Sonapax

Sonapaks is an antipsychotic drug. Has an antidepressant, antipsychotic and anti-atutic property.

In the instructions to the drug, there is information that this drug has a moderate a-adrenoblocking and m-holinoblocking action. Clinical trials have shown that Sonapax tablets block Hi-histamine and m-cholinergic receptors, eliminate anxiety, eliminate nervousness and tension.

The active component of the drug is thioridazine hydrochloride, which is widely used in psychiatry as a therapeutic or supportive agent.

Clinical and pharmacological group

Antipsychotic drug (antipsychotic).

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Sonapax cost in pharmacies? The average price is at the level of300 rubles.

Composition and form of release

The tablets are coated, round, have a light pink color, fracture - white. In the package of 20 tablets, in a cardboard box contains 3 packages.

Active substance Sonapaksa, whose international name (INN) is thioridazine, is thioridazine hydrochloride, which in one tablet contains 10 mg or 25 mg.

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As auxiliary substances are: lactose monohydrate, talc, silicon dioxide colloid, gelatin, corn starch, stearic acid.

pharmachologic effect

Sonapaks has in its composition an active substance - thioridazine, which positively affects on the nervous system and has an antidepressant, tranquilizing, antipsychotic effect. The peculiarity of this drug in a wide range of effects on the manifestations of affective pathology.

Instructions for use indicate that depending on the dosage Sonapaks can act as an antipsychotic, tranquilizer, antidepressant. So small doses of the drug help to cope with the oppressed state, have a stimulating effect. Large doses of Sonapax give a sedative effect. It should be noted the peculiarity of the mechanism of action of this drug: as the dosage is increased, the relaxing effect, i.e. even when taking high doses of Sonapax, the patient will not feel emotionally depressed.

Indications for use

The instruction on the use of Sonapaks says that due to the complex effect of the active component of Sonapax on the nervous system, this drug is indicated for treatment of:

Huntington's disease;
abstinence syndrome with alcoholism and substance abuse;
depression (only in adults);
schizophrenia;
neuroses accompanied by increased excitability, fear, anxiety, sleep disorders, obsessive states;
manic-depressive psychosis;
psychotic disorders;
behavioral disorders (hyperactivity) in children, aggressiveness, inability to prolong the concentration of attention in adults;
some other disorders of the nervous system.

As can be seen, the indications for the use of Sonapax are very extensive, and the patients' reviews speak about the effectiveness of the drug.

Contraindications

Absolute for tablets:

Comatose conditions of any origin;
Acute depressive conditions;
Simultaneous therapy with drugs that extend the QT interval;
Children under 4 years;
Significant depression of the central nervous system (CNS);
The syndrome of the extended interval QT;
Arrhythmias in the anamnesis;
Liver failure;
Congenital low activity of the isoenzyme CYP2D6;
Deficiency of lactase or sugarase / isomaltase, intolerance to fructose or lactose, glucose-galactose malabsorption;
Diseases of the blood in the anamnesis;
Hypersensitivity to the components of the drug and other phenothiazine derivatives.

Absolute for Pills:

Diseases of the blood in the anamnesis;
Comatose conditions of any origin;
Acute depressive conditions;
Children under 4 years;
Pregnancy;
Craniocerebral injury;
Progressive systemic diseases of the brain and spinal cord;
Severe cardiovascular failure;
Severe arterial hypotension;
Pheochromocytoma;
Porphyria;
The period of breastfeeding;
Hypersensitivity to the components of the drug and other phenothiazine derivatives.

General relative (Sonapaks should be used with caution, since the likelihood of complications is high):

Epilepsy;
Parkinson's disease;
Myxedema;
Chronic diseases accompanied by respiratory failure (especially in children);
Reye's syndrome;
Cachexia;
Vomiting;
Alcoholism;
Pathological changes in blood;
Mammary cancer;
Closed-angle glaucoma;
Hyperplasia of the prostate with clinical manifestations;
Renal failure;
Liver failure (for dragees);
Stomach ulcer and duodenal ulcer (during exacerbation);
Diseases accompanied by an increased risk of thromboembolic complications;
Elderly age (for pills).

In pregnancy, the use of all forms of release of Sonapax is permissible only in cases where the expected The therapeutic effect for the mother considerably exceeds the possible risk for the developing fetus. If it is necessary to administer the drug to lactating women, breastfeeding should be interrupted for the duration of treatment.

Intended use for pregnancy and lactation

Taking the drug during pregnancy and lactation is not recommended, as this can affect the development of the baby. The fact is that the active substance of the drug can penetrate the placental barrier and enter the the body of the developing fetus, affecting its central nervous system and disrupting its development.

At the same time, the drug can be excreted in the mother's breast milk and enter the child's body, also disrupting the functions of its central nervous system, gastrointestinal tract and so on. Moreover, the receipt of even small concentrations of medication in the body of a newborn child can disrupt the work of his immune system, which can lead to the development of an allergy to this drug in the future.

Dosage and route of administration

As indicated in the instructions for use, Sonapaks are taken internally. The dosage regimen is chosen individually taking into account the severity of the disease.

In schizophrenia, adults are prescribed in an initial dose of 50-100 mg 3 times / day with a gradual increase if necessary to a maximum dose of 800 mg / day. Once the effect is achieved, the dose can be reduced to a minimum maintenance dose. The total daily dose varies between 200-800 mg / day in 2-4 doses. Children are prescribed in an initial dose of 500 mcg / kg / day in several doses. If necessary, increase the dose; the maximum daily dose is 3 mg / kg / day.
Psychotic disorders, accompanied by hyperreactivity and excitement; severe behavioral disorders associated with aggressiveness, inability to prolonged concentration of attention; psychomotor agitation of various genesis: in outpatient settings - 150-400 mg / day; in the hospital - 250-800 mg / day. Treatment usually begins with low doses, 25-75 mg / day, gradually increasing to the optimal therapeutic dose, which is achieved within 7 days, and the antipsychotic effect is observed after 10-14 days. The course of treatment is several weeks. Supportive daily dose: 75-200 mg once before bedtime.

For elderly patients, the drug is usually prescribed in a low dose: 30-100 mg / day.

The drug should be withdrawn gradually.

Scheme of Sonapaks application for other indications

With neuroses with mild cognitive and emotional disorders - 30-75 mg / day, with ineffectiveness the dose is gradually increased to 50-200 mg / day.
With neuroses with a somatic component - 10-75 mg / day. Begin treatment with a low dose, gradually increasing it to the optimal therapeutic dose.
With abstinence syndrome, depending on the severity of the condition - from 10-75 mg / day to 150-400 mg / day.
When behavior disorders with increased psychomotor activity in children aged 4-7 years - 10-20 mg / day, the frequency of reception - 2-3 times / day; at the age of 8-14 years - 20-30 mg / day, the frequency of reception - 3 times / day; at the age of 15-18 years - 30-50 mg / day, the frequency of reception - 3 times / day.

Side effect

After the start of taking Sonapax tablets, it is possible to develop negative pathological reactions from various organs and systems, which include:

Allergic reactions - a rash on the skin and itching.
Metabolism is the change in the level of glucose in the blood, with its increase or decrease.
Sexual system - violation of the menstrual cycle in women, decreased attraction to the opposite sex (decreased libido).
Blood and red bone marrow - a decrease in the number of leukocytes (leukocytopenia), granulocytes (agranulocytosis) in the blood.
Skin and its appendages - increased sensitivity of the skin to light (photosensitization), changes resembling manifestations of systemic lupus erythematosus.
Nervous system - development of the phenomena of parkinsonism with violation of motor functions of the nervous system, periodic attacks seizures, increased irritability, the appearance of drowsiness, depression, delusional thoughts, a violation of thermoregulation.
The digestive system - the development of constipation, jaundice, associated with a violation of excretion of bile from the structures of the hepatobiliary system into the cavity of the duodenum.
Cardiovascular system - decrease in the level of systemic arterial pressure when the position of the body changes from horizontal to vertical (orthostatic hypotension), frequent heart contractions (tachycardia).

With the development of negative pathological reactions against the background of the use of the drug, the need for its cancellation or correction of dosage is determined by the attending physician.

Overdose

Signs of overdose can develop with a single dose of a very large dose of sonapax, or with prolonged use of the drug in moderate or high doses.

In case of an overdose with sonapax, the patient may experience:

convulsions;
visual impairment;
dry skin;
violation of breathing (until it stops);
constipation;
violation of heart rate and rhythm;
drop in blood pressure;
shock;
defeat of the heart muscle;
severe oppression of consciousness or arousal;
motor disorders;
disturbances of urination (urinary retention).

It is worth noting that it is impossible to accurately determine the toxic dose of the drug, since it differs from the different people depending on body weight, general condition, the presence of concomitant diseases and so on. It is known that when the concentration of the active substance in the blood of a patient increases to 10 mg / l there are signs of an organism intoxication. With its further increase to 50 mg / l, death occurs due to the development of complications and impaired functions of vital organs.

At the same time, it is worth noting that a single application of 50-100 mg of the drug can be considered relatively safe and will never cause symptoms of intoxication (however other side reactions may develop).

special instructions

During treatment, patients should refrain from drinking alcohol.

During the treatment it is necessary to monitor the morphological composition of the blood.

The drug weakens motor coordination and reduces the speed of psychomotor reactions, especially at the beginning of treatment, therefore, during the period Patient treatment should refrain from driving and servicing moving equipment.

Interaction with other drugs

With the combined use of Sonapax with certain drugs / substances, these effects can develop:

antithyroid drugs: increased probability of agranulocytosis;
apomorphine: a reduction in the emetic effect, an intensification of the inhibitory effect on the central nervous system;
drugs that reduce appetite (except fenfluramine): a decrease in their effectiveness;
bromocriptine: interfering with its action;
prolactin: increasing its plasma concentration;
tricyclic antidepressants, maprotiline, monoamine oxidase inhibitors, histamine H1 receptor blockers: elongation / enhancement of m-cholinoblocking and sedative effects;
Thiazide diuretics: increased hyponatremia;
beta-blockers: increased antihypertensive effect, increased probability of irreversible retinopathy, tardive dyskinesia and arrhythmia;
anticoagulants: a decrease in their effect;
general anesthetics, narcotic analgesics, barbiturates, ethanol, atropine: synergy action;
amphetamine: antagonism of action;
hypoglycemic agents: increased hepatotoxic effect;
levodopa: a decrease in the antiparkinsonian action;
epinephrine: a sudden and pronounced lowering of blood pressure;
guanethidine: a decrease in its antihypertensive effect, but an increase in the effects of other antihypertensive drugs (the probability of significant orthostatic hypotension increases);
cimetidine, preparations with anticonvulsant action: weakening the action of Sonapax;
quinidine: potentiation of cardiodepressive action;
sympathomimetics: increased arrhythmogenic effect;
ephedrine: a paradoxical reduction in blood pressure;
procainamide, probucol, astemizole, disopyramide, cisapride, pimozide, erythromycin, and quinidine: an additional prolongation of the QT interval (the risk of ventricular tachycardia increases);
lithium preparations: increased expression of extrapyramidal disorders, a decrease in their absorption in the gastrointestinal tract, an increase in the rate of excretion kidneys of lithium ions (early symptoms of lithium intoxication in the form of nausea and vomiting may mask the antiemetic effect of Sonapax);
fluvoxamine, propranolol, pindolol: increased plasma concentration of thioridazine (the probability of arrhythmias increases);
drugs that extend the QT interval (cisapride), inhibitors of the isoenzyme CYP2D6 (paroxetine, fluoxetine): an increase in the likelihood of arrhythmia, including pirouette tachycardia.

Reviews

We offer you to read reviews of people who used the drug Sonapaks:

Michael. Sonapaks - can be safely called an effective tranquilizing drug. It costs cheap, there are many indications for taking, side effects are minor. Of the minuses is worth noting only the dosage - it should be selected with particular care. Yes, and the withdrawal of the medicine does not always pass painlessly for the patient himself.
Oksana. This drug saved me from panic attacks. It was a hard case, I did not even leave the house. After the hospital I was treated for 2 months. Now the condition has improved thanks to sonapax. Before that night I could not even sleep, I was overcome with some kind of anxiety, I did not even want to live. Said friends to drink valerian with kipreem, but it was like a dead poultice
Catherine. I want to tell all my patients and even sometimes hang a sign on the door of the office that Sonapaks is released from the pharmacy under the prescription for a reason. They will find the packing with the pills left by the grandmother, read the instructions and start drinking, and then they come to the reception with a bunch of problems. The medicine is good, but you can not use it yourself!

Doctors consider sonapax to be a rather effective drug used in the treatment of psychoses, schizophrenia and other psychiatric disorders, accompanied by productive symptoms (delusions, hallucinations, motor excitement and so on). The drug quickly eliminates the existing disorders, contributing to the stabilization of the patient's condition. At the same time, when taking the drug, doctors recommend patients to be under regular medical supervision with a view to timely detection and elimination of possible adverse reactions (which, as experts admit, develop in many patients).

In general, doctors argue that the proper and adequate use of sonapax is relatively safe for health and the life of the patient, however, if the regimen is taken or dosage, the consequences can be extremely difficult.

Analogues

Structural analogs for the active substance:

Melleril;
Thiodasin;
Thioridazine;
Thioril;
Tyson.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

The shelf life of Sonapax tablets is 4 years. The preparation is important to store in its original undamaged packaging, dark, dry, inaccessible to children at an air temperature of no more than + 25 ° C.