Papaverine

Papaverin is a combined antispasmodic and antihypertensive drug with analgesic action.

The therapeutic effect is due to improved production of adenosine monophosphate and a decrease in the concentration of intracellular calcium ions. Due to this, it helps to relax smooth muscle fibers, relieve spasm and reduce pain syndrome. When the dose is raised, it can have a inhibitory effect on the conduction system of the heart, reducing the heart rate.

In addition, Papaverin, according to the instructions, has an antihypertensive effect. In high doses, the active component of the drug has a sedative effect, slows intracardiac conduction, and also helps reduce the excitability of the heart muscle. In average therapeutic doses, the drug on the central nervous system has a weak effect.

Clinical and pharmacological group

Myotropic antispasmodic.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Papaverine cost in pharmacies? The average price of tablets is 10 rubles, candles cost 90 rubles.

Form of issue and composition

Produced in such dosage forms:

• Pills. White, round. One piece contains 10 mg or 40 mg of papaverine. 10 pieces are packed in blisters or non-jawed packages of two or three per box or one without it.
• Suppositories (suppositories). White, let's say yellow or cream shade. The form is torpedo-shaped. One candle contains 20 mg of papaverine. Fasuetsya 5 units in a blister, two blisters in a cardboard package.
• Solution. Transparent, 2%, produced by manufacturers in ampoules of 2 ml with an active substance content of 20 mg / ml (per ampoule - 40 mg). It is packed in 10 ampoules in one cardboard box.

Pharmacological effect

Reception Papaverina has two types of effects:

1. Hypotensive, i.e. lowers blood pressure;
2. Spasmolytic - stops spasms of smooth muscles.

The active substance of the drug blocks individual enzymes, which leads to the removal of tone and relaxation of smooth muscles that are in all organs (GIT, vessels, lungs, urethra). Due to the relief of spasm in the intestines and other organs, it has an analgesic effect. As a result of removal of spasms of blood vessels, gently lowers blood pressure. Reception of papaverine in high doses shows a weak sedative effect.

The drug can be shown to be used as an adjunct in the period of patient preparation for surgery or general anesthesia. The half-life is from half an hour to two and can be extended to a day in the case of pathologies of the internal organs. The drug, regardless of the route of administration (oral, rectal, intravenous or intramuscular), is rapidly absorbed into the blood, metabolized by the liver and excreted by the kidneys.

Does not directly affect the cardiac and skeletal muscles.

Indications for use

What helps? A direct indication for Papaverin is spasms of almost any smooth muscle organ, as well as spasms of the vessels (more precisely, the muscle fibers of their walls).

Papaverine is useful to apply:

• with inflammation of the gallbladder (cholecystitis);
• in the period of attacks of cholelithiasis;
• with spasms of bronchi (as part of complex therapy);
• with increased uterus tone during pregnancy;
• with spasms of the kidneys (renal colic) and urinary tract;
• with functional bowel diseases (in particular, with spastic colitis);
• for removal of spasms of smooth muscles of the gastrointestinal tract, in particular when the muscles of the pyloric part of the stomach contract (pylorospasm);
• with spasms of smooth muscle fibers of coronary, cerebral and peripheral vessels that appeared against the background of angina pectoris, myocardial infarction, inflammatory and other vascular diseases.

Contraindications

According to the instructions, the drug should not be used in such cases:

1. Liver failure;
2. Glaucoma;
3. AV blockade;
4. Age up to 6 months for tablets, up to 1 year for injection, up to 18 years for rectal suppositories;
5. Elderly age (due to high probability of hyperthermia development);
6. Comatose state (injection solution);
7. Inhibition of breathing (injection solution);
8. Hypersensitivity to the components of the drug.

When prescribing Papaverine in the form of an injection solution and rectal suppositories, care should be taken for patients with the following diseases / conditions:

1. Hyperplasia of the prostate;
2. State of shock;
3. Nadzheludochkovaya tachycardia;
4. Craniocerebral injury;
5. Functional insufficiency of the adrenal glands;
6. Chronic renal failure;
7. Hypothyroidism.

Use in pregnancy and lactation

The safety of Papaverine has not been established during lactation and during pregnancy, so breastfeeding and pregnant women can take the drug only with the permission of the doctor.

Dosage and route of administration

The instructions for use indicate that papaverine in the form of tablets is taken orally up to four times a day. An adult single dose is 40-60 mg of the drug. A single dose for children depends on age:

• From 6 months to 2 years - 5 mg;
• 3-4 years - from 5 to 10 mg;
• 5-6 years - 10 mg;
• 7-9 years - from 10 to 15 mg;
• 10-14 years - from 15 to 20 mg.

The use of papaverine in the form of candles is permissible only for adults, 20-40 mg up to three times a day.

Dosage and duration of application of papaverine during pregnancy is determined individually by the doctor.

Side effects

All dosage forms of Papaverin are capable of provoking the following following side effects:

1. Reduction of blood pressure;
2. Extrasystole;
3. AV blockade;
4. Constipation;
5. Nausea;
6. Sweating;
7. Jaundice of the skin and sclera of the eye;
8. Increased activity of transaminases (ASAT, ALAT);
9. Drowsiness;
10. Eosinophilia (increase in the number of eosinophils in the blood);
11. Thrombosis (only with intravenous administration);
12. Allergic reactions.

Overdose

The cases of an overdose of the drug Papaverin were not noted, however, when large amounts of tablets are taken in the patient, the patient the increase of the above-described adverse reactions, a decrease in blood pressure, a violation of the heart rate, the development of hepatic violations.

With the occasional ingestion of a large number of tablets (which often happens in young children, left unattended), the patient should be washed out of the stomach, letting him take activated charcoal and deliver in hospital. If necessary, the patient undergoes symptomatic therapy.

special instructions

During the treatment should be excluded from drinking alcohol.

Use with caution in conditions after traumatic brain injury, with chronic renal failure, with insufficiency of adrenal function, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock states.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Reduces the hypotensive effect of methyldopa.
2. With simultaneous use with anticholinergics, anticholinergic effects may be enhanced.
3. It is believed that with simultaneous use with alprostadil for intracavernous administration, there is a risk of developing priapism.
4. There are reports of a decrease in the effectiveness of levodopa when it is used simultaneously.

Reviews

We picked up some reviews of people who used the drug Papaverin:

1. Catherine. During pregnancy she took this drug, and during the whole pregnancy this drug, in general, as a panacea for doctors. A week before the birth, I went to the hospital, so they gave it to me, but I do not have any strength, they stuff me and stuff me. In general, I did not understand the meaning of this drug, but in the middle of pregnancy, I generally stopped drinking it, because in a paid polyclinic they told me that I did not have a tonus. So before using this drug, consult yet at least one specialist, because that prescribe during pregnancy so much that I have half the pantry crammed with unknown than until now pores.
2. Elena. Rectally received papaverine during pregnancy during the tone of the uterus and intestinal colic. The advantage of the drug is the rapid on time achievement of the desired effect, approximately 20 minutes after the administration, as well as the absence of side effects. This is generally one of the rare drugs that can be taken during pregnancy to improve the condition of the mother without harm to the health of the child. Of the shortcomings would note that as soon as the spasm is removed, there comes a strong drowsiness and weakness, to lead an active life within 3-4 hours after this becomes simply impossible and even dangerous.

Analogues

Papaverine does not have synonyms that contain the same active substance. But Papaverin has analogues, which are drugs from the group of antispasmodics, containing other active substances, but with similar therapeutic effects. Also, the analogues of Papaverin are multicomponent drugs containing several active substances, one of which is papaverine.

The following drugs are analogues of Papaverin:

1. Bioshpa tablets;
2. Vero-Drotaverine tablets;
3. Droverin injection, tablets;
4. Drotaverin MS, Drotaverin forte, Drotaverin-UBF, Drotaverin-Teva and Drotaverin-FPO are tablets;
5. Drotaverine-Ellara injection;
6. Nicoverine tablets;
7. But-Shpa Tablets and Solution for Injection;
8. But-pill riffle pill;
9. Nosh-Sbar injection and tablets;
10. Papazol and Papazol-UBF tablets;
11. Platyphylline with papaverine tablets;
12. Ple-Spa tablets;
13. Spasmol injection and tablets;
14. Spasmonet and Spasmonet forte tablets;
15. Caspraine tablets;
16. Spacial injection and tablets.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep in a dry place, protected from light, out of the reach of children.

Shelf life:

• Tablets - 5 years;
• Injection solution - 2 years at a temperature of up to 25 ° C;
• Rectal suppositories - 2 years at a temperature of up to 15 ° C.

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