Suprastin

Suprastin is a popular antihistamine drug that provides anti-allergic, anti-edematous and antipruritic effect.

It is widely used for the treatment of allergic conditions and the treatment of inflammatory airway diseases in adults and children. The drug has a pronounced anti-allergic effect. It is available in the form of a solution intended for intramuscular or intravenous administration. Suprastin is used to treat diseases that are allergic.

The drug is prescribed for patients suffering from hives, conjunctivitis, dermatitis, serum sickness, eczema in acute or chronic form.

Clinical and pharmacological group

The blocker of histamine H1 receptors. Anti-allergic drug.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does Suprastin cost in pharmacies? The average price is at the level of125 rubles.

Composition and form of release

Suprastin tablets are white, round in shape and flat-cylindrical. The main active ingredient of the drug is chloropyramine, its content in one tablet is 25 mg. It also includes auxiliary substances, which include:

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Carboxymethyl starch of sodium.
Gelatin.
Potato starch.
Stearic acid.
Lactose monohydrate.
Talc.

Tablets are packaged in a blister for 10 pieces. Cardboard pack contains 2 blisters with tablets, as well as instructions for the use of the drug.

pharmachologic effect

Chloropyramine blocks specific H1-receptors. The drug is characterized by antihistamine and m-holinoblokiruyuschim action, as well as moderate spasmolytic activity.

When taking per os absorption of Suprastin in the digestive tract occurs quickly and in full. The action begins 15-30 minutes later, and the maximum effect is fixed after 1 hour and lasts from 3 to 6 hours.

The substance is evenly distributed in the body tissues and biological fluids. He freely passes the blood-brain and hematoplacental barriers. Biotransformation of the active substance takes place in the liver, and it is excreted through the kidneys. Excretion of the drug in children is much more intense.

Indications for use

What helps? Among the indications are:

allergy to medicines and food;
allergic rhinitis (rhinitis) and conjunctivitis;
serum sickness;
allergic skin rashes;
hypersensitivity reaction in bites of non-venomous insects;
itching;
atopic dermatitis;
contact dermatitis;
eczema.

With such a severe hypersensitivity reaction, like Quincke's edema, the drug is given in the form of injections (the pills are used as an adjuvant).

Contraindications

The drug is contraindicated in case of:

hypersensitivity to individual components of the drug;
deficiency of lactase and lactose intolerance;
with acute manifestations of bronchial asthma.

The drug in the form of tablets or injections with caution is prescribed for children with eye disease, kidney and liver pathology, in case of urinary retention, heart defects.

Intended use for pregnancy and lactation

During pregnancy, the appointment of Suprastin is not allowed in the first trimester and in the last month. As for the rest of the period, it is a relative contraindication. In this case, the treatment is carried out strictly for medical purposes and under the supervision of a specialist.

The active substance of the drug easily penetrates the placental barrier, its effect can negatively affect the development of the unborn child during the period of the laying of the main organs and systems. Chloropyramine easily penetrates into breast milk, so if there is a need for the drug during lactation, breastfeeding is temporarily stopped.

Dosage and route of administration

As indicated in the instructions for use, suprastin tablets are taken orally at the same time as food intake, do not chew and drink with sufficient water.

Dosing regimen:

children aged 3-6 years: ½ pcs. (12.5 mg) twice daily;
children aged 6-14 years: ½ pcs. (12.5 mg) 2-3 times a day;
children over 14 years and adults: 1 pc. (25 mg) 3-4 times a day; daily dose of 75-100 mg.

If the patient has no side effects, the dose can be gradually increased, but the maximum daily dose should not exceed 2 mg / kg of body weight.

The course of therapy depends on the symptoms of the disease, its duration and clinical course.

Side effect

Most often, suprastin causes the development of side effects from the central nervous system and digestive tract. Less often, there are violations from the cardiovascular system and hematopoiesis system. In most cases, side effects disappear 4 to 6 hours after drug withdrawal. For further treatment, you need to contact your doctor to replace your suprastin with a more appropriate drug.

There are the following side effects of suprastin from the side of the central nervous system: decreased concentration of attention;

headache;
euphoria;
psychomotor agitation;
convulsions;
tremor (trembling);
athetozopodobnye movements (twisting limbs);
violation of coordination of movements;
general weakness;
drowsiness;
depression;
increased body temperature;
anxiety;
hallucinations, etc.

There are the following side effects of suprastin from the gastrointestinal tract:

dry mouth;
diarrhea;
constipation;
nausea;
vomiting;
pain in the peritoneal region of the abdomen;
a violation of appetite, etc.

From the side of the cardiovascular system and the hemopoietic system, the following side effects are distinguished:

occurrence of arrhythmia;
agranulocytosis (decrease in the number of neutrophils, eosinophils and basophils circulating in the blood);
lowering blood pressure;
paradoxical increase in blood pressure;
increased heart rate;
leukopenia (decrease in the number of leukocytes circulating in the blood).

Among other side effects, there is sometimes an increase in intraocular pressure, especially dangerous if the patient has an angle-closure glaucoma. Such a condition can eventually lead to atrophy of the optic nerve and irreversible blindness. Also, suprastin in rare cases can aggravate the retention of urination in patients with prostatic adenoma.

Overdose

In case of an overdose of Suprastin, serious adverse reactions from the nervous system may occur. In adults, there is a violation of coordination of movements, anxiety, ataxia, fever. The period of short excitement ends with cramps, post-convulsive depression, or confluence with a coma.

In children with an overdose, the pupils are dilated, excited, anxious, red face, urinary retention, signs of tachycardia. In the absence of timely assistance, a child may fall into a coma. In such conditions, patients are rinsed with stomach, prescribe sorbents, perform symptomatic therapy or carry out rehabilitation measures.

special instructions

Before starting treatment, read the special instructions:

Taking the drug at night can increase the symptoms of reflux esophagitis.
When combined with ototoxic drugs, Suprastin can mask the early signs of ototoxicity.
Suprastin can strengthen the effect of ethanol on the central nervous system, and therefore during the use of Suprastin should avoid the use of alcoholic beverages.
Diseases of the liver and kidneys may require a change (decrease) in the dose of the drug, in connection with which the patient should inform the doctor about the presence of a liver or kidney disease.

Prolonged use of antihistamines may lead to violations of the hematopoiesis system (leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia). If during prolonged use there is an unexplained increase in body temperature, laryngitis, pale skin, jaundice, the formation of ulcers in the mouth, the appearance of hematomas, unusual and long-lasting hemorrhages, it is necessary to conduct a clinical blood test with the definition of the number of uniform elements. If the results of the analysis indicate a change in the blood formula, the drug is stopped.

Interaction with other drugs

When prescribing the drug, it is necessary to take into account interactions with other drugs:

The drug enhances the effect of barbiturates, M-holinoblokatorov, opioid analgesics.
MAO inhibitors can enhance and prolong the anticholinergic action of chloropyramine.
When combined with ototoxic drugs, Suprastin can mask the signs of ototoxicity.
Antihistamines can distort the results of cutaneous allergological tests, therefore, a few days before the planned test, the intake of this group should be stopped.

Reviews

We offer to familiarize with reviews of people who used the drug Suprastin:

Catherine. And I have allergic edema. I bought various drugs, and cheap and expensive, suprastin helps the best (in general, the only thing that helps). True, two tablets at a time. And after taking "cuts", 30-40 minutes to sleep. But everything passes.
Veronica. I can not say anything bad about this drug, as the daughters always prescribed suprastin for allergies and it helped in specific cases. There was certainly some drowsiness, but antiallergic drugs always almost cause it, it's normal. If you choose the right dosage and carefully handle the medicine, which means treating your health carefully, then there will be no global problems.
Maria. I'm allergic since childhood, an allergy to food, and it's not always possible to understand that I ate the one that caused the rash. Suprastin for me will not replace. He quickly removes allergy symptoms, a rash and itching pass for a couple of days. The only drawback is that the pills are bitter. Well, Suprastin is not cheap.

Analogues

Structural analogs for the active substance:

Chloropyramine;
Chloropyramine-Ferein;
Chloropyramine hydrochloride.

According to the mechanism of action, the main analogues of Suprastin are Dimedrol, Tavegil, Diazolin, Claritin, Cetrin, Zirtek.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Suprastinum in the form of tablets or solution for injection should be stored in a dry place at a temperature of 15 to 25 degrees. Keep away from children. Shelf life of the medicinal product is 5 years from the date of manufacture.