Amprilan

Amprilan is an antihypertensive agent that belongs to the group of angiotensin converting enzyme (ACE) inhibitors.

Has vasodilator effect, lowers arterial pressure. Effective in the therapy of chronic heart failure. After a heart attack, Amprilan reduces the risk of sudden death, prevents the development of chronic heart failure. Reduces the likelihood of developing nephropathy.

On this page you will find all information about Amprilan: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as feedback from people who have already applied Amprilan. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

ACE inhibitor.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Amprilan cost? The average price in pharmacies is at the level of300 rubles.

Form of issue and composition

Amprilan is produced in tablets. The drug is sold in blisters for 10 pcs.

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Amprilan, tablets 1.25 mg	1 tab.
Ramipril	1.25 mg
Excipients: sodium bicarbonate, lactose monohydrate, croscarmellose sodium, pregelatinized starch, sodium stearyl fumarate.

Amprilan, 5 mg tablets	1 tab.
Ramipril	5 mg
Excipients: sodium bicarbonate, lactose monohydrate, croscarmellose sodium, pregelatinized starch, sodium stearyl fumarate, dye mixture PB24899 pink (contains lactose monohydrate, iron oxide red (E172), iron oxide yellow (E172)).

Amprilan, tablets of 10 mg	1 tab.
Ramipril	10 mg
Excipients: sodium bicarbonate, lactose monohydrate, croscarmellose sodium, pregelatinized starch, sodium stearyl fumarate.

Pharmacological effect

According to the instructions for use Amprilan belongs to the group of ACE inhibitors (angiotensin-converting enzyme). The active substance Amprilana - Ramipril.

This effect of Amprilin as a reduction in pressure and hemodynamics is due to the expansion of the vessels, a decrease in peripheral resistance (the heart rhythm does not go astray). With prolonged use of Amprilan, the left ventricular hypertrophy decreases.

Decrease in pressure occurs usually one to two hours after taking a single dose of Amprilan. This effect lasts another day, and the maximum effect of Amprilan reaches in three to six hours. According to medical studies and reviews, Amprilan reduces the incidence of cardiovascular death, stroke, myocardial infarction in those at risk (those suffering from diseases peripheral vessels, diabetes, IHD, who have suffered a stroke), and are additionally susceptible to hypertension arterial, elevated cholesterol, microalbuminuria, and tobacco dependence.

According to the reviews Amprilan reduces mortality (by general indicators) and the need for revascularization. Amprilan prevents and slows the development of heart failure (chronic). In diabetics, Amprilan reduces the risk of developing nephropathy and microalbuminuria.

Indications for use

According to the instructions, Amprilan is shown in the following states:

Arterial hypertension.
Chronic heart failure, including after myocardial infarction (in combination with other drugs).
Nephropathy of a diabetic or non-diabetic nature, developed against a backdrop of chronic diffuse kidney diseases, including chronic glomerulonephritis accompanied by proteinuria.

Amprilan is also prescribed to reduce the risk of cardiovascular mortality, stroke, myocardial infarction in patients with confirmed coronary heart disease after coronary artery bypass grafting, with occlusive lesions of peripheral arteries.

Contraindications

Contraindications to the use of Amprilan are:

Pronounced arterial hypotension;
Metabolic disorders - galactose intolerance, lactase insufficiency;
The period of pregnancy and breastfeeding;
Age to 18 years;
Increased sensitivity of the body to ramipril and other components of the drug;
Angioedema in history;
Severe impairment of renal function;
Intolerance to galactose, lactase deficiency, or glucose-galactose malabsorption syndrome;
Chronic heart failure in the stage of decompensation.

According to the instructions, Amprilan should be used with caution in case of severe circulatory disorders, renal or hepatic insufficiency, diabetes mellitus.

Application in pregnancy and lactation

The presented medicine is forbidden to accept during the period of bearing of the child because it negatively affects the development of the fetus.

The baby may experience impaired kidney function, hypoplasia of the skull bones, hyperkalemia and hypoplasia of the lungs.

Therefore, before you start taking the drug in women of childbearing age, you need to exclude the presence of pregnancy. In case of diagnosing a woman's pregnancy, stop taking Amprilan as soon as possible.

If it is necessary to use the drug at the time of lactation, it is necessary to completely stop breastfeeding.

Instructions for use Amprilan

The instructions for use indicate that Amprilan tablets can not be chewed. The drug can be taken regardless of food. Dosing is selected individually. The tablet should be washed down with clean water in sufficient quantities. Long-term therapy with Amprilan is indicated.

Dosage regimens of Amprilan:

Status, indication	Initial dosage, mg	Maintenance dosage, mg	special instructions
Arterial hypertension	,	, -10	The dose is administered once a day. Increase the dose in 1-2 weeks. On the background of diuretic therapy, it is necessary to reduce the dose of diuretics three days before the start of Amprilan
CHF	, 5	, -10
Myocardial insufficiency in the post-infarction period (2-9 days)	, -5	5-10	The dose is divided into two doses. Doubling is done every few days. If the dosage is poorly tolerated at 5 mg / day, the drug is canceled
Nephropathy associated with diabetes, diffuse chronic kidney pathologies	, 5	5	Dose doubling is performed 1 time / 14 days. The dose is taken once a day
Reducing the risk of lethal cardiovascular complications	,	10	Dose doubling every week
Indications in patients with kidney pathologies (QC less than 30 ml / min)	, 5	5
Indications in patients with renal pathology	, 5	,
Indications in elderly patients	Dosage depends on the indices of blood pressure	It is important to monitor the status of patients on the background of diuretic therapy

Side effects

Amprilan, patients' reviews confirm this, can cause some side effects, this is:

From the sense organs: noise in the ears, violation of smell, sight, taste and hearing.
From the cardiovascular system: tachycardia, orthostatic collapse, orthostatic hypotension, arrhythmia, lowering blood pressure.
From the genitourinary system: a decrease in libido, proteinuria, the appearance or strengthening of signs of renal insufficiency.
On the part of the digestive system: cholestatic jaundice, nausea, vomiting, intestinal obstruction, dry mouth, glossitis, decreased appetite, stomatitis, hepatitis, pancreatitis.
On the part of the respiratory system: rhinorrhea, dyspnea, bronchospasm, rhinitis, sinusitis, bronchitis, dry cough.
From the central nervous system: anxiety, dizziness, tremor, drowsiness, weakness, excitability, frequent mood changes, headaches, muscle spasms, cerebral ischemia, paresthesia.

Also, according to reviews, Amprilan can cause allergic reactions, which are manifested: rash, hives, exudative erythema, photosensitization, swelling of extremities, larynx, pharynx, lips, tongue and face, as well as arthralgia, conjunctivitis, myositis, dermatitis, onycholysis.

Overdose

If you do not comply with the dosage developed by a specialist, then an overdose is observed, which is characterized by the presence of:

significant hypotension;
bradycardia;
pathological changes in the water-electrolyte balance;
renal failure of an acute nature;
shock state.

Therapeutic measures are aimed at cleaning the digestive tract, taking drugs with adsorbent properties, sodium sulfate.

special instructions

For patients with hepatic insufficiency, the initial dose is 1.25 mg, the maximum daily dose is 2.5 mg.
For patients with functional disorders of the kidneys, the initial dose of Amprilan should be 1.25 mg, and the maximum daily dosage should be 5 mg.
Amprilan is taken with caution in patients with systemic connective tissue diseases, diabetes mellitus, unstable angina.
When taking Amprilan during lactation, breastfeeding should be canceled.
If Amprilan is prescribed to patients taking diuretics, it is necessary to cancel or reduce the dosage of diuretics. It also requires constant monitoring of the condition of such patients, especially elderly patients (over 65 years of age).
The drug has a negative effect on the fetus (hypoplasia of the lungs and bones of the skull, hyperkalemia, disruption of the kidneys) and is contraindicated in pregnant women. Before discharge Amprilan women of childbearing age it is important to exclude pregnancy.

Drug Interactions

With the combined use of Amprilan with certain drugs / substances, the following effects are possible:

Glucocorticosteroids, tetracosactide: a decrease in antihypertensive action (due to fluid retention);
Potassium preparations, potassium-sparing diuretics, potassium-containing substitutes for edible salt: development of interaction (the combination is not recommended, regular monitoring of plasma potassium content and ECG parameters is necessary);
Lithium preparations: development of a reversible increase in serum lithium concentration;
Ethanol: increased oppressive effect on the central nervous system;
Vasopressornye sympathomimetics (norepinephrine, epinephrine): decreased antihypertensive action (with combined use, you need to carefully monitor blood pressure);
Thiazide diuretics: an increase in the concentration of lithium and the likelihood of its toxic effects;
Some drugs used in general anesthesia: increased antihypertensive action;
Oral hypoglycemic agents, insulin (in diabetes mellitus): increased hypoglycemic effect, increased tolerance to glucose (may require correction of their doses);
Non-steroidal anti-inflammatory drugs (non-selective COX inhibitors, for example, acetylsalicylic acid in anti-inflammatory effect doses): reduction of hypotensive the effect of Amprilan, an increase in the probability of functional impairment of the kidneys, an increase in serum potassium content with existing renal dysfunction;
Antipsychotic drugs (antipsychotics), tricyclic antidepressants: increased antihypertensive action and increased risk of development of orthostatic hypotension (additive effect);
Immunosuppressants, cytostatic agents, procainamide, allopurinol, glucocorticosteroids (for systemic use): an increase in the likelihood of leukopenia;
Gold preparation (intravenous injection of sodium aurothiomalate): development of nitrate-like reactions (in the form of nausea, vomiting, flushing of the facial skin, pronounced lowering of blood pressure).

Reviews

The drug has proved to be an effective tool in the therapy of heart failure of varying severity. Reviews of the tablets indicate a good tolerability of the drug and its high effectiveness in the treatment of hypertension.

Analogues

Structural analogs for the active substance:

Amprilan NL;
Amprilan ND;
Vazolong;
Dilaprel;
Korpril;
Pyrimil;
Ramigamma;
Ramicardium;
Ramipril;
Tritace;
Hartil;
Hartil D.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Amprilan should be stored in a dry place inaccessible to children. Tablets of 1.25 mg have a shelf life of 2 years, tablets 2.5 mg, 5 mg, 10 mg - 3 years.