: use lipoic acid in ampoules to eliminate pigmentation spots and wrinkles that begin. I asked the doctor to prescribe the prescription and bought it, used it in the evenings: after washing, I applied the solution instead of the tonic, and then the cream on top. For a month, the spots began to fade, the skin noticeably freshened.

Analogues

Structural analogs for the active substance:

• Alpha lipoic acid;
• Berlition 300;
• Berlition 600;
• Lipamid tablets;
• Lipoic acid;
• Liptiokson;
• Neurolephone;
• Octolipen;
• Thiocacid 600;
• Tioctacide BV;
• Thiolept;
• Thiolipone;
• Espa Lipon.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Tablets should be protected from direct sunlight, stored at room temperature.

Shelf life of the drug is 2 years for the solution and 4 years for tablets. Do not use the drug at the end of the expiration date.

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