Tizalud

Tizalud is a modern medication - central muscle relaxant.

The mechanism of action of tizanidine is completely unclear, most likely, it is associated with suppression of spinal polysynaptic reflexes, which is caused by a decrease in release excitatory amino acids from presynaptic terminals of spinal neurons, in addition, the active substance stimulates α2-adrenoreceptors. Tizanidine does not affect the transmission of excitation in neuromuscular synapses.

Effective against acute painful muscle spasms and chronic spasms of spinal and cerebral origin. Reduces spasticity and clonic convulsions, resulting in reduced resistance to passive movements and increases the volume of active movements.

Clinical and pharmacological group

Miorelaxant of central action.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Tizalud cost in pharmacies? The average price is at the level of190 rubles.

Composition and form of release

The drug is available in round, biconvex tablets that are at risk. They are white, a yellowish tint is permissible. As an active component they contain

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tizanidine hydrochloride.

In addition, the tablets contain the following excipients:

milk sugar;
ICC;
primogel;
E 572.

pharmachologic effect

The active substance of the drug Tizalud - tizanidine, is specific for the action is an agonist of a2-adrenergic receptors, belongs to the group of medications - muscle relaxants of central action.

Has a moderate central analgesic effect, helps reduce spasms, clonic convulsions, increases the force of arbitrary contractions. Tizanidine is rapidly and almost completely absorbed from the digestive tract. The maximum concentration of the drug in the blood plasma is reached after 1-2 hours after taking the drug inside. Bioavailability is 34%, binds to blood proteins by 30%. The half-life of the drug from the body is 2-4 hours.

Excretion from the body occurs mainly with kidneys with urine (60-70%), the rest is excreted by the intestine with feces (20-25%) unchanged (about 5%).

Indications for use

What helps? Tizalud is prescribed according to the instructions for the treatment of painful muscle spasms.

Here are the main indications:

painful muscular spasm associated with static and functional diseases of the spine (cervical and lumbar syndromes), and also after surgical interventions (eg, for a herniated intervertebral disc or osteoarthrosis of the hip joint);
spasticity of skeletal muscles in neurological diseases (for example, with multiple sclerosis, chronic myelopathy, degenerative diseases spinal cord, the consequences of cerebral circulation disorders, as well as infantile cerebral palsy (patients over 18 years old).

Contraindications

According to the instructions, Tizalud is contraindicated to take:

During pregnancy;
In pediatrics;
Against a background of hypersensitivity to the active (tizanidine) or auxiliary components that make up the tablets;
During lactation;
Simultaneously with powerful inhibitors of the isoenzyme CYP1A2;
Against the background of severe hepatic insufficiency.

With extreme caution, take Tisalud tablets:

With the syndrome of congenital extension of the Q-T interval;
Against the background of a bradycardia;
Simultaneously with oral contraceptives;
With arterial hypotension;
Against a background of hepatic or renal insufficiency;
Elderly people over 65 years of age.

Intended use for pregnancy and lactation

Contraindicated use of tablets Tizaluda during periods of breastfeeding and pregnancy.

Dosage and route of administration

As indicated in the instructions for use, Tizalud tablets are taken orally after meals, with a small amount of water.

The dose of the drug is determined by the doctor, however, in the initial stages of therapy, the initial dose should not exceed 2 mg per dose. Tablets are taken 3 times a day, at regular intervals.
With insufficient therapeutic effect, the dose of Tizalud is increased gradually, increasing the daily dose every 2 to 4 days by 2 mg. The maximum daily dose of the drug is 36 mg.

The experience of using the drug among patients over 65 years is very limited, therefore the treatment is carried out only under strict indications and under the supervision of a doctor.

Side effects

Tizalud can cause the following side effects:

Increased weakness;
Weakness in all muscles;
Hallucinations;
Rashes and itching on the skin;
Violation of the function of the liver;
Nausea and vomiting;
Drowsiness during daytime and insomnia at night;
Discomfort or soreness in the abdomen;
Decrease in the numbers of blood pressure.

All the symptoms go away after the drug is discontinued. With an overdose of Tizalud, the patient may experience signs of side effects, convulsions, respiratory disorders, coma and even death are also associated. If such symptoms occur, immediately wash the stomach, take sorbents and diuretics, then immediately call a doctor

Overdose

In case of an overdose of the drug, there may be symptoms such as: nausea, a significant decrease arterial pressure, coma, dizziness, vomiting, drowsiness, anxiety, respiratory failure, miosis.

Treatment is symptomatic (gastric lavage, activated charcoal forced diuresis).

special instructions

Tizalud is used with extreme caution in patients with functional disorders of the kidneys and liver.

At the beginning of therapy with the drug, when there is drowsiness, it is necessary to avoid activities requiring rapid psychomotor reactions and maximum attention concentration.