Tablets Augmentin: instructions for use

Augmentin is a combined semi-synthetic antibiotic with a wide spectrum of action.

The drug is based on a combination of two main active substances - amoxicillin and clavulanic acid. The drug is widely used to treat a number of infectious and inflammatory diseases caused by pathogenic bacteria.

On this page you will find all information about Augmentin: full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Augmentin tablets. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibiotic of a broad-spectrum penicillin group with a beta-lactamase inhibitor.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Augmentin in the form of tablets? The average price in pharmacies is at the level of300 rubles.

Form of issue and composition

Antibiotic is produced in several forms:

Tablets Augmentin for oral administration;

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A powder from which a suspension is prepared;
Powder, intended for the preparation of solution for injection.

Tablet forms of the drug are produced in a film shell, which protects active substances from the aggressive action of hydrochloric acid, produced in the stomach. Tablets for the treatment of adults and children over 12 years of age and are available in the following dosages:

Augmentin 250;
Aumentin 500;
Augmentin 875.

All three varieties contain the same amount of clavulanic acid (125 mg) and differ from each other only in the content of amoxicillin. For the treatment of young children, tablets with a lower concentration of antibiotic containing 125 mg of amoxicillin are used.

Pharmacological effect

Many gram-positive and gram-negative bacteria are susceptible to the action of Augmentin, among which:

Escherichia coli, including beta-lactamase production;
enterobacteria;
Klebsiella;
Staphylococcus aureus, including strains producing beta-lactamase;
streptococcus;
Neisseria, the causative agent of gonorrhea;
moraxella;
Proteus.

Separately note that methicillin-resistant strains of Staphylococcus aureus, which cause dangerous nosocomial infections, are insensitive to Augmentin.

The mechanism of action of Amoxicillin is extremely simple. The antibiotic blocks the synthesis of the cell wall of a sensitive microorganism and thus has a bactericidal effect. Pharmacological effect in Augmentin has only one active substance of the drug - amoxicillin. Clavulanic acid does not have antibacterial action.

Indications for use

The main indications for the appointment of the Augmentin tablets are:

Infectious and inflammatory diseases of the lower respiratory tract - recurrent chronic bronchitis, bronchopneumonia, inflammatory diseases of lung tissue.
Diseases of the upper respiratory tract and nasopharynx inflammatory and infectious origin - sinusitis, otitis, tonsillitis, pharyngitis, Bronchitis caused by sensitive to the components of the drug by pathogenic microorganisms (streptococci, staphylococci).
Pustular skin diseases - pyoderma, furuncles, carbuncles and other lesions.
Infectious processes of joints and bones - osteomyelitis, caused by the family of staphylococci.
Complications after difficult labor or abortion - endometritis, salpingo-oophoritis and other diseases of the genital organs system of women, arising from the penetration into the body of pathogenic pathogens. Often, inflammatory diseases of the uterus and its appendages can develop as a result of unscrupulous diagnostic manipulations - Hidroscope, uterine sounding, diagnostic curettage of the uterine cavity, artificial termination of pregnancy and so on.
Infectious diseases of the urogenital system caused by species of the enterobacteria, escherihia coli, staphylococcus saprophyticus, enterococci, gonococci are inflammatory processes of the bladder, inflammatory and infectious processes of the ureters, inflammation of the renal tissue (interstitial nephritis, pyelonephritis), gonorrhea, chlamydia.

One of the indications for the appointment of Augmentin tablets is also mixed abdominal infections as part of complex therapy with other drugs.

Contraindications

Antibiotic is not prescribed to patients with hypersensitivity to amoxicillin, clavulanate, β-lactams, etc. components in the anamnesis. The grounds for refusing therapy with this drug are:

age to twelve years and weight less than forty kilograms (for hard. lek. forms);
lymphoblastosis is benign, since an antibiotic can trigger the appearance of rashes, which makes it difficult to diagnose;
phenylketonuria is a hereditary disease caused by a disruption in the metabolism of α-amino-β-phenylpropionic acid;
kidney pathology and other severe disorders of function, for example, decreased creatinine;
breast age up to three months (for suspension);
previous episodes of Gospel Disease.

Application in pregnancy and lactation

In studies of reproductive function in animals, oral and parenteral administration of the Augmentin drug did not cause teratogenic effects.

In a single study in women with premature rupture of membranes, it was found that the preventive therapy with the drug may be associated with an increased risk of developing necrotizing enterocolitis in newborns. Like all medicines, Augmentin is not recommended for use during pregnancy, except for Where the expected benefit of the use for the mother exceeds the potential risk to the fetus.

The drug Augmentin can be used during breastfeeding. With the exception of the possibility of developing diarrhea or candidiasis of the oral mucosa associated with the penetration of trace amounts into breast milk active ingredients of this drug, no other adverse effects were observed in infants fed breastfeeding. In case of adverse effects in infants who are breastfeeding, it is necessary to stop breastfeeding.

Instructions for use

The instructions for use indicate that, depending on the content of active substances in them, the Augmentin tablets are recommended for adult patients according to the following scheme:

Augmentin 375 mg (250 mg + 125 mg) - one three times a day. In this dosage, the drug is indicated atinfections, which occur inlightormoderately severe form.In case of serious diseases, including chronic and recurrent, higher doses are prescribed.
Tablets 625 mg (500 mg + 125 mg) - one three times a day.
Tablets 1000 mg (875 mg + 125 mg) - one twice per day.

The dose is subject to correction for patients with impaired functional activitykidneys.

Tablets with prolonged release Augmentin SR 1000 mg / 62.5 mg are allowed only for patients over 16 years of age. The optimal dose is two tablets twice a day.

If the patient can not swallow the whole pill, it is divided in half along the fault line. Both halves are taken simultaneously.

Patients with patientskidneysthe drug is prescribed only in cases where the indicatorRheberg samplesmore than 30 ml per minute (that is, when it is not necessary to make adjustments to the dosing regimen).

Side effects

Based on clinical studies of the drug and monitoring of patients, the following possible adverse reactions were identified after taking Augmentin:

Liver: A moderate or insignificant increase in the level of the major hepatic enzymes.
Changes in blood counts: a decrease in the number of leukocytes, platelets, an increase in the number of eosinophils, and others.
From the skin: allergy in the form of itching, rash of urticaria. Candidiasis of skin and mucous membranes is less common. There is a risk of developing severe allergic reactions, for example, generalized urticaria or Stevens-Johnson syndrome.
The digestive tract: diarrhea, vomiting, nausea, flatulence and bloating, rarely sick stomach pain. There are isolated cases of development of colitis (inflammation of the large intestine), hepatitis and jaundice.
Nervous system: headaches, dizziness, trouble with sleep. Less often in patients with severe concomitant diseases of other organs, convulsions are observed.
Immune system: allergic vasculitis, edema, anaphylactic shock. This type of adverse reactions is very rare.

Overdose

Overdose Augmentinom is possible and is manifested by various disorders of the digestive tract, dehydration and violation of the concentration of blood electrolytes. Symptomatic therapy aimed at maintaining the normal functioning of organs and systems is performed.

Drug Interactions

With the simultaneous use of Augmentin and anticoagulants of indirect action (Warfarin, Thrombopop, etc.) should be monitored by INR, as it may change. In this case, it is necessary to adjust the dosage of anticoagulants for the period of their simultaneous administration with Augmentin.

Probenecid leads to an increase in the concentration of Augmentin in the blood. Allopurinol, when taken concomitantly with Augmentin, increases the risk of developing skin reactions.

Augmentin increases the toxicity of methotrexate and reduces the effectiveness of combined oral contraceptives. Therefore, against the background of the use of Augmentin, additional methods of contraception should be used.

Reviews

Approximately 80 - 85% of reviews about Augmentin are positive, which is due to the effectiveness of the drug in the treatment of a person's infection. Practically in all the reviews, people point to the high effectiveness of the drug, thanks to which a rapid cure for an infectious disease occurs.

However, concurrent with the statement of the effectiveness of Augmentin, people indicate the presence of side effects, which were unpleasant or poorly tolerated. It was the presence of side effects that was the basis for the remaining 15 to 20% of negative reviews left despite the effectiveness of the drug.

We picked up some of the people's comments about the Augmentin drug:

Original preparation of excellent quality. Effective in the treatment of inflammatory diseases, the cause of which is the pathogenic microflora of a wide spectrum of action. Portability is good. The price corresponds to the quality. The drug is highly purified, safe. The composition includes clavulanic acid, which prevents the resistance of pathogenic microflora.
As soon as my children have angina, I immediately give "Augmentin". Hyperemia, a sore throat passes for 3-4 days, the temperature decreases after the first reception. There were no side effects. In my medical practice I do not use Augmentin. But in my home medicine cabinet this drug takes a worthy place.
Have written out this preparation for my 5 month old child when at it the temperature third day has not fallen down. Took 5 days 2 times a day, no effect, but earned a terrible dysbiosis, which was then treated for a month. The child lost weight, earned dermatitis, and all because of this drug. I want to warn the other parents about this effect, be careful.
I try to minimize the intake of antibiotics, but sometimes they are necessary. In childhood I often had colds, had a sinusitis, only "Augmentin" saved me. First, there were no side effects from the gastrointestinal tract, like diarrhea or vomiting. Secondly, the taste tolerant - no, not bitter, which is very pleasing. In the winter I got bronchitis and could not bring down the temperature for a week, "Augmentin" helped me in one day, the next temperature fell, my cough decreased and my appetite appeared. I always recommend this drug, because I consider it fairly sparing and no less effective.

Analogues

The preparation has a number of structural analogues:

Amoxiclav
Augmentin SR
Ranclave
Bactockweave
Medoklav
Taromentin
Ecoclave
Augmentin EU

Augmentin The EU is intended for short-term use and is a powder from which a baby suspension is bred. Augmentin SR - prolonged-action tablets, the therapeutic effect of which is enhanced by the delayed release of amoxicillin.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The drug should be stored in a dry place inaccessible to children at a temperature of no higher than 25 ° C. Shelf life of tablets (250 mg + 125 mg) and (875 mg + 125 mg) - 2 years, tablets (500 mg + 125 mg) - 3 years. Shelf life of powder for suspension in an unopened vial is 2 years.

The prepared suspension should be stored in the refrigerator at a temperature of 2 ° to 8 ° C for 7 days.