How to take Duphaston: instructions and reviews

Dyufaston is the synthetic hormone preparation of the last generation, which is an artificial analog of the female hormone progesterone.

A unique feature of the drug is its chemical formula, which is almost identical to the structure of the natural hormone progesterone. It is necessary for the female body to ensure biological rearrangements associated with preparation for pregnancy and its normal course. The basis of the drug is a progestogen hormone - dydrogesterone. It acts directly on the uterine mucosa, which excludes most of the side effects accompanying the use of other synthetic hormones.

On this page you will find all information about Dufaston: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Dyufaston. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The active component of the drug dydrogesterone is an analog of natural progesterone. Duphaston is a hormonal drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Duphaston cost? The average price in pharmacies is at the level of480 rubles.

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Form of issue and composition

The tablets covered with a cover, 10 mg. For 20 tablets in PVC / Al blister. 1 PVC / Al blister, along with instructions for use, is placed in a cardboard box.

• In 1 tablet, coated with a coating, contains: active substance: dydrogesterone, 10 mg;
• Excipients: lactose monohydrate, hypromellose, corn starch, silicon dioxide colloid, magnesium stearate;
• Sheath: Opal white Y-1-7000 (hypromellose, polyethylene glycol 400, titanium dioxide (El 71)).

Round biconvex tablet white, with beveled edges, covered with a membrane, with a risk on one side, with an engraved "S" above the "T" sign on one side of the tablet and "155" on the other side (on either side of risks).

Pharmacological effect

Due to its molecular structure, pharmacological and chemical properties, dydrogesterone is close to natural progesterone. This element is not a derivative of testosterone, it has no side effects that are inherent in almost all synthetic progestogens, which are also called androgenic progestogens. Didrogesetron does not have glucocorticoid, anabolic, androgenic, estrogenic or thermogenic activity.

Dyufaston, as instructed, is part of a comprehensive HRT with menopazu, the drug retains a beneficial effect on the lipid profile of the blood from the side of estrogens. Unlike hormones of estrogens, which negatively affect the blood clotting system, dydrogesterone has no effect on the coagulation index. He does not have a drug for the planning of conception of negative effects on liver function, carbohydrate metabolism.

When administered orally, dydrogesterone selectively affects the endometrium, this helps prevent an increased risk of developing hyperplasia or carcinogenesis due to an excess of estrogens. Medication according to the instructions is indicated with endogenous insufficiency of progesterone. Dufaston does not have a contraceptive effect, because it is used when planning a pregnancy. The drug makes it possible to conceive, ensures the preservation of pregnancy during therapy.

Indications for use

The use of Dufaston is indicated in cases where there is or is suspected deficiency of endogenous progesterone, in cases when its positive effect is clinically proven:

• endometriosis;
• infertility due to luteal insufficiency;
• threatening abortion;
• habitual abortion;
• premenstrual syndrome;
• dysmenorrhea;
• irregular cycle.

In addition, in combination with estrogen, Dyufaston can be used for:

• secondary amenorrhea;
• dysfunctional uterine bleeding.

Contraindications

Do not take medicine:

1. Insufficiency of lactase, intolerance to galactose and glucose, malabsorption syndrome;
2. The period of breastfeeding;
3. Hypersensitivity to the components of the drug.

If a patient has a history of pruritus in the previous pregnancy, Dufaston should be used with caution.

Application in pregnancy and lactation

According to the instructions, Duphaston is used in pregnancy according to the indications.

Since dydrogesterone can be excreted in breast milk, if it is necessary to treat the drug, it is recommended to stop breastfeeding.

Instructions for use

The instructions for use indicate that Duphaston tablets are taken orally. The dosage of the drug should be consistent with the diagnosis. Treatment is carried out only according to the doctor's prescription and under medical supervision.

1. Infertility, which is caused by luteal insufficiency- appoint 1 tablet per day from the 14th to the 25th day of the cycle. The drug takes at least six months or six cycles. If conception has already occurred, then Dufaston should be taken further, as with the threat of abortion.
2. Endometriosis- a dosage of 10 mg (1 tablet) from 2 to 3 times a day. Begin either from the 5th to the 25th day of the monthly cycle, or a constant reception.
3. Habitual abortion- take 1 tablet 2 times a day. Treatment should continue until the 20th week of pregnancy, then the dosage gradually decreases.
4. Threatening abortion- take 40 mg (4 tablets) once. Then 1 tablet after 8 hours until the situation is normal. If the symptoms start to increase again, the dose should be increased again. Further, "Dufaston" should be taken until 12-20 weeks of pregnancy.
5. Prolonged absence of menstruation (amenorrhea)- Complex treatment - estrogen containing preparations 1 tablet per day starting from the 1st day of the cycle. From the 11th day of the cycle, the treatment is complemented by Dufaston. These drugs should be taken until the 25th day of the cycle. The use is calculated for a minimum of 3 menstrual cycles.
6. Painful menstruation- 1 tablet 2 times a day. The application is shown from the 5th to the 25th day of the cycle.
7. PMS- It is prescribed for 1 tablet 2 times a day. Treatment is carried out from the 11th to the 25th day of the cycle. The drug is prescribed for a period of 3 to 6 months.
8. Irregular monthly cycle- The drug is prescribed for 1 table. 2 times a day. "Dyufaston" should be used from the 11th to the 25th day of the cycle.
9. Hormone replacement therapy- is administered in paired with estrogen for 1 tablet 1 time per day for 2 weeks within the 28-day cycle. Usually, the treatment takes place in the last 14 days of the cycle. If the reaction to progesterone therapy is not detected by ultrasound and is not confirmed by the assays, the dose should be revised upwards.
10. Dysfunctional uterine bleeding- The dose is 1 table. 2 times a day. Duration of treatment is from 5 to 7 days. As the prevention of bleeding appoint the use of the drug - 1 table. 2 times a day. Therapy is carried out from the 11th to the 25th day of the cycle.

Side effects

When Dufaston is taken, side reactions may develop:

1. The hematopoiesis system can respond to the reception of the drug with symptoms of hemolytic anemia.
2. From the side of the central nervous system, dizziness and headaches are possible.
3. On the part of the genital area sometimes there are breakthrough uterine bleeding, sometimes there is soreness and swelling of the mammary glands.
4. From the skin allergic manifestations in the form of hives, itching, skin rashes. In very rare cases, there is a development of such complications as Quincke's edema.
5. In some cases, there is a poor liver condition, manifested in weakness and malaise, jaundice, some patients note that after Dufaston the stomach hurts.

Uterine bleeding when taking the drug is easily cured by increasing the dose of Dufaston. In case of adverse reactions, you should consult a doctor, you may need to adjust the dose, and in case of allergic reactions, the drug should be discontinued.

Overdose

No symptoms of overdose have been reported. At casual reception in a dose considerably above therapeutic, gastric lavage is recommended. There is no specific antidote, treatment should be symptomatic.

special instructions

At present, there is no evidence of a negative effect of dydrogesterone in chronic renal failure.

A thorough clinical examination is required if a history of a progesterone-dependent tumor is indicated (for example, meningioma), as well as in case of its progression during pregnancy or during the preceding hormonal therapy.

In the case of the appointment of dydrogesterone in combination with estrogens (for example, for hormone replacement therapy), contraindications and warnings associated with the use of estrogens should be taken into account.

Before beginning substitution therapy with hormones (HRT), a complete history should be collected. During treatment it is recommended to periodically monitor the individual tolerability of HRT. The patient should be informed about what changes in the mammary gland she should inform the doctor. Studies involving mammography should be conducted in accordance with the generally accepted screening of patients.

Sometimes, during the first months of treatment, there may be breakthrough uterine bleeding. If breakthrough bleeding occurs after a certain period of taking the drug or continues after the course treatment, the cause should be studied, an endometrial biopsy should be done to exclude malignant changes in the endometrium.

Do not prescribe Dufaston tablets to patients with genetically determined galactose intolerance, lactase deficiency or malabsorption syndrome.

Drug Interactions

There may be some decrease in Dufaston's effectiveness when taken concomitantly with Rifampicin or Phenobarbital, affecting microsomal liver enzymes. These drugs can increase the rate of biological transformation of the hormone drug Dufaston.

Dupuston's drug incompatibility with other drugs has not been reported to date.

With the parallel administration of gestagens with estrogens, it is advisable to take into account the indications and contraindications for the latter.

Reviews

We picked up some feedback from people about the Duphaston drug:

1. Anna. For the treatment of infertility, the course was appointed Dufaston. Against the background of taking the drug there was a strong thrush, but the gynecologist assured that it was not from him. Violations of menstruation to tablets were not, and in the first 2 months of admission the cycle began to gallop from 22 to 28 days. I drink the medicine for 6 months already, and the long-awaited pregnancy has not come.
2. Marina. With Dufaston, I first met when I had a second child. The first pregnancy was easy, without complications, but during the second there was a threat of miscarriage due to the low content of progesterone. It turns out that this hormonal drug helps to get pregnant and support pregnancy, preventing the threat of miscarriage. I had to take the drug for a long time. Since the threat persisted, she drank Dufaston before the 20th week of pregnancy. The price is not cheap, to undergo a course of treatment completely, had to be heavily spent. Well, you will not do it for the sake of a future child. In addition, I noticed some side reactions. At first, taking the drug did not cause any unpleasant sensations, but then after the pill began to notice increased drowsiness, by the end of the working day it was hard, I always wanted to sleep. Maybe the drug is not to blame, it's just that the body reacted so much to pregnancy, but this was not the case with the first child. In the end, everything ended well, I gave birth to my daughter, and this helped me Duphaston.
3. Katerina. Good day! I took a long time to decide on the use of this drug. I've been reading reviews and, I must say, most of them are not positive. The drug is hormonal, moreover, completely synthetic, which carries a great danger. I agree with everyone who wrote about ineradicable pimples, it's just a disaster. I drank Duphaston for only two months, and the body was upset as after a powerful hormone therapy. On all face red, rigid hypodermic spots, to them and will touch painfully, not that to spend with them any manipulations. The entire neck, especially in the thyroid gland, was covered with "goosebump which indicates a clear hormonal failure and imbalance, the skin on the hands became dry. About the depressive state generally silent. Girls, of course, the organism is different and reacts differently. But such as I am the majority with such a pimple. I have never been a supporter of the use of hormones. Now I had to succumb to the persuasions of the gynecologist, tk. there was no pregnancy within a year.
   All health and cherished two strips!
4. Eve. On djufaston I sit 3 years at the insistence of the endocrinologist. Very good drug, and I perfectly approached, on it I lost weight. And my girlfriend during pregnancy prescribed djufaston, but she did not apply it and as a result - she had a ST. Now his elbows are biting. After all, this drug is very active and it will not be written out just like that. And the taste is well-received, even you do not understand that you drank some kind of pill. And what is especially pleasing is the price.

According to women's reviews, Dufaston increases the likelihood of conception (with the correct diagnosis and compliance with the treatment regimen), significantly alleviates the symptoms that appear in the climacteric period, is effective in endometriosis, ovarian cyst and polycystic ovary. After the course of treatment, the majority of patients stabilize the menstrual cycle. There are also data on the effectiveness of the drug in uterine myomas.

Among the adverse reactions described by women who took Dufaston, the most common were nausea, abdominal pain, loose stools, general weakness and weight gain. However, despite undesirable side effects, positive reviews of the drug are more common.

Analogues

The closest analogue of the drug is Utrozhestan. It is rich in natural progesterone, which is obtained from plant extracts. This analogue of Dufaston during pregnancy can be taken. It is available in the form of tablets and candles. Doctors recommend taking them together in order to achieve a better effect in the fight against endometriosis and miscarriages.

In pharmacies you can find the following analogues of Dufaston:

• Inzhesta;
• Dufaston;
• Dydrogesterone;
• Progesterone.

Before using analogues, consult your doctor.

Duphaston or Utrozhestan - which is better?

Comparison of these drugs indicates that both drugs have similar indications for use. But to determine what the difference is, it's not difficult: as part of Utrozhestan, unlike Dufaston, natural progesterone from plant raw materials is contained. Which is better - Dyufaston or Utrozhestan - during pregnancy, can only be determined individually. But Utrozestan also has a sedative effect on the body.

In some cases, both drugs are prescribed simultaneously during pregnancy.

Storage conditions and shelf life

Tablets should be kept in places with a minimum level of humidity, in a sealed factory package. Storage temperature should not exceed + 30 ° C.

The acceptable shelf life is 5 years from the date of issue (indicated on the packaging).

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