Dermovate ointment and cream: instructions for use

width = Dermovayte is considered quite effective in the treatment of skin diseases.

Refers to preparations of steroid origin. Has glucocorticoid activity. There are two forms of the drug - ointment and cream. The ointment is intended for application to the skin, which is prone to drying out, since the base of this form allows to prevent loss of moisture. The cream is discharged in the opposite situation, when there is wetting on the inflamed area.

On this page you will find all information about the Dermovajt: full instructions for use on this medicated medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Dermovate. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

GCS for external use.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Dermovayt? The average price in pharmacies is at the level of500 rubles.

Form of issue and composition

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For the dermatological agent, two pharmaceutical forms are provided - cream and ointment.

The content of the active substance is the same - 50 mg of clobetasol propionate per 100 g of drugs. The difference lies in the composition of the auxiliary ingredients that provide the structure and other characteristics of the drug:

Ointment: E1520, emulsifier sesquioleate sorbitan, white paraffin.
The cream contains glyceryl in the form of monostearate, arlacel-165, analogue of beeswax, a mixture of cetyl and stearyl alcohols, E1520, chlorocresol, E331, monohydrate of citric acid, purified water /

Pharmacological effect

The active substance - clobetasol propionate - glucocorticosteroid, which is used for topical application in dermatology. Clobetasol propionate has a nonspecific anti-inflammatory and anti-allergic effect due to vasoconstriction and decreased collagen formation in the skin. Clobetasol propionate also has the property of eliminating edema, relieving congestion and itching.

The penetration of clobetasol propionate through the skin in different people is different and increases with the use of an exclusive bandage. In people with healthy skin, peak concentrations of clobetasol propionate in plasma, 3 ng / ml, were observed eight hours after application of the drug to the skin. In people with skin diseases: psoriasis, eczema, peak concentrations of the drug (, and, ng / ml) were observed 3 hours after a single dose of Dermovate on the skin.

After absorption through the skin, the drug most likely passes the same metabolic pathway as corticosteroids after systemic administration. However, the systemic metabolism of Dermovate has not been fully understood.

Indications for use

Medications are highly active, used in external treatment with:

Discoid lupus erythematosus;
Dermatoses that can not be treated with other drugs;
Psoriasis (except for extensive plaque);
Different types of eczema;
Red flat lichen (red dermatitis).

Choosing between ointment or cream, you should proceed from the nature of skin lesions: since the ointment contributes to the preservation of moisture, it is better to use it on dry, hyperkeratotic and coarsened areas. The cream has a light texture, so it is better for a delicate skin.

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Contraindications

Do not use the drug in these situations:

genital and perianal itching;
perioral dermatitis;
cancer of the skin;
acne vulgar;
nodular pruritus of Gaida;
period of breastfeeding;
children under 1 year;
common pustular and plaque psoriasis;
hypersensitivity to the constituent ingredients of the drug Dermovate;
fungal, viral and bacterial pathologies of the skin (including chickenpox, herpes simplex, actinomycosis, skin tuberculosis).

Application in pregnancy and lactation

Ointment and cream Dermovajt during pregnancy can appoint or nominate only the doctor. In any case, during this period, do not use local corticosteroids for a long time or in large doses.

During the lactation period, the safety of Dermoveit's application has not been established.

Instructions for use

The instructions for use indicate that the ointment and Cream Dermoveit are used only externally.

The application of the cream is particularly suitable for wet or wet surfaces.

Cream or ointment Dermoveit is applied in a thin layer in an amount sufficient to cover the entire affected area, 1-2 times / day, gently rubbed. Duration of application - before the appearance of the effect or, if necessary, up to 4 weeks. Can not be treated for more than 4 weeks. If prolonged treatment is necessary, gradually reduce the frequency of application or use less active drugs. After each application of the preparation, it is necessary to provide sufficient time for absorption before applying the emollient.

To prevent exacerbations of skin diseases, short (intermittent) courses of treatment with Dermoveit are carried out.

In particularly resistant cases, especially in the presence of hyperkeratosis, the effect of the cream for external use of Dermovayt can be enhanced by overlap overnight in the field of application of the preparation of an occlusive dressing (polyethylene film), which is usually accompanied by a positive dynamics symptoms. In the future, the achieved effect can be maintained without the use of an occlusive dressing.

If the condition worsens or does not improve within 2-4 weeks, the diagnosis and treatment should be reviewed. The maximum weekly dose should not exceed 50 g / week.

Special instructions for patients with eczema:

In the case of an acute disease, as soon as the effect of continuous treatment of GCS for the external application, the possibility of its intermittent use (1 time / day, 2 times a week, without occlusive bandages). It is shown that such treatment effectively reduces the frequency of relapse.
Application of the drug should be continued on all previously affected areas of the skin or to known areas of potential exacerbation. Such a scheme of application should be combined with routine daily application of emollients. A regular assessment of the condition, as well as the benefits and risks of continuing treatment, should be carried out.

Special instructions for patients with atopic dermatitis:

Treatment with Dermovayt should be gradually withdrawn immediately after the control of the disease is achieved, and treatment with an emollient should be continued as maintenance therapy.
Sudden abolition of Dermovayt may lead to a relapse of previously available dermatoses.

Special instructions for children:

Children are more likely to develop local and systemic side effects with external GKS therapy for external use and, as a rule, they require shorter courses of treatment with less active means than adults.
Caution should be exercised when using Dermoveit in children to ensure that it is applied in a minimal amount that provides a therapeutic effect.

Special instructions for patients with impaired renal and / or liver function:

In the case of systemic absorption of the drug (when applied to large areas of the skin for a prolonged period period), its metabolism and excretion can slow down, leading to an increased risk of developing a systemic toxicity. Therefore, it should be used in such patients in minimal amounts and for as short a period as possible, while achieving the necessary clinical effect.

Side effects

During therapy, it is possible to develop disorders on the part of certain body systems, manifested as the following side effects:

The immune system: very rarely - hypersensitivity;
Parasitic and infectious diseases: very rarely - infections caused by opportunistic organisms;
Endocrine system: very rarely - oppression of the hypothalamic-pituitary-adrenal system, signs of a cushingoid (obesity by the central type, lunar face), growth retardation and / or delayed increase body weight in children, glaucoma, osteoporosis, glucosuria and / or hyperglycemia, hypertension, cataracts, obesity or weight gain, alopecia, decreased endogenous cortisol, fragility hair;
Skin and subcutaneous tissue: often - soreness or burning sensation, itching; infrequently - striae, local skin atrophy, telangiectasia; very rarely - thinning, wrinkled skin, urticaria, aggravation of symptoms of the disease, dry skin, hypertrichosis, pigmentation change, pustular psoriasis, allergic contact dermatitis, rash, erythema (many of the described skin manifestations are secondary to systemic and / or local effects of oppression hypothalamic-pituitary-adrenal system);
General disorders: very rarely - soreness and / or irritation at the site of application.

When Dermoveit is applied to large surfaces over a long period of time (for example, more than 14 days), patients can develop such systemic side effects, such as: symptoms of hypercortisism, gastritis, increased intraocular pressure, ulceration of the mucous membrane of the gastrointestinal tract.

Overdose

With prolonged and uncontrolled use of ointment and cream Dermoveit, as well as with the application of dressings with the drug, the symptoms of overdose develop rapidly in patients, which consist in the following

Change in the indicators of the clinical picture of blood;
Syndrome Itenko-Cushing;
Dysfunction of the liver
Oppression of adrenal function.

As a rule, these symptoms are reversible and easily pass after drug withdrawal or dose reduction. If necessary, the patient is symptomatically treated.

special instructions

When applying to the eyelids, do not allow the drug to enter the eyes.
The use of Dermovayt for the treatment of children should be done under systematic supervision of the doctor, at least once a week.
It is not recommended to apply Dermovajt on a face skin, and in case of acute necessity treatment should last no more than three days.
If there is a concomitant infection, it is important to carry out antibiotic therapy, if necessary, temporarily stop the use of the drug.
To avoid the occurrence of bacterial infection when using occlusive dressings, before each wrapping, the affected area should be thoroughly cleaned.

Drug Interactions

According to the studies, the combination of Dermoveit with drugs that can suppress CYP3A4 (such as Itraconazole and Ritonavir), there is a slowdown in the metabolic processes of corticosteroids.

As a result, it can provoke an increased systemic effect. Also should take into account the dosage of drugs, methods of administration of glucocorticosteroids and the power of exposure to CYP3A4.

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Reviews

We picked up some of the people's comments about Dermovate:

Leonid. I suffer from psoriasis, mainly on the outside of the hand. On the advice of the attending physician I try the cream "Dermovate to be honest, there is no result for a month already. The only thing - the steamed hands softens well, but it does any ointment that is used for treatment. In a word, I still do not see the result!
Tanya. I use this preparation already half a year. A special effect of its use is not noticed. Maybe he helps with psoriasis, but the granuloma on the finger can not be cured. Although my doctor recommended this ointment as the best in the class of these drugs. Dermovate did not help me.

Reviews of this drug indicate the successful treatment of psoriasis and other skin diseases. However, as with any other drug, before using Dermovayt, it is worth to visit the appropriate doctor. He will put an accurate diagnosis and prescribe an effective treatment.