Phthalazole

Phthalazole is a broad spectrum antibacterial agent. It belongs to the group of sulfonamide antibiotics.

Prevents the assimilation of bacterial cells of folic acid, which is the main substance necessary for the formation of bacterial DNA and RNA. In addition to the antimicrobial effect, it has an anti-inflammatory effect, which is developed by reducing the migration of leukocytes and the production of anti-inflammatory substances.

The medicine is used mainly for the treatment of infectious processes of the gastrointestinal tract and for preoperative preparation on the intestine.

Clinical and pharmacological group

Antibacterial agent, a sulfonamide derivative.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does phthalazole cost in pharmacies? The average price is at the level of25 rubles.

Composition and form of release

Phthalazole is available in the form of tablets for oral administration. Tablets of white color, packed in blisters of 10 pieces in a cardboard box, a detailed instruction with a description of the characteristics is attached to the preparation.

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Each tablet of the drug Ftalazol contains active active substance - Phthalylsulfatiazole 500 mg, as well as a number of additional auxiliaries.

The drug is effective against staphylococci, streptococci, gonococcus, pneumococcus, Pseudomonas aeruginosa and others.

Pharmacological effect

Phthalazol is a sulfanilamide preparation that exerts a pronounced bacteriostatic effect on the body. He is active against gram-positive and gram-negative microorganisms, which provoke the development of intestinal infections.

After ingestion, the drug is not practically absorbed by the blood. The main therapeutic effect is directly in the digestive tract. The mechanism of action of phthalylsulphothiazole is based on a violation of the synthesis of folic acid and dihydrofolic acid, which act as growth factors for microorganisms.

In addition to antibacterial properties, Ftalazol has an anti-inflammatory effect, which is provided by its ability to reduce the number of migrating white blood cells and stimulate the production of GCS.

What helps?

Phthalazole can be used for various violations of the intestinal functions that have occurred under the influence of a violation of the quantitative composition and diet. That is, after a period of a strict diet or a way out of starvation. In addition, the drug reduces the phenomenon of increased levels of gas formation (flatulence).

Phthalazol is intended for the treatment of such diseases:

dysentery,
colitis, enterocolitis, gastroenteritis,
diarrhea of different genesis.

In addition, this drug has a good effect in the case of its use to prevent purulent complications in operations on the intestine.

Phthalazol is indicated to patients without infectious lesions of the intestinal mucosa, if they are trained for surgery. Also, the remedy is prescribed to children in case of neglected cases of dysbacteriosis, which is triggered by the use of a wide range of antibacterial pharmaceuticals. In this case, he stops the symptoms of dysbiosis.

Contraindications

In the presence of the following contraindications, the drug should not be taken under any conditions:

intestinal obstruction;
allergic reactions to certain components of the drug;
impaired blood clotting;
diseases of the thyroid (Basedova disease);
chronic kidney and liver diseases;
hypersensitivity to the components of the drug.

Intended use for pregnancy and lactation

According to the instructions for use it can not be taken during pregnancy and breastfeeding, very young children, since the drug is bad enough. Phthalylsulfatiazole penetrates the placenta and adversely affects the fetus. Also during pregnancy, a great burden on the kidneys and excretory system in general, and the phthalazole is quite toxic.

Dosage and route of administration

As indicated in the instructions for use, the dosage and duration of treatment should be prescribed by a specialist, depending on the degree of sensitivity of the intestinal microflora to sulfonamides.

According to the instructions for Ftalazol, the daily dose should not exceed 7 grams, single dose - 2 grams.

When acute disease is prescribed:

1-2 days - 2 tablets, every 4 hours;
3-4 day - 2 tablets, every 6 hours;
5-6 day - 2 tablets - every 8 hours.

Further treatment:

1-2 day - 2 tablets in 4 hours, at night - one (in the total - 10);
3-4 day - 8 tablets per day, with an interval of 4 hours, except for night time;
Day 5 - 6 tablets, after 4 hours each.

Instructions for the use of phthalazole in children

The duration of the course of therapy for any diarrhea, regardless of its cause, is seven days. If the child's diarrhea has stopped earlier, the use of phthalazole can be stopped 12 hours after the absence of a loose stool. Dosage and frequency of reception of phthalazole is determined by the age of the child and the cause of diarrhea.

Children younger than 12 years with nondisenteric diarrhea take Ftalazol according to the following scheme:

On the first day of the disease, Ftalazol is taken in an individual dosage, calculated by body weight, based on a ratio of 100 mg per kg of body weight. The calculated dosage of phthalazole is divided into three doses per day. For example, a child weighs 10 kg, which means that the daily dosage of Phthalazole for him is 100 * 10 = 1000 mg, which corresponds to two tablets. These two tablets should be divided into five, resulting in 0.4 (2/5). Hence, the child should be given 0.4 (2/5) tablets every four hours with a break for night sleep;
In the second and subsequent days of the disease, it is necessary to take Ftalazol at a dosage of 250 to 500 mg (half a whole tablet) per 1 kg of body weight per day. This means that the daily dosage of Phthalazole is exactly the same calculated depending on the weight of the child's body. So, for a child weighing 10 kg, the daily dosage will be 250 * 10 - 500 * 10 = 2500 - 5000 mg, which corresponds to 5 - 10 tablets. This number is divided into 3 to 4 doses, which are performed during the day at regular intervals. That is, the child should be given 1 to 2 tablets 3 to 4 times a day. During a night's sleep, take a break in the use of pills.

In acute dysentery, the dosage of phthalazole depends on the age of the child:

Children aged 0 - 3 years take Ftalazolum half tablet every 4 to 6 hours;
Children aged 3 to 7 years take one tablet of Ftalazol (500 mg) every 4 to 6 hours;
Children aged 7 to 12 years take 1 to 1.5 tablets (500 to 750 mg) every 4 to 6 hours.

Children over 12 years with any diarrhea take Ftalazol in adult dosages.

Adverse Reactions

Use of the drug Ftalazol can cause the following side effects:

On the part of the blood system: agranulocytosis, leukopenia, hemolysis of erythrocytes, thrombocytopenia. With prolonged use of the drug, anemia can occur, associated with a deficiency of pteroylglutaric and pantothenic acids produced by microbes.
From the nervous system: a depressed mood, headaches, dizziness.
On the part of the digestive tract: damage to the oral cavity (gingivitis, stomatitis, glossitis), diarrhea, nausea, vomiting, gastritis, hepatitis, cholangitis, vitamin B deficiency.
From the cardiovascular system: cyanosis, myocarditis.
From the urinary system: the development of urolithiasis.
On the part of the respiratory organs: eosinophilic pneumonia.
Allergic reactions: a rash on the skin (up to nodular and multiforme exudative erythema); in rare cases - swelling of the lips and face, Lyell's syndrome, nodular periarteritis.

Overdose

Overdose with phthalazole is possible and is manifested by the development of pancytopenia (a sharp decrease in the content of all cellular elements of the blood), nausea, vomiting and headache. In case of an overdose, it is necessary to cancel the use of phthalazole. If necessary, symptomatic therapy is performed.

special instructions

If necessary, phthalazole is combined with sulfonamides or antibiotics that are well absorbed from the digestive tract.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

The drug reduces the effectiveness of oxacillin.
With simultaneous use with indirect anticoagulants, their effect is enhanced.
Paraminosalicylic acid and barbiturates increase the activity of sulfonamides.
In combination with thioacetazone and levomitsetin increases the risk of agranulocytosis.
In combination with nitrofurans, the risk of anemia and methemoglobinemia increases.
Phthalazole is chemically incompatible with acids and acid-binding agents, hexamethylenetetramine, adrenaline solution.
In combination with drugs such as novocaine, anesthesin, dicaine, the antibacterial activity of sulfanilamide is competitively inactivated. The effect is enhanced by antibiotics and well-absorbed sulfonamides.

Reviews

We offer you to read reviews of people who used Ftalazol:

Marina. The child did not try. And I was saved with prolonged debilitating diarrhea, when in the intestines I literally did not hold anything. Prior to him, I drank an expensive drug-effect zero, a week later the illness even staggered, and 2 days after the start of taking phthalazole, all symptoms were stopped.
Victor. A beautiful ancient preparation - it perfectly helps. In pharmacies it is not recommended, it is cheap and it is necessary to pull money out of grandmothers. After all, the pharmacy now, according to its revenues, beats all records. I advise and recommend. First, take loperamide - diarrhea will stop, and phthalazole will already destroy the pathogens.
Lyudmila. She asked in a drugstore a cystitis remedy, gave phthalazole. Another reason for visiting the doctor - came omoy, it turned out that he generally does not apply to such cases, I had to go to another pharmacy, buy a monoal. Pharmacists are now very busy, and not all of them own information, there is a very high risk of buying not what you need.

Analogues

The drug Ftalazol has on the domestic pharmaceutical market numerous synonyms. Synonyms are medicines that, like Ftalazol, contain phthalylsulfatiazole as an active, active substance. In view of the fact that the drug was developed in the USSR, when there were no commercial names and patents, then drugs are produced by different pharmaceutical plants under the same name - Ftalazol. It is drugs produced by different pharmaceutical plants under the same name that are synonymous.

In addition to synonyms, Ftalazol has analogues, which include drugs with a similar spectrum of action and therapeutic activity, but containing an excellent active substance. To the analogues of phthalazole are the following medicines:

Bactrim;
Berlocid;
Biseptol;
Briefeptol;
Dvseptol;
Co-trimoxazole;
Methosulfabol;
Oriprim;
Sinersul;
Sulotrim;
Sulgin;
Phytazine;
Furazolidone.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Keep the tablets out of reach of children and direct sunlight, away from sources of moisture. Shelf life of the drug is indicated on the packaging and is 3 years from the date of manufacture. At the end of the expiration date, tablets should not be taken orally.