What helps De-Nol: instructions and feedback

De-Nol is a new generation antibiotic that exerts antiulcer, anti-inflammatory action against bactericidal activity against Helicobacter pylori.

It also has anti-inflammatory, antacid and astringent effects. Forms an insoluble protective coating at the site of the ulcer. Improves the protective properties of the gastrointestinal mucosa. Increases the production of mucus, the stability of the mucous membrane to the effects of pepsin, hydrochloric acid and enzymes.

On this page you will find all the information about De-Nol: complete instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied De-Nol. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antiulcer agent with bactericidal activity against Helicobacter pylori.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is De-Nol? The average price in pharmacies is at the level of580 rubles.

Form of issue and composition

One De-Nol tablet contains 120 mg of active substance. The main component (bismuth tricalium dicitrate) after penetration into the stomach at the site of the lesion forms a protective layer that does not allow the gastric acid to erode the damaged mucosa.

Medication additives:

• ammonium and potassium citrates;
• Povidone To 30;
• polucrilin potassium;
• magnesium stearate;
• corn starch;
• macrogol 6000;
• hydroxypropylmethylcellulose.

The preparation is available in the form of tablets coated with a film membrane. In the blister for 32, 56 or 112 pcs.

Pharmacological effect

Anti-ulcer drug leads to direct death of microorganisms, i.e. has a bactericidal effect on the bacteria Helicobacter pylori. De-nol is also characterized by astringent and anti-inflammatory effect. In acidic gastric content, insoluble bismuth citrate and oxychloride compounds are deposited on the mucosa. On the surface of erosive and ulcerative lesions, a protective film is formed in the form of chelate compounds with protein molecules.

Reception of De-nol leads to stimulation of the activity of mechanisms that protect cells, and to enhance the stability of the gastric mucosa to the negative effects of hydrochloric acid, the proteolytic enzyme pepsin, as well as enzymes and bile salts. These effects are due to activation of the synthesis of prostaglandin E, bicarbonate and mucus.

Against the background of treatment, the activity of the proenzyme pepsinogen and the enzyme pepsin is reduced.

Indications for use

The drug De-Nol excellently helps in the treatment of many problems of the gastrointestinal tract:

1. Gastroduodenitis;
2. Ulcerative disease of the stomach, as well as with ulcer of the duodenum;
3. Irritable bowel syndrome;
4. With gastritis, De-Nol reception also helps, regardless of whether the illness is chronic or acute;
5. He also cures the consequences of taking non-steroidal anti-inflammatory drugs.

Properly prescribed course helps to forget about these diseases of the stomach and intestines, as well as the symptoms accompanying them.

Contraindications

The following conditions are among the main contraindications for De-Nol treatment:

• individual immunity to the drug or its intolerance;
• pregnancy and the period of breastfeeding;
• impaired renal function, including decompensated renal failure;
• abnormal liver function;
• children's age (up to 4 years).

Application in pregnancy and lactation

Contraindicated in pregnancy. Also, its administration to nursing women should be avoided.

Instructions for use

The instructions for use indicate that the daily dose of the drug De-Nol and the duration of the course of therapy should be determined by the doctor. It depends on the patient's body weight, age, severity of the pathological process, the presence of complications and individual drug tolerance.

Averaged Dosages:

1. Adults and children older than 4 years - inside 2-4 times / day for 30 minutes before meals. The dose depends on the age of the patient.
2. The course of treatment is 4-8 weeks. For the next 8 weeks, do not take drugs containing bismuth.

With the eradication of H. pilory, the drug is administered in combination with other antibacterial agents that are active against this microorganism.

Side effects

Nausea, vomiting, more frequent stool, diarrhea. With long-term use of the drug in high doses - encephalopathy associated with the accumulation of bismuth in the central nervous system.

Overdose

When using the drug for a long time at elevated dosages, there is a possibility of an overdose with the drug, in which the kidneys can be disturbed. In cases of drug overdose, the patient is washed with a stomach, activated charcoal in combination with salt laxatives. After these measures, symptomatic treatment is performed.

Do not use any other medicines within 30 minutes before and after taking the drug, also During this time, one should refrain from eating food and liquids (especially milk and fruit juices). When taking De-Nol tablets, it is possible to stain the feces in a dark color (this is due to the formation of bismuth sulphide). At some patients at reception of a preparation mildly darkening of tongue can be marked.

special instructions

1. In the treatment, staining of feces is observed in black.
2. Simultaneous adoption of De-Nol with food, milk, fruits, juices reduces its effectiveness.
3. To enhance bactericidal action against Helicobacter pylori in some cases, it is advisable to combine with metronidazole and / or amoxicillin for 1-2 weeks.

Drug Interactions

With the simultaneous administration of other medicines, as well as food and liquids, in particular antacids, milk, fruits and fruit juices, a change in the efficiency of bismuth in tricalium dicitrate is possible.

Reviews

We picked up some of the people's comments about the De-Nol product:

1. Lisa. The most important thing is that it helps. Twice I had an exacerbation of erosive gastritis, each time in appointment was de-nol and fosfalugel in combination with diet. The pains passed in a week, and a month later I already forgot about the problem with the cavity.
2. Eugene. After the examination, the diagnosis of "stomach ulcer" was diagnosed, Helicobacter pylori was detected. The doctor appointed a comprehensive treatment, it included antibiotics, Trichopol and De-Nol drug. In the process of treatment, nausea, metallic taste in the mouth appeared, but the doctor said that this is normal and will become better in a few days. Indeed, a week later I felt fine, but the stool turned black. It turns out that this is a reaction to the active substance De Nola-bismuth salt. So it is not necessary to be frightened. As a result, after the course of treatment, the control probing showed that the erosions are well tightened, and the pathogen is absent in the analyzes. Now the general state of health is excellent, I hope, the recurrence of the disease will not be.
3. Sergei. To all lovers of de-zero: if you have an itch and an eruption after the second-third reception, immediately throw the reception! It's not an allergy, it's bismuth poisoning. Some people, for some reason, it's absorbed into the blood through the stomach, why this happens, scientists do not know, but modestly silent about it in the annotation to the medicine. There will be a strong itchy rash all over the body, a temperature is possible, but the defeat of internal organs is unknown to us.
4. Anna. De-nol contains bismuth, which stains the stools in a characteristic black color. At first I was frightened, because somewhere in my memory from the Internet's debris it was postponed that a sharp darkening of the stool without changing the diet could be a sign of gastric bleeding.

Doctors in the reviews of De-Nol point out that the best result can be achieved if the drug is used as part of complex therapy. The most effective were quadruple regimens in which Omeprazole, Trichopolum and the antibiotic Clarithromycin or Amoxicillin were used along with bismuth subcitrate tablets.

Analogues

The following medicines are similar in their therapeutic effect with the drug De-Nol:

• Ranitidine;
• Omeprazole;
• Omez;
• Gastrofit;
• Gastal;
• Pepsan;
• Nolpaz.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The drug should be contained in the original packaging at an air temperature of 15 to 25 degrees. It should not be exposed to direct sunlight. With proper storage of the medication, the shelf life is four years, after which the drug is prohibited, even if the package has not been opened.

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