What helps Creon 10000: detailed instructions

Creon is an enzyme medication used to improve digestion for adults and children.

The mechanism of action of the drug consists in mixing the mincrosses of pancreatin with intestinal contents. After reaching the small intestine by the small intestine, at a pH level greater than the value the enteric coating dissolves.

Due to the release of pancreatic enzymes with amylolytic, lipolytic and proteolytic activity, more complete cleavage of food components (fats, carbohydrates and proteins) occurs.

Clinical and pharmacological group

This drug is able to replenish the deficiency of enzymes in the pancreas.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much is Creon 10000? The average price in pharmacies is at the level of300 rubles.

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Form of issue and composition

The medication is released in the form of enteric-soluble hard capsules containing light brown minicrospheres - pancreatin (active ingredient):

• Creon 10000 - containing 150 mg of pancreatin (which corresponds to 1, 00 ED Ph. Eur. lipases);
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• Creon 25000 - with a content of 300 mg of pancreatin (corresponding to 2, 00 ED Ph. Eur. lipases);
• Creon 40000 - with the content of 400 mg of pancreatin (which corresponds to 40000 ED Ph. Eur. lipase).

When using medicines for children, it should be borne in mind that Creon 1000 is not released, and in pediatrics, Creon 10000 is used, the dose of which is calculated by the doctor based on the age and body weight of the child.

The medication is issued in vials of 20, 50 and 100 pieces.

Pharmacological effect

The composition of Creon includes pancreatin of porcine origin in the form of enteric-coated minimocrospheres. The contents of the capsule are resistant to acidic medium, dissolves quickly, releasing granules. This provides excellent mixing of the drug with the contents of the stomach, transportation to the intestine and a good distribution of enzymes in it.

When microspheres enter the small intestine, the membrane dissolves, releasing lipolytic, amylolytic and proteolytic enzymes. They provide the splitting of fats, carbohydrates and proteins. After pancreatic digestion, the products are absorbed immediately or after digestion by intestinal enzymes of the intestinal contents. According to research, the effect of the drug manifests itself in the lumen of the gastrointestinal tract.

According to the scientists who conducted the experiments, the medicine does not show toxicity in the small intestine and other parts of the intestine.

Indications for use

The preparation Creon 10000 is used in the replacement therapy of exocrine pancreatic insufficiency in cause of disruption of the production of enzymes or their excessive destruction in the intestinal lumen on the background of the gastrointestinal tract pathologies.

As a rule, Creon is prescribed in pathological conditions like:

1. Cystic fibrosis;
2. After surgery on the pancreas;
3. Obstruction of pancreatic or bile ducts;
4. After gastric gastrectomy;
5. Partial removal of the stomach;
6. Chronic pancreatitis;
7. After a recent attack of acute pancreatitis;
8. Syndrome Shvahmana-Diamond;
9. Oncology of the pancreas;
10. When preparing for X-ray or ultrasound diagnosis of abdominal organs.

Also, the drug is often recommended for eating disorders, when it is impossible to thoroughly chew food, hypodynamic life, as well as patients who are forced to long-term bed rest.

Contraindications

The list of contra-indications at Creon is modest. It can be taken even by young children on breastfeeding, but sometimes it is necessary to abstain from taking the medicine on the basis of a contraindication.

Do not take the drug with an individual intolerance of one of the components that make up the creona-10000. If a child swallows the capsule and has an allergic reaction, stop taking the medication immediately. You can not start treatment on your own without a thorough examination by a doctor. Hyperfunction of the pancreas is a direct contraindication to the ingestion of enzymes.

Use in pregnancy and lactation

Data on how safe to take the CREON medication during pregnancy and lactation are missing. This applies in general to any pancreatic enzyme. Therefore, the use of the drug is permissible only when the expected benefit from the treatment for the mother significantly exceeds the probable danger to the fetus or baby.

Dosage and route of administration

The instructions for use indicate: Creon capsules 10000 are taken orally during meals or immediately after each meal, including light snacks. They must be swallowed whole and washed down with a sufficient amount of liquid.

Patients who experience difficulty in swallowing, and children of the capsule can be gently opened and added contained in They minimize the microcircle to a soft food that does not require chewing and has an acidic taste, or taken together with a liquid with acidic taste. The admissible for mixing food products are: apple puree, yoghurt, fruit juices (apple, pineapple and orange) with pH

1. The dose of Creon 10000 (in terms of lipase) is selected individually, taking into account the type of disorder, the severity of the disease, the composition of the diet and the body weight of the patient.
2. In cystic fibrosis at the beginning of treatment, adults and children from 4 years of age are prescribed 500 units / kg, children under 4 years of age - 1000 units / kg with each meal. Depending on the severity of the symptoms of the disease, the results of control of steatorrhea and individual sensitivity, the dose can be adjusted. For most patients, the daily dose does not exceed 1, 00 U / kg body weight or 4000 U / g consumed fat.
3. In other conditions accompanied by an enzymatic insufficiency of the pancreas, the dose is determined in dependence from the individual characteristics of the patient, including the degree of insufficiency of digestion and the content of fat in the diet power supply. With a basic meal, usually taking a dose of 2, 00-80000 units of lipase, with light snacks - ½ of the therapeutic dose.

Children of Creon 10000 are used only in accordance with the prescriptions of the doctor.

Side effects

The drug is well tolerated by patients. In some cases, with increased individual sensitivity to enzymes in patients on the background of therapy with Creon, the following side effects may develop:

1. Allergic reactions - rash on the skin, hyperemia, severe itching, urticaria;
2. On the part of the organs of the digestive canal - pain in the epigastric region, nausea, increased salivation, the urge to vomit, constipation, bloating, increased appetite;

In rare cases, it is possible to develop angioedema or anaphylaxis.

Overdose

If the recommended dose is significantly exceeded, the signs of overdose may develop in patients:

1. Salivation;
2. Severe abdominal pain;
3. Nausea and vomiting.

Perhaps the development of hyperuricosuria and hyperuricemia. When the patient develops signs of an overdose, symptomatic treatment is performed.

special instructions

Before you start using the drug, read the special instructions:

1. Chewing, grinding or adding a minimrocross to food with a pH more, leads to the destruction of their shell, which protects against the action of gastric juice.
2. During treatment, it is important to ensure sufficient fluid intake, because its absence can lead to increased constipation.
3. To rule out lesions of the colon, as a precautionary measure in patients with cystic fibrosis is recommended monitor all unusual symptoms or changes in the abdominal cavity, especially in patients taking more than 1, 00 units lipase / kg per day.
4. Children with cystic fibrosis who take CREON 2, 00 for a long time should be under constant medical supervision.
5. The preparation Creon can be taken to patients who profess Judaism and Islam.

The drug has no adverse effect on the rate of reactions and the ability to concentrate attention.

Drug Interactions

Clinical studies on drug interactions with other medications have not been conducted.

If a person besides Creon-1, 00, is forced to take other drugs, it is better not to take risks and make a gap between medicines and enzymes for at least 2 hours.

Reviews

We picked up some reviews of people taking the drug Creon 10000:

1. Yura. After acute pancreatitis, I began to closely monitor my nutrition and health. The first month after the recovery, he took capsules Creon. The doctors explained that they are better than Mezim, because they work faster. The drug and the truth showed itself from the best side, did not cause side effects, it did not make me sick.
2. Dasha. Creon is considered a fairly popular drug, all my friends in different life situations periodically took it. So, somehow, I started to worry about the problems associated with poor digestion of food and frequent diarrhea. Of course, the drug is expensive, but in comparison with other drugs it is more effective. Before him, Pancreatin was drunk, there was no such quick and pronounced therapeutic effect from him.
3. Valentina. The first time I heard about the "Creon" preparation, when a child, in a year, got into an infectious hospital. Doctors along with all the antibiotics prescribed "Creon" (to separate the capsule, mix it with water and give). In the child it was impossible to pour anything, or come back through the top, or through the bottom. A dehydrated poor child began to recover on the third day. Antibiotics killed the whole microflora, but, as the doctors said, that "Creon" will help to normalize everything. On the third day the child began to eat a little, and a week later we were already preparing for discharge. "Creon" doctors prescribed even after the hospital, it was restored. A month later, my child was already eating well and there were no problems with digestion.

Analogues

If the cost of this drug does not suit you, then with the permission of the doctor you can replace it with a cheaper analogue, the composition of which is identical. Cheap analogs. which are most often offered to replace, the prescription prescribed in the prescription is as follows:

• Pancreatin;
• Pancreatym;
• Pangrol;
• Mikrazim;
• Mezim Forte;
• Gastenorm Forte;
• Penzital;
• Festal;
• Hermitage.

Before using analogues, consult your doctor.

Creon or pancreatin is better?

These two drugs are essentially the same medicine. But they have minimal differences. So Pancreatin (in Latin Pancreatinum) begins to work in the stomach, and Creon in the intestines. The first is available in tablets and is much cheaper, so it often replaces.

What is better is often determined by the patient himself after treatment according to the instructions for use and his own feelings. At doctors opinion on the account of both preparations is divided.

Storage conditions and shelf life

Store in a place inaccessible to children at a temperature of: Creon 10000 and 25000 in blisters - up to 20 ºС, Creon 10000 and 25000 in bottles - up to 25 ºС, Creon 40000 - up to 30 ºС in tightly closed containers.

Shelf life:

• Creon 10000 and 25000 in blisters, Creon 10000 in bottles - 2 years;
• Creon 25000 and 40000 in vials - 3 years.

After opening the bottle, the expiration date is 6 months.

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