Contents of the article:
- Characteristics of the composition of preparations
- Therapeutic effect of preparations: which is better?
- How quickly drugs work, withdrawal from the body
- Comparison of indications and contraindications: which is better?
- Features of the application
- Comparative analysis of the side effects
- Special instructions
- Other characteristics of the
The phlebodia 600 and detralex are angioprotectors - a remedy for the treatment of heart and vascular diseases. These drugs are used for violations of venous circulation: venous and lymphatic insufficiency, varicose veins and hemorrhoids.
There is no simple and simple answer to the question, what drug is better - phlebodia 600 or detralex, since the indications, therapeutic effects and many properties they have very much the same. Although there are minor differences in contraindications and admission regimen, as well as differences in the pharmacological treatment of active components( which affects the rate of assimilation of active substances), which we also consider below.
This article is a comparison of these two drugs by their characteristics. As a basis for comparison, I took official instructions to these medicines. This information will help you better understand the effects of the drugs, in order to subsequently discuss this with the attending physician.
| Phlebodia 600 | Detraleks | |
|---|---|---|
| active substance | Diosmin - 600 mg | Diosmin - 450 mg Hesperidin - 50 mg |
| Contraindications | There | Hypersensitivity |
| Side effects | There | There |
| Pregnancy | By appointment | physician Not applicable |
| effect | Quick | Gradual |
| Maximum concentration in blood | After 5 hours | After 2-3 hours |
| Recipe | Do not need | Do not need |
| Average price | 900 руб.for 30 tab. | 800 руб.for 30 tab. |
To make the right choice, you need to consult a phlebologist. He will determine what is best for you, based on the history, the results of the examination and the presence or absence of contraindications.
At the reception of the phlebologist Next, you will learn from the article how the angioprotectors of phlebodia 600 and detralex differ, what similarities they have, the features of their application in varicose veins, and much more concerning the reception of these funds.
Characteristics of the preparation
Both preparations contain the active substance diosmin. Detralex added another compound - hesperidin. Consider their therapeutic properties.
Hesperidin
Hesperidin is mainly found in the citrus peel. In the jar - a powder of gesperedina from dried young oranges Hesperidin is a plant bioflavonoid( bioflavonoid is a natural chemical compound), which has many effects on the body. Among its therapeutic effects on the state of blood vessels and blood are the following:
- vascular strengthening;
- elimination of spasms;
- decrease in the content of fatty acids and cholesterol;
- improvement of rheological properties of blood( viscosity and fluidity);
- reduction of inflammation;
- antioxidant effect.
Diosmin
Diosmin is mainly found in the extract of orange fruits( other names of the orange are bitter orange or Syvil orange).In the jar - powder of diosmine from dried oranges Diosmin also belongs to the group of flavonoids. The drug diosmin is artificially altered by hesperidin. Its use has the following effects:
- enhancement of the vasoconstrictive effect of norepinephrine - thus reducing the extensibility and capacity of the vessels;
- increase in the number of contractions of lymphatic vessels;
- increased intensity of contractions of lymphatic vessels;
- weakening of the ability of leukocytes to adhere to the vascular wall, eliminating the inflammatory process.
The combined action of diosmin and hesperidin reduces the internal pressure of lymph, reduces the lumen of the lymph vessels, strengthens the capillaries and normalizes the microcirculation of blood and lymph.
Therapeutic effects of drugs: which is better?
According to the instructions for use, both drugs have pronounced venotonic properties. They help reduce the dilatability of veins, reduce the permeability of the vascular wall of capillaries, increasing their resistance to mechanical effects.
Both phlebodia 600 and detralex restore lymph flow.
Thus, the medicinal properties of the drugs are the same.
Results of the use of drugs for varicose How quickly drugs work, withdrawal from the body
Angioprotector flebodia 600 can be detected in the blood after two hours after use. Its peak concentration comes in about five hours. Elevated levels of detralex in the blood are determined after 2-3 hours after the use of the drug.
The rapid absorption of detralex is due to the peculiarity of the pharmaceutical treatment of the active substance. Diosmin and hesperidin, which are part of detraleks, are subjected to micronization - this is the process of grinding the compound, allowing microparticles to penetrate into the blood at a higher rate. Thanks to this, the effect of detralex comes faster.
Mechanisms for drug withdrawal are different. Flebodia 600 is excreted from the body mainly by the kidneys( 79%), only 11% of the remedy passes through the intestine. Removal detraleksa, basically, occurs with kalovymi masses, and only 14% of substances are deduced with urine.
Comparison of indications and contraindications for
preparations The choice of the drug for varicose also depends on the indications and contraindications. Compare the indications of phlebodia 600 and detralex in the tables below.
| Phlebodia 600 | Detraleks | |
|---|---|---|
| severity in legs | + | + |
| Feeling of fatigue in the legs | + | + |
| Pain in legs | + | + |
| Edema | + | + |
| capillary fragility | + | + |
| Varicosity | + | + |
| Convulsions | + | + |
| Burning in the legs | + | + |
| Hemorrhoids | + | + |
As can be seen from the table, indications for the use of phlebodia 600 and detralex are absolutely identical.
Contraindications comparison: .
| Flebodia 600 | Detralex | |
|---|---|---|
| Intolerance of components | + | + |
| Lactation | + | + |
| Pregnancy | + | Not determined |
| Children under 18 years of age | + | Not established |
No negative effects on the fetus were found when examining the use of both drugs. But the use of both of these medicines is not recommended in the first three months of pregnancy. In the second and third trimester, the administration of phlebodia 600 and detralex should be coordinated with the phlebologist and obstetrician-gynecologist.
Comparison of the application of
Both drugs are taken orally, orally.
According to the instructions, the use of both drugs depends on the intake of food and time of day. Flebodia 600 should be taken on an empty stomach, in the morning. And detraleks should be used at lunchtime and in the evening, and its reception should coincide with the intake of food.
The dosage of these angioprotectants is also different. The number of Flebodia 600 taken once a day is one tablet, that is 600 mg of active substance( diosmina) per day. The dose of a single dose of detralex is also one tablet, but, given the two-time administration, the total content of flavonoids per day is 1000 mg( 900 mg - diosmin).
Based on differences in the way of application, everyone can decide which drug is the best for him.
The duration of treatment in both cases is determined by the attending physician. He also establishes the need for re-treatment. Most often, the duration of the therapeutic intake of both drugs in the case of varicose is about two months.
Side effects
Due to the fact that both drugs have the same active ingredient, phlebodia 600 and detralex have the same side effects:
- dizziness,
- headache,
- nausea,
- heartburn,
- abdominal pain,
- rash,
- skin itching.
The most common of these effects are GI disorders. However, in general, both drugs rarely cause problematic effects;in general, their occurrence is a consequence of an increased sensitivity of the organism. If there are negative effects, as well as their enhancement as the drug is taken, it is necessary to consult your doctor. It may be necessary to reconsider the treatment regimen and prescribe another angioprotector.
Special instructions
In the instructions for use, special instructions for varicose veins are only described for detralex. These are additional measures during the treatment period that will speed up the process of recovery in varicose veins:
-
use of special stockings;
-
avoiding hot spaces and a long time in the sun;
-
reduction of time spent on legs;
-
getting rid of excess weight.
Compression stockings accelerate the recovery process for varicose Although there are no such recommendations in the instructions for phlebodia 600, it would be logical to assume the same measures during treatment and this drug.
Comparison of other characteristics of preparations
I also compared the additional characteristics of drugs: overdose, interaction with other drugs, terms of sale and storage, and others.
| Flebodia 600 | Detralex | |
|---|---|---|
| Form of issue | Tabletted For 15 or 30 pcs.in the package | Tablet For 30 or 60 pcs.in the package |
| Effects | overdose not described | not described |
| interaction with other drugs | not mentioned | not mentioned |
| Impact on transportation management | No | No |
| Interaction with | alcohol is not recommended | Not recommended |
| Conditions of Sale | Free | Free |
| Termsand shelf life | 3 years, at a temperature not higher than 30 degrees | 4 years, no special conditions required |
| Average packing cost 30 tablets | 900 rubles | 800 rubles |
The average cost of drugs in Russia, I determined on the basis of reference data of pharmaceutical sites. Since both drugs have the same effect and have the same indications, you can calculate which drug is better for your budget( more profitable).Due to the fact that phlebodia 600 should take one tablet a day, and detralex two - phlebodia is cheaper approximately twice.
