Diane-35 tablets

Diane-35 is a combined low-dose monophasic oral contraceptive with antiandrogenic effect.

The drug contains estrogen - ethinyl estradiol and antiandrogen with gestagenic activity - cyproterone acetate. This component inhibits the effect of androgens, which are also produced in the female body. Thus, it becomes possible to treat diseases caused by increased formation of androgens or specific sensitivity to these hormones.

On this page you will find all information about Diane-35: full instructions for use for this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Diana-35. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Monophasic oral contraceptive with antiandrogenic properties.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Diane 35 cost? The average price in pharmacies is at the level of1 200 rubles.

Form of issue and composition

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Contraceptive tablets Diane-35 are made in the form of pills, which are contained in a blister - a special calendar pack of 21 pcs. It is put in a cardboard box.

The composition of tablets Diane-35 contains active components of cyproterone acetate and ethinyl estradiol, as well as a number of additional components: lactose monohydrate, povidone, corn starch, magnesium stearate, magnesium hydrosilicate.

The dragees are light yellow in color, round, biconvex.

Pharmacological effect

The contraceptive effect is achieved through the complementary action of active substances that contribute to the following effects:

Suppress the process of ovulation.
Influence the composition of cervical mucus.

As a result, spermatozoa can not penetrate into the cervical mucus. Patients who take monophasic oral contraceptives are less likely to develop anemia. Admission to Diana 35 normalizes the menstrual cycle, eliminates pain syndrome, which can occur during menstruation, reduces the intensity and duration of bleeding.

Patients who take Diana 35 decreases the functioning of the sebaceous glands, which in turn prevents the development of seborrhea and acne.

Indications for use

Diane-35 is used for contraception in women with increased production of male hormones (androgenation).

Also, the drug is prescribed to patients with androgen-dependent diseases: seborrhea, acne, acne, hirsutism, androgenetic alopecia in mild form, excessive hair loss or baldness due to excessive production of male hormones in the female body.

Contraindications

Deny the use of contraceptive pills Diane-35 is subject to availability:

Syndromes of Dubin-Johnson / Rotor.
Tumors of the endometrium.
Pregnancy and lactation.
Liver diseases.
Idiopathic jaundice.
Itching of the skin layer.
Thrombosis / thromboembolism.
Angina pectoris.
Diabetes mellitus.
Vaginal bleeding.
Breast Cancer.
Obesity.
Dermatosis is of bubble form.
Otosclerosis.
Tumors of a malignant nature, depending on hormones.

Instructions for use

The instructions for use indicate that Diane-35 tablets are taken orally, without chewing, with a small amount of liquid, preferably immediately after breakfast or dinner.

Dosage of the drug - 1 dragee per day.

The reception begins on the first day of the cycle, using from the calendar packing the dragees of the corresponding day of the week, at the convenient patient time, with the proviso that subsequent techniques will necessarily be carried out at this particular hour of the day.

For each following method, a dragee is used from the cell pointed to by the arrow on the foil from the previous one. Following the direction on the calendar package, the woman takes all 21 pills and takes a break of 7 days, during which bleeding occurs like menstrual flow. One course of therapy lasts 28 days, of which 21 days - taking dragees and 7 days - a break. It must be remembered that the reception should not be interrupted for more than 7 days and the first 7 days of taking the pills are required to achieve the appropriate suppression of the hypothalamic-pituitary-ovarian system.

The day of taking the drug from the next package must coincide with the day of the week on the calendar packing of the previous course and start on the 8th day after the start of the break at a strictly fixed time.

To switch from combined oral contraceptives to Diane-35, the reception should be started the day after the last dragee from the package with the active substances of the previous product, for calendar packing on 28 dragees and not later than 1 day after the 7-day break, for contraceptives with 21 tablets.
To switch from drugs consisting only of progestogens ("mini-drank"), Diane-35 reception can be started without interruption, with injectable forms of contraception - from the day of the next injection, from the implant - on the day of its removal. For each of these transitions, it is additionally necessary to use the barrier method of contraception during the first 7 days.

During an abortion in the first trimester of pregnancy, oral contraception is started immediately, in this case additional methods of contraception are not required.

In the absence of sexual contacts after abortion in the second trimester of pregnancy or childbirth, it is recommended to start the drug on the 21-28th day. If the woman started taking the procedure later, then during the first 7 days, the barrier method of contraception should be used in parallel. Patients who have lived sexually in the interval between abortion or childbirth and the beginning of the drug, should wait for the first menstruation or exclude the presence of pregnancy.

If the woman missed taking the pills at the set time, it should be taken as soon as possible, and the next dragee at the usual time. The reliability of contraception is not impaired when being late for less than 12 hours.

In the case when more than 36 hours have passed since the last reception (over 12 hours late), the missed dragee should be taken immediately, as soon as they remembered, even if it would be taking two pills at the same time, with the next dose being taken at the usual time. If the violation occurred in the first or second week of use, it is necessary to use the barrier method of contraception for the next 7 days. In case of being late for more than 12 hours during the third week of reception, at the end of the calendar packing, there is no need to stop the reception, it is necessary to continue reception from the next blister. During the reception from the second package, a woman may have bloody spotting discharge or breakthrough uterine bleeding.

If the patient had vomiting after taking the pills (in the first 3-4 hours), the absorption of the active substances may be broken and incomplete, so you should use the recommendations for the case when you miss a reception.

To delay the onset of menstruation, you must continue taking the pills from the new calendar package without taking a 7-day break. Take the pills from the second package can be until its end. It should be noted that during this period, the patient may have spotting or breakthrough bleeding. After 7 days of interruption, Diana-35 should be continued from the new packaging.

To change the day of the beginning of the menstrual cycle to another, the nearest break should be reduced by the required number of days. The fewer days of interruption, the greater the likelihood of no withdrawal bleeding and the presence of smearing spotting during the period of taking the pills.

The duration of the drug in the treatment of hyperandrogenic pathologies depends on the severity of the condition, after the disappearance of signs of the disease, the dragee is recommended to continue for 3-4 months. If relapse occurs, you can repeat the course of therapy.

Side effects

Diane-35 can be used to cause side effects from various organs and systems, including:

Eyes - development of intolerance of contact lenses.
The digestive system - nausea, vomiting, abdominal pain, diarrhea, changes in the functional activity of the liver and bile ducts.
Metabolic disorders - fluid retention in the body with the development of peripheral edema, weight gain and triglyceride levels in the blood.
The reproductive system and mammary glands are intermenstrual bleeding, an increase in mammary glands in the volume, their soreness, the appearance of secretions from the vagina or secretion from the mammary glands.
Nervous system - headache, migraine, the development of transient mental disorders (mood reduction, depression, excessive increase or decrease in libido).
Cardiovascular system - increase in the index of systemic arterial pressure (arterial hypertension), thromboembolism (formation of a thrombus in the lumen of the vessel with its subsequent migration in the bloodstream).
Allergic reactions - skin rash and itching, urticaria (a characteristic rash and swelling of the skin, which outwardly resemble a nettle burn). Changes in the skin in the form of nodal erythema (appearance of characteristic red spots) can develop less often. The development of severe allergic reactions in the form of Quincke edema (severe swelling of soft tissues) or anaphylactic shock (vascular collapse with a decrease in blood pressure and multiple organ failure) was not documented.

In case of side effects, the drug should be discontinued and consult a doctor.

Overdose

Symptoms of an overdose: nausea, vomiting, small vaginal bleeding (in girls).

special instructions

Before the application of Diane-35 it is necessary to conduct a general medical examination (including mammary glands and cytological study of cervical mucus), exclude pregnancy, violations of the blood coagulation system. With prolonged use of the drug, preventive check-ups should be performed every 6 months.
In the presence of risk factors, the potential risk and the expected benefits of therapy should be carefully evaluated and discussed with the woman before she decides to start taking the drug. With weighting, strengthening, or the first manifestation of any of these conditions or risk factors, it may be necessary to cancel the drug.
The patient should be warned that with the development of symptoms of venous or arterial thrombosis should immediately consult a doctor. These symptoms include unilateral leg pain and / or swelling; sudden severe pain in the chest with irradiation in the left arm or without irradiation; sudden shortness of breath; a sudden attack of coughing; any unusual, strong, prolonged headache; increased frequency and severity of migraine; sudden partial or complete loss of vision; Diplomacy; slurred speech or aphasia; dizziness; collapse with or without partial seizure; weakness or very significant loss of sensitivity, suddenly appeared on one side or in one part of the body; motor disorders; symptomatic complex "sharp" abdomen.
The estimated incidence of venous thromboembolism (VTE) with oral low-dose oral contraceptives (less than 50 μg ethinylestradiol) is up to 4 per 10 000 women per year compared to 0.5-3 per 10 000 women who do not take oral contraceptives. At the same time, the frequency of VTE when taking combined oral contraceptives is less than the frequency of VTE associated with pregnancy (6 per 10 000 pregnant women per year).
If there are violations of the liver function, it may be necessary to temporarily cancel Diane-35 before normalizing laboratory parameters. Recurrent cholestatic jaundice, which develops for the first time during pregnancy or previous reception of sex hormones, requires discontinuation of combined oral contraceptives.
The relationship between the administration of combined oral contraceptives and hypertension has not been established. If there is persistent arterial hypertension, Diane-35 should be canceled and appropriate antihypertensive therapy should be prescribed. Reception of a contraceptive can be continued at normalization of a BP.
Women with a tendency to chloasma when taking combined oral contraceptives should avoid prolonged exposure to the sun and exposure to ultraviolet radiation.
Although combined oral contraceptives have an effect on insulin resistance and tolerance to glucose, there is usually no need to correct the dose of hypoglycemic drugs in patients with diabetes mellitus. Nevertheless, this category of patients should be under careful medical supervision.
Against the background of Diane-35, occasional bleeding (spotting or breakthrough bleeding) can occur, especially during the first months of therapy. Therefore, any irregular bleeding should be assessed only after an adaptation period of approximately 3 cycles.
If in women with hirsutism the symptoms developed recently or significantly increased, in the course of differential diagnosis Other causes, such as an androgen-producing tumor, congenital adrenal cortex dysfunction should be considered.
If irregular bleeding recurs or develops after previous regular cycles, then nonhormonal reasons and implemented adequate diagnostic measures to exclude malignant neoplasms or pregnancy. These can include diagnostic scraping.
In some cases, bleeding cancellation may not develop during a break in taking the pills. If the pellet is taken irregularly or if there are no two menstrual bleeding in a row, you should exclude pregnancy before continuing with the drug.

Drug Interactions

With the simultaneous use of Diane-35 with inducers of microsomal hepatic enzymes (hydantoins, barbiturates, primidon, carbamazepine and rifampicin, and also, possibly, with oxcarbazepine, topiramate, felbamate and griseofulvin), the clearance of ethinyl estradiol and cyproterone increases, which can lead to breakthrough uterine bleeding or a decrease in contraceptive reliability.

With simultaneous use with ampicillins and tetracyclines, the contraceptive reliability of Diane-35 decreases.

Reviews

We picked up some of the women's comments about the Diane-35 drug:

Anna. Took Diana 35 very long ago at the age of 23 years. Very good tolerability. the ideal drug. After that, she also took it as early as 30 years of age, too, felt great. Girls do not listen to what they say about it. The drug is good and very good for acne and hormonal androgenia.
Nastya. Accepted oral contraceptives Diana 35. But I noticed that they have side effects. The doctor advised taking with him the drug Lavit. It helps the health of nails and hair, the skin looks better, and when you stop using oral contraceptives, it helps you get pregnant sooner. There is one disadvantage, I was sold it when I was given too much crumpled packaging.
Vitalina. Contraceptives decided to take 3 months after delivery. My gynecologist advised "Diana-35". After a month of use, she threw the pills, as the weight increased by 4 kilograms, the skin showed acne, the libido decreased significantly. Why the drug did not fit me I do not know. And the doctor advised, and analyzes on hormones before application has handed over. I have not been able to lose weight for 4 months already, and my menstrual cycle has completely lost weight. Hormonal background seems to have suffered too. With skin problems 2 months struggled. Maybe the drug is not bad, but I personally need to look for another option, and "Diane-35" will not take any more risks.
Nadia. I have been drinking oral contraceptives for two years already. They gave me COC after they found a cyst on the ovary. And she was not small, 3 cm. The cyst has resolved on the third cycle. They began to get dirty less hair, clean skin. I personally did not notice weight gain. But I still drink contraceptives with the female complex of vitamins "Lavita". I take them in the morning after breakfast, and a pill of contraceptives at three. All on schedule) Against the backdrop of vitamins my hair has become more powerful and faster to grow.

In the discussion of Diana-35, doctors' reviews are often positive. Reviews of gynecologists suggest that the drug as a whole is effective. Nevertheless, in the network there are many complaints related to negative actions as a consequence of taking this contraceptive. In particular, women write about nausea, weight gain, rapid heartbeat, a general decrease in tone, etc. There are also many testimonials indicating that the pregnancy after the use of this drug has occurred in cases where previously women could not conceive a child.

Analogues

Analogues of this contraceptive are drugs Bellun-35, Erica-35, Chloe. Selection of the most suitable means should be performed by the doctor individually.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The shelf life of the Diane-35 dragee is 5 years from the date of manufacture. The drug should be stored out of reach of children at an air temperature of not more than +30 ° C.