Tranquilizer Grandaxin

Grandaxin is a tranquilizer that reduces anxiety.

The active substance is a benzodiazepine derivative. It is different in its characteristics from its other derivatives (atypical benzodiazepine).

Unlike many other tools included in this group, Grandaxin's instruction positions itself as a strong anti-anxiety and an easy stimulant that has a subtle sedative effect. The difference is that when it is taken, there is almost no anticonvulsant and muscle relaxant activity of the active substance.

On this page you will find all information about Grandaxin: the full instructions for use for this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Grandaxin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Tranquilizer (anxiolytic).

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Grandaxin? The average price in pharmacies is at the level of450 rubles.

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Form of issue and composition

The form of release - tablets of 50 mg. 2 or 6 blisters of 10 tablets together with the instruction are placed in a separate cardboard package.

1 tablet contains 50 mg of tofizopam, excipients are stearic acid, magnesium stearate, gelatin, talc, complex carbohydrates (lactose monohydrate, potato starch, microcrystalline cellulose).

Externally, Grandaxin is a round, flat disk-shaped tablets of white color, sometimes with a grayish hue, there is a chamfer, with a risk on one side tablets and the inscription "GRANDAKH" on the other hand, almost odorless.

Pharmacological effect

Grandaxin is a tranquilizer of the benzodiazepine series. The main action is anxiolytic (soothing). Unlike other benzodiazepine tranquilizers, it does not have sedative, hypnotic, miorelaxing, anticonvulsant effects.

The medication regulates psychovegetatics, relieves of various vegetative disorders. Has a moderate stimulating effect. These pharmacological properties cause the drug to belong to daytime anxiolytics. Due to the absence of a muscle-relaxing effect, the drug can be taken with patients with myasthenia gravis and myopathy.

Atypicality of the chemical formula Tofizopama, which is very different from the structure of the classic anxiolytic benzodiazepine series, gives the drug a number of advantages:

in the therapeutic dose does not enhance the effect of ethanol;
does not cause withdrawal syndrome;
does not cause mental or physiological addiction.

The mechanism of action is associated with a stimulating effect on benzodiazepine receptors in the brain. Their excitation leads to an increase in the sensitivity of GABA receptors to the neurotransmitter. As a result, chlorine canals start to work more efficiently, hyperpolarization of nerve cell membranes increases, neuronal activity is weakened.

Indications for use

What helps? Grandaxin is used to treat:

Premenstrual syndrome;
Alcohol withdrawal syndrome;
Cardialgia (both as a monotherapeutic agent, and in combination with other drugs);
Reactive (psychogenic) depression with mildly expressed psychopathological symptoms;
Serious mental post-traumatic disorders associated with a single psychotraumatic situation or systematically recurring episodes;
Neuroses and pseudo-neurotic conditions (neuropsychiatric disorders, characterized by emotional stress, moderate increased anxiety, apathy, decreased activity, the appearance of compulsive experiences, autonomic disorders);
Neurogenic muscular atrophy, myopathy, myasthenia gravis and other pathological conditions that are accompanied by secondary neurotic symptoms and in which the use of anxiolytics (tranquilizers), which have a pronounced myorelaxing effect, is contraindicated;
Pathological menopause (in the annotation it is indicated that with a menopausal syndrome the drug can be prescribed both as an independent agent and as an adjunct to hormonal therapy).

Contraindications

Contraindications to taking medication are:

Decompensated respiratory failure.
Period of pregnancy (in particular, I trimester) and breastfeeding (lactation).
Hypersensitivity to the active ingredient or other auxiliary components of the drug.
Conditions accompanied by aggressiveness, irritability, marked psychomotor agitation or depression.
Joint use with cyclosporine, sirolimus, tacrolimus.
Congenital lack of lactase, galactose intolerance or malabsorption syndrome of galactose and glucose (Granaxin includes lactose monohydrate).
Syndrome of stopping breathing in a dream (available in a patient's history).

Grandaxin is administered with extreme caution in: acute respiratory failure in a patient's history, epilepsy, angle-closure glaucoma, decompensated chronic respiratory distress, organic brain damage (for example, with atherosclerosis).

Application in pregnancy and lactation

Grandaxin is contraindicated in the first trimester of pregnancy and lactation (breastfeeding).

Instructions for use

The instructions for use indicate that the dosage of Grandaxin is set individually, taking into account the patient's condition, clinical form of the disease and individual sensitivity to the drug.

Usually adults are prescribed 50-100 mg (1-2 tablets) 1-3 times / day.
With occasional use, you can take 1-2 tablets.
The maximum daily dose is 300 mg.

Elderly patients and patients with renal insufficiency daily dose reduced by about 2 times.

Side effects

The use of grandaxin can cause the following side effects from the central nervous system:

Psychomotor agitation;
Convulsive seizures (in patients with epilepsy);
Headache;
Confusion of consciousness;
Insomnia;
Increased irritability.

Grandaxin can cause the following side effects on the part of the digestive system:

Dry mouth;
Flatulence;
Cholestatic jaundice (in some cases);
Decreased appetite;
Nausea;
Constipation

On the part of the respiratory system, the use of grandaxin can lead to respiratory depression, the musculoskeletal system - to muscle pain and muscle tension.

Against the background of the use of the drug in some cases, allergic reactions in the form of exanthema (including scarlet fever exanthema) and skin itching.

Overdose

When ingestion of Grandaxin in high doses (50-120 mg / kg body weight) symptoms of oppression of functions can be observed CNS: blurred consciousness, vomiting, oppression of the respiratory center and / or epileptic seizures, coma.

If there is severe suppression of the CNS functions, do not induce vomiting. Gastric lavage is recommended. The purpose of activated carbon can reduce absorption of the drug. It is necessary to constantly monitor the main physiological parameters and conduct appropriate symptomatic therapy. Respiratory depression is an indication for artificial ventilation. Introduction of CNS stimulants is not recommended.

Hypotension is preferably eliminated by intravenous administration of fluids and by placing the patient in the Trendelenburg position. If these measures do not lead to normalization of blood pressure, the administration of norepinephrine (noradrenaline) or dopamine is allowed. The effectiveness of dialysis and forced diuresis is not proven. In extreme cases, it is possible to use flumazenil, a specific antagonist of benzodiazepine, but its use in an overdose of Tofizopam has not been adequately studied.

special instructions

Avoid drinking alcoholic beverages during treatment with this drug.
Each tablet of Grandaxin contains 92 mg of lactose, which should be taken into account for patients with lactose intolerance.
In patients with epilepsy, tofisopam may increase the threshold of convulsive readiness.
It should be borne in mind that in patients with mental retardation, elderly patients, in patients with impaired kidney and / or liver function more often than other patients, side effects can occur.
Care must be taken when treating patients with depersonalization, as well as with organic brain damage (for example, with atherosclerosis).
It is not recommended to apply tofizopam for chronic psychosis, phobia or obsessive conditions. In these cases, the risk of suicidal attempts and aggressive behavior increases. Therefore, Grandaxin is not recommended as a monotherapy for depression or depression accompanied by anxiety.

Grandaxin does not significantly reduce attention and the ability to concentrate.

Drug Interactions

Interaction of drugs can occur both with drugs taken earlier, and with those that are planned to be taken in the future. Please inform your doctor or pharmacist if you are currently or have recently taken any medicines, even non-prescription drugs. If you need to start taking any other drug (especially if it acts on the central nervous system) during treatment with Grandaxin or within one month after completion of treatment, please inform your doctor about treatment with Grandaxin.

Caution (medical supervision) is necessary if Grandaxin tablets are taken concomitantly with the following drugs:

if you take drugs acting on the central nervous system (eg, sedatives, drugs for depression, epilepsy, allergies, conditions psychosis, general anesthetics, hypnotics), immunosuppressive drugs, anticoagulants, antifungals, antiarrhythmics, cardiac glycosides (eg, digoxin), antihypertensive drugs, antacid and oral contraceptives, be sure to inform your doctor. Also, tell me if you drink alcoholic beverages all the time.

In these cases, direct medical observation or adjustment of the dose of concomitant medications may be necessary.

Reviews

We picked up some of the people's feedback on the drug Grandaxin:

Marina. I drank it once in a moment of intense stress. It really helps, it muffles emotions, it all happens a little bit, not with you. I drank a few days, then noticed that the action was not so strong, or the body was used to, or the stressful emotions began to be perceived differently, and I stopped taking it.
Nastya. It helped a lot in the moment of an unpleasant life situation. Removes obsessive experiences that prevent you from resting at night. In general, improves mood, there is no drowsiness and inhibition. Well suited to those who have heart problems in order to experience less. For severe cases, it does not work, but with mild depression and a decrease in mood at the time. Naturally, without the recommendation of a doctor can not be accepted.
Julia. These pills were attributed to my husband - after a series of career failures, the nerves were completely embarrassed. Already bought a medicine, and he somewhere read that Grandaxin on potency can influence - and in any of them to drink! Although I found information that this influence was not noticed, this is not an argument for him. I had to go to the doctor - ask to appoint an acceptable analog.
Karina. An excellent product! For my family was absolutely no money! Mom after surgery on the thyroid gland, my sister, during the postpartum severe depression, I sometimes take a pill at some time tension, depressive mood, decreased vitality, etc. As my aunt says: I drank a pill and the sun shines brighter! Excellent drug, it's a pity that a prescription! Sometimes one tablet would be enough just to not be depressed!