Elevated cholesterol and lipid balance disorder in most patients lead to the development of obliterating atherosclerosis of the lower limbs. I'll have to be reserved for perseverance and patience to stop the disease, but this is for everyone.
Before treating atherosclerosis of the vessels of the lower extremities, it is worthwhile to understand the features of the drugs that doctors use.
Drug group
Which drugs groups are usually prescribed by doctors for the medical treatment of atherosclerosis of the vessels of the lower extremities and how do they affect the disease?
- Statins - drugs that can balance the content of "harmful" and "useful" fats in the blood of a person. More well known is their cholesterol lowering function. All groups of statins act in a similar way - they block specific enzymes and prevent the formation of excess cholesterol.
This is a "basic therapy" that eliminates the cause of the disease. They are not able to release arteries from existing plaques , but do not allow them to increase and close the lumens of blood vessels.
- Fibrates of are given if statins are contraindicated or do not fully cope with their function. They act on receptors, eliminating cholesterol and fats from the plasma.
- ACE inhibitors are used to control blood pressure. Of all antihypertensive drugs, this group was used in clinical trials in the treatment of obliterating diseases of the arteries. They do not act directly on atherosclerosis, but they reduce the likelihood of heart attack and stroke.
- Beta-blockers is used in hypertension, when intermittent claudication is accompanied by ischemic heart disease. Until recently, it was believed that this group reduces the lumen of the vessels of the legs. However, recent clinical studies have refuted the erroneous opinion.
- Antiaggregants .Cholesterol plaque not only physically narrows the lumen of the artery, but also damages the vessel wall. Blood tends to eliminate the defect, forming a thrombus. Therefore, patients are shown drugs that make blood fluid and less prone to clot formation.
Aspirin handles these tasks. Support for the patency of arterial shunts is provided by clopidogrel.
Anticholesterol medications
Treatment of atherosclerosis of lower limb arteries with anti-cholesterol drugs is the use of statins and fibrates to prevent the growth of cholesterol plaque in the vessels of the legs and worsen symptoms.
Vasilip( simvastatin)
Produced in the form of tablets of 10, 20 and 40 mg. Assign, depending on the level of cholesterol, 10 to 80 mg .Reception single.
is contraindicated, like all other statins, with severe liver damage, individual intolerance, pregnancy and lactation.
Statins are used with caution in alcoholism, certain genetic diseases, endocrine disorders. It is necessary to warn the doctor about taking other preparations, since simvastatin is not compatible with amiodarone, gemfibrosin, cyclosporine, fenofibrate, verapamil, diltiazem and high doses of nicotinic acid.
The drug belongs to the average price category. Domestic analogues( Atherostat, Ovenkor, Simvastatin) and foreign( Simvor, Simlo, Sincard) are more accessible. European simvastatin costs more. The most famous are Simgal, Simvastol and Simvakol.
Lovastatin
This hypolipidemic substance is able to block the production of cholesterol in the early stages. The drug is absorbed better with food, so it can not be taken on an empty stomach.
Tablets for 20 or 40 mg are taken twice a day by , at breakfast and dinner. If needed, the dose is raised to a maximum of 80 mg per day. The contraindications are the same as for simvastatin. Caution should be given to patients with kidney disease, taking antibiotics and antifungal agents.
Lovastatin is included in the average price category. In Russia, you can buy a domestic analog with the trade name Cardiostatin, Lovastatin of the Belarusian manufacturer and the Slovenian Holetar .
Find out all about the treatment of folk remedies for atherosclerosis of the vessels of the lower extremities - can this be carried away and helps to get rid of the problem. Than atherosclerosis of cerebral vessels is dangerous and how it manifests itself - find out by clicking here.
And about the drugs from atherosclerosis of the brain read in another material - right here.
Atorvastatin
It stands out from other statins that the property restores the balance between the "useful" and "harmful" lipoproteins .
For the convenience of reception is issued in tablets of 10, 20, 30 and 40 mg. Starting at 10 mg, the dose is gradually increased to 80 mg per day.
Contraindicated in exacerbating liver disease and allergy to the drug. The drug does not affect the functioning of the kidneys.
Traykor
A popular preparation of a group of fibrates. The active ingredient is fenofibrate .Contraindicated in liver lesions.
Tablets for 145 and 160 mg take once a day , regardless of food intake. After the initial course at 3 months, evaluate the result by analysis and decide whether to cancel or continue taking.
The Russian plant produces an analog - Fenofibrate canon , and French - Lipantil .
Ramipril from hypertension
Ramipril has proven in studies of efficacy and safety for patients with obliterating atherosclerosis .Therefore, doctors prefer it to the rest of the ACE inhibitors.
Tablets of 2.5 mg, 5 mg and 10 mg are taken at any time. Treatment continuous .Contraindicated with intolerance, increased production of aldosterone and renal failure.
Antiaggregants
- Aspirin( or acetylsalicylic acid) in low doses "dilutes" the blood. At an atherosclerosis of vessels of the bottom extremities the dose of 150 mg is applied. Take aspirin after dinner, daily. Severe diseases of the stomach and liver, severe bronchial asthma and allergies are a contraindication.
- Plavix( clopidogrel) replaces aspirin if there are absolute contraindications. It is also included in the recommendations after stent implantation. Assign 1 tablet, 75 mg, once. The drug is a high price category. Pharmacies sell brands: Zilt, Lopirel, Agregal, Detromb.
There are a number of new promising drugs that are at the stage of clinical trials and are not yet used to treat obliterating atherosclerosis of the lower limbs medically. Hopes are placed on iloprost and alprostadil .
What can not be done during therapy?
- There are foods rich in cholesterol .Taking medication does not replace the diet, but only supplements it( the diet is similar to that prescribed for atherosclerosis of the brain).It is important not to overload the food with fats and not drink grapefruit juice - some statins are not absorbed in his presence.
- Smoking .Nicotine narrows the vessels, and with atherosclerosis, a bad habit, without exaggeration, leads to limb amputation.
- Do yourself self-education .Therapeutic exercise is important, but improperly chosen exercises and excessive loads exacerbate the disease.
- Take pentoxifylline, heparin, high-dose group B vitamins .Until recently, these substances were used to relieve intermittent claudication. Recent studies prove their low efficacy and a high risk of complications.
Learn more about how to treat the disease, from this video:
Atherosclerosis of the lower extremities is a serious progressive disease of .But, thanks to proper nutrition, lifestyle changes and the use of modern medicines, it is possible to avoid surgical intervention and stop the development of the disease.
